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| 1 | Apical hypertrophic cardiomyopathy显示文摘We describe a patient with asymptomatic apical hypertrophic cardiomyopathy(AHCM)who later developed cardiac arrhythmias,and briefly discuss the diagnostic modalities,differential diagnosis and treatment option for this condition.AHCM is a rare form of hypertrophic cardiomyopathy which classically involves the apex of the left ventricle.AHCM can be an incidental finding,or patients may present with chest pain,palpitations,dyspnea,syncope,atrial fibrillation,myocardial infarction,embolic events,ventricular fibrillation and congestive heart failure.AHCM is frequently sporadic,but autosomal dominant inheritance has been reported in few families.The most frequent and classic electrocardiogram findings are giant negative T-waves in the precordial leads which are found in the majority of the patients followed by left ventricular(LV)hypertrophy.A transthoracic echocardiogram is the initial diagnostic tool in the evaluation of ACHM and shows hypertrophy of the LV apex.AHCM may mimic other conditions such as LV apical cardiac tumors,LV apical thrombus,isolated ventricular non-compaction,endomyocardial fibrosis and coronary artery disease.Other modalities,including left ventriculography,multislice spiral computed tomography,and cardiac magnetic resonance imagings are also valuable tools and are frequently used to differentiate AHCH from other conditions.Medications used to treat symptomatic patients with AHCM include verapamil,beta-blockers and antiarrhythmic agents such as amiodarone and procainamide.An implantable cardioverter defibrillator is recommended for high risk patients. | Syed Wamique Yusuf Jaya D Bathina Jose Banchs Elie N Mouhayar Iyad N Daher | 2011 | World Journal of Cardiology2011，3，7： | 4 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Aldose reductase deficiency reducedvascular changes in neonatal mouse retina in oxygen-induced retinop-athy显示文摘 | Fu ZJ Li SY Kociok N | 2012 | Invest Ophthalmol Vis Sci2012，53，9： | 1 |
| 5 | Apoptosis as a novel target for cancer chemoprevention显示文摘 | Sun SY Hail N Jr Lotan R | 2004 | J Natl Cancer Inst2004，96，9： | 1 |
| 6 | Orbital hemangiopericytoma and solitary fibrous tumor: a morphologic continuum显示文摘 | Goldsmith JD van de Riji M Syed N | 2001 | Int J Surg Pathol2001，9，4： | 1 |
| 7 | Residual bodies activate Sertoli cell interleukin 1 alpha (IL-1 alpha) release, which triggers IL-6 production by an autoerine mechanism, through the lipoxygenase pathway显示文摘 | Syed V Stephan JP Gerard N | 1995 | Endocrinology1995，136，7： | 1 |
| 8 | Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells显示文摘 | Khan N Afaq F Syed DN | 2008 | Carcinogenesis2008，29，5： | 1 |
| 9 | Apoptosis as a novel target for cancer chemoprevention 显示文摘 | Sun SY Hail N Jr Lotan R | 2004 | J Natl Cancer lnst2004，96，9： | 1 |
| 10 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Sere Cancer Biol2007，，17： | 1 |
| 11 | Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initia- tion factor 4E 显示文摘 | Ko SY Guo H Barengo N | 2009 | Clin Cancer Res2009，15，13： | 1 |
| 12 | Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenografts显示文摘 | Han SY Zhao W Sun H Zhou N Zhou F An G | 2015 | Phytomedicine2015，22，5： | 1 |
| 13 | Surgical treatment of patients with lennox-gastaut syndrome phenotype显示文摘 | Liu SY An N Fang X | 2012 | Scientific World Journal2012，2012，： | 1 |
| 14 | Impact of combined (18)F-FDG PET/CT in head and neck tumours 显示文摘 | Syed R Bomanji JB Nagabhushan N | 2005 | Br J Cancer2005，92，6： | 1 |
| 15 | New symptomatic vertebral compression fractures within a year following vertebroplasty inosteoporotic women显示文摘 | Syed M Patel N Jan S | 2005 | AJNR2005，26，： | 1 |
| 16 | Network information flow显示文摘 | Ahlswede R Cai N Li SY R | | 0，，04： | 1 |
| 17 | Genetic mapping and QTL analysis of fiber related traits 显示文摘 | MEI M Syed N H Gao W | 2004 | Theor Appl Genet2004，108，： | 1 |
| 18 | Effects of propolis treatmenton the quality ofdried squid显示文摘 | Yang SY Lee N H Hong SP | 1999 | Korean Journal of Food Science and Technology1999，31，2： | 1 |
| 19 | A homodimer of the β-subunit of inhibin A stimulates the secretion of pituitary follicle stimulating hormone显示文摘 | Ling N Ying SY Ueno N | 1986 | Biochem Biophys Res Commum1986，138，： | 1 |
| 20 | Urinary catecholamines and metabolites in the immediate postoperative period following major surgery显示文摘 | Syed A A Wheatley H A Badminton M N | 2004 | J Clin Pathol2004，57，5： | 1 |
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