|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 2 | Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry显示文摘 | Cédric Bovet Benoit Plet Marc Ruff Sylvia Eiler Florence Granger Andreas Panagiotidis Ryan Wenzel Alexis Nazabal Dino Moras Renato Zenobi | 2009 | Toxicology in Vitro2009，，4： | 2 |
| 3 | Oxyfluoride Tellurite Glasses Doped by Erbium:Thermal Analysis,Structural Organization and Spectral Properties显示文摘 | Nazabal V Todoroki S Nukui A | 2003 | J Non-Cryst Solids2003，325，： | 1 |
| 4 | Morphology and Mechanical Performance of Pregenerated and 'In-situ' PP/Vectra B Composites 显示文摘 | F J Vallejo J I Eguiazabal J Nazabal | 1999 | Polymer Engineering and Science1999，39，9： | 1 |
| 5 | Transition and mechanical properties in polyoxymethylene / phenoxy blend显示文摘 | Erro R GazteJumendi M Nazabal J | 1996 | Journal of Polymer Science Part B : Polymer Physics1996，34，： | 1 |
| 6 | Posterior alien hand syndrome after a right thalamic infarction显示文摘 | Lopez JM nazabal ER Magdalena LA | 2002 | J Neurol Neurosurg Psychiatry2002，73，： | 1 |
| 7 | Er^3+-doped GeGaSbS glasses for mid-IR fiber laser application: synthesis and rare earth spectroscopy 显示文摘 | MOIZAN V NAZABAL V TROLES J | 2008 | Opt Mater2008，31，1： | 1 |
| 8 | , Thermally Poled New Borate Glasses for Second-harmonic Generation显示文摘 | Nazabal V Fargin E Ferreira B | 2001 | J Noncryst Solids2001，290，： | 1 |
| 9 | The influence of surface modification on the structure and properties of a nanosilica filled thermoplastic elastomer显示文摘 | Aso O Eguiza' Bal J I Nazabal J | 2007 | Composites Science and Technology2007，67，： | 1 |
| 10 | Super toughness and critical interparticle distance dependence in poly (butylene terephthalate ) and poly ( ethylene-co-glycidyl methacrylate ) blends 显示文摘 | AROSTEGUI A NAZABAL J | 2003 | J Appl Polym Sci (Part B): Polym Phys2003，41，： | 1 |
| 11 | Compatibilization of a poly(butylene terephthalate)/poly(ethylene octene)copolymer blends with different amounts of an epoxy resin显示文摘 | Arostegui A Nazabal J | 2004 | J Ploy Sci2004，91，1： | 1 |
| 12 | 显示文摘 | Garcia M Eguiazabal J I Nazabal I | 2001 | Journal of Applied Polymer Science2001，81，： | 1 |
| 13 | Structure and mechanical properties of poly (sulfone of bisphenol A) / poly (butylene terephthalate) blends显示文摘 | RETOLAZA A EGUIAZABAL JI NAZABAL J | 2004 | Polym Int2004，53，12： | 1 |
| 14 | Toughened Poly(butylene terephthalate) by Blending with a Metallocenic POE Copolymer显示文摘 | Arostegui A Gaztelumendi M Nazabal J | 2001 | Polymer2001，42，： | 1 |
| 15 | Processability,morphology and mechanical properties of glass fiber reinforced poly (ether sulfone) modified by a liquid crystalline copolyester显示文摘 | GARCIA M EGUIAZABAL J I NAZABAL J | 2003 | Polym Compos2003，24，6： | 1 |
| 16 | Toughened poly(butylenes terephthalate) by blending with a metallocenic poly(ethylene-octene) copolymer显示文摘 | AROSTEGUI A GAZTELUMENDI M NAZABAL J | 2001 | Polymer2001，42，： | 1 |
| 17 | New Clay-Reinforced Nanocomposites Based on a Polycarbonate/Polycaprolactone Blend 显示文摘 | Gonzalez I Eguiazabal J I Nazabal J | 2006 | Polymer Eng Sci2006，46，： | 1 |
| 18 | Crystalline phase responsible for the permanent second- harmonic generation in chalcogenide glass ceramics 显示文摘 | GUIGNARD M NAZABAL V ZHANG X H | 2007 | Optical Materials2007，30，2： | 1 |
| 19 | Posterior alien hand syndrome after a rught thalamic in- farct显示文摘 | Marey- Lopez J Rubio- Nazabal E Alonso- Magdalena L | 2002 | Neurol Neurosurg Psychiatry2002，73，： | 1 |
| 20 | Toughened poly(butylene terephthalate) by blending with a metallocenic poly (ethlene-octene) copolymer 显示文摘 | Arostegui A Gaztelumendi M Nazabal J | 2001 | Polymer2001，42，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员