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| 1 | SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir,nirmatrelvir,and the combination显示文摘Dear Editor,Since the first outbreak in late 2019,the RNA genome of SARS-CoV-2 has been undergoing constant evolution.This is largely attributed to the viral polymerase that is intrinsically error prone and the selection pressures exerted by the host immune system.Several variants of concern harboring multiple mutations in the spike protein have emerged in the past year.The currently fast-spreading Omicron variant contains many more mutations compared with the previous variants,and most of these mutations are located around the receptor binding domain of the spike protein. | Pengfei Li Yining Wang Marla Lavrijsen Mart M.Lamers Annemarie C.de Vries Robbert J.Rottier Marco J.Bruno Maikel P.Peppelenbosch Bart L.Haagmans Qiuwei Pan | 2022 | Cell Research2022，32，3： | 11 |
| 2 | 人工合成相关寡肽抑制poly I:C诱发性流产的作用显示文摘探讨寡肽蛋-苏-精-缬(MTRV)是否具有抗多聚次黄苷酸-胞苷酸(poly I:C)诱发的小鼠胚胎吸收的作用及其免疫机制。给予异基因妊娠BALB/c×C57BL/6小鼠腹腔注射poly I:C建立胚胎吸收模型;在孕期多个时点腹腔注射MTRV,观察其对胚胎吸收率的影响,并采用四色流式细胞术检测妊娠9.5 d和13.5 d外周血和胎盘各种免疫活性细胞的百分率。结果显示,寡肽MTRV不能显著改变poly I:C所引起的小鼠胎盘多种免疫活性细胞相对数量的增多,但是对poly I:C增高CD45+IL-12+细胞百分率的作用具有显著抑制,并能显著降低poly I:C所引起的孕13.5d胚胎吸收率的增高。寡肽MTRV可调节母-胎界面局部免疫活性细胞的功能状态,从而抑制poly I:C诱发的小鼠胚胎吸收。 | 仲艳敏 林羿 李莉平 Nisar Khan 狄静芳 曾山 Robbert Benner | 2007 | 现代免疫学2007，27，2： | 9 |
| 3 | 人工合成相关寡肽抑制流产发生的免疫机制研究显示文摘研究寡肽蛋-苏-精-缬(MTRV)抑制多聚次黄苷酸-胞苷酸(poly I∶C)诱发的小鼠胚胎吸收的免疫机制。给予异基因妊娠BALB/c×C57BL/6小鼠腹腔注射poly I∶C建立诱发性胚胎吸收模型;在孕期多个时点腹腔注射MTRV,观察其对胚胎吸收率的影响,并采用流式细胞术检测妊娠9.5 d和13.5 d妊娠子宫内各种免疫活性细胞的百分率。结果显示,MTRV不能显著改变poly I∶C所引起的Toll样受体3阳性细胞和CD80阳性细胞增多,但是可显著抑制poly I∶C所引起的IFN-γ阳性细胞增多和转化生长因子-β阳性细胞减少,并降低流产率。提示寡肽MTRV可纠正poly I∶C所引起的妊娠子宫内细胞因子表达紊乱,从而抑制poly I∶C所诱发的流产。 | 王丽丽 曾山孙 Nisar Khan 林羿 Robbert Benner 芦春斌 | 2010 | 现代免疫学2010，30，1： | 3 |
| 4 | Tumor Marker Evolution: Comparison with Imaging for Assessment of Response to Chemotherapy in Patients with Colorectal Liver Metastases显示文摘 | Robbert J. Haas Dennis A. Wicherts Eduardo Flores Michel Ducreux Francis Lévi Bernard Paule Daniel Azoulay Denis Castaing Antoinette Lemoine René Adam | 2010 | Annals of Surgical Oncology2010，，4： | 2 |
| 5 | Osmic acid staining of myelin sheath in normal and regenerated peripheral nerves显示文摘 | 卫丽萍 何风春 陈逊文 卢士璧 Marco Lanzetta Robbert De Iongh | 2007 | Chinese Journal of Traumatology2007，10，2： | 2 |
| 6 | The rdationship between social comparison processes and personality显示文摘 | Karen Vander Zee Bram Buunk & Robbert Sandemlan | 1996 | El- sevier Science Ltd1996，20，5： | 1 |
| 7 | Long‐term outcomes after hepatic resection for colorectal metastases in young patients显示文摘 | Robbert J.de Haas Dennis A.Wicherts ChadiSalloum PaolaAndreani DobromirSotirov RenéAdam DenisCastaing DanielAzoulay | 2010 | Cancer2010，，3： | 1 |
| 8 | Cryptogamic epiphytes in primary and recovering upper montane oak forests of Costa Rica – species richness, community composition and ecology显示文摘 | Ingo Holz Robbert S. Gradstein | 2005 | Plant Ecology2005，，1： | 1 |
| 9 | The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy显示文摘 | Roy van der Meel Marc H. Symons Robert Kudernatsch Robbert J. Kok Raymond M. Schiffelers Gert Storm William M. Gallagher Annette T. Byrne | 2011 | Drug Discovery Today2011，，5： | 1 |
| 10 | p27kip1–838C>A Single Nucleotide Polymorphism Is Associated With Restenosis Risk After Coronary Stenting and Modulates p27kip1 Promoter Activity显示文摘 | Claudia M. van Tiel Peter I. Bonta Saskia Z.H. Rittersma Marcel A.M. Beijk Edward J. Bradley Anita M. Klous Karel T. Koch Frank Baas J Wouter Jukema Douwe Pons M Lourdes Sampietro Hans Pannekoek Robbert J. de Winter Carlie J.M. de Vries | 2009 | Circulation2009，，： | 1 |
| 11 | Long-term outcome after an early invasive versus selective invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome and elevated cardiac troponin T (the ICTUS trial): a follow-up study显示文摘 | Alexander Hirsch Fons Windhausen Jan GP Tijssen Freek WA Verheugt Jan Hein Cornel Robbert J de Winter | 2007 | The Lancet . 2007 (9564)2007，，9564： | 1 |
| 12 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 13 | Relation Between the Assessment of Microvascular Injury by Cardiovascular Magnetic Resonance and Coronary Doppler Flow Velocity Measurements in Patients With Acute Anterior Wall Myocardial Infarction显示文摘 | Alexander Hirsch Robin Nijveldt Joost D.E. Haeck Aernout M. Beek Karel T. Koch José P.S. Henriques Rene J. van der Schaaf Marije M. Vis Jan Baan Robbert J. de Winter Jan G.P. Tijssen Albert C. van Rossum Jan J. Piek | 2008 | Journal of the American College of Cardiology2008，，23： | 1 |
| 14 | Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer显示文摘 | ROBBERT VAN DER VOORT TAHER E I TAHER | 2000 | American Journal of Pathology2000，157，： | 1 |
| 15 | COCA:A secure distributed on_line certification authority显示文摘 | Lidong Zhou Fred B Schneider Robbert van Renesse | 2002 | ACM Trans on Computer Systems2002，，20： | 1 |
| 16 | Nutrition in the head-injuried Patient显示文摘 | Robbert PR | 1995 | New Hoviz1995，3，： | 1 |
| 17 | Additional value of contrast enhanced intraoperative ultrasound for colorectal liver metastases显示文摘 | Bram Fioole Robbert J. de Haas Dennis A. Wicherts Sjoerd G. Elias Jolanda M. Scheffers Richard van Hillegersberg Maarten S. van Leeuwen Inne H.M. Borel Rinkes | 2007 | European Journal of Radiology2007，，1： | 1 |
| 18 | Activated partialthromboplati time (aPTT) monitoring to achieve therapeutic anticoagulation befor and after introducing a nomogram for adjunctive hepar in treatmeen with thromobolytic therapy for acute myocardial infarction显示文摘 | Chamuleau Robbert J de Winter | 1998 | Inter Journal of Cardiology1998，6724，： | 1 |
| 19 | The Role of Benzoate in Anaerobic Degradation of Terephthalate显示文摘 | Robbert Kleerebezem | | 0，，03： | 1 |
| 20 | Nutrtion in the head-injuried patient显示文摘 | Robbert PR | 1995 | New Hoviz1995，3，： | 1 |
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