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| 1 | 血栓形成的抗栓治疗和预防,第9版:美国胸科医师学院循证的临床实践指南显示文摘【缩写】ACS=急性冠脉综合征;AF=心房纤颤;AIS=动脉性缺血性卒中;APLA=抗磷脂抗体;ASA=阿司匹林;AT9=第9版血栓的抗栓治疗和预防:美国胸科医师学院循证的临床实践指南;BMS=裸金属支架;CABG=冠状动脉旁路移植术;CAD=冠状动脉疾病;CDT=导管接触溶栓;CHADS2=充血性心力衰竭,高血压,年龄≥75岁,糖尿病,有卒中或TIA病史; | 潘元美 曹雯炜 秦洁行 周洁茹 金海峰 朱莹 李焰生 Guyatt GH Akl EA Crowther M Gutterman DD Schu nemann HJ | 2012 | 神经病学与神经康复学杂志2012，9，1： | 195 |
| 2 | 鄂尔多斯盆地三叠系镜质体反射率与地热史显示文摘鄂尔多斯盆地庆36井三叠系镜质体反射率为0.61%~1.06%,其碳化梯度(Rm/km)较高,达0.36%。运用不同方法分析表明,该盆地中生代古地温梯度可达35~57℃/km,高于现今地温梯度。其它地温分析结果支持这一推论。推测高古地温梯度的原因可能是中生代时地壳厚度较薄和中侏罗世末一期热事件。讨论了高古地温梯度对于油气形成与勘探的影响。 | 赵孟为 Behr,HJ | 1996 | 石油学报1996，17，2： | 67 |
| 3 | Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma显示文摘BACKGROUND:Hepatocellular carcinoma (HCC) is characterized by a multi-cause,multi-stage and multi-focus process of tumor progression.Its prognosis is poor and early diagnosis is of utmost importance.This study was undertaken to investigate the dynamic expression of oncofetal antigen glypican-3 (GPC-3) and GPC-3 mRNA in hepatocarcinogenesis and to explore their early diagnostic value for HCC.METHODS:A hepatoma model was induced in male Sprague-Dawley rats with 0.05% 2-fluorenylacetamide and confirmed by hematoxylin and eosin staining and gamma-glutamyltransferase (GGT) expression.Total RNA was purified and transcribed into cDNA by reverse transcription.Fragments of the GPC-3 gene were amplified by nested RT-PCR,and confirmed by sequencing.GPC-3 was analyzed by immunohistochemistry,Western blotting or ELISA.RESULTS:Positive GPC-3 expression showed as brown granule-like staining localized in the cytoplasm.Histological examination of hepatocytes revealed three morphological stages of granule-like degeneration,atypical hyperplasia (precancerous),and cancer formation,with a progressive increase of liver total RNA and GGT expression.The incidence of liver GPC-3 mRNA and GPC-3,and serum GPC-3 was 100%,100% and 77.8% in the HCC group,100%,100%,and 66.7% in the precancerous group,83.3%,83.3%,and 38.9% in the degeneration group,and no expression in the liver or blood of the control group,respectively.There was a positive correlation between liver GPC-3 mRNA and total RNA level (r=0.475,P<0.05) or liver GPC-3 (r=1.0,P<0.001) or serum GPC-3 (r= 0.994,P<0.001).CONCLUSION:Abnormal oncofetal antigen GPC-3 and GPC-3 mRNA expression in hepatocarcinogenesis may be promising molecular markers for early diagnosis of HCC. | Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong 226001,China (Yao M,Yao DF,Qiu LW,Wu W,Sai WL,Yang JL and Zhang HJ) Department of Oncology,Yancheng First People’s Hospital,Yancheng 224001,China (Bian YZ) Department of Oncology,Second Affiliated Hospital,Nanjing Medical University,Nanjing 210011,China (Zhang CG) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 51 |
| 4 | 聚乙二醇化干扰素a-2b治疗HBeAg阳性慢性乙型肝炎:HBsAg转阴与HBV基因型相关显示文摘HBsAg转阴是慢性乙型肝炎抗病毒治疗完全应答的纯正标志。方法为在一项多中心随机对照试验中,266例HBeAg阳性慢性乙型肝炎病人接受聚乙二醇化干扰素a-2b(100μg/d)联合拉米夫定(100mg/d)或安慰剂的治疗,疗程52wk;治疗结束后随访26wk。 | Flink HJ van Zonneveld M Hansen BE 陆伟(摘译) 张占卿(审校) | 2006 | 世界感染杂志2006，6，4： | 45 |
| 5 | 胰腺微创手术迈阿密国际循证指南(2020)显示文摘国际微创胰腺外科研究组(I-MIPS)基于2019年迈阿密国际微创胰腺手术会议专家共识及既往研究的基础上制定了微创胰腺手术国际性循证指南,对微创胰腺手术规范、技术、开展条件和手术效果等6大议题26个临床热点问题进行了系统评价。对有明确推荐意见的热点问题予以摘译如下:问题1不考虑适应症,在条件合适时|微创远端胰腺切除术相对开放手术应当优先使用吗? | Asbun HJ 崔笑(译) 耿小平(审校) | 2020 | 肝胆外科杂志2020，28，6： | 41 |
| 6 | CT仿真内窥镜对鼻腔结构与病变显示能力的研究显示文摘目的通过与纤维内窥镜比较,评价CT仿真内窥镜的显示能力和临床应用价值。方法将11例病人(2个鼻腔)的轴位螺旋CT资料进行计算机工作站Explorer软件处理,制作成仿真内窥镜影像并观察分析,其中9例(18个鼻腔)进行了纤维内窥镜检查。结果CT仿真内窥镜能清楚地显示鼻腔内解剖结构、鼻中隔弯曲、鼻道狭窄和阻塞、鼻甲肥大和直径>3mm的肿块,但可出现“假性粘连”,不能评价粘膜状况及帮助组织学诊断。结论CT仿真内窥镜这一新的、非侵袭性显示方法对鼻腔内结构和病变的显示能力相当于纤维内窥镜,可作为纤维内窥镜的补充检查方法。 | 韩萍 Bram.,HJ | 1999 | 中华放射学杂志1999，33，1： | 38 |
| 7 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 8 | Dynamic and ultrastructural study of sphincter of Oddi in early-stage cholelithiasis in rabbits with hypercholesterolemia显示文摘AIM To study the relationship between pre-formation of gallstone and the kinetics and ultra-structure of sphincter of Oddi.METHODS Adult female rabbits were used anddivided into 3 groups,and fed with either normalor high cholesterol diet for four or eight weeks.Each group contained eight rabbits.Themanometry of sphincter of Oddi,biliarycineradiography,gallbladder volumemeasurement and ultrastructure observationunder electron microscope were performed.RESULTS In groups Ⅰ and Ⅱ,the basalpressure in low-pressure ampulla or highpressure zone of sphincter of Oddi waselevated,the amplitude of phasic contractionwas decreased and the volume of gallbladderwere increased,with a significant difference(P<0.01)from those of control.Gallstones werefound in group Ⅱ rabbits(7/8).Undercineradiography,low-pressure ampulla showeda spasmodic status without apparent peristalticcontraction.Under electron microscope,insidethe muscular cells of sphincter of Oddi,loosening of microfilament and swelling ofplasmosomes which congregated at the top wereobserved.The amount showed no obviouschange under nitric oxide synthase(NOS)stain.CONCLUSION Twisting of the microfilamentand disarrangement of kink macula densa insidethe muscular ceils suggested that the sphincterof Oddi was under spasmodic status.Theimpaired diastolic function caused andaggravated the stasis of cystic bile.Theswelling plasmosome could be one of theimportant factors in elevating the tonic pressureof sphincter of Oddi. | Wei JG Wang YC Du F Yu HJ | 2000 | World Journal of Gastroenterology2000，6，1： | 19 |
| 9 | 感染性休克病人的血流动力学特点及意义显示文摘目的 了解感染性休克病人早期血流动力学改变的特点及与预后关系。方法 临床前瞻性研究 ,监测感染性休克早期血流动力学改变并分析与预后的关系。结果 共连续观察 4 8例病人 ,其中 2 5例(5 2 % )死亡。一些指标的水平在死亡者与生存者间差别较大 ,其中包括平均肺动脉压 (MPAP)、肺动脉楔压 (PAWP)、体 /肺循环阻力指数 (SVRI/PVRI)、左 /右心做功 (LCW/RCW )和左 /右心每搏动 (LCSW/RCSW)等血流动力学指标和氧合指数、动脉混合静脉血含氧量差 (a vDO2 )、全身性炎症反应综合征(SIRS)指标积分等。结论 感染性休克病情凶险 。 | 赵擎宇 贾清颜 Weigand MA Martin E Bardenheuer HJ | 2002 | 中华急诊医学杂志2002，11，3： | 16 |
| 10 | Echoplanar diffusion - weighted MRI with intravenous gadolinium - DTPA显示文摘It is occasionally necessary to repeat diffusion weighted imaging(DWI)after giving intravenous contrast medium(CM).However,the effects of CM on DWI and apparent diffusion coefficients(ADC)have not been fully ex-amined.The aim of this prospective study was to investigate whether there are any diagnostically significant dif-ferences between echo-planar imaging(EPI)-DWI before and after intravenous CM.EPI-DWI was acquiredtwice in 203 consecutive patients before and after i.v.CM.Three blinded readers rated the diagnostic | Fitzek C Mentzel HJ Fitzek S Sauner D Kaiser WA Reichenbach JR | 2003 | 中国神经肿瘤杂志2003，1，4： | 15 |
| 11 | 全髋关节置换非骨水泥型股骨柄假体髓腔准备的精确性研究显示文摘目的观察非骨水泥型股骨柄假体在股骨近端髓腔中与骨组织的接触情况及使用机器人辅助手术与传统手术结果的比较。方法在10具新鲜成人尸体股骨标本上,分别采用传统手术及机器人辅助手术行股骨近端髓腔准备后植入近端固定的非骨水泥型股骨柄假体(Osteolock)。经一系列处理后,用钻石刀按层厚3mm行硬组织切片,摄片,扫描输入计算机并用特殊软件(IDL)分析假体近端情况。分别测量假体与骨组织间缝隙的宽度以及假体表面缝隙的长度及其所占假体周径的百分比,假体表面与骨直接接触所占的百分比。结果机器人辅助手术组(实验组)平均假体近端表面与骨直接接触率达93.2%(87.6%~99.7%),假体表面与骨组织间存在由手术造成的缝隙率仅为2.9%(0.3%~7.8%),最大缝隙宽度小于1mm;而传统手术组(对照组)骨直接接触率为60.1%(49.2%~70.4%),由手术造成的缝隙率达32.8%(25.1%~39.9%),最大缝隙宽度达3mm。采用机器人辅助手术可使假体表面与骨直接接触率较传统手术增加约33%,手术误差造成的缝隙率仅为传统手术的9%,最大缝隙宽度为传统手术的26%。结论机器人辅助手术可使股骨近端髓腔与非骨水泥型股骨柄的直接接触率明显提高(P<0.001)。 | 吴立东 HJ Hahne J Hassenpflug | 2002 | 中华骨科杂志2002，22，5： | 15 |
| 12 | 术前肌电图和脑干听觉诱发电位与面肌痉挛微血管减压术后迟发性面瘫发生的关系(英文)显示文摘Background Delayed facial palsy ( DFP) after microvascular decompression ( MVD) in patients with hemifacial spasm ( HFS) is not uncommon,but the cause remains unknown. Objectives To assess whether intraoperative electromyography ( EMG) and brainstem auditory evoked potential ( BAEP) can predict DFP after MVD. Methods Between September 2009 and February 2011 we examined 86 patients,9 of whom ( 10. 4% ) developed DFP after MVD on the same side. All patients underwent MVD and were followed - up for a median period of 13 months ( range 6-22) . We retrospectively examined intraoperative facial EMG and BAEP findings using our MVD patients' registry. We excluded secondary HFS and immediate postoperative facial palsy after MVD in this study. We assessed the prevalence and clinical characteristics of DFP and compared EMG and BAEP findings between DFP and non-DFP groups. Results: All pa- tients recovered completely,with a mean time to recovery of 37. 8 days ( range 22-57) . There were no significant differences between DFP and non - DFP patients in terms of the amplitude and latency of intraoperative EMG and BAEP. Conclusion The usefulness of intraoperative facial EMG and BAEP is limited and cannot predict DFP after MVD for HFS. We speculate that DFP after MVD is not associated with permanent nerve damage according to the EMG findings. | Kim HJ Park YS Ryu JS Huh R Han I Shin DA Kim TG Cho KG Chung SS | 2012 | 中华神经外科疾病研究杂志2012，11，4： | 13 |
| 13 | Current and future therapies for inherited cholestatic liver diseases显示文摘Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases. | Wendy L van der Woerd Roderick HJ Houwen Stan FJ van de Graaf | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 14 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 15 | Luminescence Properties of the Ternary Terbium Complexes with (Ortho and Para) Aminobenzoic acids and 1,10-Phenanthroline Incorporated in Silica Matrix by a Sol-gel Method显示文摘Ternary complexes of terbium with ortho (and para) aminobenzoic acid and 1.10 phenanthroline were introduced into silica gel by the sol-gel method. The luminescence behavior of the solid-state samples was studied during the sol-gel aging process by means of emission, excitation spectra, lifetimes and quantum efficiencies. | Yan, B Zhang, HJ Wang, SB Ni, JZ | 1997 | Chinese Chemical Letters1997，8，7： | 10 |
| 16 | 牙缺失预测心肌梗死、心力衰竭、卒中和死亡显示文摘本研究调查了以缺牙为代表的口腔健康状况是否与心血管疾病风险增加有关,包括心肌梗死(MI)、心力衰竭(HF)、卒中和全因死亡率.选取韩国国民健康保险随访2007年至2008年期间接受常规牙科检查和健康体检的受试者(n=4.440,970),主要随访指标包括MI、HF、卒中和死亡,随访至2016年,随访时间为 7.56 a。 | Lee HJ Choi EK Park JB 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，2： | 10 |
| 17 | 环糊精在纺织品加工上的应用显示文摘 | 何中琴 Busc.,HJ | 1999 | 丝绸技术1999，7，3： | 8 |
| 18 | 胫骨高位截骨术治疗膝内侧室骨关节炎的长期随访显示文摘目的 观察胫骨高位截骨术治疗膝内侧室骨关节炎的远期治疗效果。方法 随访了1985~ 1996年 12年间在德国基尔大学骨科医院行胫骨高位截骨术的 194例 (2 15膝 )膝内侧室骨关节炎的患者。结果 有 16 1膝获得随访 ,平均随访时间 7 5年 (1 5~ 12年 )。手术后 2年内的优良率为 97 3% ,5年内的优良率为 93 6 % ,手术后 5年以上的优良率为 78 2 %。 12膝发生手术并发症(5 6 % ) ,主要为感染 (1例深部感染 ,5例浅表感染 ) ,骨不连或骨延迟愈合 5例 ,腓总神经损伤 1例。手术后有 19膝 (11 8% )因治疗效果的下降须再次行全膝关节置换手术。以全膝置换为失败标准的手术成功率分别为 :2年 98 7% ,5年 95 0 %及 10年为 84 1%。结论 胫骨高位截骨术是治疗膝关节内侧骨关节炎的一种有效手段 ,术中下肢力线的适当过度纠正是手术成功的关键 ,远期疗效呈下降趋势 ,有一部分患者须再次行全膝关节置换手术。 | 吴立东 HJ Hahne J Hassenpflug | 2004 | 中华外科杂志2004，42，8： | 8 |
| 19 | comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats显示文摘AIM To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress(WIRS).METHODS Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil(vehicle) and the two treatment groups were given omeprazole(20 mg/kg) or tocotrienol(60 mg/kg) by oral gavage. After 28 d of treatment, rats from one control group and both treated groups were subjected to WIRS one time for 3.5 h. Gastric lesions were measured and gastric tissues were obtained to measure vascular endothelial growth factor(VEGF), epidermal growth factor(EGF), basic fibroblast growth factor(b FGF), and transforming growth factor-alpha(TGF-α) m RNA expression. RESULTS Rats exposed to WIRS for 3.5 h demonstrated the presence of considerable ulcers in the form of gastric erosion. The lesion index in the stressed control(S) group was increased(P < 0.001) compared to the tocotrienol treated and omeprazole treated groups. Stress led to a decrease in gastric VEGF(P < 0.001), b FGF(P < 0.001) and TGF-α(P < 0.001) m RNA levels and caused an increase in EGF m RNA(P < 0.001) that was statistically significant compared to the nonstressed control group. Although both treatment agents exerted similar ulcer reducing ability, only treatment with tocotrienol led to increased expression of VEGF(P = 0.008), b FGF(P = 0.001) and TGF-α(P = 0.002) m RNA.CONCLUSION Tocotrienol provides gastroprotective effects in WIRSinduced ulcers. Compared to omeprazole, tocotrienol exerts a similar protective effect, albeit through multiple mechanisms of protection, particularly through up-regulation of growth factors that assist in repair of gastric tissue injuries. | Mohd Fahami Nur Azlina Hj Mohd Saad Qodriyah Kien Hui Chua Yusof Kamisah | 2017 | World Journal of Gastroenterology2017，23，32： | 8 |
| 20 | 氩等离子体表面凝固在支气管病学中的应用显示文摘氩等离子体表面凝固(argoplasmacoagulation,APC)是一种应用高频电流将电离的氢气(等离子体)无接触地热凝固组织的方法。由364例患者的前瞻性研究,表明APC是一种有效、安全的支气管肿瘤摘除和止血方法。它不仅可在局麻下由可曲支气管镜,而且也可在全麻下由硬质支气管镜进行,与激光相比,APC费用少,而止血效果更好,与其他方法合用,可丰富支气管介入内镜学手段。 | Reichle G Freitag L Kullmann HJ Prenzel R Macha HN Farin G 刘辉国 高亚东 华中科技大学同济医学院附属同济医院呼吸内科 | 2000 | 国外医学(呼吸系统分册)2000，20，4： | 7 |
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