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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 3 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 4 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 5 | Human glandular kallikrein 2: a potential serum marker for predicting the organ confined versus nonorgan confined growth of prostate cancer显示文摘 | Haese A Becker C Noldus J | 2000 | J Urol2000，163，5： | 1 |
| 6 | Chromosomal aberrations in follicular non-Hodgkin lymphomas of Japanese patients,detected with comparative genomic hybridization and polymerase chain reaction analysis显示文摘 | D'Haese J G Tsukasaki K Cremer F W | 2005 | Cancer Genet Cytogenet2005，162，2： | 1 |
| 7 | Treatment options in painful chronic pancreatitis: a systematic review显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Elke Tieftrunk Helmut Friess | 2014 | HPB2014，，6： | 1 |
| 8 | Romosozumab in postmenopausal women with osteopenia显示文摘 | Evenepoel P D'Haese P Brandenburg V | 2014 | N Engl J Med2014，370，17： | 1 |
| 9 | Self-organizing feature maps with self-adjusting learning parameter 显示文摘 | HAESE K | 1998 | IEEE Transaction on Neural Networks1998，9，6： | 1 |
| 10 | Human Glandular Kallikrein2:A Potential Serum for Predicting the Organ Confined Versus Non-organ Confined Growth of Prostate Cancer显示文摘 | Noldus J | 2000 | Urol2000，163，： | 1 |
| 11 | High prevalence of adynamic bone disease diagnosed by biochemical markers in a wide sample of the European CAPD population显示文摘 | Couttenye MM D'Haese PC Deng JT | 1997 | Nephrol Dial Transplant1997，12，： | 1 |
| 12 | Vascular calcification and bone disease:The calcification paradox显示文摘 | Persy V D'Haese P | 2009 | Trends Mol Med2009，15，： | 1 |
| 13 | Significance and metabolism of complexed and noncomplexed prostate-specific antigen (PSA)forms and human glandular kallikrein 2 (hk2) in localized prostate cancer before and after radical prostatectomy显示文摘 | Lilja H Haese A Bjork T | 1999 | J Urol1999，162，2： | 1 |
| 14 | A muhicenter study on the effects of lanthanum carbonate( Fosrenol TM)and calcium carbonate on renal bone disease in dialysis patients 显示文摘 | Haese PC Spasovski GB Sikole A | 2003 | Kidney Int2003，，： | 1 |
| 15 | The relationship between Prostate Cancer gene 3 (PCA3) and prostate cancer significance显示文摘 | VAN POPPEL H HAESE A GRAEFEN M | 2012 | BJU Int2012，109，3： | 1 |
| 16 | Restoration of Bone Mineralization by Cinacalcet is Associated with a Significant Reduction in Calcitriol-Induced Vascular Calcification in Uremic Rats显示文摘 | Tineke M. Schutter Geert J. Behets Susanne Jung Ellen Neven Patrick C. D’Haese Uwe Querfeld | 2012 | Calcified Tissue International2012，，5： | 1 |
| 17 | Al and Si:their speciation,distribution,and toxicity显示文摘 | Glen F Van Landeghem Marc E De Broe Patrick C D'Haese | 1998 | Clinical Biochemistry1998，31，5： | 1 |
| 18 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 19 | Mitochondrial genome data alone are not enough to unambiguously resolve the relationships of Entognatha, Insecta and Crustacea sensu lato (Arthropoda)显示文摘 | Cameron S L Miller K B D'Haese C A | 2004 | Cladistics2004，20，： | 1 |
| 20 | High prevalence of adynamic bone disease diagnosed by biochemical markers in a wide sample of the European CAPD population显示文摘 | Couttenye MM D' Haese PC Deng JT Van Hoof VO | 1997 | Nephrol Dial Transplant1997，12，10： | 1 |
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