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| 1 | Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development显示文摘epigenetic 领域里的最近的进展之一是蛋白质的 Tet 家庭能够催化 DNA 的 5-methylcytosine (5mC ) 的变换到 5-hydroxymethylcytosine (5hmC ) 的示范。有趣地,最近的研究证明了 5hmC 能被 Tet 蛋白质进一步氧化产生 5-formylcytosine (5fC ) 和 5-carboxylcytosine (5caC ) ,它能被胸腺嘧啶 DNA glycosylase (TDG ) 移开。决定到 5fC 和 5caC 的 5mC 的催化 Tet 的变换是否在接合子发生在 vivo,我们产生了为 5fC 和 5caC 特定的抗体。由 immunostaining,我们证明在父亲的前核的 5mC 的损失与 5fC 和 5caC 的外观是并发的,类似于 5hmC 的。而不是快速通过催化酶的进程被移开,重要地, 5fC 和 5caC 在鼠标 preimplantation 开发期间展出复制依赖者冲淡。这些结果不仅在接合子表明 5mC 的变换到 5fC 和 5caC,而且显示 5fC 和 5caC 是相对稳定的并且可能在 preimplantation 开发期间功能。和以前的研究,我们的学习建议到 5hmC/5fC/5caC 的 5mC 的那催化 Tet 的变换在 preimplantation 开发期间为父亲的 DNA demethylation 由复制依赖者冲淡报道列在后面。 | Azusa Inoue Li Shen Qing Dai Chuan He Yi Zhang | 2011 | Cell Research2011，21，12： | 11 |
| 2 | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer显示文摘AIM: To examine the expression of Sph K1, an oncogenic kinase that produces sphingosine 1-phosphate(S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid(LPA) receptor overexpressed in various cancers, in human colorectal cancer.METHODS: Real-time reverse-transcription polymerase chain reaction was used to measure the m RNA expression of Sph K1, LPAR2, and the three major S1 P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of Sph K1 and LPAR2.RESULTS: C o l o r e c t a l c a n c e r t i s s u e i n 2 2 o f 2 7 patients had higher levels of Sph K1 m RNA than in normal tissue. In two-thirds of the samples, Sph K1 m RNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 m RNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1 P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between Sph K1 and LPAR2 expression [Pearson's correlation coefficient(r) = 0.784 and P < 0.01]. The m RNA levels of Sph K1 and LPAR2 did not correlate with TNM stage.CONCLUSION: Our findings suggest that S1 P andLPA may play important roles in the development ofcolorectal cancer via the upregulation of Sph K1 andLPAR2, both of which could serve as new therapeutictargets in the treatment of colorectal cancer. | Dai Shida Satoru Inoue Yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 3 | Clinical and radiological feature of lymphoepithelial cyst of the pancreas显示文摘A lymphoepithelial cyst(LEC)of the pancreas is a rare benign lesion.Because patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment strategy.Previous studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of LECs.We reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical factors.We found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings. | Hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue Kazuto Kozaka Toshifumi Gabata Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，45： | 4 |
| 4 | Preparation and property of acrylic acid rare earth complex and its hydrosilylation 显示文摘 | Zhang Ming Chen Haiyan Chen Xiaosong Dai Shaojun Inoue Shinich Okamoto Hiroshi | 2004 | Journal of Rare Earths2004，22，6： | 1 |
| 5 | Impact of Admission Hyperglycemia and Diabetes Mellitus on Short- and Long-Term Mortality After Acute Myocardial Infarction in the Coronary Intervention Era显示文摘 | Masaharu Ishihara Eisuke Kagawa Ichiro Inoue Takuji Kawagoe Yuji Shimatani Satoshi Kurisu Yasuharu Nakama Tatsuya Maruhashi Keisuke Ookawa Kazuoki Dai Yasuyuki Aokage | 2007 | The American Journal of Cardiology2007，，12： | 1 |
| 6 | Effects of Diurnal Variation of the Lighting on Physiological and Psychological Functions in Office Environment显示文摘 | Dai Q Inoue M Shimomura Y | 2001 | J Physiol Anthropol2001，20，2： | 1 |
| 7 | Tu1588 Usefulness of Japan Esophageal Society Classification of Magnified Endoscopy for the Diagnosis of Superficial Esophageal Squamous Cell Carcinoma显示文摘 | Tsuneo Oyama Ryu Ishihara Manabu Takeuchi Dai Hirasawa Miwako Arima Haruhiro Inoue Kenichi Goda Akihisa Tomori Kumiko Momma | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 8 | Clinical application of real-time polymerase chain reaction for diagnosis of herpetic diseases of the anterior segment of the eye显示文摘 | Akiko Kakimaru-Hasegawa Chuan-Hui Kuo Naoki Komatsu Keiko Komatsu Dai Miyazaki Yoshitsugu Inoue | 2008 | Japanese Journal of Ophthalmology2008，，1： | 1 |
| 9 | Metachronous colonic metastasis from pancreatic cancer seven years post-pancreatoduodenectomy显示文摘Colonic metastasis from other organs is very rare.Here we report the case of a 62-year-old man with a history of pancreatoduodenectomy for stage IIB pancreatic head cancer performed seven years back.He presented with abdominal distension and pain.Under the preoperative diagnosis of bowel obstruction,surgical treatment was performed,and a circumferential lesion causing bowel obstruction of the ascending colon was detected.A right hemicolectomy with lymph node dissection was performed.The specimen showed a 5-cm wall thickening with a cobble-stone like appearance of the ascending colon,which morphologically appeared scirrhous.Histological examination revealed cancer nests invading from the subserosa to the muscular and submucosal layers of the colon.Immunohistochemical analysis of the tumor cells demonstrated positive staining for cytokeratin 7,but negative for cytokeratin 20,which was the same as the previous pancreatic cancer specimen.These pathological and immunohistochemical features strongly supported the diagnosis of colonic metastasis from the pancreas.Thereafter,the patient received systemic chemotherapy,but unfortunately,he died 14 mo after the surgery. | Kentaro Inada Dai Shida Kazumasa Noda Satoru Inoue Masahiro Warabi Nobutaka Umekita | 2013 | World Journal of Gastroenterology2013，19，10： | 0 |
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