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| 1 | Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure显示文摘Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic infection.Guidelines recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is weak.Since HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily immunemediated.Therefore,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B.Here wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters. | Jan-Hendrik Bockmann Maura Dandri Stefan Lüth Nadine Pannicke Ansgar W Lohse | 2015 | World Journal of Gastroenterology2015，21，7： | 13 |
| 2 | Unraveling the Acidithiobacillus caldus complete genome and its central metabolisms for carbon assimilation显示文摘Acidithiobacillus caldus 是在 bioleaching 反应堆的主导的氧化硫的细菌之一。它在在 bioleaching 过程期间维持减少的无机的硫混合物的高酸味和氧化起必要作用。在这份报告, A 的完全的染色体顺序。caldus SM-1 被介绍。染色体由一个染色体(2,932,225 bp ) 和四 plasmids 组成(pLAtc1, pLAtc2, pLAtc3, pLAtcm ) 并且它富于重复序列(为 11% 全部的染色体的财务) ,它经常与 transposable 被联系基因元素。特别地, ISAtfe 的 12 个拷贝和 ISAtc1 的 37 个拷贝被识别了,建议他们是在染色体的活跃 transposons。A。caldus SM-1 为中央新陈代谢和碳混合物, 29 蛋白质 / 酶与 proteomic 工具在之中是可看作是相同的吸收编码所有酶。SM-1 改正 CO2via 古典 CalvinBasshamBenson (CBB ) 周期,和罐头操作完全的 Embden-Meyerhof 小径(EMP ) ,戊糖磷酸盐小径(PPP ) ,和 gluconeogenesis。它有一个不完全的 tricarboxylic 酸周期(TCA ) 。涉及糖类举起的四通常认为的 transporters 被识别。一起拿,结果建议 SM-1 能吸收糖类,因为在基本的盐媒介的 1% 葡萄糖或蔗糖的增加显著地增加了 SM-1 的生长,这随后试验性地被证实。SM-1 的完全的染色体为它的生理学和遗传的进一步的调查提供了基本数据,这被结束,除了在这研究揭示的碳新陈代谢。 | Xiao-Yan You Xu Guo Hua-Jun Zheng Ming-Jiang Zhang Li-Jun Liu Yong-Qiang Zhu Baoli Zhu Sheng-YueWang Guo-Ping Zhao Ansgar Poetsch Cheng-Ying Jiang Shuang-Jiang Liu | 2011 | Journal of Genetics and Genomics2011，38，6： | 5 |
| 3 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 4 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 5 | Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue显示文摘 | Kirsten Muri Boberg Roger W. Chapman Gideon M. Hirschfield Ansgar W. Lohse Michael P. Manns Erik Schrumpf | 2010 | Journal of Hepatology2010，，2： | 4 |
| 6 | Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism显示文摘 | Gottfried Novacek Ansgar Weltermann Anna Sobala Herbert Tilg Wolfgang Petritsch Walter Reinisch Andreas Mayer Thomas Haas Arthur Kaser Thomas Feichtenschlager Harry Fuchssteiner Peter Knoflach Harald Vogelsang Wolfgang Miehsler Reingard Platzer Wolfgang T | 2010 | Gastroenterology2010，，3： | 4 |
| 7 | Autoimmune hepatitis显示文摘 | Ansgar W. Lohse Giorgina Mieli-Vergani | 2010 | Journal of Hepatology2010，，1： | 3 |
| 8 | 活体牙周膜有限元仿真的可行性研究显示文摘目的通过现代有限元方法研究牙周膜上的静平衡应力状态。方法提出了两种用于分析牙周膜应力状态的有限元方法,把牙周膜看做是整个下颌模型的一部分,通过有限元方法来处理仿真的牙齿并加载,来研究牙周膜对牙周组织的应力应变分布的作用,计算得到的静平衡应力和牙齿根吸收状态进行比较。结果牙周膜的最大应力发生在接近最高点位置,在中跟位置附近存在局部最大应力,而牙周膜顶点区域的应力要大于牙周膜中根附近的局部最大应力。齿槽顶部的舌侧牙周膜部位可以发现静平衡应力。静平衡应力是和位置有关的,有静平衡应力的部位就会发生牙根吸收。结论人类切牙和单根前臼齿一样,植入物会导致其牙周膜顶点附近静平衡应力的增长,这一点同之前的发现相一致。人类切牙根吸收经常作用于牙周膜的顶点部位。 | Ansgar Hohmann Cornelia Kober Thomas Radtke Philippe Young Martin Geiger Andrew Boryor Christian Sander Franz Gunter Sander | 2008 | 医用生物力学2008，23，1： | 3 |
| 9 | Unmet clinical need in autoimmune liver diseases显示文摘 | Jessica K. Dyson Gwilym Webb Gideon M. Hirschfield Ansgar Lohse Ulrich Beuers Keith Lindor David E.J. Jones | 2014 | Journal of Hepatology2014，，： | 2 |
| 10 | Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-α in Chimeric Mice显示文摘 | Marc Lütgehetmann Till Bornscheuer Tassilo Volz Lena Allweiss Jan–Hendrick Bockmann Joerg M. Pollok Ansgar W. Lohse Joerg Petersen Maura Dandri | 2011 | Gastroenterology2011，，7： | 2 |
| 11 | Association of autoimmune hepatitis and systemic lupus erythematodes:A case series and review of the literature显示文摘Liver test abnormalities have been described in up to 60% of patients with systemic lupus erythematodes(SLE) at some point during the course of their disease.Prior treatment with potentially hepatotoxic drugs or viral hepatitis is commonly considered to be the main cause of liver disease in SLE patients.However,in rare cases elevated liver enzymes may be due to concurrent autoimmune hepatitis(AIH).To distinguish whether the patient has primary liver disease with associated autoimmune clinical and laboratory features resembling SLE- such as AIH- or the elevation of liver enzymes is a manifestation of SLE remains a difficult challenge for the treating physician.Here,we present six female patients with complex autoimmune disorders and hepatitis.Patient charts were reviewed in order to investigate the complex relationship between SLE and AIH.All patients had coexisting autoimmune disease in their medical history.At the time of diagnosis of AIH,patients presented with arthralgia,abdominal complaints,cutaneous involvement and fatigue as common symptoms.All patients fulfilled the current diagnostic criteria of both,AIH and SLE.Remission of acute hepatitis was achieved in all cases after the initiation of immunosuppressive therapy.In addition to this case study a literature review was conducted. | Claudia Beisel Christina Weiler-Normann Andreas Teufel Ansgar W Lohse | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 12 | Tissue factor exposing microparticles in inflammatory bowel disease显示文摘 | Julia Palkovits Gottfried Novacek Marietta Kollars Gregor Hron Wolf Osterode Peter Quehenberger Paul Alexander Kyrle Harald Vogelsang Walter Reinisch Pavol Papay Ansgar Weltermann | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 13 | Proteomic and molecular investigations revealed that Acidithiobacillus caldus adopts multiple strategies for adaptation to NaCl stress显示文摘Acidithiobacillus caldus plays an important role in commercial bioleaching.To understand how NaCl stress adaptation occurs in A.caldus,we grew A.caldus strain SM-1 in media containing high NaCl concentrations.SM-1 grew at concentrations of up to 1.0-mol L^(-1)NaCl,but growth was severely inhibited at higher concentrations.Proteomic analysis showed that SM-1 used multiple strategies to respond to NaCl stress.In addition to several heatshock proteins,enzymes involved in proline biosynthesis increased under NaCl stress.In addition,two DNA-binding proteins and a third protein of unknown function(Atc_(1291)),which was subsequently identified as a putative single-stranded DNA-binding protein,were up-regulated in the presence of NaCl stress.These DNA-binding proteins might play a role in response to osmotic stress.Atc_(1291)was cloned and expressed in Escherichia coli.Surprisingly,we found that E.coli BL21/pET28a-atc_(1291)grew to higher cell densities than E.coli BL21/pET28a,regardless of NaCI stress.Homologs to Atc_(1291)were identified in several groups of Proleohacleria.The role of Atc_(1291)in enhancing cell growth needs further investigation. | Xu Guo Chengying Jiang Yuanming Luo Mingjiang Zhang Ansgar Poetsch Shuangjiang Liu | 2014 | Chinese Science Bulletin2014，59，3： | 2 |
| 14 | Evaluation of Nonlinear Frame Finite-Element Models显示文摘 | Ansgar Neuenhofer Filip C. Filippou | 1997 | Journal of Structural Engineering1997，，7： | 2 |
| 15 | Presence of EpCAM‐positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma显示文摘 | Kornelius Schulze Christin Gasch Katharina Staufer Bj?rn Nashan Ansgar W. Lohse Klaus Pantel Sabine Riethdorf Henning Wege | 2013 | Cancer2013，，9： | 2 |
| 16 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 17 | Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis显示文摘 | Johannes Hartl Hanno Ehlken Christina Weiler-Normann Marcial Sebode Benno Kreuels Nadine Pannicke Roman Zenouzi Claudia Glaubke Ansgar W. Lohse Christoph Schramm | 2014 | Journal of Hepatology2014，，： | 2 |
| 18 | Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia显示文摘 | Anya Pedersen Markus Diedrich Florian Kaestner Katja Koelkebeck Patricia Ohrmann Gerald Ponath Frank Kipp Simone Abel Ansgar Siegmund Thomas Suslow Christof von Eiff Volker Arolt Matthias Rothermundt | 2008 | Progress in Neuropsychopharmacology & Biological Psychiatry2008，，： | 1 |
| 19 | Intelligent Electronic Systems in Commercial Vehicles for Enhanced Traffic Safety显示文摘 | Palkovics Laszlo Fries Ansgar | 2001 | Vehicle System Dynamics2001，35，45： | 1 |
| 20 | Anatomical characterization of cytoglobin and neuroglobin mRNA and protein expression in the mouse brain显示文摘 | Christian Ansgar Hundahl Gregg C. Allen Jens Hannibal Katrine Kjaer Jens F. Rehfeld Sylvia Dewilde Jens R. Nyengaard Jesper Kelsen Anders Hay-Schmidt | 2010 | Brain Research2010，，： | 1 |
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