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| 1 | Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: A review and report of personal experience显示文摘选择 cyclooxygenase (艇长)-2 禁止者(coxibs ) 作为反煽动性的药之一被开发避免 non-steroidal 的各种各样的副作用反煽动性的药(NSAID ) 。然而, coxibs 也有一个能力禁止各种各样的类型的肿瘤开发 NSAID 的一样的方法。用细胞线和动物模型的许多试验性的研究表明了一个能力阻止 COX-2 禁止者的肿瘤增长。在为息肉 chemoprevention 执行使随机化的研究以后,与家庭腺瘤息肉病( FAP )在病人学习,它证明有 celecoxib 的治疗, coxibs 之一,显著地减少了颜色的数字在 2000 的表面的息肉,美国食物药品管理局(食物及药品管理局)立即为 FAP 病人同意了临床的使用 celecoxib 。然而,某 coxibs 最近被报导包括心脏病和击增加严肃的心血管的事件的风险。在这篇文章,我们在胃肠道的致癌作用考察 COX-2 的一个角色,例如食管,胃和 colorectum,并且也为胃肠道肿瘤的 chemoprevention 分析 coxibs 的前景。 | Takashi Fujimura Tetsuo Ohta Katsunobu Oyama Tomoharu Miyashita Koichi Miwa | 2006 | World Journal of Gastroenterology2006，12，9： | 33 |
| 2 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 3 | Life prognosis of sentinel node navigation surgery for early-stage gastric cancer:Outcome of lymphatic basin dissection显示文摘BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be performed.The oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully investigated.We hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the guidelines.AIM To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines surgery.METHODS This was a retrospective cohort study.Patients were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March 2016.Patients from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University Hospital.Patients who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively collected.The overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were investigated.Patients with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control group.RESULTS A total of 239 patients in the SNNS group and 423 patients in the control group were included.Pathological nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,respectively.The diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,respectively.In the SNNS group,81.6%of patients underwent modified gastrectomy or functionpreserving curative gastrectomy with lymphatic basin dissection,in which the extent of nodal dissection was further reduced compared to the guidelines.The OS rate in the SNNS group was 96.8%at 5 years and was significantly better than 91.3%in the control group(P=0.0014).The RFS rates were equal in both groups.After propensity score matching,there were 231 patients in both groups,and the cumulative recurrence rate was 0.43%at 5 years in the SNNS group and 1.30%in the control group,which was not statistically different.CONCLUSION The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery. | Shinichi Kinami Naohiko Nakamura Tomoharu Miyashita Hidekazu Kitakata Sachio Fushida Takashi Fujimura Yasuo Iida Noriyuki Inaki Toru Ito Hiroyuki Takamura | 2021 | World Journal of Gastroenterology2021，27，46： | 5 |
| 4 | Clinical and radiological feature of lymphoepithelial cyst of the pancreas显示文摘A lymphoepithelial cyst(LEC)of the pancreas is a rare benign lesion.Because patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment strategy.Previous studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of LECs.We reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical factors.We found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings. | Hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue Kazuto Kozaka Toshifumi Gabata Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，45： | 4 |
| 5 | Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma显示文摘 | Etsuro Bando Yutaka Yonemura Keizo Taniguchi Toshiaki Yasui Sachio Fushida Takashi Fujimura Gen-ichi Nishimura Koichi Miwa | 1999 | The American Journal of Surgery1999，，3： | 2 |
| 6 | PTD classification: proposal for a new classification of gastric cancer location based on physiological lymphatic flow显示文摘 | Shinichi Kinami Takashi Fujimura Eisuke Ojima Sachio Fushida Toshihiko Ojima Hiroshi Funaki Hideto Fujita Hiroyuki Takamura Itasu Ninomiya Genichi Nishimura Masato Kayahara Tetsuo Ohta Zen Yoh | 2008 | International Journal of Clinical Oncology2008，，4： | 2 |
| 7 | Comprehensive proteomics analysis of autophagy-deficient mouse liver显示文摘 | Naomi Matsumoto Junji Ezaki Masaaki Komatsu Katsuyuki Takahashi Reiko Mineki Hikari Taka Mika Kikkawa Tsutomu Fujimura Mitsue Takeda-Ezaki Takashi Ueno Keiji Tanaka Eiki Kominami | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 1 |
| 8 | Hyperthermo-chemotherapy combined with cytoreductive surgery for the treatment of gastric cancer with peritoneal dissemination显示文摘 | Yutaka Yonemura M.D. Takashi Fujimura M.D. Sachio Fushida M.D. Shigeru Takegawa M.D. Toru Kamata M.D. Kanji Katayama M.D. Takeo Kosaka M.D. Akio Yamaguchi M.D. Kouichi Miwa M.D. Ituo Miyazaki M.D | 1991 | World Journal of Surgery1991，，4： | 1 |
| 9 | Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma显示文摘 | Etsuro Bando Yutaka Yonemura Keizo Taniguchi Toshiaki Yasui Sachio Fushida Takashi Fujimura Gen-ichi Nishimura Koichi Miwa | 1999 | The American Journal of Surgery1999，，3： | 1 |
| 10 | The role of human peritoneal mesothelial cells in the fibrosis and progressionof gastric cancer显示文摘 | Tomoya Tsukada Sachio Fushida Shinichi Harada Yasumichi Yagi Jun Kinoshita Katsunobu Oyama Hidehiro Tajima Hideto Fujita Itasu Ninomiya Takashi Fujimura Tetsuo Ohta | 2012 | International Journal of Oncology2012，，2： | 1 |
| 11 | The management of a remnant pancreatic stump for preventing the development of postoperative pancreatic fistulas after distal pancreatectomy: current evidence and our strategy显示文摘 | Isamu Makino Hirohisa Kitagawa Hisatoshi Nakagawara Hidehiro Tajima Itasu Ninomiya Sachio Fushida Takashi Fujimura Tetsuo Ohta | 2013 | Surgery Today2013，，6： | 1 |
| 12 | Continuous hyperthermic peritoneal perfusion for the prevention of peritoneal recurrence of gastric cancer: Randomized controlled study显示文摘 | Takashi Fujimura Yutaka Yonemura Keiichi Muraoka Hiroyuki Takamura Yasuo Hirono Hiroyuki Sahara Itasu Ninomiya Hisashi Matsumoto Kouichiro Tsugawa Gen-ichi Nishimura Kazuo Sugiyama Kouichi Miwa Itsuo Miyazaki | 1994 | World Journal of Surgery1994，，1： | 1 |
| 13 | Continuous hyperthermic peritoneal perfusion for the prevention of peritoneal recurrence of gastric cancer: Randomized controlled study显示文摘 | Takashi Fujimura M.D. Yutaka Yonemura M.D. Keiichi Muraoka M.D. Hiroyuki Takamura M.D. Yasuo Hirono M.D. Hiroyuki Sahara M.D. Itasu Ninomiya M.D. Hisashi Matsumoto M.D. Kouichiro Tsugawa M.D. Gen-ichi Nishimura M.D. Kazuo Sugiyama M.D. Kouichi Miwa M.D. I | 1994 | World Journal of Surgery1994，，1： | 1 |
| 14 | Hyperthermo-chemotherapy combined with cytoreductive surgery for the treatment of gastric cancer with peritoneal dissemination显示文摘 | Yutaka Yonemura M.D. Takashi Fujimura M.D. Sachio Fushida M.D. Shigeru Takegawa M.D. Toru Kamata M.D. Kanji Katayama M.D. Takeo Kosaka M.D. Akio Yamaguchi M.D. Kouichi Miwa M.D. Ituo Miyazaki M.D | 1991 | World Journal of Surgery1991，，4： | 1 |
| 15 | A COX-2 inhibitor prevents the esophageal inflammation-metaplasia-adenocarcinoma sequence in rats 显示文摘 | Oyama Katsunobu Fujimura Takashi Ninomiya Itasu | 2005 | Carcinogenesis2005，，3： | 1 |
| 16 | Transectional gastrectomy: An old but renewed concept for early gastric cancer显示文摘 | Takashi Fujimura Sachio Fushida Masato Kayahara Tetsuo Ohta Shinichi Kinami Koichi Miwa | 2010 | Surgery Today2010，，5： | 1 |
| 17 | Outcome of ratio of lymph node metastasis in gastric carcinoma显示文摘 | Etsuro Bando MD Yutaka Yonemura MD Keizo Taniguchi MD Sachio Fushida MD Takashi Fujimura MD Koichi Miwa MD | 2002 | Annals of Surgical Oncology2002，，8： | 1 |
| 18 | Outcome of ratio of lymph node metastasis in gastric carcinoma显示文摘 | Etsuro Bando MD Yutaka Yonemura MD Keizo Taniguchi MD Sachio Fushida MD Takashi Fujimura MD Koichi Miwa MD | 2002 | Annals of Surgical Oncology2002，，8： | 1 |
| 19 | Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice显示文摘 | Yasumichi Yagi Sachio Fushida Shinichi Harada Tomoya Tsukada Jun Kinoshita Katsunobu Oyama Hideto Fujita Itasu Ninomiya Takashi Fujimura Masato Kayahara Seigo Kinuya Masakazu Yashiro Kousei Hirakawa Tetsuo Ohta | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 1 |
| 20 | Sivelestat Sodium Hydrate Inhibits Neutrophil Migration to the Vessel Wall and Suppresses Hepatic Ischemia–Reperfusion Injury显示文摘 | Seisho Sakai Hidehiro Tajima Tomoharu Miyashita Shin-ichi Nakanuma Isamu Makino Hironori Hayashi Hisatoshi Nakagawara Hirohisa Kitagawa Sachio Fushida Takashi Fujimura Hidehito Saito Seiichi Munesue Yasuhiko Yamamoto Tetsuo Ohta | 2014 | Digestive Diseases and Sciences2014，，4： | 1 |
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