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| 1 | 胃癌患者术前新辅助化疗应用观察显示文摘目的观察胃癌患者术前新辅助化疗(FOLFOX方案,奥沙利铂+5-氟尿嘧啶+甲酰四氢叶酸)的应用效果。方法 62例进展期胃癌患者随机分为观察组和对照组各31例,两组均采用胃癌D2根治术,观察组术前加用新辅助化疗。观察化疗疗效及R0切除率及D2淋巴结清扫率,采用酶联免疫吸附法检测血清糖类抗原72-4(CA72-4)和血管内皮生长因子(VEGF)。结果观察组新辅助化疗后CR 2例,PR 13例,SD15例,PD 1例,总有效率为48.4%。观察组R0切除率、D2淋巴结清扫率分别为87.1%(27/31)、80.6%(25/31),对照组分别为64.5%(20/31)、58.1%(18/31),两组比较,P均<0.05。与同组治疗前比较,两组治疗后CA72-4、VEGF水平降低(P均<0.01);与对照组治疗后比较,观察组治疗后CA72-4、VEGF水平均降低(P均<0.01)。结论胃癌患者术前新辅助化疗应用效果较好,R0切除率、D2淋巴结清扫率高,且可降低血清CA72-4、VEGF水平。 | 高皓阳 王静 | 2015 | 山东医药2015，55，11： | 8 |
| 2 | Role of genetic detection in peritoneal washes with gastric carcinoma: The past, present and future显示文摘The most frequent cause of treatment failure following surgery for gastric cancer is peritoneal dissemination, mainly caused by the seeding of free cancer cells from the primary gastric cancer, which is the most common type of spread. Unfortunately, there is no standard modality of intraperitoneal free cancer cells detection to predict peritoneal metastasis until now. We reviewed English literature in Pub Med was done using the Me SH terms for gastric cancer, peritoneal wash, and reverse transcriptase polymerase chain reaction. All the articles were reviewed and core information was tabulated for reference. After a comprehensive review of all articles, the data was evaluated by clinical implication and predictive value of each marker for peritoneal recurrence. There are still many limitations to overcome before the genetic diagnosis for free cancer cells detection can be considered as routine assay. To make it a reliable diagnostic tool for detecting free cancer cells, the process and method of genetic detection with peritoneal washes should be standardized, and the development of simple diagnostic devices and easily available kits are necessary. Herein, we reviewed the past, present and future perspectives of the peritoneal lavage for the detection of intraperitoneal free cancer cells in patients with gastric cancer. | Hyun-Dong Chae | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 1 |
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