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| 1 | Colorectal cancer in inflammatory bowel disease:What is the real magnitude of the risk?显示文摘The association between inflammatory bowel disease(IBD) and colorectal cancer(CRC) has been recognised since 1925 and still accounts for 10%-15% of deaths in IBD.IBD-associated CRC(IBD-CRC) affects patients at a younger age than sporadic CRC.The prognosis for sporadic CRC and IBD-CRC is similar,with a 5-year survival of approximately 50%.Identifying at risk patients and implementing appropriate surveillance for these patients is central to managing the CRC risk in IBD.The increased risk of colorectal cancer in association with IBD is thought to be due to genetic and acquired factors.The link between inflammation and cancer is well recognised but the molecular biology,immune pathobiology and genetics of IBD-CRC are areas of much ongoing research.This review examines the literature relating to IBD-CRC,focusing on the incidence of IBD-CRC and examining potential risk factors including age at diagnosis,gender,duration and extent of colitis,severity of inflammation,family history of sporadic CRC and co-existent primary sclerosing cholangitis(PSC).Confirmed risk factors for IBD-CRC are duration,severity and extent of colitis,the presence of co-existent PSC and a family history of CRC.There is insufficient evidence currently to support an increased frequency of surveillance for patients diagnosed with IBD at a younger age.Evidence-based guidelines advise surveillance colonoscopy for patients with colitis 8 to 10 years after diagnosis,with the interval for further surveillance guided by risk factors(extent of disease,family history of CRC,post-inflammatory polyps,concomitant PSC,personal history of colonic dysplasia,colonic strictures).There is a move away from using random colonic biopsies towards targeted biopsies aimed at abnormal areas identified by newer colonoscopic techniques(narrow band imaging,chromoendoscopy,confocal microendoscopy). | Jessica K Dyson Matthew D Rutter | 2012 | World Journal of Gastroenterology2012，18，29： | 22 |
| 2 | Squamous cell cancer of the rectum显示文摘Squamous cell carcinoma of the rectum is a rare malignancy.It appears to be associated with chronic inflammatory conditions and infections.The clear association seen between Human Papilloma Virus and various squamous cancers has not been firmly established for the squamous cell cancer of the rectum. The presentation is nonspecific and patients tend to present with advanced stage disease.Diagnosis relies on endoscopic examination with biopsy of the lesion.Distinction from squamous cell cancer of the anus can be difficult,but can be facilitated by immunohistochemical staining for cytokeratins.Staging of the cancer with endoscopic ultrasound and computed tomography provides essential information on prognosis and can guide therapy.At present,surgery remains the main therapeutic option;however recent advances have made chemoradiation a valuable therapeutic addition. Squamous cell carcinoma of the rectum is a distinct entity and it is of crucial importance for the practicing Gastroenterologist to be thoroughly familiar with this disease.Compared to adenocarcinoma of the rectum and squamous cell cancer of the anal canal,squamous cell carcinoma of the rectum has different epidemiology, etiology,pathogenesis,and prognosis but,most importantly,requires a different therapeutic approach. This review will examine and summarize the available information regarding this disease from the perspective of the practicing gastroenterologist. | Tara Dyson Peter V Draganov | 2009 | World Journal of Gastroenterology2009，15，35： | 5 |
| 3 | Unmet clinical need in autoimmune liver diseases显示文摘 | Jessica K. Dyson Gwilym Webb Gideon M. Hirschfield Ansgar Lohse Ulrich Beuers Keith Lindor David E.J. Jones | 2014 | Journal of Hepatology2014，，： | 2 |
| 4 | Effect of oxygen and nitrogen functionalization on the physical and electronic structure of graphene显示文摘graphene 的共有原子价 functionalization 为定制它的性质提供机会并且是一些 graphene 合成技术的不可避免的后果。然而, functionalization 导致的变化很好没被理解。由使用原子来源控制氧和氮 functionalization 的程度,我们在原子规模在结构和性质学习了进化。虽然,原子氧 reversibly 介绍 epoxide 组,在类似的条件下面,原子氮不可逆转地创造包括的多样的功能代理, pyridinic,和 pyrrolic 氮。原子氧在迪拉克点离开费密能量(即, undoped ) ,虽然原子氮导致网做 n;然而,试验性的结果与为两是转变从的主导的电子效果一致去除到局部性的状态,和因此签名的损失 graphene 的电子结构。 | Alexander J. Marsden Peter Brommer James J. Mudd M. Adam Dyson Robert Cook Maria Asensio Jose Avila Ana Levy Jeremy Sloan David Quigley Gavin R. Bell Neil R. Wilson | 2015 | Nano Research2015，8，8： | 2 |
| 5 | Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide 显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 6 | The regulation of E2F by pRB-family proteins显示文摘 | Dyson N | 1998 | Genes Dev1998，12，15： | 1 |
| 7 | The cardiovascular dose-response efects of isoflurane alone and combined with butorphanol in the green iguana( Iguana iguana)显示文摘 | Mosley CA Dyson D Smith DA | 2004 | Vet Anaesth Analg2004，31，1： | 1 |
| 8 | Atrial-like phenotype is associated with embryonic ventricular failure in RXRa-/- mice 显示文摘 | Dyson E Sucov HM Kubalak SW | 1995 | Proc Natl Acad Sci USA1995，92，16： | 1 |
| 9 | Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis显示文摘 | Chan Y L Orie N N Dyson A | 2012 | Crit Care Med2012，40，4： | 1 |
| 10 | Mechanism of coupled folding and binding of an intrinsically disordered protein显示文摘 | Sugase K Dyson H J Wright P E | 2007 | Nature2007，447，7147： | 1 |
| 11 | Peptides that block hepatitis B virus assembly:analysis by cryomicroscopy,mutagenesis and transfection显示文摘 | Bttcher B Tsuji N Takahashi H Dyson M R Zhao S Crowther R A Murray K | 1998 | EMBO J1998，17，23： | 1 |
| 12 | Some observations on yarn irregularity显示文摘 | Dyson E | 1974 | J Text Inst1974，65，2： | 1 |
| 13 | Using tomography of GPS TEC to routinely determine ionospheric average electron density profiles 显示文摘 | E Yizengaw M B Moldwina P L Dyson | 2007 | Journal of Atmospheric and Solar-Terrestrial Physics2007，69，： | 1 |
| 14 | p107 and p130: Versatile Proteins with Interesting Pockets显示文摘 | Marie Classon Nicholas Dyson | 2001 | Experimental Cell Research2001，，1： | 1 |
| 15 | Novel therapeutic targets in primary biliary cirrhosis显示文摘 | Dyson JK Hirschfield GM Adams DH | 2015 | Nat Rev Gastroenterol Hepatol2015，12，3： | 1 |
| 16 | A review of low and reduced carbohydrate diets and weight loss in type 2 diabetes显示文摘 | Dyson PA | 2008 | J Hum Nutr Diet2008，21，： | 1 |
| 17 | A study of the physical and mechanical propertiesof wheat straw显示文摘 | Dougherty M J HubertJ A Dyson A | 2005 | Journal of Engineering Research2005，62，2： | 1 |
| 18 | Esmolol attenuates cardiovascular responses to extubation显示文摘 | Dyson A Isaac PA Pennant JH | 1990 | Anesth Analg1990，71，： | 1 |
| 19 | The synthesis and antiviral properties of E-5- (2-bromovinyl) -4'-thio-deoxyurichine 显示文摘 | Dyson M R Coe P L Walker R T | 1991 | J Chem Soc Chem Commun1991，，： | 1 |
| 20 | Production of sol- uble mammalian proteins in Eschefichia coli:identification of protein features that correlate with successful Expression 显示文摘 | Dyson MR Shadbolt SP Vincent KJ | 2004 | BMC Biotechnology2004，4，： | 1 |
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