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| 1 | 完全切除的Ⅰ期,Ⅱ期和ⅢA期非小细胞肺癌术后放疗联合辅助化疗对生存率的影响:国际诺维本辅助治疗组织随机临床试验显示文摘研究背景:1998年术后放疗( post operative radiotherapy, PORT )的meta分析表明术后放疗相关死亡率风险增加21%,术后放疗的作用一直是探讨的热点。PORT对于pN0和pN1患者显示出较差的生存率,而对于Ⅲ期和pN2的患者仅轻微提高生存率。通过对术后放疗研究,辅助放疗的作用地位明显下降,随之出现的其他变化如顺铂的使用增加。 | Douillard JY Rosell R de Lena Mario 金冶宁 | 2009 | 中国癌症杂志2009，19，3： | 33 |
| 2 | 特异性神经元抗核抗体——Hu抗体的研究显示文摘为探讨Hu抗体在神经系统副肿瘤综合征(PNSNS)发病中的作用。用亲合免疫细胞组织化学ABC法及免疫印迹技术测定17例患者血清、脑脊液及尿液中的Hu抗体。结果显示17例患者血清中Hu抗体滴度为1∶1000至1∶64000;脑脊液(15例)中滴度为1∶10~1∶4000;尿液(5例)中滴度为1∶20~1∶200。Hu抗体识别的抗原分子量为35~40万。提示Hu抗体是与PNSNS有关的一种高度特异性自身抗体,PNSNS可能为一种自身免疫性疾病,Hu抗体在致病过程中起重要作用。 | 陈齐鸣 宋文英 温伟 Delatre JY Poison M | 1996 | 中华神经科杂志1996，29，3： | 28 |
| 3 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 4 | Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome显示文摘 | Ma,X Fan,L Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 20 |
| 5 | Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy显示文摘AIM: To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.METHODS: Consecutive patients who underwent capsule endoscopy du ring the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and small bowel transit time, and the small bowel image quality were compared.RESULTS: Twenty-four patients received oral erythromycin whereas 14 patients were not given any prokinetic agent.Patients who received erythromycin had a significantly lower gastric transit time than control (16 min vs70 min, P= 0.005),whereas the small bowel transit time was comparable between the two groups (227 min vs183 min, P = 0.18).Incomplete small bowel examination was found in three patients of the control group and in one patient of the erythromycin group. There was no significant difference in the overall quality of small bowel images between the two groups. A marked reduction in gastric transit time was noted in two patients who had repeat capsule endoscopy after oral erythromycin.CONCLUSION: Use of oral erythromycin significantly reduces the gastric transit time of capsule endoscopy. | Wai K Leung Francis KL Chan Sara SL Fung Mei-Yin Wong Joseph JY Sung | 2005 | World Journal of Gastroenterology2005，11，31： | 16 |
| 6 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 7 | Effect of Helicobacter pylori infection on gastric epithelial cell proliferation显示文摘INTRODUCTION Helicobacter pylori(H.pylori)infection is one ofthe main pathogens of chronic gastritis and duodenalulcer(DU),and it may be considered as a riskfactor in the incidence of gastric cancer.H.pylori infection may lead to the anomaly of gastricepithelial cell proliferation which is closely relatedto the development of gastric cancer.Vacuolatingcytotoxin(VacA)is an important virulence andvacA subtype determines the toxic activity.According to its signal sequence,it can be groupedinto type sla,slb,slc and s2.Strains harboringvacAsla are more closely related with digestivediseases and may be the strains with high toxicity.The effect of H.pylori infection on | Gao H Wang JY Shen XZ Liu JJ | 2000 | World Journal of Gastroenterology2000，6，3： | 14 |
| 8 | 点阵激光联合富血小板血浆治疗痤疮瘢痕显示文摘背景富血小板血浆(PRP)因其富含大量的生长因子,已经被应用于增强激光治疗痤疮瘢痕的临床疗效,但是其具体作用机制尚不得而知。目的 本研究旨在探讨PRP联合点阵激光治疗痤疮瘢痕背后的分子机制。方法 受试者的痤疮瘢痕程度从轻度到中度,采用自身对照的方法,受试者在使用点阵CO_2激光治疗后,一侧面部使用PRP辅助治疗,另一侧不使用PRP。设立患者皮肤活检状态的基线,在治疗后第1天、第3天、第7天和第28天分别获得皮肤活检标本并进行检测,研究激光联合PRP后皮肤相关变化的分子层面因素。结果 激光联合PRP治疗痤疮瘢痕的临床疗效更佳,降低了红斑、肿胀和渗出等不良反应的严重程度。 | Min S Yoon JY Park SY | 2018 | 中国医疗美容2018，8，1： | 12 |
| 9 | 用智能手机高血压指导或追踪应用程序进行家庭血压监测对未控制高血压患者的影响显示文摘移动应用程序(App)可能有助于改善高血压的自我管理。该文旨在探究促进家庭监测和高血压相关行为的人工智能手机指导App与血压追踪App对收缩压水平的影响。设计、设置和参与者:该研究为2组开放性随机临床试验。在2016-2017年招募高血压未控制的参与者,并随访6个月。在2019年4-12月进行数据分析。干预:干预组参与者接受智能手机指导App以促进家庭监测和高血压自我管理相关行为改变,并进行家庭血压监测。 | Persell SD Peprah YA Lipiszko D Lee JY Li JJ Ciolino JD Karmali KN Sato H 袁源(摘译) 练桂丽(审校) | 2020 | 中华高血压杂志2020，28，12： | 11 |
| 10 | 绝经后骨质疏松妇女血清相关激素水平的改变显示文摘目的 通过分析绝经后骨质疏松妇女某些骨代谢相关激素的血清水平的改变 ,探讨其与绝经后骨质疏松的关系。方法 6 2名绝经 2年以上妇女 ,测量腰椎骨密度 ,分为骨质疏松组 (30名 )和对照组 (32名 )。隔夜空腹取血测定血清LH、FSH、E1、E2 、DHEA、DHEA S、SHBG、GH、CT、PTH、2 5 (OH)D3 。结果 绝经后妇女骨质疏松组和对照组在年龄上无差异 (5 9 5 6± 6 6 5vs 5 9 35± 7 6 3,P>0 0 5 )。骨质疏松组体重指数BMI (2 4 2 7± 2 4 6 )低于对照组 (2 6 83± 4 16 ,P <0 0 5 )。绝经后妇女血清E1(r= 0 6 0 0 ,P <0 0 0 1)、DHEA(r= 0 70 8,P <0 0 0 1)、DHEAS(r = 0 5 82 ,P <0 0 0 1)与年龄负相关。骨密度与LH负相关 (r= 0 4 39,P <0 0 5 )。骨质疏松组与对照组相比 ,LH、SHBG显著增高 (P<0 0 5 ) ,DHEA、DHEAS显著降低 (P <0 0 5 )。FSH、CT、PTH、2 5 (OH)D3 、GH、E1、E2 差异无显著性。 | 单春艳 郑少雄 陈莉明 JY Reginster | 2004 | 中国骨质疏松杂志2004，10，3： | 11 |
| 11 | The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells显示文摘 | Liu X Wu JY Zhou F Sun XL Yao HH Yang Y Ding JH Hu G | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 12 | Measurement of liver volume and its clinical significance in cirrhotic portal hypertensive patients显示文摘 | Zhu JY Leng XS Dong N Qi GY Du RY | 1999 | World Journal of Gastroenterology1999，5，6： | 10 |
| 13 | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na^+/K^+- ATPase显示文摘 | Ronald JY CHEN Tse-yu CHUNG Feng-yin LI Wei-hung YANG Tzyy-rong JINN Jason TC TZEN | 2010 | Acta Pharmacologica Sinica2010，31，6： | 10 |
| 14 | Effect of sugar positions in ginsenosides and their inhibitory potency on Na^+/K^+-ATPase activity显示文摘 | Ronald JY CHEN Tse-yu CHUNG Feng-yin LI Nan-hei LIN Jason TC TZEN | 2009 | Acta Pharmacologica Sinica2009，30，1： | 10 |
| 15 | Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats显示文摘AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from anus.At 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were evaluated.At 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation resolution.At 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,P<0.05).At 4 wk post TNBS,the pathological score in high and median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,P<0.05);(2)Intracolonic TNBS administration position affected the persistence of visceral hyperalgesia.At 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,P<0.05).At 8 wk post TNBS,AWR threshold pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,P<0.05);(3)Ethanol percentage affected the TNBS-induced inflammation severity and visceral hyperalgesia.In TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR threshold pressure were significantly elevated(36.33±0.61 mmHg vs 23.33±1.33 mmHg,P<0.05);and(4)TNBS(5 mg/0.8 mL per rat, in 50%ethanol,8 cm from anus)-treated rats recovered completely from the inflammation with acquired visceral hyperalgesia and EC cell hyperplasia at 4 wk after TNBS administration.CONCLUSION:TNBS dosage,concentration,intraco-lonic administration position,and ethanol percentage play important roles in developing visceral hyperalgesia and EC cell hyperplasia of TNBS-induced PI-IBS rats. | Hong-Yan Qin Hai-Tao Xiao Justin CY Wu Brian M Berman Joseph JY Sung Zhao-Xiang Bian | 2012 | World Journal of Gastroenterology2012，18，20： | 10 |
| 16 | Epidermal growth factor prevents gut atrophy and maintains intestinal integrity in rats with acute pancreatitis显示文摘INTRODUCTIONThere is abundant evidence that stressful insults suchas acute pancreatitis may significantly alter themetabolism of the gut mucosa and therefore itsbarrier integrity,resulting in an increase in mucosalpermeability and subsequent translocation of entericbacteria and their cndotoxins.The fact thatmost bacteria associated with acute pancreatic andperipancreatic infections are of enteric originimplies that the gut plays a major role in | Chen DL Wang WZ Wang JY | 2000 | World Journal of Gastroenterology2000，6，5： | 10 |
| 17 | Effects of HBV gene variations on disease development and antiviral therapy for patients with chronic hepatitis B显示文摘Viral variation may change pathogenicity, escape immunity, lead to persistence infection, and cause drug resistance against antiviral therapy. This study was undertaken to investigate the effects of HBV gene variation on the progression of disease and on the efficacy of antiviral therapy for patients with chronic hepatitis B(CHB). METHODS:Hepatitis B virus (HBV) gene mutational sites were detected using gene chip in selected hepatitis B patients. RESULTS:In the patients HBeAg did not show serologic conversion or HBeAg(-)/anti-HBe(+), but their HBV DNA remained positive 24 weeks after α-interferon therapy, which was associated with mutations of nt1896, nt1814, nt1762 and nt1764. In the patients, that HBV DNA levels decreased or were undetectable, but rebounded later after antiviral therapy by lamivudine was associated with mutations of aa528 and(or) aa552(i.e.YMDD mutation), which resulted in lamivudine-resistance. YMDD mutation was prone to occur 52 weeks after lamivudine therapy in some chronic hepatitis B patients (26.4%). Nt1896 mutation was common in most chronic hepatitis B patients (68.5%). Chronic severe hepatitis, cirrhosis, and primary liver carcinoma were related to the mutations of nt1896, nt1762 and nt1764. CONCLUSIONS:HBV gene mutations could aggravate patient’s condition and affect the efficacy of antiviral therapy. The regular detection of HBV gene mutation is helpful for identification of disease prognosis and adjustment of therapeutic strategy. | Shenzhen Eastlake Hospital, Shenzhen 518020, China (Chen JY) and National Key Laboratory of Virology (Wuhan University) Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan 430060, China(Wang LW, Sun XM and Gong ZJ) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 8 |
| 18 | Active ingredients in Chinese medicines promoting blood circulation as Na+/K+-ATPase inhibitors显示文摘心脏的 glycosides 的积极 inotropic 效果在人的心肌层在膜界限 Na+/K+-ATPase 上躺在他们的可逆抑制。包含类似于心脏的 glycosides 的核心结构的像类固醇的混合物在通常使用支持血循环的许多中国药被发现。他们中的一些被表明是 Na+/K+-ATPase 禁止者并且这样为他们经由象心脏的 glycosides 的一样的分子的机制的治疗学的效果通常认为地负责。在另一方面, danshen 的镁 lithospermate B 也被建议由有效地禁止 Na+/K+-ATPase 施加它的心脏的治疗学的效果。理论建模建议氢契约的数字和在在 Na+/K+-ATPase 的有约束力的衣袋附近的各种各样的药和残余的有效成分之间的恐水病的相互作用的力量为这些活跃成分的禁止的力量是关键的。人参皂甙,在人参和 sanqi 的活跃成分,当糖一半仅仅被纳入他们的像类固醇的结构的 C-3 位置时,实质地禁止 Na+/K+-ATPase,等价于在心脏的 glycosides 的糖位置。然而,当糖一半被连接到 C-6 或类固醇原子核的 C-20 位置时,他们的禁止的力量被废除;大概,这些糖附件为人参皂甙的入口导致位的阻碍者进 Na+/K+-ATPase 的有约束力的衣袋。心脏的 glycosides,几像类固醇的混合物,和对 ischemic 击的镁 lithospermate B 的 Neuroprotective 效果是因此在一个外皮的大脑观察到基于片的试金模型,和累积数据支持那在大脑的 Na+/K+-ATPase 的有效禁止者能是为 ischemic 的治疗的潜在的药中风。 | Ronald JY CHEN Tzyy-rong JINN Yi-ching CHEN Tse-yu CHUNG Wei-hung YANG Jason TC TZEN | 2011 | Acta Pharmacologica Sinica2011，32，2： | 8 |
| 19 | Effects of somatostatin on splanchnic hemodynamics in cirrhotic patients with portal hypertension显示文摘INTRODUCTIONEsophageal variceal bleeding (EVB) is one of themost common complications of cirrhosis with portalhypertension.In recent years,great progress hasbeen made in medicinal treatment.Somatostatin hasbeen widely used in clinics,for it can effectivelylower the portal venous pressure (PVP) with | Zhu JY Leng XS Wang D Du RY | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 20 | Involvement of apoptosis of alveolar epithelial cells in acute pancreatitis-associated lung injury显示文摘INTRODUCTIONAcute pancreatitis in a common and potentially fataldisease which is associated with considerablemorbidity and a mortality rate of approximately30%;its pathogenesis remains unknown.Thecause of death is often due to multiple organ | Yuan YZ Gong ZH Lou KX Tu SP Zhai ZK Xu JY | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
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