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| 1 | Squamous cell carcinoma of the oral cavity and circulating tumour cells显示文摘Due to a lack of substantial improvement in the outcome of patients suffering from oral squamous cell carcinoma(OSCC) during the past decades, current staging methods need to be revised. This disease is associated with poor survival rates despite considerable advances in diagnosis and treatment. The early detection of metastases is an important indicator of survival, prognosis and relapse. Therefore, a better understanding of the mechanisms underlying metastasis is crucial. Exploring alternative measures apart from common procedures is needed to identify new prognostic markers. Similar to previous findings predominantly for other solid tumours, recently published studies demonstrate that circulating tumour cells(CTCs) and disseminated tumour cells(DTCs) might serve as prognostic markers and could supplement routine staging in OSCC. Thus, the detection of CTCs/DTCs is a promising tool todetermine the individual need for therapeutic intervention. Encouraging results and new approaches point to the future use of targeted therapies for OSCC, an exceedingly heterogeneous subgroup of head and neck cancer. This review focuses on summarising technologies currently used to detect CTCs/DTCs. The translational relevance for OSCC is highlighted. The inherent challenges in detecting CTCs/DTCs will be emphasised. | Johannes Wikner Alexander Grobe Klaus Pantel Sabine Riethdorf | 2014 | World Journal of Clinical Oncology2014，5，2： | 8 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | Circulating Tumor Cells and Circulating Tumor DNA显示文摘 | Catherine Alix-Panabières Heidi Schwarzenbach Klaus Pantel | 2012 | Annual Review of Medicine2012，，： | 3 |
| 4 | Presence of EpCAM‐positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma显示文摘 | Kornelius Schulze Christin Gasch Katharina Staufer Bj?rn Nashan Ansgar W. Lohse Klaus Pantel Sabine Riethdorf Henning Wege | 2013 | Cancer2013，，9： | 2 |
| 5 | Circulating tumor cells as therapy-related biomarkers in cancer patients显示文摘 | Tobias M. Gorges Klaus Pantel | 2013 | Cancer Immunology, Immunotherapy2013，，5： | 2 |
| 6 | Heterezygons nonsense mutation in exon 3 of the growth hormone receptor (GHR) in severe GH insensitivity (Laren syndrome) and the issue of the origin and function of the GHRd3 isoform 显示文摘 | Pantel J Grulich-Henn J Bettendorf M | 2003 | J Clin Endocrinol Metab2003，88，4： | 1 |
| 7 | Pharmacological Treatment of Mild Cognitive Impairment as a Prodromal Syndrome of Alzheimer’s Disease显示文摘 | Tarik Karakaya Fabian Fu?er Johannes Schroder Johannes Pantel | 2013 | Current Neuropharmacology2013，，1： | 1 |
| 8 | Detection,clinical relevance and specific biological properties of disseminat- ing turnout cells 显示文摘 | Pantel K Brakenhoff RH Brandt B | 2008 | Nat Rev Cancer2008，8，5： | 1 |
| 9 | Circulating tumour ceils in cancer patients:challenges and perspeetives显示文摘 | Pantel K Alix-Panabieres C | 2010 | Trends Mol Med2010，16，9： | 1 |
| 10 | Personalized ventila- tion as a control measure for airborne transmissible disease spread显示文摘 | Pantelic J Sze-To GN Tham KW | 2009 | J R Soc Interface2009，6，6： | 1 |
| 11 | Circulating tumor cells: liquid bi- opsy of cancer 显示文摘 | Alix-Panabiares C Pantel K | 2013 | Clin Chem2013，59，： | 1 |
| 12 | The circulating tumor cells:liquid biopsy of cancer显示文摘 | Alix-Panabieres C Pantel K | 2014 | Klin Lab Diagn2014，，4： | 1 |
| 13 | In vivo depletion of B cells using a combination of high dose cytosine arabinoside/mitoxantrone and rituximab for autografting in patients with non-Hodgkin's lymphoma显示文摘 | Voso MT Pantel G Weis M | 2000 | Br J Haematol2000，109，4： | 1 |
| 14 | Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells 显示文摘 | Wischnewski F Pantel K Schwarzenbach H | 2006 | Mol Cancer Res2006，4，5： | 1 |
| 15 | Detection,clinical relevance and specific biological properties of disseminating tumour cells显示文摘 | Pantel K Brakenhoff RH Brandt B | | 0，，05： | 1 |
| 16 | Cytokeratin-positive cells in the bone marrow and survival of patients with stage Ⅰ , Ⅱ , or Ⅲ breast cancer显示文摘 | Braun S Pantel K Muller P | 2000 | N Engl J Med2000，342，8： | 1 |
| 17 | PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis显示文摘 | Wikman H Pantel K Haigis MC | 2014 | Nature cell biology2014，16，10： | 1 |
| 18 | Detection and clinical importance of micrometastatic disease显示文摘 | Cote RJ Fodstad O | 1999 | J Natl Cancer Inst1999，91，13： | 1 |
| 19 | Cytokeratin-positive cells in the bone marrow and survival of patients with stage I,II,or III breast cancer显示文摘 | Braun S Pantel K Müller P | 2000 | N Engl J Med2000，342，8： | 1 |
| 20 | Frequency and prognostic significance of isolated tumor cells in bone marrow of patients with non-small cell lung cancer without overt metastases 显示文摘 | Pantel K Lzbicki J Passlick B | 1996 | Lancet1996，347，9002： | 1 |
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