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| 1 | Apical hypertrophic cardiomyopathy显示文摘We describe a patient with asymptomatic apical hypertrophic cardiomyopathy(AHCM)who later developed cardiac arrhythmias,and briefly discuss the diagnostic modalities,differential diagnosis and treatment option for this condition.AHCM is a rare form of hypertrophic cardiomyopathy which classically involves the apex of the left ventricle.AHCM can be an incidental finding,or patients may present with chest pain,palpitations,dyspnea,syncope,atrial fibrillation,myocardial infarction,embolic events,ventricular fibrillation and congestive heart failure.AHCM is frequently sporadic,but autosomal dominant inheritance has been reported in few families.The most frequent and classic electrocardiogram findings are giant negative T-waves in the precordial leads which are found in the majority of the patients followed by left ventricular(LV)hypertrophy.A transthoracic echocardiogram is the initial diagnostic tool in the evaluation of ACHM and shows hypertrophy of the LV apex.AHCM may mimic other conditions such as LV apical cardiac tumors,LV apical thrombus,isolated ventricular non-compaction,endomyocardial fibrosis and coronary artery disease.Other modalities,including left ventriculography,multislice spiral computed tomography,and cardiac magnetic resonance imagings are also valuable tools and are frequently used to differentiate AHCH from other conditions.Medications used to treat symptomatic patients with AHCM include verapamil,beta-blockers and antiarrhythmic agents such as amiodarone and procainamide.An implantable cardioverter defibrillator is recommended for high risk patients. | Syed Wamique Yusuf Jaya D Bathina Jose Banchs Elie N Mouhayar Iyad N Daher | 2011 | World Journal of Cardiology2011，3，7： | 4 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Sere Cancer Biol2007，，17： | 1 |
| 5 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | | 0，，： | 1 |
| 6 | Sebaceous cell carcinoma of the ocular adnexa: clinical presentations, histopathology, and outcomes 显示文摘 | Song A Carter K D Syed N A Song J Nerad J A | 2008 | Ophthal Plast Reconstr Surg2008，24，： | 1 |
| 7 | Orbital hemangiopericytoma and solitary fibrous tumor:a morphologic continuum显示文摘 | Goldsmith J D van de Rijn M Syed N | 2001 | Int J Surg Pathol2001，9，10： | 1 |
| 8 | Dietary flavonoid fisetin:A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management显示文摘 | Adhami V M Syed D Khan N | | 0，，： | 1 |
| 9 | Stenotrophomonas maltophilia ; a new potential bio-control agent of Ralstonia solanacearum, causal agent of potato brown rot 显示文摘 | Messiha NAS van Diepeningen A D Farag N Sy | 2007 | European Journal of Plant Pa-thology2007，118，： | 1 |
| 10 | Organochlorine pesticides in air and soil and estimated air-soil exchange in Punjab, Pakistan显示文摘 | Syed J H Malik R N Liu D | 2013 | Science of the Total Environment2013，444，： | 1 |
| 11 | Pomegranate derived products for cancer chemoprevention显示文摘 | SYED D N AFAQ F MUKHTAR H | 2007 | Seminars in Cancer Biology2007，17，5： | 1 |
| 12 | S elective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice显示文摘 | Kim H Choi HK Shin JH Kim KH Huh JY Lee SA Ko CY Kim HS S hin HI Lee HJ J eong D Kim N Choi Y Lee SY | | 0，，： | 1 |
| 13 | Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/beta-catenin signaling and decreased Mitf levels显示文摘 | Syed D N Afaq F Maddodi N | | 0，，06： | 1 |
| 14 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Seminars in Cancer Biology2007，17，5： | 1 |
| 15 | Dietary agents for chemoprevention of prostate cancer 显示文摘 | SYED D N SUH Y AFAQ F | 2009 | Cancer Letters2009，265，2： | 1 |
| 16 | Genetic mapping and QTL analysis of fiber-related traits in cotton (Gossypium)显示文摘 | Mei M Syed N H Gao W Thaxton P M Smith C W Stelly D M Chen Z J | 2004 | TAG Theoretical and Applied Genetics2004，108，2： | 1 |
| 17 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Seminars in Cancer Biology2007，173，： | 1 |
| 18 | Adequacy of cervical sampling in hysterectomy specimens for endometrial cancer显示文摘 | Syed S Reed N Millan D | 2015 | Ann Diagn Pathol2015，19，2： | 1 |
| 19 | Dietary agents for chemoprevention of prostate cancer显示文摘 | Syed D N Suh Y Afaq F | 2008 | Cancer Lett2008，265，： | 1 |
| 20 | Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes 显示文摘 | I SYED D N AFAQ F MUKHTAR H | 2012 | Photochem Photobiol2012，88，5： | 1 |
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