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| 1 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 2 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 3 | Control of Bird Feeding Behavior by Tannin1 through Modulating the Biosynthesis of Polyphenols and Fatty Acid-Derived Volatiles in Sorghum显示文摘Bird predation during seed maturation causes great loss to agricultural production.In this study,through GWAS analysis of a large-scale sorghum germplasm diversity panel,we identified that Tannin1,which encodes a WD40 protein functioning in the WD40/MYB/bHLH complex,controls bird feeding behavior in sorghum.Metabolic profiling analysis showed that a group of sorghum accessions preferred by birds contain mutated tan1-a/b alleles and accumulate significantly lower levels of anthocyanins and condensed tannin compounds.In contrast,a variety of aromatic and fatty acid-derived volatiles accumulate at significantly higher levels in these bird-preference accessions.We subsequently conducted both sparrow feeding and sparrow volatile attractant assays,which confirmed,respectively,the antifeedant and attractant functions of these differentially accumulated metabolites.In addition,the connection between the biosynthesis pathway of anthocyanin and proanthocyanidin and the pathway of fatty acid–derived volatile biosynthesis was demonstrated by discovering that Tannin1 complex modulates fatty acid biosynthesis by regulating the expression of SbGL2 in sorghum,thus affecting the accumulation of fatty acid-derived volatiles.Taken together,our study identified Tannin1 as the gene underlying the major locus controlling bird feeding behavior in sorghum,illustrating an example of the identification of an ecologically impactful molecular mechanism from field observation and providing significant insights into the chemistry of bird–plant ecological interactions. | Peng Xie Jiayang Shi Sanyuan Tang Chengxuan Chen Aimal Khan Fengxia Zhang Ying Xiong Chao Li Wei He Guodong Wang Fumin Lei Yaorong Wu Qi Xie | 2019 | Molecular Plant2019，12，10： | 8 |
| 4 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 5 | An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T(CAR-T) cells显示文摘Anti-CD19 chimeric antigen receptor-modified T(CAR-T-19) cells have emerged as a powerful targeted immunotherapy for B-cell lineage acute lymphoblastic leukemia with a remarkable clinical response in recent trials. Nonetheless, few data are available on the subsequent clinical monitoring and treatment of the patients, especially those with disease recurrence after CAR-T-19 cell infusion. Here, we analyzed three patients who survived after our phase I clinical trial and who were studied by means of biomarkers reflecting persistence of CAR-T-19 cells in vivo and predictive factors directing further treatment. One patient achieved 9-week sustained complete remission and subsequently received an allogeneic hematopoietic stem cell transplant. Another patient who showed relapse after 20 weeks without detectable leukemia in the cerebrospinal fluid after CAR-T-19 cell treatment was able to achieve a morphological remission under the influence of stand-alone low-dose chemotherapeutic agents. The third patient gradually developed extensive extramedullary involvement in tissues with scarce immune-cell infiltration during a long period of hematopoietic remission after CAR-T-19 cell therapy. Long-term and discontinuous increases in serum cytokines(mainly interleukin 6 and C-reactive protein) were identified in two patients(Nos. 1 and 6) even though only a low copy number of CAR molecules could be detected in their peripheral blood. This finding was suggestive of persistent functional activity of CAR-T-19 cells. Combined analyses of laboratory biomarkers with their clinical manifestations before and after salvage treatment showed that the persistent immunosurveillance mediated by CAR-T-19 cells would inevitably potentiate the leukemia-killing effectiveness of subsequent chemotherapy in patients who showed relapse after CAR-T-19-induced remission. | Yajing Zhang Wenying Zhang Hanren Dai Yao Wang Fengxia Shi Chunmeng Wang Yelei Guo Yang Liu Meixia Chen Kaichao Feng Yan Zhang Chuanjie Liu Qingming Yang Suxia Li Weidong Han | 2016 | Science China(Life Sciences)2016，59，4： | 6 |
| 6 | GATA family members as inducers for cellular reprogramming to pluripotency显示文摘GATA 蛋白质家庭的成员在系说明和 transdifferentiation 起重要作用。以前的报告证明 GATA 蛋白质家庭罐头的一些成员也由代替 Oct4 在体的房间导致 pluripotency,一个关键联系 pluripotency 的因素。然而,连接指定系的暗示的机制和 pluripotency 的激活留下逃犯。这里,我们报导所有 GATA 家庭成员能代替让 Oct4 导致 pluripotency。我们发现 GATA 家庭的所有成员能禁止 overrepresented ectodermal 系基因,它与以前的报告显示不同指定系的力量的平衡为 pluripotency 的恢复是重要的一致。一根保存锌手指在 C 终点的 DNA 有约束力的领域是批评的让 GATA 家庭导致 pluripotency。用 RNA-seq 和 ChIP-seq,我们决定 pluripotency 相关的基因 Sall4 在 reprogramming 期间是 GATA 家庭成员的一个直接目标并且用作连接指定系的 GATA 家庭到 pluripotency 电路的一座桥。因此, GATA 家庭是所有成员能作为 reprogramming 进程的 inducers 工作并且能代替 Oct4 的第一个蛋白质家庭。我们的结果建议在 reprogramming 的 GATA 家庭的角色被低估了并且 GATA 家庭可以担任房间命运变换的一个重要调停人。 | Jian Shu Ke Zhang Minjie Zhang Yao Sida Shao Fengxia Du Caiyun Yang Wenhan Chen Chen Wu Weifeng Yang Yingli Sun Hongkui Deng | 2015 | Cell Research2015，25，2： | 5 |
| 7 | Clinical value of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy in the treatment of advanced non-small cell lung cancer: a Meta-analysis显示文摘OBJECTIVE: To investigate the clinical efficacy and safety of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy in the treatment of advanced non-small celllung cancer(NCSLC) compared with chemotherapy alone.METHODS: Databases including Chinese National Knowledge Infrastructure, China Biology Medicine Disc, Wanfang, and MEDLINE were searched until April 1, 2014. Two assessors independently reviewed each trial. The primary outcome was the effective rate(ER) of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy. The secondary outcomes included quality of life improvement rate(QOLIR) and adverse reactions. Statistical calculations were performed by using Cochrane Collaboration Review Manager 5.2.RESULTS: A total of 888 patients from 15 studies,13 randomized controlled trials(RCT) and two controlled clinical trials, were included. Compared with chemotherapy alone, Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract plus chemotherapy significantly improved ER [Risk ratio(RR) =1.32, 95% CI,(1.14, 1.54)](based on 15 studies) and QOLIR [RR = 2.04, 95% CI,(1.69, 2.47)](based on 13studies). Compared with chemotherapy alone,Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract plus chemotherapy significantly inhibited chemotherapy-induced white blood cell decline [RR = 0.79, 95% CI,(0.70, 0.90)(based on 10 studies), chemotherapy-induced platelet decline[RR = 0.77, 95% CI,(0.60, 0.98)](based on 8 studies),and significantly alleviated nausea and vomiting(NV) [RR = 0.83, 95% CI,(0.71, 0.97)](based on 7studies). There was no significant difference in hemoglobin decline between the two therapies [RR =0.88, 95% CI,(0.70, 1.09)](based on 6 studies).CONCLUSION: This Meta-analysis suggests that Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy may be more efficacious in the treatment of advanced NSCLC than chemotherapy alone. This effect includes enhancing ER and QOLIR, and weakening chemotherapy toxicity. However, large-scale RCTs are required to further investigate the short- and long-term effects of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract. | Zhang Haiming Zhang Junli Ding Hao Chen Rui Liang Fengxia | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 4 |
| 8 | Hexagonal boron nitride:A metal-free catalyst for deep oxidative desulfurization of fuel oils显示文摘Oxidative desulfurization(ODS)has been proved to be an efficient strategy for the production of clean fuel oil.Numerous metal-based materials have been employed as excellent ODS catalysts,but being hindered by their high-cost and potential secondary pollution.In this work,we employed graphene analogous hexagonal boron nitride(h-BN)as a metal-free catalyst for ODS with hydrogen peroxide(H2O2)as the oxidant.The h-BN catalyst was characterized and proved to be a few-layered structure with relatively high specific surface areas.The h-BN catalyst showed a 99.4%of sulfur removal in fuel oil under the optimized reaction conditions.Besides,the h-BN can be recycled for 8 times without significant decrease in the catalytic performance.Detailed mechanism analysis found that it is the boron radicals in h-BN activated H2O2 to generate·OH species,which can readily oxidize sulfides to corresponding sulfones for separation.This work would provide another choice in choosing metal-free catalysts for ODS. | Peiwen Wu Linjie Lu Jing He Linlin Chen Yanhong Chao Minqiang He Fengxia Zhu Xiaozhong Chu Huaming Li Wenshuai Zhu | 2020 | Green Energy & Environment2020，5，2： | 3 |
| 9 | A TiO_(2)nanotubes film with excellent antireflective and near-perfect self-cleaning performances显示文摘SiO_(2)/TiO_(2)composite films have been frequently used to realize the functions of self-cleaning and antireflection.Increasing the TiO_(2)volume ratio in SiO_(2)/TiO_(2)composite film is beneficial to enhance the self-cleaning effect,while high TiO_(2)content leads to a strong Rayleigh scattering and depresses the antireflective performance,resulting in a bottleneck problem for the dual-functional application.Here,we have achieved a high-quality TiO_(2)nanotubes film with excellent antireflective and near-perfect selfcleaning performances.Ultrasound assisted pickling method has been developed to effectively prepare the well-dispersed protonated titanate nanotubes colloid.After spin-coating and annealing treatment,glass substrate coated with double-side TiO_(2)nanotubes film has a peak transmittance of 99.2%and average transmittance of 97.4%at 400-800 nm.Ultra-high porosity of TiO_(2)nanotubes film(80%)and ultra-fine size of TiO_(2)nanotubes(8.6 nm in outer diameter)lead to excellent antireflective performance.With high UV absorptivity(80%at 254 nm)and formal quantum efficiency of stearic acid(10.9×10^(-3)),TiO_(2)nanotubes film shows near-perfect self-cleaning performance.A persistent anti-fogging ability is also presented.This study demonstrates the feasibility to fabricate pure TiO_(2)antireflective coating for glass substrate,extends application field of the classic TiO_(2)nanotubes,and sheds lights on the practical applications of high-powered TiO_(2)nanotube-based multi-functional films. | Kaibin Li Ming Li Chang Xu Zengyan Du Jiawang Chen Fengxia Zou Chongwen Zou Sichao Xu Guanghai Li | 2021 | Journal of Materials Science & Technology2021，，29： | 3 |
| 10 | Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals显示文摘The global Coronavirus disease 2019(COVID-19)pandemic caused by SARS-CoV-2 has affected more than eight million people.There is an urgent need to investigate how the adaptive immunity is established in COVID-19 patients.In this study,we proled adaptive immune cells of PBMCs from recovered COVID-19 patients with varying disease severity using single-cell RNA and TCR/BCR V(D)J sequencing.The sequencing data revealed SARS-CoV-2-specic shufing of adaptive immune repertories and COVID-19-induced remodeling of peripheral lymphocytes.Characterization of variations in the peripheral T and B cells from the COVID-19 patients revealed a positive correlation of humoral immune response and T-cell immune memory with disease severity.Sequencing and functional data revealed SARS-CoV-2-specic T-cell immune memory in the convalescent COVID-19 patients.Furthermore,we also identied novel antigens that are responsive in the convalescent patients.Altogether,our study reveals adaptive immune repertories underlying pathogenesis and recovery in severe versus mild COVID-19 patients,providing valuable information for potential vaccine and therapeutic development against SARS-CoV-2 infection. | Fan Zhang Rui Gan Ziqi Zhen Xiaoli Hu Xiang Li Fengxia Zhou Ying Liu Chuangeng Chen Shuangyu Xie Bailing Zhang Xiaoke Wu Zhiwei Huang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 11 | A novel recombinant DNA vaccine encodingMycobacterium tuberculosis ESAT-6 and FL protects againstMycobacterium tuberculosis challenge in mice显示文摘Mycobacterium tuberculosis 6-kDa early secretory antigenic target(ESAT-6)is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis.The fms-like tyrosine kinase 3 ligand(FL)that induces potent immune response has been used as an adjuvant in vaccine development.In this study,a new recombinant plasmid(pIRES-epitope-peptides-FL)encoding three T cell epitopes of ESAT-6 and FL was constructed,and the immunogenicity of the DNA vaccine was assessed in C57BL/6 mice immunized with the plasmid DNA vaccine.Additionally,a strategy of intramuscular injection with the DNA vaccine(prime)and intranasal administration of the epitope peptides(boost)was employed to induce higher immune reaction of the mice.The results showed that mice vaccinated with the recombinant plasmid DNA vaccine and boosted with the peptides not only increased the levels of Th1 cytokines(IFN-γand IL-12),the number of IFN-γ+T cells and activities of cytotoxic T lymphocytes as well as IgG,but also enhanced protection against Mycobacterium tuberculosis challenge.In conclusion,these data indicate that the novel recombinant pIRES-epitope-peptides-FL plasmid is a useful DNA vaccine for preventing Mycobacterium tuberculosis infection. | Qingtao Jiang Jing Zhang Xia Chen Mei Xia Yanlai Lu Wen Qiu Ganzhu Feng Dan Zhao Yan Li Fengxia He Guangyong Peng Yingwei Wang | 2013 | The Journal of Biomedical Research2013，27，5： | 2 |
| 12 | The pathogens of pelvic inflammatory disease 显示文摘 | LEI Ying WANG Chen XUE Fengxia | 2013 | J Pract Obstet Gynecol2013，29，10： | 1 |
| 13 | Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations显示文摘 | Jing Chen Wenzhao Wang Shen Lv Peiyuan Yin Xinjie Zhao Xin Lu Fengxia Zhang Guowang Xu | 2009 | Analytica Chimica Acta2009，，1： | 1 |
| 14 | Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways显示文摘 | Yong Gao Yun Zhao Jingzi Pan Liu Yang Tingting Huang Xiaomin Feng Chao Li Shujing Liang Dingfu Zhou Chan Liu Fengxia Tu Cai Tao Xiang Chen | 2014 | Brain Research2014，，： | 1 |
| 15 | Analysis of adverse events following the treatment of autologous cytokine-induced killer cells for adoptive immunotherapy in malignant tumour sufferers显示文摘 | Yajing Zhang Lei Xia Yan Zhang Yao Wang Xuechun Lu Fengxia Shi Yang Liu Meixia Chen Kaixhao Feng Wenying Zhang Xiaobing Fu Weidong Han | 2015 | Expert Opinion on Biological Therapy2015，，： | 1 |
| 16 | Pollution status of the Bohai Sea: An overview of the environ- mental quality assessment related tra-ce metals显示文摘 | Gao Xuelu Zhou Fengxia Chen C T A | 2014 | Environment International2014，62，： | 1 |
| 17 | Transformation of microstructure and phase of disodium guanosine 5′-monophosphate: Thermodynamic perspectives显示文摘Microstructure and phase transformation of disodium guanosine 5′-monophosphate(5′-GMPNa_2) are extremely important for controlling the process and understanding the mechanism of crystallization. In this work, the thermodynamic properties of polymorphous 5′-GMPNa_2 especially the solubility were studied, the solubility results show that 5′-GMPNa_2 is more soluble in ethanol–water(E–W) than in isopropanol–water(I–W). The amorphous form of 5′-GMPNa_2 is more soluble than the crystalline form at the same mole fraction and temperature. Meanwhile, the crystalline forms and morphologies of the residual solids were characterized by PXRD and SEM. The results indicate that solid forms of 5′-GMPNa_2 transformed spontaneously from amorphous to crystalline when the ethanol proportion is ≥20%. In addition, increasing the pH facilitates the dissolution of 5′-GMPNa_2 and helps to maintain the crystalline form. The associated Gibbs free energy values were calculated to verify the trend of transformation from amorphous to crystalline 5′-GMPNa_2. These results should help to guide the industrial crystallization process and to obtain the crystalline form of 5′-GMPNa_2. | Qiao Chen Fengxia Zou Pengpeng Yang Jingwei Zhou Jinglan Wu Wei Zhuang Hanjie Ying | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 18 | Regulation of nitrogen starvation responses by the alarmone(p)ppGpp in rice显示文摘Nitrogen is an essential macronutrient for all living organisms and is critical for crop productivity and quality.In higher plants,inorganic nitrogen is absorbed through roots and then assimilated into amino acids by the highly conserved glutamine synthetase/glutamine:2-oxoglutarate aminotransferase(GS/GOGAT)cycle.How nitrogen metabolism and nitrogen starvation responses of plants are regulated remains largely unknown.Previous studies revealed that mutations in the rice ABNORMAL CYTOKININ RESPONSE1(ABC1)gene encoding Fd-GOGAT cause a typical nitrogen deficiency syndrome.Here,we show that ARE2(for ABC1 REPRESSOR2)is a key regulator of nitrogen starvation responses in rice.The are2 mutations partially rescue the nitrogen-deficient phenotype of abc1 and the are2 mutants show enhanced tolerance to nitrogen deficiency,suggesting that ARE2 genetically interacts with ABC1/Fd-GOGAT.ARE2 encodes a chloroplast-localized Rel A/Spo T homolog protein that catalyzes the hydrolysis of guanosine pentaphosphate or tetraphosphate(p)pp Gpp,an alarmone regulating the stringent response in bacteria under nutritional stress conditions.The are2 mutants accumulate excessive amounts of(p)pp Gpp,which correlate with lower levels of photosynthetic proteins and higher amino acid levels.Collectively,these observations suggest that the alarmone(p)pp Gpp mediates nitrogen stress responses and may constitute a highly conserved mechanism from bacteria to plants. | Hanwen Li Jinqiang Nian Shuang Fang Meng Guo Xiahe Huang Fengxia Zhang Qing Wang Jian Zhang Jiaoteng Bai Guojun Dong Peiyong Xin Xianzhi Xie Fan Chen Guodong Wang Yingchun Wang Qian Qian Jianru Zuo Jinfang Chu Xiaohui Ma | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 19 | Diagnostic and therapeutic advancements for aerobic vaginitis显示文摘 | Cha Han Wenjuan Wu Aiping Fan Yingmei Wang Huiying Zhang Zanjun Chu Chen Wang Fengxia Xue | 2015 | Archives of Gynecology and Obstetrics2015，，2： | 1 |
| 20 | Wearable multichannel pulse condition monitoring system based on flexible pressure sensor arrays显示文摘Pulse diagnosis is an irreplaceable part of traditional Chinese medical science.However,application of the traditional pulse monitoring method was restricted in the modernization of Chinese medical science since it was difficult to capture real signals and integrate obscure feelings with a modern data platform.Herein,a novel multichannel pulse monitoring platform based on traditional Chinese medical science pulse theory and wearable electronics was proposed.The pulse sensing platform simultaneously detected pulse conditions at three pulse positions(Chi,Cun,and Guan).These signals were fitted to smooth surfaces to enable 3-dimensional pulse mapping,which vividly revealed the shape of the pulse length and width and compensated for the shortcomings of traditional single-point pulse sensors.Moreover,the pulse sensing system could measure the pulse signals from different individuals with different conditions and distinguish the differences in pulse signals.In addition,this system could provide full information on the temporal and spatial dimensions of a person’s pulse waveform,which is similar to the true feelings of doctors’fingertips.This innovative,cost-effective,easily designed pulse monitoring platform based on flexible pressure sensor arrays may provide novel applications in modernization of Chinese medical science or intelligent health care. | Jie Wang Yirun Zhu Zhiyong Wu Yunlin Zhang Jian Lin Tao Chen Huicong Liu Fengxia Wang Lining Sun | 2022 | Microsystems & Nanoengineering2022，8，1： | 1 |
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