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| 1 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 2 | Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study显示文摘AIM To identify certain clinical factors other than the type of gastrectomy which affect the postoperative quality of life(QOL) of patients after gastrectomy.METHODS The postgastrectomy syndrome assessment scale(PGSAS)-45 was designed to assess the severity of symptoms, the living status and the QOL of gastrectomized patients. It consists of 45 items, of which 22 are original items while 23 were retrieved from the SF-8 and Gastrointestinal Symptoms Rating Scale questionnaires with permission. A nationwide surveillance study to validate PGSAS was conducted and 2368 gastric cancer patients who underwent various types of gastrectomy at 52 medical institutions were enrolled. Of these, 1777 patients who underwent total gastrectomy(TG) reconstructed with Roux-Y(n = 393), distal gastrectomy(DG) reconstructed with Billroth-I(n = 909), or DG reconstructed with Roux-Y(n = 475) were evaluated in the current study. The influence of the type of gastrectomy and other clinical factors such as age, sex, duration after surgery, the symptom severity, the degree of weight loss, dietary intake, and the ability for working on the postoperative QOL(i.e., dissatisfaction for daily life subscale, physical component summary and mental component summary of the SF-8) were examined by multiple regression analysis(MRA). In addition, importance of various symptoms such as esophageal reflux, abdominal pain, meal-related distress, indigestion, diarrhea, constipation and dumping on the postoperative living status and QOL were also appraised by MRA.RESULTS The postoperative QOL were significantly deteriorated in patients who underwent TG compared to those after DG. However, the extent of gastrectomy was not an influential factor on patients' QOL when adjusted by the MRA. Among various clinical factors, the symptom severity, ability for working, and necessity for additional meals were the most influential factorsto the postoperative QOL. As for the individual symptoms, meal-related distress, dumping, abdominal pain, and esophageal reflux significantly affected the postoperative QOL in that order, while the influence of indigestion, diarrhea and constipation was insignificant. CONCLUSION Several clinical factors such as the symptom severity(especially in meal-related distress and dumping), ability for working and necessity for additional meals were the main factors which affected the patients' wellbeing after gastrectomy. | Koji Nakada Masazumi Takahashi Masami Ikeda Shinichi Kinami Masashi Yoshida Yoshikazu Uenosono Yoshiyuki Kawashima Sayumi Nakao Atsushi Oshio Yoshimi Suzukamo Masanori Terashima Yasuhiro Kodera | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 3 | Sentinel Node Micrometastases Have High Proliferative Potential in Gastric Cancer显示文摘 | Shigehiro Yanagita Shoji Natsugoe Yoshikazu Uenosono Tsutomu Kozono Katsuhiko Ehi Takaaki Arigami Hideo Arima Sumiya Ishigami Takashi Aikou | 2008 | Journal of Surgical Research2008，，2： | 4 |
| 4 | Clinical Significance of Lymph Node Micrometastasis in Gastric Cancer显示文摘 | Takaaki Arigami Yoshikazu Uenosono Shigehiro Yanagita Akihiro Nakajo Sumiya Ishigami Hiroshi Okumura Yuko Kijima Shinichi Ueno Shoji Natsugoe | 2013 | Annals of Surgical Oncology2013，，2： | 3 |
| 5 | Quality of life after total vs distal gastrectomy with Rouxen-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45显示文摘AIM To investigate the detrimental impact of loss of reservoir capacity by comparing total gastrectomy(TGRY) and distal gastrectomy with the same Rouxen-Y(DGRY) reconstruction. The study was conducted using an integrated questionnaire, the Postgastrectomy Syndrome Assessment Scale(PGSAS)-45, recently developed by the Japan Postgastrectomy Syndrome Working Party.METHODS The PGSAS-45 comprises 8 items from the Short Form-8, 15 from the Gastrointestinal Symptom Rating Scale, and 22 newly selected items. Uni-and multivariate analysis was performed on 868 questionnaires completed by patients who underwent either TGRY(n = 393) or DGRY(n = 475) for stage I gastric cancer(52 institutions). Multivariate analysis weighed of six explanatory variables, including the type of gastrectomy(TGRY/DGRY), interval after surgery, age, gender, surgical approach(laparoscopic/open), and whether the celiac branch of the vagus nerve was preserved/divided on the quality of life(QOL).RESULTS The patients who underwent TGRY experienced the poorer QOL compared to DGRY in the 15 of 19 main outcome measures of PGSAS-45. Moreover, multiple regression analysis indicated that the type of gastrectomy, TGRY, most strongly and broadly impaired the postoperative QOL among six explanatory variables. CONCLUSION The results of the present study suggested that TGRY had a certain detrimental impact on the postoperative QOL, and the loss of reservoir capacity could be a major cause. | Masazumi Takahashi Masanori Terashima Hiroshi Kawahira Eishi Nagai Yoshikazu Uenosono Shinichi Kinami Yasuhiro Nagata Masashi Yoshida Keishiro Aoyagi Yasuhiro Kodera Koji Nakada | 2017 | World Journal of Gastroenterology2017，23，11： | 3 |
| 6 | Evaluation of sentinel node concept in gastric cancer based on lymph node micrometastasis determined by reverse transcription-polymerase chain reaction显示文摘 | Arigami T Natsugoe S Uenosono Y | 2006 | Ann Surg2006，243，3： | 1 |
| 7 | Microstructural development during gas-pressure sintering of α-silicon nitride显示文摘 | MITOMO M UENOSONO S | 1992 | J Am Ceram Soc1992，75，1： | 1 |
| 8 | Infiltration of antitumor immunocytes into the sentinel node in gastric cancer显示文摘 | Sumiya Ishigami M.D. Shoji Natsugoe M.D. Yoshikazu Uenosono M.D. Yoichi Hata M.D. Aikihiro Nakajo M.D. Futoshi Miyazono M.D. Masataka Matsumoto M.D. Shuichi Hokita M.D. Takashi Aikou M.D | 2003 | Journal of Gastrointestinal Surgery2003，，6： | 1 |
| 9 | Clinical significance of the B7-H4 coregulatory molecule as a novel prognostic marker in gastric cancer 显示文摘 | Arigami T Uenosono Y Ishigami S | 2011 | World J Surg2011，35，9： | 1 |
| 10 | CCR7 and CX- CR4 expression predicts lymph node status including mi- crometastasis in gastric cancer显示文摘 | Arigami T Natsugoe S Uenosono Y | 2009 | Int J Oncol2009，35，1： | 1 |
| 11 | Vascular endothelial growth factor - C and Dexpression correlates with lymph node micrometastasis in pN0 early gastric cancer 显示文摘 | Arigami T Natsugoe S Uenosono Y | 2009 | Journal of Surgical Oncology2009，99，3： | 1 |
| 12 | Clinical significance of the B7-H4 coregulatory molecule as a novel prognostic marker in gastric cancer显示文摘 | Arigami T Uenosono Y Ishigami S | 2011 | World J Surg2011，35，9： | 1 |
| 13 | Evaluation of sentinel node concept in gastric cancer based on lymph node micrometastasls determined by reverse transcription polymerase chain reaction 显示文摘 | Arigami T Natsugoe S Uenosono Y | 2006 | Ann Surg2006，243，3： | 1 |
| 14 | Vascular endothelial growth factor-C and-D expression correlates with lymph node micrometastasis in pN0 early gastric cancer显示文摘 | Arigami T Natsugoe S Uenosono Y | | 0，，： | 1 |
| 15 | Evaluation of sentinel node concept in gastric cancer based on lymph node micrometastasis determined by reverse transcription-polymerase chain reaction显示文摘 | Arigami T Natsugoe S Uenosono Y | 2006 | Ann Surg2006，243，3： | 1 |
| 16 | Expression of B7-tt4 in blood of patients with gastric cancer predicts tumor progression and prognosis 显示文摘 | Arlgami T Uenosono Y tlirata M | 2010 | J Surg Onco12010，102，7： | 1 |
| 17 | Vascular endothelial growth factor-C and -D expression correlates with lymph node micrometastasis in pNO early gastric cancer 显示文摘 | Arigami T Natsugoe S Uenosono Y | 2009 | J Surg Oncol2009，99，3： | 1 |
| 18 | Comparison of effects of six main gastrectomy procedures on patients’ quality of life assessed by Postgastrectomy Syndrome Assessment Scale-45显示文摘BACKGROUND The effects of various gastrectomy procedures on the patient’s quality of life(QOL)are not well understood.Thus,this nationwide multi-institutional crosssectional study using the Postgastrectomy Syndrome Assessment Scale-45(PGSAS-45),a well-established questionnaire designed to clarify the severity and characteristics of the postgastrectomy syndrome,was conducted.AIM To compare the effects of six main gastrectomy procedures on the postoperative QOL.METHODS Eligible questionnaires retrieved from 2368 patients who underwent either of six gastrectomy procedures[total gastrectomy with Roux-en-Y reconstruction(TGRY;n=393),proximal gastrectomy(PG;n=193),distal gastrectomy with Roux-en-Y reconstruction(DGRY;n=475),distal gastrectomy with Billroth-I reconstruction(DGBI;n=909),pylorus-preserving gastrectomy(PPG;n=313),and local resection of the stomach(LR;n=85)]were analyzed.Among the 19 main outcome measures of PGSAS-45,the severity and characteristics of postgastrectomy syndrome were compared for the aforementioned six gastrectomy procedures using analysis of means.RESULTS TGRY and PG significantly impaired the QOL of postoperative patients.Postoperative QOL was excellent in LR(cardia and pylorus were preserved with minimal resection).In procedures removing the distal stomach,diarrhea subscale(SS)and dumping SS were less frequent in PPG than in DGBI and DGRY.However,there was no difference in the postoperative QOL between DGBI and DGRY.The most noticeable adverse effects caused by gastrectomy were mealrelated distress SS,dissatisfaction at the meal,and weight loss,with significant differences among the surgical procedures.CONCLUSION Postoperative QOL greatly differed among six gastrectomy procedures.The severity and characteristics of postgastrectomy syndrome should be considered to select gastrectomy procedures,overcome surgical shortcomings,and enhance postoperative care. | Koji Nakada Yoshiyuki Kawashima Shinichi Kinami Ryoji Fukushima Hiroshi Yabusaki Akiyoshi Seshimo Naoki Hiki Keisuke Koeda Mikihiro Kano Yoshikazu Uenosono Atsushi Oshio Yasuhiro Kodera | 2021 | World Journal of Gastrointestinal Surgery2021，13，5： | 1 |
| 19 | Sentinel node micrometastases have high proliferative potential in gastric cancer显示文摘 | Yanagita S Natsugoe S Uenosono Y | 2008 | J Surg Res2008，145，2： | 1 |
| 20 | Sentinel node micrometastases have high proliferative potential in gastric cancer显示文摘 | Yanagita S Natsugoe S Uenosono Y | 2008 | J Surg Res2008，145，2： | 1 |
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