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| 1 | Real-time sono-elastography in the diagnosis of diffuse liver diseases显示文摘AIM: To analyze whether computer-enhanced dynamic analysis of elastography movies is able to better characterize and differentiate between different degrees of liver fibrosis. METHODS: The study design was prospective. A total of 132 consecutive patients with chronic liver diseases and healthy volunteers were examined by transabdominal ultrasound elastography. All examinations were done by two doctors.RESULTS: Due to the limitations of the method, we obtained high-quality elastography information in only 73.48% of the patients. The κ-means clustering method was applied to assess the inter-observer diagnosis varia- bility, which showed good variability values in accordance with the experience of ultrasound examination of every observer. Cohen’sκ test indicated a moderate agreement between the study observers (κ = 0.4728). Furthermore, we compared the way the two observers clustered the patients, using the test for comparing two proportions (t value, two-sided test). There was no statistically significant difference between the two physicians, regardless of the patients’ real status. CONCLUSION: Transabdominal real-time elastography is certainly a very useful method in depicting liver hard- ness, although it is incompletely tested in large multicenter studies. | Dan Ionut Gheonea Adrian S ǎftoiu Tudorel Ciurea Florin Gorunescu Sevastita Iordache Gabriel Lucian Popescu Smaranda Belciug Marina Gorunescu Larisa Sǎndulescu | 2010 | World Journal of Gastroenterology2010，16，14： | 9 |
| 2 | From portal to splanchnic venous thrombosis:What surgeons should bear in mind显示文摘The present study aims to review the evolution of surgical management of portal(PVT) and splanch-nic venous thrombosis(SVT) in the context of liver transplantation over the last 5 decades. PVT is more commonly managed by endovenous thrombectomy, while SVT requires more complex technical expedients. Several surgical techniques have been proposed, such as extensive eversion thrombectomy, anastomosis to collateral veins, reno-portal anastomosis, cavo-portal hemi-transposition, portal arterialization and combined liver-intestinal transplantation. In order to achieve satisfactory outcomes, careful planning of the surgical strategy is mandatory. The excellent results that are ob-tained nowadays confirm that, even extended, splanch-nic thrombosis is no longer an absolute contraindication for liver transplantation. Patients with advanced portal thrombosis may preferentially be referred to specialized centres, in which complex vascular approaches and even multivisceral transplantation are performed. | Quirino Lai Gabriele Spoletini Rafael S Pinheiro Fabio Melandro Nicola Guglielmo Jan Lerut | 2014 | World Journal of Hepatology2014，6，8： | 6 |
| 3 | Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C显示文摘We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs. | Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 4 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 5 | 微重力条件下90°弯管气液两相流型研究显示文摘本文报道了微重力条件下90°弯管内气液两相流型实验结果。弯管内径12.7 mm,弯曲半径76.5mm,气、 液两相表观流速分别为1.0—23.6 m/s和0.09—0.5 m/s。本文分析了观测到的弹状流、弹-环过渡流和环状流的典型特 征,比较了与微重力直管内相应流型间及常重力弯管两相流型间的异同。 | 赵建福 K S Gabriel | 2004 | 工程热物理学报2004，25，5： | 3 |
| 6 | A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘 | Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac | 2013 | Gastroenterology2013，，1： | 3 |
| 7 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 8 | A novel extra-glissonian approach for totally laparoscopic left hepatectomy显示文摘 | Fernando Rotellar Fernando Pardo Alberto Benito Pablo Martí-Cruchaga Gabriel Zozaya Nicolás Pedano | 2012 | Surgical Endoscopy2012，，9： | 2 |
| 9 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 10 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 11 | Effect of whole wheat feeding on the development of the digestive tract of broiler chicken显示文摘 | Gabriel I Mallet S Leconte M | 2008 | Animal Feed Science and Technology2008，142，： | 1 |
| 12 | Anti -angiogenic treatment strategies for malignant brain tumor 显示文摘 | Matthias K Gabriele S Peter McB | 2000 | J Neuro Oncol2000，50，： | 1 |
| 13 | A novel mechanism underlying drug resistance in chronic epilepsy显示文摘 | Remy S Gabriel S Urban BW | 2003 | Ann Neurol2003，53，5： | 1 |
| 14 | Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer显示文摘 | Gabriel B Mildenberger S Weisser C W | 2004 | Anticancer Res2004，24，2： | 1 |
| 15 | Integralattachment using snap-fit features: A key to assembly automation 显示文摘 | MESSLER R W GENC S GABRIELE G A | 1997 | Assembly Autom1997，17，2： | 1 |
| 16 | Higher Body Mass Index Is Not Associated with Worse Pain Outcomes After Primary or Revision Total Knee Arthroplasty (TKA) 显示文摘 | Jasvinder A Singh S Gabriel I)(3 | 2011 | J Arthroplasty2011，26，3： | 1 |
| 17 | Anthocyanin pigments of sweet potatoes-Ipomoea batatas显示文摘 | Shi Z Bassa I A Gabriel S L | 1992 | Journal of Food Science1992，57，75： | 1 |
| 18 | RF MEMS phased shifters: Design and applications显示文摘 | Gabriel M Rebeiz Guan-Leng Tan Joseph S Hayden | 2002 | IEEE Microwave Magazine2002，3，2： | 1 |
| 19 | Use of sterile and ozonized water as a strategy stablize the quality of stored refrigerated fresh fish显示文摘 | Pastorizal L Bernardez M Gabriel S | 2008 | Food Control2008，，19： | 1 |
| 20 | The traffic equilibrium problem with nonadditive path costs 显示文摘 | GABRIEL S BERNSTEIN D | 1997 | Transportation Science1997，31，4： | 1 |
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