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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Sere Cancer Biol2007，，17： | 1 |
| 3 | Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initia- tion factor 4E 显示文摘 | Ko SY Guo H Barengo N | 2009 | Clin Cancer Res2009，15，13： | 1 |
| 4 | Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenografts显示文摘 | Han SY Zhao W Sun H Zhou N Zhou F An G | 2015 | Phytomedicine2015，22，5： | 1 |
| 5 | Genetic mapping and QTL analysis of fiber related traits 显示文摘 | MEI M Syed N H Gao W | 2004 | Theor Appl Genet2004，108，： | 1 |
| 6 | Effects of propolis treatmenton the quality ofdried squid显示文摘 | Yang SY Lee N H Hong SP | 1999 | Korean Journal of Food Science and Technology1999，31，2： | 1 |
| 7 | Urinary catecholamines and metabolites in the immediate postoperative period following major surgery显示文摘 | Syed A A Wheatley H A Badminton M N | 2004 | J Clin Pathol2004，57，5： | 1 |
| 8 | Occurrence of polycyelie aromatic hydrocarbons in the Soan River, Pakistan : Insights into distribution, composition, sources and ecological risk assessment 显示文摘 | Aziz F Syed J H Malik R N | 2014 | Ecotoxicology and Environmental Safety2014，109，： | 1 |
| 9 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | | 0，，： | 1 |
| 10 | Occurrence of polycyclic aromatic hydrocarbons in the Soan River, Pakistan: insights into distribution, composition, sources and ecological risk assessment 显示文摘 | Aziz F Syed J H Malik R N | 2014 | Ecotoxicology and Environmental Safety2014，109，： | 1 |
| 11 | Genetic mappingand QTL analysis of fiber-related traits in cotton{Gossypium)显示文摘 | Mei M Syed N H Gao W? | 2004 | Theor Appl Genet2004，108，： | 1 |
| 12 | Organochlorine pesticides in air and soil and estimated air-soil exchange in Punjab, Pakistan显示文摘 | Syed J H Malik R N Liu D | 2013 | Science of the Total Environment2013，444，： | 1 |
| 13 | Pediatric intractable epilepsy syndromes: Reason for early surgical intervention显示文摘 | Liu SY An N Yang H | 2007 | Brain Dev2007，29，2： | 1 |
| 14 | Fast and reliable geno-type validation using microsatellite markers in Arabidopsis thaliana显示文摘 | Virk P G Pooni H S Syed N H | 1999 | Theor ApplGenet1999，98，： | 1 |
| 15 | Photocatalyticactivity of titania hollow spheres : Photodecompositionof methylene blue as a target molecule 显示文摘 | SY 0U FIA N A SATRIYA 0 H NAKASHIMA K | | CatalysisCommunications0，8，5： | 1 |
| 16 | Pomegranate derived products for cancer chemoprevention显示文摘 | SYED D N AFAQ F MUKHTAR H | 2007 | Seminars in Cancer Biology2007，17，5： | 1 |
| 17 | Formulation and evaluation of natural gum-based sustained release matrix tablets of flurbiprofen using response surface methodology显示文摘 | Syed N H S Sajid A Muhammad A C | 2009 | Drug Development and Industrial Pharmacy2009，35，12： | 1 |
| 18 | TECTA mutations in Japanese with mid-frequency hearing loss affected by zona pellucida do-main protein secretion显示文摘 | Moteki H Nishio SY Hashimoto S Takumi Y Iwasaki S Takeichi N Fukuda S Usami S | | 0，，09： | 1 |
| 19 | S elective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice显示文摘 | Kim H Choi HK Shin JH Kim KH Huh JY Lee SA Ko CY Kim HS S hin HI Lee HJ J eong D Kim N Choi Y Lee SY | | 0，，： | 1 |
| 20 | Comparison of gastroesophageal re- flux disease symptoms and proton pump inhibitor response using gastroesophageal reflux disease impact scale questionnaire显示文摘 | J o SY Kim N Lira J H | 2013 | J Neurogastroenterol Motil2013，19，1： | 1 |
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