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| 1 | Crown and leaf traits as predictors of subtropical tree sapling growth rates显示文摘Aims Growth rates of plants are driven by factors that influence the amount of resources captured and the efficiency of resource use.In trees,the amount of light captured and the efficiency of light use strongly depends on crown characteristics and leaf traits.Although theory predicts that both crown and leaf traits affect tree growth,few studies have yet to integrate these two types of traits to explain species-specific growth rates.Using 37 broad-leaved tree species of subtropical forests in SE China,we investigated how interspecific differences in wood volume growth rates were affected by crown and leaf traits.We tested the hypotheses that(i)larger crown dimensions promote growth rates,(ii)species-specific growth rates are positively related to leaf stomatal conductance,leaf water potential and leaf chemical components,and negatively related to leaf C/N and leaf toughness and(iii)the two sets of traits better explain growth rates in combination than either alone.Methods Our study was conducted in a large-scale forest Biodiversity and Ecosystem Functioning experiment in China(BEF-China),located in a mountainous region in Jiangxi Province.We related 17 functional traits(two crown dimension and three crown structure traits;six physiological and six morphological leaf traits)to the mean annual growth rate of wood volume of young trees of the studied species.Interrelationships between crown and leaf traits were analyzed using principal component analysis.Simple linear regression analysis was used to test the effect of each trait separately.We used multiple regression analysis to establish the relationship of growth rate to each set of traits(crown traits,physiological and morphological leaf traits)and to the combination of all types of traits.The coefficients of determination(R^(2)_(adj))of the best multiple regression models were compared to determine the relative explanatory power of crown and leaf traits and a combination of both.Important Findings The species-specific growth rates were not related to any of the single crown traits,but were related positively to leaf stomatal conductance and leaf water potential individually,and negatively to leaf toughness,with approximately 13%variance explained by each of the traits.Combinations of different crown traits did not significantly explain the species-specific growth rates,whereas combinations of either physiological or morphological leaf traits explained 24%and 31%,respectively.A combination of both crown and leaf traits explained 42%of variance in species-specific growth rates.We concluded that sets of traits related to carbon assimilation at the leaf-level and to overall amount of leaves exposed at the crown-level jointly explained species-specific growth rates better than either set of traits alone. | Ying Li Wenzel Kröber Helge Bruelheide Werner Härdtle Goddert von Oheimb | 2017 | Journal of Plant Ecology2017，10，1： | 18 |
| 2 | Biliary complications in liver transplantation: Impact of anastomotic technique and ischemic time on short- and long-term outcome显示文摘AIM: To elucidate the impact of various donor recipient and transplant factors on the development of biliary complications after liver transplantation.METHODS: We retrospectively reviewed 200 patients of our newly established liver transplantation(LT) program, who received full size liver graft. Biliary reconstruction was performed by side-to-side(SS), end-to-end(EE) anastomosis or hepeaticojejunostomy(HJ). Biliary complications(BC), anastomotic stenosis, bile leak, papillary stenosis, biliary drain complication, ischemic type biliary lesion(ITBL) were evaluated by studying patient records, corresponding radiologic imaging and reports of interventional procedures [e.g., endoscopic retrograde cholangiopancreatography(ERCP)]. Laboratory results included alanine aminotransferase(ALT), gammaglutamyltransferase and direct/indirect bilirubin with focus on the first and fifth postoperative day, six weeks after LT. The routinely employed external bile drain was examined by a routine cholangiography on the fifth postoperative day and six weeks after transplantation as a standard procedure, but also whenever clinically indicated. If necessary, interventional(e.g., ERCP) or surgical therapy was performed. In case of biliary complication, patients were selected, assigned to different complication-groups and subsequently reviewed in detail. To evaluate the patients outcome, we focussed on appearance of postoperative/post-interventional cholangitis, need for rehospitalisation, retransplantation, ITBL or death caused by BC.RESULTS: A total of 200 patients [age: 56(19-72), alcoholic cirrhosis: n = 64(32%), hepatocellular carcinoma: n = 40(20%), acute liver failure: n = 23(11.5%), cryptogenic cirrhosis: n = 22(11%), hepatitis B virus /hepatitis C virus cirrhosis: n = 13(6.5%), primary sclerosing cholangitis: n = 13(6.5%), others: n = 25(12.5%) were included. The median follow-up was 27 mo until June 2015. The overall biliary complication rate was 37.5%(n = 75) with anastomotic strictures(AS): n = 38(19%), bile leak(BL): n = 12(6%), biliary drain complication: n = 12(6%); papillary stenosis(PS): n = 7(3.5%), ITBL: n = 6(3%). Clinically relevant were only 19%(n = 38). We established a comprehensive classification for AS with four grades according to clinical relevance. The reconstruction techniques [SS: n = 164, EE: n = 18, HJ: n = 18] showed no significant impact on the development of BCs in general(all n < 0.05), whereas in the HJ group significantly less AS were found(P = 0.031). The length of donor intensive care unit stay over 6 d had a significant influence on BC development(P = 0.007, HR = 2.85; 95%CI: 1.33-6.08) in the binary logistic regression model, whereas other reviewed variables had not [warm ischemic time > 45 min(P = 0.543), cold ischemic time > 10 h(P = 0.114), ALT init > 1500 U/L(P = 0.631), bilirubin init > 5 mg/d L(P = 0.595), donor age > 65(P = 0.244), donor sex(P = 0.068), rescue organ(P = 0.971)]. 13%(n = 10) of BCs had no therapeutic consequences, 36%(n = 27) resulted in repeated lab control, 40%(n = 30) received ERCP and 11%(n = 8) surgical therapy. Fifteen(7.5%) patients developed cholangitis [AS(n = 6), ITBL(n = 5), PS(n = 3), biliary lesion BL(n = 1)]. One patient developed ITBL twelve months after LT and subsequently needed retransplantation. Rehospitalisation rate was 10.5 %(n = 21) [AS(n = 11), ITBL(n = 5), PS(n = 3), BL(n = 1)] with intervention or reinterventional therapy as main reasons. Retransplantation was performed in 5(2.5%) patients [ITBL(n = 1), acute liver injury(ALI) by organ rejection(n = 3), ALI by occlusion of hepatic artery(n = 1)]. In total 21(10.5%) patients died within the follow-up period. Out of these, one patient with AS developed severe fatal chologenic sepsis after ERCP.CONCLUSION: In our data biliary reconstruction technique and ischemic times seem to have little impact on the development of BCs. | Stefan Kienlein Wenzel Schoening Anne Andert Daniela Kroy Ulf Peter Neumann Maximilian Schmeding | 2015 | World Journal of Transplantation2015，5，4： | 14 |
| 3 | 废旧磷酸铁锂正极粉磷酸浸出过程的优化及宏观动力学显示文摘随着新能源汽车产业快速发展,磷酸铁锂动力电池退役量爆发式增长,回收需求迫切,但面临回收利用经济性较差的难题。正极材料价值较高,本文提出采用磷酸浸出废旧正极材料以制备电池用磷酸铁,但铝等杂质的分离是关键。本文以含铝的磷酸铁锂正极粉为原料,开展了磷酸浸出过程优化及宏观动力学研究,重点研究了酸料比、浸出温度、液固比、搅拌速度等参数对磷酸铁锂及铝浸出效果的影响规律,并考察了磷酸铁锂在磷酸溶液中浸出的宏观动力学。研究结果表明,在酸料比1.1mL/g、温度20℃、液固比(5∶1)mL/g、搅拌速度400r/min、浸出时间120min条件下,磷酸铁锂浸出率大于93%,铝浸出率小于20%;磷酸铁锂正极粉磷酸浸出过程符合无固态产物层的收缩核模型,表观活化能为24.62kJ/mol,浸出过程受扩散控制。 | 万青珂 张洋 郑诗礼 张盈 王晓健 娄文博 JAN J.Weigand MARCO Wenzel | 2020 | 化工进展2020，39，6： | 9 |
| 4 | Grade of donor liver microvesicular steatosis does not affect the postoperative outcome after liver transplantation显示文摘BACKGROUND:The potential effect of graft steatosis on the postoperative liver function is discussed controversially. The present study aimed to evaluate the effect of the donor liver microvesicular steatosis on the postoperative outcome after liver transplantation.METHODS:Ninety-four patients undergoing liver transplantation at the University Hospital Aachen were included in this study. The patient cohort was divided into three groups according to the grade of microvesicular steatosis(MiS):MiS <30%(n=27), MiS 30%-60%(n=41) and MiS >60%(n=26).The outcomes after liver transplantation were evaluated, including the 30-day and 1-year patient and graft survival rates and the incidences of early allograft dysfunction(EAD) and primary nonfunction(PNF). RESULTS:The incidences of EAD and PNF did not differ significantly between the groups. We observed 5 cases of PNF,one occurred in the MiS <30% group and 4 in the MiS 30%-60% group. The 30-day and 1-year graft survivals did not differ significantly between groups. The 30-day patient survival rates were 100% in all groups. The 1-year patient survival rates were 94.4% in the MiS <30% group, 87.9% in the MiS 30%-60% group and 90.9% in the MiS >60% group.CONCLUSION:Microvesicular steatosis of donor livers has no negative effect on the postoperative outcome after liver transplantation. | Anne Andert Tom Florian Ulmer Wenzel Schoning Daniela Kroy Marc Hein Patrick Hamid Alizai Christoph Heidenhain Ulf Neumann Maximilian Schmeding | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 7 |
| 5 | A global perspective in asthma: from phenotype to endotype显示文摘Asthma affects about 300 million people worldwide,placing an enormous strain on health resources in many countries.Evidence is increasing that asthma is a complex condition with different underlying pathophysiologies.1 Scientists around the world have devoted much effort to unveiling this heterogeneity,from phenotyping initially focused on combinations of clinical characteristics,towards endotypes evolving which link pathophysiological mechanism to subtypes of asthma.2The identification of these endotypes,either by matching biology,genetics and therapeutic responses with clinically defined phenotypes or through unbiased genomic approaches,remains limited.3 Moving forward,ongoing studies that expand on these insights into the molecular signatures should enhance our ability to define the endotypes and lead to more targeted approaches to asthma therapy. | Min Xie Sally E. Wenzel | 2013 | Chinese Medical Journal2013，，1： | 6 |
| 6 | 妊娠期高血压免疫因子、肿瘤坏死因子α、血管紧张素Ⅱ1型受体自身抗体对妊娠可溶性fms样酪氨酸1和可溶性Endoglin产物的影响显示文摘最近研究发现先兆子痫中血管新生因子、可溶性fms样酪氨酸激酶(sFlt-1)和可溶性Endoglin(sEn-doglin)不平衡;然而尚不清楚它们过度分泌的启动机制。方法:长期给予怀孕大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)或抗血管紧张素Ⅱ受体的自身抗体(AT1-AA),测定其循环和胎盘的sFlt-1和(或)sEndoglin以确定这些因素的免疫调节作用。 | Parrish MR Murphy SR Rutland S Wallace K Wenzel K Wallukat G Keiser S Ray LF Dechend R Martin JN Granger JP La Marca B 黄晓斌 | 2010 | 中华高血压杂志2010，18，12： | 5 |
| 7 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 8 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 9 | Different cava reconstruction techniques in liver transplantation:piggyback versus cava resection显示文摘BACKGROUND: Originally, cava reconstruction(CR) in liver transplantation meant complete resection and reinsertion of the donor cava. Alternatively, preservation of the recipients inferior vena cava(IVC) with side-to-side anastomosis(known as 'piggyback') can be performed. Here, partial clamping maintains blood flow of the IVC, which may improve cardiovascular stability, reduce blood loss and stabilize kidney function. The aim of this study was to compare both techniques with particular focus on kidney function.METHODS: A series of 414 patients who had had adult liver transplantations(2006-2009) were included. Among them,176(42.5%) patients had piggyback and 238 had classical CR operation, 112(27.1%) of the patients underwent CR accompanied with veno-venous bypass(CR-B) and 126(30.4%)without a bypass. The choice of either technique was based on the surgeons' individual preference. Kidney function [serum creatinine, calculated glomerular filtration rate(GFR), RIFLE stages] was assessed over 14 days.RESULTS: Lab-MELD scores were significantly higher in CR-B(22.5±11.0) than in CR(17.3±9.0) and piggyback(18.8±10.0)(P=0.008). Unexpectedly, the incidences of arterial stenoses(P=0.045) and biliary leaks(P=0.042) were significantly increased in piggyback. Preoperative serum creatinine levels were the highest in CR-B [1.45±1.17 vs 1.25±0.85(piggyback)and 1.13±0.60 mg/dL(CR); P=0.033]. Although a worsening of postoperative kidney function was observed among all groups,this was most pronounced in CR-B [creatinine day 14: 1.67±1.40 vs 1.35±0.96(piggyback) and 1.45±1.03 mg/dL(CR); P=0.102].Accordingly, the proportion of patients displaying RIFLE stages≥2 was the highest in CR/CR-B(26%/19%) when compared to piggyback(18%).CONCLUSIONS: Piggyback revealed a shorter warm ischemic time, a reduced blood loss, and a decreased risk of acute kidney failure. Thus, piggyback is a useful technique, which should be applied in standard procedures. When piggyback is unfeasible,cava replacement, which displayed a lower incidence of vascular and biliary complications in our study, remains as a safe alternative. | Volker Schmitz Wenzel Schoening Ines Jelkmann Brigitta Globke Andreas Pascher Marcus Bahra Peter Neuhaus Gero Puhl | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 5 |
| 10 | Changes in hospital admissions and inpatient tariff associated with a Diabetes Integrated Care Initiative: Preliminary findings (与糖尿病综合护理计划相关的住院以及住院费用的变化:初步调查结果)显示文摘 | David Simmons Dahai Yu Helmut Wenzel | 2014 | Journal of Diabetes2014，，1： | 3 |
| 11 | Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study显示文摘Twenty-three recommendations were summarized by the Enhanced Recovery After Surgery(ERAS)society for liver surgery.The aim was to validate the protocol especially with regard to adherence and the impact on morbidity.Methods:Using the ERAS Interactive Audit System(EIAS),ERAS items were evaluated in patients undergoing liver resection.Over a period of 26 months,304 patients were prospectively enrolled in an observational study(DRKS00017229).Of those,51 patients(non-ERAS)were enrolled before and 253 patients(ERAS)after the implementation of the ERAS protocol.Perioperative adherence and complications were compared between the two groups.Results:Overall adherence increased from 45.2%in the non-ERAS group to 62.7%in the ERAS group(P<0.001).This was associated with significant improvements in the preoperative and postoperative phase(P<0.001),rather than in the outpatient and intraoperative phase(both P>0.05).Overall complications decreased from 41.2%(n=21)in the non-ERAS group to 26.5%(n=67)in the ERAS group(P=0.0423),which was mainly due to the reduction of grade 1-2 complications from 17.6%(n=9)to 7.6%(n=19)(P=0.0322).As for patients undergoing open surgery,implementation of ERAS lead to a reduction of overall complications in patients scheduled for minimally invasive liver surgery(MILS)(P=0.036).Conclusions:Implementation of the ERAS protocol for liver surgery according to the ERAS guidelines of the ERAS Society reduced Clavien-Dindo grade 1-2 complications particularly in patients who underwent MILS.The ERAS guidelines are beneficial for the outcome,while adherence to the various items has not yet been satisfactorily defined. | Moritz Schmelzle Felix Krenzien Paul Dahlke Alina Krombholz Nora Nevermann Linda Feldbrügge Axel Winter Wenzel Schoning Christian Benzing Johann Pratschke Jens Neudecker | 2023 | Hepatobiliary Surgery and Nutrition2023，12，1： | 3 |
| 12 | 含铝废LiFePO_(4)正极粉在H2SO_(4)溶液中的浸出性能显示文摘研究含铝废LiFePO_(4)(LFP)正极粉中LFP和Al的浸出行为及浸出动力学。考察温度(273~368 K)、搅拌速率(200~950 r/min)、反应时间(0~240 min)、酸料比(0.1:1~1:1 mL/g)和液固比(3:1~9:1 mL/g)对浸出过程的影响。结果表明,反应物浓度和温度对Al浸出影响较大。在优化的浸出条件下,LFP和Al的浸出率分别为91.53%和15.98%。动力学研究表明,LFP的浸出受表面化学反应与扩散混合控制,活化能为22.990 kJ/mol;而Al的浸出仅受表面化学反应的控制,活化能为46.581 kJ/mol。在废LFP正极材料酸浸过程中控制浸出体系低温能有效抑制铝的溶解。 | 娄文博 张洋 张盈 郑诗礼 孙沛 王晓健 李建中 乔珊 张懿 Marco WENZEL Jan JWEIGAND | 2021 | Transactions of Nonferrous Metals Society of China2021，31，3： | 2 |
| 13 | Endothelial Microparticle–Mediated Transfer of MicroRNA-126 Promotes Vascular Endothelial Cell Repair via SPRED1 and Is Abrogated in Glucose-Damaged Endothelial Microparticles显示文摘 | Felix Jansen Xiaoyan Yang Marion Hoelscher Arianna Cattelan Theresa Schmitz Sebastian Proebsting Daniela Wenzel Sarah Vosen Bernardo S. Franklin Bernd K. Fleischmann Georg Nickenig Nikos Werner | 2013 | Circulation2013，，18： | 2 |
| 14 | Long term effects of non invasive mechanical ventilation on pulmonary haemodynamics in patients w ith chronic respiratory failure显示文摘 | Schonhofer B Barchfeld T Wenzel M | 2001 | Thorax2001，56，： | 2 |
| 15 | Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies显示文摘 | Sally Wenzel Darren Wilbraham Rick Fuller Elise Burmeister Getz Malinda Longphre | 2007 | The Lancet2007，，9596： | 2 |
| 16 | Role of assisted natural remediation in environmental cleanup显示文摘 | D.C. Adriano W.W. Wenzel J. Vangronsveld N.S. Bolan | 2004 | Geoderma2004，，2： | 2 |
| 17 | Pathophysiology of severe asthma显示文摘 | Busse WW Banks Schlegel S Wenzel SE | | 0，，： | 2 |
| 18 | 三维场景全自动建模及精度分析显示文摘针对摄影测量三维建模向全自动化发展的背景,该文基于SURE摄影测量软件,实现了自动化建立三维场景。阐述了主要的处理环节,包括密集匹配、平差交会、三角构网及贴图等,可生产的产品包括密集点云、真正射影像、数字表面模型、不规则三角网及三维贴图场景;通过分析匹配效率及点云和数字表面模型的精度,显示出其产品均可达到测量级精度。使用高重叠度或倾斜影像,SURE还可以生产出精美的三维城市模型;充分挖掘每一个像素的高精度三维坐标,是其在同类软件中的一大特色。 | 付海龙 ROTHERMEL Mathias WENZEL Konrad HALAA Norbert | 2017 | 测绘科学2017，42，2： | 2 |
| 19 | Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry显示文摘 | Cédric Bovet Benoit Plet Marc Ruff Sylvia Eiler Florence Granger Andreas Panagiotidis Ryan Wenzel Alexis Nazabal Dino Moras Renato Zenobi | 2009 | Toxicology in Vitro2009，，4： | 2 |
| 20 | Warm HTK donor pretreatment reduces liver injury during static cold storage in experimental rat liver transplantation显示文摘BACKGROUND: Organ shortage has led to an increased number of transplantations from extended criteria donors. These organs are more vulnerable to ischemia-reperfusion injury. Thus,improvement of organ preservation is needed. HTK is a widely used preservation solution for static cold storage in liver transplantation. The present study was to investigate the beneficial effect of warm HTK donor pretreatment on liver preservation.METHODS: Male inbred Wistar rats(weighing 230-260 g) served as donors and recipients(n=6/group). Donors of treatment groups received i.v. 0.01 m L/g body weight(BW) warm(21 ℃) HTK systemically 15 minutes prior to cold perfusion. Control groups received 0.01 m L/g BW warm(21 ℃) Na Cl 0.9%. Following pretreatment,donors were flushed with 4 ℃ cold HTK,livers were explanted and stored in 4 ℃ HTK for six hours. Thereafter orthotopic liver transplantation was performed. Recipients were harvested four hours,two and five days after reperfusion and blood and liver tissue samples were obtained. Blood samples were analyzed for AST,ALT,lactate dehydrogenase and bilirubin. Liver histological analysis as well as tissue analysis for pro-MMP2,MMP2 and pro-MMP9 using zymography was conducted.RESULTS: Treatment groups showed significantly lower ALT and lactate dehydrogenase levels as well as significantly lower activities of pro-MMP2,MMP2 and pro-MMP9. Histological analysis revealed only minor damage in all groups.CONCLUSIONS: The new concept of warm HTK pretreatment significantly reduced ischemia-reperfusion injury. The reduced ischemia-reperfusion injury was due to MMP inhibition. Warm HTK donor pretreatment is easy to handle and could further improve HTK's potency in liver preservation. | Wenzel Schoening Veeravorn Ariyakhagorn Thomas Schubert Peter Olschewski Andreas Andreou Peter Neuhaus Johann Pratschke Gero Puhl | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 2 |
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