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| 1 | Shanghai Score: A Prognostic and Adjuvant Treatment-evaluating System Constructed for Chinese Patients with Hepatocellular Carcinoma after Curative Resection显示文摘 | Hui-Chuan Sun Lu Xie Xin-Rong Yang Wei Li Jian Yu Xiao-Dong Zhu Yong Xia Ti Zhang Yang Xu Bo Hu Li-Ping Du Ling-Yao Zeng Jian Ouyang Wei Zhang Tian-Qiang Song Qiang Li Ying-Hong Shi Jian Zhou Shuang-Jian Qiu Qian Liu Yi-Xue Li Zhao-You Tang Yu Shyr Feng Shen Jia Fan | 2017 | Chinese Medical Journal2017，，22： | 15 |
| 2 | Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans显示文摘Little is known about the inheritance of very low heteroplasmy mitochondria DNA(mtDNA)variations.Even with the development of new next-generation sequencing methods,the practical lower limit of measured heteroplasmy is still about 1%due to the inherent noise level of the sequencing.In this study,we sequenced the mitochondrial genome of 44 individuals using Illumina high-throughput sequencing technology and obtained high-coverage mitochondria sequencing data.Our study population contains many mothere offspring pairs.This unique study design allows us to bypass the usual heteroplasmy limitation by analyzing the correlation of mutation levels at each position in the mtDNA sequence between maternally related pairs and non-related pairs.The study showed that very low heteroplasmy variants,down to almost 0.1%,are inherited maternally and that this inheritance begins to decrease at about 0.5%,corresponding to a bottleneck of about 200 mtDNA. | Yan Guo Chung-I Li Quanhu Sheng Jeanette F.Winther Qiuyin Cai John D.Boice Yu Shyr | 2013 | Journal of Genetics and Genomics2013，40，12： | 4 |
| 3 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 4 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 5 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor显示文摘 | Anne E. Powell Yang Wang Yina Li Emily J. Poulin Anna L. Means Mary K. Washington James N. Higginbotham Alwin Juchheim Nripesh Prasad Shawn E. Levy Yan Guo Yu Shyr Bruce J. Aronow Kevin M. Haigis Jeffrey L. Franklin Robert J. Coffey | 2012 | Cell2012，，1： | 2 |
| 6 | Treatment of Complicated Hepatolithiasis with Intrahepatic Biliary Stricture by Ductal Dilatation and Stenting: Long-term Results显示文摘 | Yu Fan Cheng Tze Yu Lee Shyr Ming Sheen-Chen Tung Liang Huang Tai Yi Chen | 2000 | World Journal of Surgery2000，，6： | 2 |
| 7 | Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies显示文摘 | Lehmann Brian D Bauer Joshua A Chen Xi Sanders Melinda E Chakravarthy A Bapsi Shyr Yu Pietenpol Jennifer A | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 8 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，： | 1 |
| 9 | Solid codes and disjunctive domains显示文摘 | H. J. Shyr S. S. Yu | 1990 | Semigroup Forum1990，，1： | 1 |
| 10 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 1 |
| 11 | Impact resistance and damagecharacteristics of composite laminates显示文摘 | SHYR Tien Wei PAN Yu Hao | 2003 | Composite Structrues2003，62，： | 1 |
| 12 | Treatment of Complicated Hepatolithiasis with Intrahepatic Biliary Stricture by Ductal Dilatation and Stenting: Long-term Results显示文摘 | Yu Fan Cheng Tze Yu Lee Shyr Ming Sheen-Chen Tung Liang Huang Tai Yi Chen | 2000 | World Journal of Surgery2000，，6： | 1 |
| 13 | Wavelet-based procedures for proteomic mass spectrometry data processing 显示文摘 | Chen Shou Hong Dong Yu Shyr | 2007 | Computational Statistics& Data Analysis2007，52，： | 1 |
| 14 | Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis显示文摘 | Li Yang Laura M. DeBusk Koari Fukuda Barbara Fingleton Brenda Green-Jarvis Yu Shyr Lynn M. Matrisian David P. Carbone P.Charles Lin | 2004 | Cancer Cell2004，，： | 1 |
| 15 | Treatment of Complicated Hepatolithiasis with Intrahepatic Biliary Stricture by Ductal Dilatation and Stenting: Long-term Results显示文摘 | Yu Fan Cheng Tze Yu Lee Shyr Ming Sheen-Chen Tung Liang Huang Tai Yi Chen | 2000 | World Journal of Surgery2000，，6： | 1 |
| 16 | Solid Codes and Disjunctive Domains 显示文摘 | Shyr H J Yu S S | 1990 | Semigroup Forum1990，41，1： | 1 |
| 17 | Reponse to combined modality therapy correlates with survival in locally non-small- cell lung cancer显示文摘 | Dong Wook Kim Yu Shyr Heidi Chen | 2005 | Int J Radiat Oncol Biol Phys2005，63，4： | 1 |
| 18 | Midst-languages显示文摘 | Yu S S | 1998 | Scoochow Journal of Mathematics1998，24，： | 1 |
| 19 | Solid codes and disjunctive domains显示文摘 | Shyr H J Yu S S | 1990 | Semigroup Forum1990，41，1： | 1 |
| 20 | Integrative Omics Analysis Reveals the Importance and Scope of Translational Repression in microRNA-mediated Regulation显示文摘 | Qi Liu Patrick J. Halvey Yu Shyr Robbert J. C. Slebos Daniel C. Liebler Bing Zhang | 2013 | Molecular & Cellular Proteomics2013，，7： | 1 |
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