|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 2 | 人肿瘤坏死因子受体I死亡域融合蛋白基因的克隆与表达显示文摘通过设计4个引物进行重叠(overlapping)PCR,由此克隆了人肿瘤坏死因子受体I死亡域(deathdomain)与氯霉素乙酰转移酶(CAT)的融合蛋白基因(DdLcat)。该融合蛋白基因经测序,证明与设计的序列相同。构建成的重组表达质粒pLT10DdLcat转化大肠杆菌后发酵,IPTG诱导2h,SDS-PAGE测定DdLcat蛋白质的分子量为39kD。Western印迹实验进一步作了鉴定。表达产物大部分为包涵体。DdLcat经Q-Sepharose柱层析后纯度大于95%。 | 林丽珠 李昌本 赵寿元 DeWilde G.Haegeman G.FiersW. | 1998 | 生物化学与生物物理学报1998，30，6： | 2 |
| 3 | The human brain hexacoordinated neuroglobin three-dimensional structure 显示文摘 | Pesce A Dewilde S Nardini M | 2004 | Micron2004，35，1： | 1 |
| 4 | Globins in the brain 显示文摘 | Moens AW Dewilde S | 2000 | Nature2000，407，： | 1 |
| 5 | Use of clopidogrel with or without aspirin in patients taking oral an- ticoagulant therapy and undergoing percutaneous coronary in- tervention: an open label, randomized, controlled trial 显示文摘 | Dewilde W J M Oirbans T Verheugt F W A | 2013 | Lancet2013，381，9872： | 1 |
| 6 | Subspace model identification (I): The output-error state-space model identification class of algorithms显示文摘 | Verhaegen M Dewilde P | 1992 | InternationalJournal of Control1992，56，5： | 1 |
| 7 | Coupling of the home and an internal disulfide bond in human neuroglobin 显示文摘 | Hamdane D Kiger L Dewilde S | 2004 | Micron2004，35，1： | 1 |
| 8 | Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR 显示文摘 | FORDEL E GEUENS E DEWILDE S | 2004 | Biochem Biophys Res Commun2004，319，2： | 1 |
| 9 | Anatomical characterization of cytoglobin and neuroglobin mRNA and protein expression in the mouse brain显示文摘 | Christian Ansgar Hundahl Gregg C. Allen Jens Hannibal Katrine Kjaer Jens F. Rehfeld Sylvia Dewilde Jens R. Nyengaard Jesper Kelsen Anders Hay-Schmidt | 2010 | Brain Research2010，，： | 1 |
| 10 | Subspace model identification (11): Analysis of the elementary output-error state-space model identification algorithm显示文摘 | Verhaegen M Dewilde P | 1992 | InternationalJournal of Control1992，56，5： | 1 |
| 11 | Hypoxia/ischemia and the regulation of neuroglobin and cytoglobin expression显示文摘 | Fordel E Geuens E Dewilde S | 2004 | IUBMB Life2004，56，1112： | 1 |
| 12 | Crystal structure of cytoglobin:the fourth globin type discovered in man displays heme hexa-coordination显示文摘 | de SD Dewilde S Pesce A | 2004 | J Mol Biol2004，336，4： | 1 |
| 13 | The human brainhexacoordinated neuroglobin three-dimensional structure显示文摘 | Pesce A Dewilde S Nardini M | 2004 | Micron2004，35，12： | 1 |
| 14 | Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real - time PCR 显示文摘 | Fordel E Geuens E Dewilde S | 2004 | Biochem Biophys Res Commun2004，319，2： | 1 |
| 15 | A meta-analysis of P50 studies in patients with schizophrenia and relatives: dif?ferences in methodology between research groups显示文摘 | deWilde OM Bour D Dingemans PM | 2007 | Schizophr Res2007，97，13： | 1 |
| 16 | Functional differentiation of myoglobin isoforms in hypoxia- tolerant carp indicates tissue-specific protective roles 显示文摘 | Helbo S Dewilde S Williams D R | 2012 | American Journal of Physiology-Regulatory Integrative and Comparative Physiology2012，302，6： | 1 |
| 17 | Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin: Molecular mechanisms and physiological significance 显示文摘 | Fago A Hundahl C Dewilde S | 2004 | J Biol Chem2004，279，44： | 1 |
| 18 | Unusual stability of hu-man neuroglobin at low pH-molecular mechanisms and bi-ological significance显示文摘 | Picotti P Dewilde S Fago A | 2009 | FEBS J2009，276，： | 1 |
| 19 | Longitudinal study on the influence of Nd: YAG laser irradiation on microleakage associated with two filling techniques显示文摘 | Meire M Mavridou A Dewilde N | 2009 | Photomed Laser Surg2009，27，4： | 1 |
| 20 | Use of clopidogrel with or without aspirin in pa- tients taking oral anticoagulant therapy and undergo- ing percutaneous coronary intervention: an open:la- bel, randomised, controlled trial显示文摘 | DEWILDE W J OIRBANS T VERHEUGT F W | 2013 | Lancet2013，381，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员