|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Genome and virulence deter- minants of high virulence community-acquired MRSA 显示文摘 | Baba T Takeuchi F Kuroda M | 2002 | The Lancet2002，359，5： | 1 |
| 3 | Meta-analysis of genomewide association studies identifies common variants associated with blood pressure variation in east Asians显示文摘 | Kato N Takeuchi F Tabara Y | | 0，，： | 1 |
| 4 | Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals显示文摘 | Takeuchi F Yamamoto K Katsuya T | 2011 | Diabetologia2011，54，6： | 1 |
| 5 | Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase,ccrC显示文摘 | Ito T Ma XX Takeuchi F | 2004 | Antimicrob Agents Chemother2004，48，7： | 1 |
| 6 | Clinical pancreatitis caused by autoimmune abnormality; proposal of the concept of autoimmune pancreatitis显示文摘 | YOSHIDA K TOKI F TAKEUCHI T | 1995 | Dig Dis Sci1995，40，7： | 1 |
| 7 | Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non- classic lipopolysaccharides 显示文摘 | Lapaque N Takeuchi O Corrales F | 2006 | Cell Microbiol2006，8，3： | 1 |
| 8 | Pleuroparenchymalfibroelastosis and non-specific interstitial pneumonia: frequentpulmonary sequelae of haematopoietic stem cell transplantation 显示文摘 | Takeuchi Y Miyagawa-Hayashino A Chen F | 2015 | Histopathology)2015，66，4： | 1 |
| 9 | Association of DMA and DMB with RA in Japanese显示文摘 | Takeuchi F Nabeta H Kuwata S | 1997 | Clin Exp Rhanmatol1997，15，2： | 1 |
| 10 | Expressive and receptive language areas determined by a non - invasive reliable method using functional magnetic resonance imaging and magnetoeneephalography 显示文摘 | Kamada K Sawamura Y Takeuchi F | 2007 | Neurosurgery2007，60，2： | 1 |
| 11 | Blood pressure and hy- pertension are associated with 7 loci in the Japanese population 显示文摘 | Takeuchi F Isono M Katsuya T | 2010 | Circulation2010，121，21： | 1 |
| 12 | Chronic pancreatitis caused by an autoimmune abnormality:proposal of the concept of autoimmune pancreatitis显示文摘 | Yoshida K Toki F Takeuchi T Watanabe S Shiratori K Hayashi N | 1995 | Dig Dis Sci1995，40，： | 1 |
| 13 | Confirmation of multiple risk Loci and genetic impacts by a genome-wide associa- tion study of type 2 diabetes in the Japanese population 显示文摘 | Takeuchi F Serizawa M Yamamoto K | 2009 | Dia- betes2009，58，7： | 1 |
| 14 | Genome and virulence determi-nants of high virulence community - acquired MRSA显示文摘 | Baba T Takeuchi F Kuroda al | 2002 | Lancet2002，359，9320： | 1 |
| 15 | A genome-wide as- sociation study confirms VKORC1,CYP2C9,and CYP4F2 as principal genetic determinants of warfarin dose显示文摘 | Takeuchi F McGinnis R Bourgeois S | 2009 | Plos Genet2009，5，10： | 1 |
| 16 | Current and surface potential induced by stress-activated positive holes in igneous rocks显示文摘 | Takeuchi A Bobby W S L Friedemann T F | 2006 | Physics and Chemistry of the Earth2006，31，： | 1 |
| 17 | Genetic contribution of the CD14-159C/T dimorphism in the promoter region in Japanese RA 显示文摘 | Takeuchi F Nakaue N Kobayashi N et ol | 2008 | Clini Exp Rheumatol2008，26，2： | 1 |
| 18 | Identifi- cation and characterization of CaMKP-N, nuclear-cal-mo- dulin-dependent protein kinase phosphatase显示文摘 | TAKEUCHI F ISHIDA A KAMESHITA I | 2001 | J Biochem2001，130，： | 1 |
| 19 | Total synthesis and antihepatitis C virus activity of MA026显示文摘 | Shimura S Ishima M Nakajima S Fujii T Himeno N Ikeda K Izaguirre-Carbonell J Murata H Takeuchi T Kamisuki S Suzuki T Kuramochi K Watashi K Kobaya-shi S Sugawara F | 2013 | J Am Chem Soc2013，135，18： | 1 |
| 20 | Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians显示文摘 | Kato N Takeuchi F Tabara Y | 2011 | Nature genetics2011，43，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员