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| 1 | Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: A review and report of personal experience显示文摘选择 cyclooxygenase (艇长)-2 禁止者(coxibs ) 作为反煽动性的药之一被开发避免 non-steroidal 的各种各样的副作用反煽动性的药(NSAID ) 。然而, coxibs 也有一个能力禁止各种各样的类型的肿瘤开发 NSAID 的一样的方法。用细胞线和动物模型的许多试验性的研究表明了一个能力阻止 COX-2 禁止者的肿瘤增长。在为息肉 chemoprevention 执行使随机化的研究以后,与家庭腺瘤息肉病( FAP )在病人学习,它证明有 celecoxib 的治疗, coxibs 之一,显著地减少了颜色的数字在 2000 的表面的息肉,美国食物药品管理局(食物及药品管理局)立即为 FAP 病人同意了临床的使用 celecoxib 。然而,某 coxibs 最近被报导包括心脏病和击增加严肃的心血管的事件的风险。在这篇文章,我们在胃肠道的致癌作用考察 COX-2 的一个角色,例如食管,胃和 colorectum,并且也为胃肠道肿瘤的 chemoprevention 分析 coxibs 的前景。 | Takashi Fujimura Tetsuo Ohta Katsunobu Oyama Tomoharu Miyashita Koichi Miwa | 2006 | World Journal of Gastroenterology2006，12，9： | 33 |
| 2 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 3 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 4 | Assessing pre/post-weaning neurobehavioral development for perinatal exposure to low doses of methylmercury显示文摘Fetuses and neonates are known to be high-risk groups for Methylmercury(MeHg)exposure.MeHg can be transferred to the fetus through the placenta and to newborn offspring through breast milk.The aim of the present study was to investigate the neurotoxic effects of low doses of MeHg(1 and 5 μg/m L in drinking water) administration,from gestational day 1 to postnatal day(PND) 21,on the neurobehavioral development of rats.The results showed that the no-observed-effect level of MeHg is somewhere in the range of 1–4 μg/mL.Neurobehavioral development analysis revealed a delayed appearance of cliff drop and negative geotaxis reflexes in the 5 μg/mL MeHg exposure group.Developmental exposure to MeHg affected locomotor activity functions for the females,but not for the males,implying that the female pups were more vulnerable than the male pups.All pups exposed to 5 μg/mL of MeHg showed a significant deficit in motor coordination in the rotarod test compared with controls,and the highest accumulated concentrations of Hg were found in the cerebellum,followed by the hippocampus and cerebral cortex,indicating that the cerebellum is a possible target for MeHg toxicity.We demonstrated adverse effects of developmental exposure to MeHg associated with tissue concentrations very close to the current human body burden of this persistent and bioaccumulative compound. | Jinping Cheng Masatake Fujimura Dandan Bo | 2015 | Journal of Environmental Sciences2015，27，12： | 6 |
| 5 | Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature显示文摘BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE.CONCLUSION This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation. | Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa | 2019 | World Journal of Gastroenterology2019，25，15： | 5 |
| 6 | Life prognosis of sentinel node navigation surgery for early-stage gastric cancer:Outcome of lymphatic basin dissection显示文摘BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be performed.The oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully investigated.We hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the guidelines.AIM To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines surgery.METHODS This was a retrospective cohort study.Patients were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March 2016.Patients from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University Hospital.Patients who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively collected.The overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were investigated.Patients with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control group.RESULTS A total of 239 patients in the SNNS group and 423 patients in the control group were included.Pathological nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,respectively.The diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,respectively.In the SNNS group,81.6%of patients underwent modified gastrectomy or functionpreserving curative gastrectomy with lymphatic basin dissection,in which the extent of nodal dissection was further reduced compared to the guidelines.The OS rate in the SNNS group was 96.8%at 5 years and was significantly better than 91.3%in the control group(P=0.0014).The RFS rates were equal in both groups.After propensity score matching,there were 231 patients in both groups,and the cumulative recurrence rate was 0.43%at 5 years in the SNNS group and 1.30%in the control group,which was not statistically different.CONCLUSION The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery. | Shinichi Kinami Naohiko Nakamura Tomoharu Miyashita Hidekazu Kitakata Sachio Fushida Takashi Fujimura Yasuo Iida Noriyuki Inaki Toru Ito Hiroyuki Takamura | 2021 | World Journal of Gastroenterology2021，27，46： | 5 |
| 7 | Clinical and radiological feature of lymphoepithelial cyst of the pancreas显示文摘A lymphoepithelial cyst(LEC)of the pancreas is a rare benign lesion.Because patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment strategy.Previous studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of LECs.We reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical factors.We found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings. | Hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue Kazuto Kozaka Toshifumi Gabata Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，45： | 4 |
| 8 | Immunohistochemical study on tumor angiogenic factors in non-small cell lung cancer显示文摘 | Aikawa H Takahashi H Fujimura S | 1999 | Anticancer Res1999，19，： | 3 |
| 9 | Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma显示文摘 | Etsuro Bando Yutaka Yonemura Keizo Taniguchi Toshiaki Yasui Sachio Fushida Takashi Fujimura Gen-ichi Nishimura Koichi Miwa | 1999 | The American Journal of Surgery1999，，3： | 2 |
| 10 | Association of primary biliary cirrhosis with idiopathic thrombocytopenic purpura显示文摘Although both primary biliary cirrhosis (PBC) and idiopathic thrombocytopenic purpura (ITP) are autoimmune diseases, the association of the 2 diseases is rare. Here, we report a case of ITP that developed during the follow-up of PBC in a 74-year- old man. The patient had been diagnosed with PBC 12 years previously, and had received treatment with ursodeoxycholic acid. The platelet count decreased from approximately 60 × 109/L to 8 × 109/L, and the association of decompensated liver cirrhosis (PBC) with ITP was diagnosed. Steroid and immune gamma globulin therapy were successful in increasing the platelet count. Interestingly, human leukocyte antigen genotyping detected the alleles DQB10601 and DRB10803, which are related to both PBC and ITP in Japanese patients. This case suggests common immunogenetic factors might be involved in the development of PBC and ITP. | Nobuyuki Toshikuni Ryumei Yamato Haruhiko Kobashi Ken Nishino Nobu Inada Ritsuko Sakanoue Mitsuhiko Suehiro Yoshinori Fujimura Gotaro Yamada | 2008 | World Journal of Gastroenterology2008，14，15： | 2 |
| 11 | Cerebral infarction in the caudate nucleus associated with acute epidural hematoma and diffuse brain injury in a child after severe head injury显示文摘 | Miki Fujimura Motonobu Kameyama Osamu Motohashi Hiroyuki Kon Kiyoshi Ishii Takehide Onuma | 2004 | Child’s Nervous System2004，，6： | 2 |
| 12 | Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma显示文摘AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan. METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative patients.RESULTS:HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients. CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage. | Takehiro Tanaka Atsushi Fujimura Koichi Ichimura Hiroyuki Yanai Yasuharu Sato Katsuyohi Takata Hiroyuki Okada Seiji Kawano Shunsuke Tanabe Tadashi Yoshino | 2012 | World Journal of Gastroenterology2012，18，43： | 2 |
| 13 | Aquaporin-4 detection in mice reduces brain edema after acute water intoxication and ischemic stroke显示文摘 | Manley GT Fujimura M Ma T | 2000 | Nat Med2000，6，： | 2 |
| 14 | Purification and characterization of caffeine synthase from tea leaves显示文摘 | Kato M Mizuno K Fujimura T | 1999 | Plant Physiology1999，120，： | 2 |
| 15 | Novel Biological Based Method for Robot Navigation and Localization显示文摘The capability and reliability are crucial characteristics of mobile robots while navigating in complex environments. These robots are expected to perform many useful tasks which can improve the quality of life greatly. Robot localization and decisionmaking are the most important cognitive processes during navigation. However, most of these algorithms are not efficient and are challenging tasks while robots navigate through complex environments. In this paper,we propose a biologically inspired method for robot decision-making, based on rat's brain signals. Rodents accurately and rapidly navigate in complex spaces by localizing themselves in reference to the surrounding environmental landmarks. Firstly, we analyzed the rats' strategies while navigating in the complex Y-maze, and recorded local field potentials(LFPs), simultaneously.The recorded LFPs were processed and different features were extracted which were used as the input in the artificial neural network(ANN) to predict the rat's decision-making in each junction. The ANN performance was tested in a real robot and good performance is achieved. The implementation of our method on a real robot, demonstrates its abilities to imitate the rat's decision-making and integrate the internal states with external sensors, in order to perform reliable navigation in complex maze. | Endri Rama Genci Capi Yusuke Fujimura Norifumi Tanaka Shigenori Kawahara Mitsuru Jindai | 2018 | Journal of Electronic Science and Technology2018，16，1： | 2 |
| 16 | PTD classification: proposal for a new classification of gastric cancer location based on physiological lymphatic flow显示文摘 | Shinichi Kinami Takashi Fujimura Eisuke Ojima Sachio Fushida Toshihiko Ojima Hiroshi Funaki Hideto Fujita Hiroyuki Takamura Itasu Ninomiya Genichi Nishimura Masato Kayahara Tetsuo Ohta Zen Yoh | 2008 | International Journal of Clinical Oncology2008，，4： | 2 |
| 17 | 日粮中添加维生素E对热应激肉鸡肉品质、颜色、持水能力和剪切力的影响显示文摘试验旨在评价饲粮中添加维生素E(VE)对处于慢性热应激(HS)条件下的肉鸡的肉品质尤其是PSE肉(苍白色、柔软、渗水)的影响。将28日龄的雌性罗斯肉鸡分别饲养在24℃(常温:NT)和34℃(高温:HT)条件的独立笼中。NT组肉鸡饲喂基础饲粮。HT组肉鸡分别饲喂基础饲粮(HT)和在基础饲粮中添加VE 200 mg·kg-1(HT+E)。在38日龄时进行屠宰称重。测定胸肌的肉色、pH、持水力(WHC)和剪切力(SFV)。结果表明,与NC组相比,HT和HT+E组的体增重和采食量显著下降,补充VE对生长性能无显著影响,10 d 30℃的慢性热应激会导致PSE肉皮质进一步恶化,对胸肌韧性影响显著。在饲粮中添加VE可有效的抑制慢性热应激条件下PSE肉的产生。 | Hashizawa Y Kubota M Kadowaki M Fujimura S | 2014 | 饲料博览2014，，1： | 2 |
| 18 | Reduction of the DNA base excision repair protei,XRCC1,may contribute to DNA fragmentation after cold injury-induced brain trauma in mice显示文摘 | Miki Fujimura Yuiko Morita-Fujimura Nobuo Noshita | 2000 | Brain Res2000，869，12： | 2 |
| 19 | Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice显示文摘 | Fujimura M Mortia-Fujimura Y Kawase M | 1999 | Cereb Blood Flow Metab1999，19，5： | 2 |
| 20 | Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion显示文摘 | Fujimura M Gasche Y Fujimura YM | 1999 | Brain Research1999，842，： | 2 |
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