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74篇 您的检索式:作者名="Samani NJ"
    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2A meta-analysis of the association of the deletion allele of the angiotensinconverting enzyme gene with myocardial infarction显示文摘Samani NJ Thompson JR O'Toole L 1996Circulation1996,94,:1
3Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis显示文摘Brouilette SW Whittaker A Stevens SE van der Harst P Good- all AH Samani NJ 2008Heart2008,94,4:1
4Novel platelet membrane glycoprotein Ⅵ dimorphism is a risk factor for myocardial infarction显示文摘Croft SA Samani NJ Teare MD 2001circulation2001,,13:1
5Genomewideassociation analysis of coronary artery disease显示文摘Samani NJ Erdmann J HaIL AS 2007N Engl J Med2007,357,5:1
6Telomete shortening in the roselerosis显示文摘Samani NJ Boultly R Bulter R 2001Lancet2001,358,9280:1
7Genomewide association analysis of coronary artery disease显示文摘Samani NJ Erdmann J Hall AS 2007N Engl J Med2007,357,5:1
8A genomewide linkage study of 1, 933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study显示文摘Samani NJ Burton P Mangino M 2005Am J Hum Genet2005,77,6:1
9Genomewide association analysis of coronary artery disease显示文摘Samani NJ Erdmann J HallAS 2007N Engl J Med2007,357,5:1
10Alpha-adducin Polymorphism in hypertensive of south African ancestry显示文摘Barlassina C Norton GR Samani NJ 2000Am J Hypertens2000,13,61:1
11Genom &ndash : wide associ- tion anakysis of coronary artery disease显示文摘Samani Nj Erdmnn J Hall AS 2007N Engl J Med2007,357,44:1
12Saturated fatty acids do not directly stimulate Toll-like receptor signaling 显示文摘Erridge C Samani NJ 2009Artefioscler Thromb Vasc Biol2009,29,11:1
13Telomere shortening in atherosclerosis显示文摘Samani NJ Boultby R Butler R 0,,9280:1
14Elevated C-reactive protein in atherosclerosis-chicken or egg显示文摘Schunkert H Samani NJ 2008N Engl J Med2008,359,18:1
15Genomewide association analysis of coronary artery disease显示文摘Samani NJ Erdmann J Hall AS 2007N Engl J Med2007,357,5:1
16Novel platelet membrane glycoprotein Ⅵ dimorphism is a risk factor for myocardial infarction显示文摘Croft SA Samani NJ 2001Circulation2001,104,:1
17T594M variant of the epithelial sodium channel beta-subunit gene and hypertension in individuals of African ancestry in South At/'ica 显示文摘Nkeh B Samani NJ Badenhorst D 2003Am J Hypertens2003,16,:1
18Telomere shortening in atherosclerosis 显示文摘Samani NJ Bouhby R Butler R 2001Lancet2001,358,9280:1
19Telomere shortening in atherossclerosis 显示文摘Samani NJ Boultby R Michael E 2003Lancet2003,358,9280:1
20Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis显示文摘Samani NJ Raitakari OT Sipil K 2008Arterioscler Thromb Vasc Biol2008,28,:1
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