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| 1 | Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse显示文摘AIM: To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS: The multi-herbal medicine Juzentaihoto (JTX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism (T-RFLP) method was used. To identify the changed bacteria, DNA sequencing was performed. RESULTS: Heat shock protein gene expression,documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver. | Miho Kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe | 2007 | World Journal of Gastroenterology2007，13，16： | 5 |
| 2 | Expression of HGF and TGF-β1 mRNA After Partial Hepatectomy in Rats with Liver Cirrhosis显示文摘 | Mitsue S Hamanoue M Tanabe G | | 0，，03： | 1 |
| 3 | Non‐contrast enhanced MR angiography: Physical principles显示文摘 | Andrew J. Wheaton Mitsue Miyazaki | 2012 | J Magn Reson Imaging2012，，2： | 1 |
| 4 | Efficacy of lafutidine, a histamine H2-receptor antagonist, for taxane-induced peripheral neuropathy in patients with gynecological malignancies显示文摘 | Hiroaki Nagano Hideomi Sanai Mitsue Muraoka Koichiro Takagi | 2012 | Gynecologic Oncology2012，，1： | 1 |
| 5 | Comprehensive proteomics analysis of autophagy-deficient mouse liver显示文摘 | Naomi Matsumoto Junji Ezaki Masaaki Komatsu Katsuyuki Takahashi Reiko Mineki Hikari Taka Mika Kikkawa Tsutomu Fujimura Mitsue Takeda-Ezaki Takashi Ueno Keiji Tanaka Eiki Kominami | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 1 |
| 6 | Cytokine Regulation of Chemokine (IL-8, MCP-1, and RANTES) Gene Expression in Human Pancreatic Periacinar Myofibroblasts显示文摘 | Akira Andoh Hiroki Takaya Takao Saotome Mitsue Shimada Kazunori Hata Yoshio Araki Fumiyasu Nakamura Yutaka Shintani Yoshihide Fujiyama Tadao Bamba | 2000 | Gastroenterology2000，，1： | 1 |
| 7 | Synthesis of silicon nitride by a combustion reaction under high nitrogen pressure显示文摘 | KIYOSHI Hirao YOSHINARI Miyamoto MITSUE Koizumi | 1986 | J Am Ceram Soc1986，69，4： | 1 |
| 8 | Visualization of cerebrospinal fluid movement with spin labeling at MR imaging:preliminary results in normal and pathophysiologic conditions显示文摘 | Shinya Y Mitsue M Hitoshi K | 2008 | Radiology2008，249，2： | 1 |
| 9 | Aniracetam re- stores motivation reduced by satiation in a choice reac- tion task in aged rats显示文摘 | Kazuo Nakamura Mitsue Kurasawa | 2001 | Pharmacol Biochem Behav2001，86，1： | 1 |
| 10 | Physiological and pathological cardiac hypertrophy induce different molecular phenot-es in the rat显示文摘 | Ie mitsu M Miyauchi H Maeda S | 2001 | Am J Physiol Regul Integr Comp Physiol2001，081，6： | 1 |
| 11 | Toshiwo Inhibition of DNA topoisomerases Ⅰ and Ⅱ, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide显示文摘 | Umemura Ken Yanase Kae Suzuki Mitsue | 2003 | Biochemical Pharmacology2003，66，3： | 1 |
| 12 | Surgical treatment of hepatic metastases from breast cancer显示文摘 | Masataka Yoshimoto Takashi Tada Mitsue Saito Kaoru Takahashi Masujiro Makita Yoshihiro Uchida Fujio Kasumi | 2000 | Breast Cancer Research and Treatment2000，，2： | 1 |
| 13 | The effect of heterogeneous solvent systems on sonochemicalreactions: accelerated degradation ofalkyl thiols in emulsion 显示文摘 | Hajime Sohmiya Takahide Kimura Mitsue Fujita | 2004 | Ultrasonics Sonochemistry2004，11，6： | 1 |
| 14 | Survival after curative resection for mucinous adenocarcinoma of the colorectum显示文摘 | Kane mitsu Y Kato T Hirai T yasui K | 2003 | Dis Colon Rectum2003，46，： | 1 |
| 15 | Palonosetron plus dexamethasone versus granisetron plus dexanethasone for preven- tion of nausea and vomiting during chemotherapy: a double - blind, double - dummy, 显示文摘 | Mitsue Saito Kenjiro Aogi Ikuo Sekine | 2009 | The Lancet Ontology2009，10，2： | 1 |
| 16 | Palonosetron plus dexa- methasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy : a double - blind, double - dummy, randomised, comparative phase III trial 显示文摘 | Mitsue Saito Kenjiro Aogi Ikuo Sekine | 2009 | The Lancet On- cology2009，10，2： | 1 |
| 17 | Facilitatory effect of immobilized lipase-producing Rhizopus oryzae cells on a acyl migration in biodiesel-fuel production 显示文摘 | MITSU HIRO O MASARU K SHINJI H | 2005 | Biochemical Engineering Journal2005，，23： | 1 |
| 18 | IL-6 Secretion by Human Pancreatic Periacinar Myofibroblasts in Response to Inflammatory Mediators显示文摘 | Mitsue S Akira A Kazunori H | | 0，，02： | 1 |
| 19 | Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy : a double -blind,double -dummy,randomised,comparative phase RI trial 显示文摘 | Mitsue Saito Kenjiro Aogi Ikuo Sekine | 2009 | The Lancet Ontology2009，10，2： | 1 |
| 20 | Methods for myo- metrium closure and other factors impacting effects on ce- sarean section scars of the uterine segment detected by the ultrasonography 显示文摘 | Hayakawa H Itakura A Mitsu! T | 2006 | Acta Obstet Gynecol Scand2006，85，4： | 1 |
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