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| 1 | Oral administration of a non-absorbable plant cellexpressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis显示文摘AIM To evaluate the immunomodulatory effect of oral administration of PRX-106 in the high-fat diet model.METHODS For 22 wk, C57BL/6 HFD-fed mice received daily oral treatments with BY-2 cells expressing recombinant antitumor necrosis factor alpha fusion protein(PRX-106). Mice were followed for serum liver enzyme and triglyceride levels, liver histology and intrahepatic and systemic FACS.RESULTS The orally administered non-absorbable PRX-106 w a s b i o l o g i c a l l y a c t i v e. A l t e r e d d i s t r i b u t i o n o f CD4+CD25+Fox P3+ between the liver and spleen and an increase in the intrasplenic-to-intrahepatic CD4+CD25+Fox P3+ ratio and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+Fox P3+ ratio were observed. An increase in intrahepatic NKT cells and a decrease in the intrasplenic-to-intrahepatic NKT ratio were noted. Assessment of the CD4-to-CD8 ratios showed sequestration of CD8+ lymphocytes in the liver. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice.CONCLUSION Orally administered PRX-106 shows biological activity and exerts an immunomodulatory effect, alleviating liver damage. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis. | Yaron Ilan Ami Ben Ya'acov Yehudit Shabbat Svetlana Gingis-Velitski Einat Almon Yoseph Shaaltiel | 2016 | World Journal of Gastroenterology2016，22，39： | 3 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | Formation damage and the crastal chemistry of calys显示文摘 | Almon W R Davis D K | | 0，，07： | 1 |
| 4 | , 1968, Recent Methodological Advances in Input-output in the United States and Canada显示文摘 | Almon C | 1968 | Fourth International Con{erence on Input-Output Techniques1968，，： | 1 |
| 5 | Fiber-type discrimination in disuse and glucocorticoid-induced atrophy显示文摘 | Almon RR DuBois DC | 1990 | Med Sci Sports Exerc1990，22，3： | 1 |
| 6 | Pharmacokinetic/pharmacodynamic modeling of corticosterone suppression and lymphocytopenia by methylprednisolone in rats 显示文摘 | Yao Z Dubois DC Almon RR | 2007 | J Pharm Sci2007，，： | 1 |
| 7 | Circadian variations in rat liver gene expression: relationships to drug actions显示文摘 | Almon RR Yang E Lai W | 2008 | J Pharmacol Exp Ther2008，326，3： | 1 |
| 8 | Dose-dependence and repeated-dose studies for receptor / genemediated pharmacodynamic of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aninotransferase induction in rat liver显示文摘 | DuBios DC Almon RR Pyszczyhski NA Jusko WJ | 1998 | J Pharmacokinet Biopharm1998，26，6： | 1 |
| 9 | Fiber-type discrimination in disuse and glucocorticoid-induced atrophy显示文摘 | ALMON RR DUBOIS DC | 1990 | Med Sci Sport Exerc1990，90，： | 1 |
| 10 | Simultaneous loss of expression of syndecan-1 and E-cadherin in the embryonic pal- ate during epithelial-mesenchymal transformation 显示文摘 | Sun D Mc Almon KR Davies JA | 1998 | Dev Bi- ol1998，42，5： | 1 |
| 11 | Formation damage and the crastal chemistry of clays显示文摘 | Davies D K | 1985 | Mineralogical Association of Canada1985，，7： | 1 |
| 12 | Variation in the bread makin g quality and rheological properties of wheat in relation to sulphur nutrition u nder field conditions显示文摘 | Zhao F J Almon S E Withers P T A | 1999 | Journal of Cereal Science1999，30，： | 1 |
| 13 | The nature, extent and effects of emotional abuse on primary school pupils by teachers in Zimbabwe显示文摘 | Almon Shumba | 2002 | Child Abuse & Neglect2002，26，： | 1 |
| 14 | Tex- tural and sequence-stratigraphic controls on sealing capacity of Lower and Upper Cretaceous shales, Denver Basin, Colorado显示文摘 | Sutton S J Ethridge F G Almon W R et at | 2004 | AAPG Bulletin2004，88，8： | 1 |
| 15 | The Craft of Economic Modeling显示文摘 | Almon C | | 0，，： | 1 |
| 16 | The INFORUM Approach to Interindustry Modeling显示文摘 | Almon C | | 0，，： | 1 |
| 17 | Fifth-generation model for corticosteroid pharmacodynamics:application to steadystate receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats显示文摘 | Ramakrishnan R Du Bois D C Almon R R | 2002 | J Pharmacokinet Pharmacodyn2002，29，1： | 1 |
| 18 | Diagenesis of the Frontier Formation offshore bar sandstones, Spearhead Ranchfield, Wyoming显示文摘 | Tillman R W Almon W R | 1979 | SEPM Special Publication1979，26，： | 1 |
| 19 | Demographics and tumor characteristics of colorectal cancers in the United States, 1998-2001 显示文摘 | Matanoski G Tao XG Almon L | 2006 | Cancer2006，107，5： | 1 |
| 20 | Circadian Rhythms in Gene Expression: Relationship to Physiology, Disease, Drug Disposition and Drug Action 显示文摘 | SukumaranS Almon RR DuBois DC | 2010 | Adv Drug Deliv Rev2010，62，10： | 1 |
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