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| 1 | Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer. | Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 3 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 4 | Mutations in the DNA mismatch repair gene homologue hMLH1 is associated with HNPCC显示文摘 | Bronner CE Baker SM morrism PT | 1994 | Nature1994，368，6468： | 2 |
| 5 | The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome显示文摘 | Philip M. Brown Douglas A. Drossman Alastair J.J. Wood Gary A. Cline Kenny S. Frazier Jessica I. Jackson Johanna Bronner Joel Freiman Brian Zambrowicz Arthur Sands Michael D. Gershon | 2011 | Gastroenterology2011，，2： | 2 |
| 6 | Hepatitis C,iron status,and disease severity:relationship with HFE mutations显示文摘 | TUNG B Y EMOND M J BRONNER M P | 2003 | Gastroenterology2003，124，2： | 1 |
| 7 | The UHRF fam- ily: oncogenes that are drugable targets for cancer therapy in the nearfuture? 显示文摘 | BRONNER C ACHOUR M ARIMA Y l | 2007 | Pharmacology and Therapeutics2007，115，3： | 1 |
| 8 | Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas显示文摘 | Yen TW Aardal NP Bronner MP | 2002 | Surgery2002，131，2： | 1 |
| 9 | Long-term outcome in polymyositis and dermatomyositis显示文摘 | Bronner IM Visser M Kalmijn S | 2006 | Ann Rheum Dis2006，65，11： | 1 |
| 10 | Excess FoxG1 causes overgrowth of the neural tube显示文摘 | Ahlgren S Vogt P Bronner F M | 2003 | J Neurobiol2003，57，3： | 1 |
| 11 | Down-regulation of nuclearprotein ICBP90 by p53/p21Cipl/WAFl~dependent DNA-damagecheckpoint signals contributes to cell cycle arrest at Gi/S transi-tion显示文摘 | Arima Y Hirota T Bronner C | 2004 | Genes Cells2004，9，2： | 1 |
| 12 | Vacationers and e WOM:who posts,and why,where,and what?显示文摘 | Bronner F De hoog R | 2010 | Journal of Travel Research2010，，1： | 1 |
| 13 | Neural crest specification regulated by the helix - loop - helix repressor Id2 显示文摘 | Bronner - Fraser M | 1998 | Science1998，281，5379： | 1 |
| 14 | An analysis of intestinal calcium transport across rat intestine显示文摘 | Bronner F Pansu D Stein WD | 1986 | Am J Physiol1986，250，51： | 1 |
| 15 | Method for determining the content of catechins in tea infusions by high-performance liquid chromatograph显示文摘 | W E Bronner | 1998 | J chromatogr A1998，805，： | 1 |
| 16 | Intestinal calcium absorption : mecha- nisins and applications 显示文摘 | Felixelix Bronner | 1987 | J Nutr1987，117，13： | 1 |
| 17 | Autoimmune pancreatitis:a mimic of pancreatic cancer显示文摘 | Law R Bronner M Vogt D | | 0，，： | 1 |
| 18 | Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants显示文摘 | Hinney A Nguyen T T Scherag A Friedel S Bronner G Muller T D Grallert H Illig T Wichmann H E Rief W Schafer H and Hebebrand J | | 0，，12： | 1 |
| 19 | Insights into neural crest develop- ment and evolution from genomic analysis 显示文摘 | Simoes-Costa M Bronner ME | 2013 | Genome Res2013，23，7： | 1 |
| 20 | Recognizing acetabular dysplasia in the young adult显示文摘 | Mast JW Bronner RL Zebrack J | 2004 | Clin Orthop2004，418，： | 1 |
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