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| 1 | GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Thl cell-specific factors显示文摘 | Jinfang Zhu Hidehiro Yamane Javier Cote-Sierra Liying Guo William E Paul | 2006 | Cell Research2006，16，1： | 48 |
| 2 | Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis显示文摘AIM: To examine the effects of anti-high mobility group box 1 (HMGB1) neutralizing antibody in experimental se-vere acute pancreatitis (SAP).METHODS: SAP was induced by creating closed duode-nal loop in C3H/HeN mice. SAP was induced immediately after intraperitoneal injection of anti-HMGB1 neutralizing antibody (200 μg). Severity of pancreatitis, organ injury (liver, kidney and lung), and bacterial translocation to pancreas was examined 12 h after induction of SAP.RESULTS: Anti-HMGB1 neutralizing antibody significant-ly improved the elevation of the serum amylase level and the histological alterations of pancreas and lung in SAP. Anti-HMGB1 antibody also significantly ameliorated the elevations of serum alanine aminotransferase and cre-atinine in SAP. However, anti-HMGB1 antibody worsened the bacterial translocation to pancreas.CONCLUSION: Blockade of HMGB1 attenuated the development of SAP and associated organ dysfunction, suggesting that HMGB1 may act as a key mediator for inflammatory response and organ injury in SAP. | Hidehiro Sawa Takashi Ueda Yoshifumi Takeyama Takeo Yasuda Makoto Shinzeki Takahiro Nakajima Yoshikazu Kuroda | 2006 | World Journal of Gastroenterology2006，12，47： | 45 |
| 3 | Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate显示文摘A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor(GIST) . Computed tomography(CT) and magnetic resonance imaging(MRI) 107 mo after the operation,revealed a cystic mass(14 cm in diameter) and a solid mass(9 cm in diameter) in the right and left lobes of the liver,respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate(IM) treatment,400 mg/day orally. Following the IM treatment for a period of 35 mo,the patient underwent partial hepatectomy(S4 + S5) . The effect of IM on the metastatic lesions was interpreted as pathologic complete response(CR) . Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported. | Seiji Suzuki Koji Sasajima Masayuki Miyamoto Hidehiro Watanabe Tadashi Yokoyama Hiroshi Maruyama Takeshi Matsutani Aimin Liu Masaru Hosone Shotaro Maeda Takashi Tajiri | 2008 | World Journal of Gastroenterology2008，14，23： | 11 |
| 4 | Assessment of GIAHS in Shizuoka: The Traditional Tea-grass Integrated System显示文摘1 Introduction In 2013,Chagusaba,which is traditional tea-grass integrated system in Shizuoka,were accepted as new world heritage site of agriculture.Shizuoka prefecture occupies a variety of elevations,from 0 to 3000m or more above sea level.Because of the diversity of land features and climates,this area produces 167 agricultural commodities.In addition,a lot of traditional agriculture and over200 local native varieties of crops have been conserved in | INAGAKI Hidehiro KUSUMOTO Yoshinobu | 2014 | Journal of Resources and Ecology2014，5，4： | 4 |
| 5 | 全球重要农业文化遗产静冈传统茶草综合系统:价值、保护与行动(英文)显示文摘日本静冈的传统茶草综合系统是当地政府申请的日本第一个全球重要农业遗产系统(GIAHS)。本文介绍了当初发现该系统的背景、为申报GIAHS所采取的措施以及被列入全球重要农业文化遗产名录后,静冈茶草系统当前的作用和面临的新情况。自2013年入选全球重要农业遗产系统,目前日本的半天然草原大幅减少,但在静冈的茶草系统里发现了独特的半天然草原,茶园里生物多样性非常丰富。这些茶草系统和采用的传统耕作方法被称为'Chagusaba'。然而,GIAHS的申请过程并不容易,因为许多当地农民不了解他们传统耕作方法和GIAHS品牌的价值。在Chagusaba入选GIAHS名单之后,我们的主要工作是相关的品牌推广,努力使传统农业生产出高品质的茶叶。随着日本农业节省劳动力技术的进步,劳动力成本降低,优质茶叶的价格也有所下降,因此,执行低效传统耕作方式的农民数量越来越少。有必要正确地重新认识传统农业方法种植的茶叶的价值,并在价格上得以体现。静冈县当地政府目前正致力于实施认证体系,包括利用GPS进行科学评估,以及引入生物多样性指标等等。 | Hidehiro INAGAKI Yoshinobu KUSUMOTO | 2019 | Journal of Resources and Ecology2019，10，5： | 4 |
| 6 | Clinical and radiological feature of lymphoepithelial cyst of the pancreas显示文摘A lymphoepithelial cyst(LEC)of the pancreas is a rare benign lesion.Because patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment strategy.Previous studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of LECs.We reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical factors.We found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings. | Hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue Kazuto Kozaka Toshifumi Gabata Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，45： | 4 |
| 7 | A case report of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct显示文摘We herein report a case of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct.A 76-year-old male was referred to our hospital for treatment of a pancreatic tumor.Preoperative examinations revealed a poorly defined tumor in the main pancreatic duct in the body of the pancreas,accompanied with severe dilatation of the main pancreatic duct,which was diagnosed as an intraductal papillary-mucinous neoplasm.We performed distal pancreatectomy and splenectomy.The pathological examination revealed that the tumor consisted of a mixture of anaplastic carcinoma(giant cell type)and adenocarcinoma in the pancreas.There was a papillary projecting tumor composed of anaplastic carcinoma in the dilated main pancreatic duct.The patient is now receiving chemotherapy because liver metastasis was detected 12 mo after surgery.In this case,we could observe a remarkable intraductal tumor growth into the main pancreatic duct.We also discuss the pathogenesis and characteristics of this rare tumor with specific tumor growth. | Mitsuyoshi Okazaki Isamu Makino Hirohisa Kitagawa Shinichi Nakanuma Hironori Hayashi Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hiroyuki Takamura Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，3： | 2 |
| 8 | Intraductal papillary neoplasm of the bile duct accompanying biliary mixed adenoneuroendocrine carcinoma显示文摘We present the first case of an intraductal papillary neoplasm of the bile duct(IPNB) accompanying a mixed adenoneuroendocrine carcinoma(MANEC).A 74-yearold woman presented with fever of unknown cause.Laboratory data revealed jaundice and liver injury.Contrast-enhanced computed tomography revealed a 20 mm polypoid tumor in the dilated distal bile duct,which exhibited early enhancement and papillary growth.Upper gastrointestinal endoscopy revealed mucus production from the papilla of Vater,characterized by its protruding and dilated orifice.Endoscopic ultrasonography visualized the polypoid tumor in the distal bile duct,but no invasive region was suggested by diagnostic imaging.Therefore,the initial diagnosis was IPNB.After endoscopic nasobiliary drainage,a pylorus-preserving pancreaticoduodenectomy was performed.Pathological examination of the resected bile duct revealed papillary proliferation of biliary-type cells with nuclear atypia,indicating pancreaticobiliary-type IPNB.In addition,solid portions comprised of tumor cells with characteristic salt-and-pepper nuclei were evident.Immunohistochemistry revealed expression of the neuroendocrine marker synaptophysin in this solid component,diagnosing it as a neuroendocrine tumor(NET).Furthermore,the MIB-1 proliferation index of NET was higher than that of IPNB,and microinvasion of the NET component was found,indicating neuroendocrine carcinoma(NET G3).This unique case of MANEC,comprising IPNB and NET,provides insight into the pathogenesis of biliary NET. | Ichiro Onishi Hirohisa Kitagawa Kenichi Harada Syogo Maruzen Seisyo Sakai Isamu Makino Hironori Hayashi Hisatoshi Nakagawara Hidehiro Tajima Hiroyuki Takamura Takashi Tani Masato Kayahara Hiroko Ikeda Tetsuo Ohta Yasuni Nakanuma | 2013 | World Journal of Gastroenterology2013，19，20： | 2 |
| 9 | Sensing and tracking enhanced by quantum squeezing显示文摘Quantum sensing, along with quantum communications and quantum computing, is commonly considered as the most important application of quantum optics. Among the quantum-sensing experiments, schemes based on squeezed states of light are popular choices due to their natural quadrature components. Since the first experimental demonstration of quantum-squeezing-enhanced phase measurement beyond the shot-noise limit in 1987, quantum-squeezing techniques toward practical sensing and tracking have been extensively investigated. In this paper, we briefly review the recent developments of quantum squeezing and its applications in several advanced systems for measurements of position, rotation, dynamic motion, magnetic fields, and gravitational waves. We also introduce the recent experimental efforts to combine the quantum-squeezing lights into fiber sensing systems. | CHUAN XU LIDAN ZHANG SONGTAO HUANG TAXUE MA FANG LIU HIDEHIRO YONEZAWA YONG ZHANG MIN XIAO | 2019 | Photonics Research2019，7，6： | 2 |
| 10 | Smoking is associated with advanced coronary atherosclerosis in youth显示文摘 | Arthur W. Zieske C. Alex McMahan Henry C. McGill Satoki Homma Hidehiro Takei Gray T. Malcom Richard E. Tracy Jack P. Strong | 2004 | Atherosclerosis2004，，1： | 2 |
| 11 | Neoadjuvant chemotherapy with gemcitabine for pancreatic cancer increasesin situ expression of the apoptosis marker M30 and stem cell marker CD44显示文摘 | Hidehiro Tajima Tetsuo Ohta Hirohisa Kitagawa Koichi Okamoto Seisho Sakai Jun Kinoshita Isamu Makino Hiroyuki Furukawa Hironori Hayashi Keishi Nakamura Katsunobu Oyama Masafumi Inokuchi Hisatoshi Nakagawara Hideto Fujita Hiroyuki Takamura Itasu Ninomiya S | 2012 | Oncology Letters2012，，： | 2 |
| 12 | Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report显示文摘BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas.Some previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic resection.CASE SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before ESD.The resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and submucosa.The final diagnosis was submucosa-invasive poorly differentiated gastric adenocarcinoma.Accordingly,additional gastrectomy was recommended to obtain a complete cure.One patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular complications.Both patients remained in remission for more than half a year.EBV positivity was determined by EBV-encoded RNA in situ hybridization.We also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by ESD.CONCLUSION Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is required.Further prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection. | Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 2 |
| 13 | Molecular cloning and expression analysis of interferon regulatory factor 10 (IRF10) in Japanese flounder,Paralichthys olivaceus显示文摘 | Yoshiaki Suzuki Motoshige Yasuike Hidehiro Kondo | 2011 | Fish Shellfish Immunology2011，30，： | 1 |
| 14 | On the scaling-up of a two-stage air blown en- trained flow coal gasifier 显示文摘 | CHEN Caixia MIYOSHI Takahiro KAMIYA Hidehiro | 1999 | The Canadian Journal of Chemical Engineering1999，77，4： | 1 |
| 15 | Analysis of the action mechanism of polymer dispersant on dense ethanol alumina suspension using colloidal probe AFM显示文摘 | Toshio Kakui Takeshi Miyauchi Hidehiro Kamiya | 2004 | Journal of the European Ceramic Society2004，，5： | 1 |
| 16 | Impurity effects on grain boundary strength in struc tural ceramics显示文摘 | YUICHI IKUHARA HIDEHIRO YOSHIDA TAKETO SAKUMA | 2001 | Materials Science and Engineering A2001，321，： | 1 |
| 17 | Molecular cloning and expression study on Toll-like receptor 5 paralogs in Japanese flounder, Paralichthys olivaceus显示文摘 | Seong Don Hwang Takashi Asahi Hidehiro Kondo | 2010 | Fish Shellf Immunol2010，29，4： | 1 |
| 18 | Identification and characterization of a myeloid differentiation factor88(MyD88)cDNA and gene in Japanese flounder,Paralichthys olivaceus显示文摘 | Ikuo H Hidehiro K | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 19 | Bifidobac- teria can protect from enteropathogenic infection through production of acetate 显示文摘 | Fukuda S Hidehiro Toh Koji Hase | 2011 | Nature2011，469，7： | 1 |
| 20 | Telmisartan, a possible PPAR-δ agonist, reduces TNF-α-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells显示文摘 | Hideki Kimura Daisuke Mikami Kazuko Kamiyama Hidehiro Sugimoto Kenji Kasuno Naoki Takahashi Haruyoshi Yoshida Masayuki Iwano | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
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