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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | 油膜轴承变形和压力分析显示文摘轧机油膜轴承最新试验结果表明,实测油膜厚度比计算机模型预测值大3~5倍。这意味着,油膜厚度增加是由于锥套和衬套变形的结果,这种变形会导致锥套和衬套压力场扩大,进而导致油膜厚度增加。如果油膜厚度真的比预想的高3~5倍,则不但可以充分利用轴承固有的安全系数,而且还可以提高轴承的最大运行负荷。为确认试验结果,DanOil油膜轴承工程师构建了因液体动压场变化而导致的锥套变形模型,然后将这种变形用于复杂的计算机轴承模拟程序,来计算新的压力场。对压力场和锥套变形进行重复迭代计算,直到计算结果收敛为止。介绍了这一分析方法和计算结果。 | Thomas E Simmons Andrea Contarini Nonino Gianni 苏宏蕾 | 2009 | 钢铁2009，44，3： | 7 |
| 3 | 汉语方言通音显示文摘本文为除闽方言之外的汉语方言构建一个共通的音韵体系,即'汉语方言通音'。一般汉语方言共同音系的制定主要通过两种途径:一为使用语言学的比较方法,立足于现代方言进行归纳和构建,二为借用《切韵》的音类,系统地去除现代汉语方言中所没有的音类与特征。第二种方法相对更益于操作也更有效。汉语方言通音的基本音韵框架是基于对现今方言的语音材料的相比较而获得的,这并不需要借助历史材料或汉日、汉韩等国外语音标注材料。通过对《切韵》音类的削减和重新整理,本文初步地列出了简略而又相对全面的'汉语方言通音'的音系。 | 罗杰瑞 R. VanNess Simmons 史皓元 张艳红(译) | 2011 | 方言2011，33，2： | 5 |
| 4 | Inundative field releases and evaluation of three predators for Bemisia tabaci (Hemiptera: Aleyrodidae) management in three vegetable crops显示文摘sweetpotato whitefly, Bemisia tabaci (Gennadius )( 半翅类:Aleyrodidae ) ,是众多的庄稼上的一个全球害虫,包括蔬菜。一个 coccinellid 食肉动物的每周的 inundative 版本(Coccinella undecimpunctata L。[翘目:Coccinellidae ]) ,一个普通绿草蜻蛉食肉动物(Chrysoperla carnea 史蒂芬[Neuroptera:Chrysopidae ]) ,并且一个 mirid 食肉动物(Macrolophus caliginosus [瓦格纳][ 半翅类:Miridae ]) 独立地在三蔬菜庄稼被做(卷心菜[Brassica oleracea var。capitata L.] ,黄瓜[Cucumis sativus L.] ,并且挤压[Cucurbita pepo L.]) 为 sweetpotato 的管理 whitefly。约 100 万在 20 个星期期间在蔬菜庄稼被释放到每个食肉动物的 250 万个幼虫或美女。Whitefly,人口被 25%45% 在每个食肉动物被释放的每庄稼在大多数季节期间减少。每个食肉动物的效果 whitefly 开是类似的人口减小。在人口 whitefly 是低的季节(10 月) 迟了,通常,没有利益从释放食肉动物被获得。在所有庄稼在采样期间恢复的食肉动物的数字为 C 是最大的。carnea,而是这与这个食肉动物的更多的个人在实验比任何另外的食肉动物被释放的事实相应。这些结果帮助为管理 B 定义这些生来的敌人的用途。在蔬菜庄稼的 tabaci。 | Alvin M. Simmons Shaaban Abd-Rabou | 2011 | Insect Science2011，18，2： | 4 |
| 5 | An improved understanding of soil Cd risk to humans and low cost methods to phytoextract Cd from contaminated soils to prevent soil Cd risks显示文摘 | Rufus L. Chaney Philip G. Reeves James A. Ryan Robert W. Simmons Ross M. Welch J. Scott Angle | 2004 | BioMetals2004，，5： | 4 |
| 6 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 7 | Changes in hospital admissions and inpatient tariff associated with a Diabetes Integrated Care Initiative: Preliminary findings (与糖尿病综合护理计划相关的住院以及住院费用的变化:初步调查结果)显示文摘 | David Simmons Dahai Yu Helmut Wenzel | 2014 | Journal of Diabetes2014，，1： | 3 |
| 8 | 输血相关的急性肺损伤引起的死亡显示文摘美国食品和药品管理局(FDA)生物评估和研究中心(CBER)是一所负责监督由生物制品(包括血液和血液成分)引起严重事件和死亡事件的机构.采血或输血引起的致命性并发症必须向该机构报告.在过去的几年里,该机构每年接到70~80例死亡报告,常见的导致死亡的输血并发症是溶血性输血反应/ABO血型不合、血液产品细菌污染引起的败血症和输血相关的急性肺损伤(TRALI). | Holness L Knippen MA Simmons L 赵凤绵 张燕 董碧晨 | 2005 | 国外医学(输血及血液学分册)2005，28，3： | 3 |
| 9 | Laparoscopic Radical Versus Partial Nephrectomy for Tumors >4 cm: Intermediate-term Oncologic and Functional Outcomes显示文摘 | Matthew N. Simmons Christopher J. Weight Inderbir S. Gill | 2009 | Urology2009，，： | 3 |
| 10 | A new binder for powder injection molding titanium and other reactive metals显示文摘 | K. Scott Weil Eric Nyberg Kevin Simmons | 2006 | Journal of Materials Processing Tech2006，，1： | 3 |
| 11 | Relationships among student and graduate caring ability and professional school climate显示文摘 | Priscilla R. Simmons Sally H. Cavanaugh | 2000 | Journal of Professional Nursing2000，，2： | 3 |
| 12 | Energy use associated with different travel choices显示文摘 | Susanne Becken David G Simmons Chris Frampton | 2002 | Tourism Management2002，，3： | 2 |
| 13 | Statistical optics applied to high-power glass lasers显示文摘 | Manes K R Simmons W W | 1985 | J Opt Soc Am A1985，2，4： | 2 |
| 14 | Living on the Edge: A Complexity-Informed Exploration of the Human–Water Relationship显示文摘 | Bruce Simmons Robert Woog Vladimir Dimitrov | 2007 | World Futures (-)2007，，3： | 2 |
| 15 | Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype显示文摘 | Li A Simmons P J Kaur P | 1998 | Proc Natl Acad Sci U S A1998，95，7： | 2 |
| 16 | Application of DNA barcodes in Hedyotis L.(Spermacoceae,Rubiaceae)显示文摘The potential application of DNA barcodes of plastid(matK,trnH-psbA,petD,and rbcL) and nuclear(internal transcribed spacer(ITS) of rDNA) DNA regions was investigated for 25 Hedyotis taxa.The ITS showed the best species discrimination by resolving 23 of the species as exclusive lineages with no shared alleles between any of the 24 distinct species(H.assimilis and H.mellii are not supported as distinct species based on our molecular and morphological data).Conversely,rbcL performed the worst and only resolved 10 of the species as exclusive lineages,and 10 species with shared alleles.Using ITS has the advantage of high PCR amplification success and it provides good intra-and interspecific variation distribution patterns.The most powerful plastid markers were petD and trnH-psbA,but we could amplify and sequence trnH-psbA for only 83% of the accessions sampled.Combination of ITS and petD performed extremely well,with all 24 of the distinct species resolved as exclusive lineages and no shared alleles between any of the distinct species.We therefore recommend ITS,or a combination of ITS and petD,as the standard DNA barcode in Hedyotis,but acknowledge that there are no shared alleles between distinct species for matK and rbcL combined. | Xing GUO Mark R SIMMONS Paul Pui-Hay BUT Pang-Chui SHAW Rui-Jiang WANG | 2011 | Journal of Systematics and Evolution2011，49，3： | 2 |
| 17 | Energy consumption patterns in the accommodation sector—the New Zealand case显示文摘 | Susanne Becken Chris Frampton David Simmons | 2001 | Ecological Economics2001，，3： | 2 |
| 18 | Overview: high-nitrogen alloying of stainless steels显示文摘 | J.W. Simmons | 1996 | Materials Science & Engineering A1996，，2： | 2 |
| 19 | 航空发动机内部齿轮箱主腔流场的数值模拟显示文摘通过建立的内部齿轮箱主腔简化模型,应用RNGk-ε湍流模型,对航空发动机内部齿轮箱主腔流场进行了CFD数值模拟,分析了进口旋流对主腔内流动的影响。结果表明:进口速度增加时,进入主腔内的流体会更快穿过主腔流出,并减少与腔内低能流动的混合,且流体在腔内的停留时间与其进口速度存在一定程度的关联,速度越高越快离开主腔;腔内流场以出口位置作为径向分界面,可大致分为上部受进口旋流影响的区域,和底部不受进口气流影响的低速流动区域;在上部区域,由于进口旋流的作用,流场中生成了4个大小不等的旋涡,使得流动掺混增强。 | 王春利 Kathy Simmons Adam Turner | 2014 | 燃气涡轮试验与研究2014，27，6： | 2 |
| 20 | Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix显示文摘 | S Gronthos P.J Simmons S.E Graves P G. Robey | 2001 | Bone2001，，2： | 2 |
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