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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Relationship between volatile sulphide compounds concentration and oral bacteria species detection in the elderly显示文摘 | Senpuku H Tada A Yamaga T | 2004 | International Dental Journal2004，54，： | 1 |
| 3 | Hyperhomocysteinemia is a risk factor for comonary arteriosclerosis in Japanese patients with type 2 diabetes显示文摘 | Oida K Tada H | 1999 | Diabetes Care1999，22，： | 1 |
| 4 | Long2 term effect ofepaL- restat, an aLdose reductaseinhibitor, on the development ofincip ient diabetic nephropathy in type 2diabetic patients 显示文摘 | Is O K Tada H Kubold K | 2001 | J Diabetes CompLications2001，15，7： | 1 |
| 5 | In vitro anti-mycobacterial activities of a new quinolone,balofloxacin 显示文摘 | KAWAHARA S TADA A NAGARE H | 2001 | Kekkaku2001，76，1： | 1 |
| 6 | Hyperhomocysteinemia is a risk factor for coronary arterisosclerosis in Japanese patients with type 2 diabetes显示文摘 | OKADA E OIDA K TADA H | 1999 | Diabetes Care1999，22，： | 1 |
| 7 | Double potentials along the ablation line as a guide to radiofrequency ablation of typical atrial flutter显示文摘 | Tada H Oral H Sticherling C | 2001 | J Am Coll Cardiol2001，38，3： | 1 |
| 8 | High glucose level s enhance TGF-β1-thrombospondin-1 path way in cultured human mesangial cells via mechanisms dependent on glucose-induced PKC activation 显示文摘 | Tada H Kuboki K Nomura K | 2001 | J Diabetes Complications2001，15，： | 1 |
| 9 | Differential effects of LPS and TGF-β on the production of IL-6 and IL-12 by langerhans cells,splenic dendritic cells,and macrophages显示文摘 | Tada Y Asahina A Fujita H | | 0，，04： | 1 |
| 10 | Clopidogrel resistance in Japanese patients scheduled for percutaneouscoronary interventionl 显示文摘 | Hoshino K Horiuchi H Tada T | 2009 | Circulation2009，133，2： | 1 |
| 11 | Successful catheter ablation of atrial tachycardia originating near the atrioventricular node fromthe noncoronary sinus of valsalva显示文摘 | Tada H Naito S Miyazaki A | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 12 | Pulmonary vein isolation for paroxysmal and persistent atrial fibrillation显示文摘 | Oral H Knight BP Tada H | 2002 | Circulation2002，105，： | 1 |
| 13 | An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-beta and protein kinase C activity in cultured mesangial cells显示文摘 | Ishii H Tada H Isogai S | 1998 | Diabetologia1998，41，3： | 1 |
| 14 | Cervical myelopathy secondary to multiple spondyloticprotrusions:a clinico-pathologic study显示文摘 | Ono K Ota H Tada K | 1977 | Spine1977，2，10： | 1 |
| 15 | Maximum ventricular dyssynchrony predicts clinical improvement and reverse remodeling during cardiac resynchronization therapy 显示文摘 | TADA H TOIDE H OKANIWA H | 2007 | Pacing Clin Electrophysiol2007，30，1： | 1 |
| 16 | Pluripotential competence of cells associated with Nanog activity显示文摘 | Hatano SY Tada M Kimura H | 2005 | Mech Dev2005，122，1： | 1 |
| 17 | Tumor markers in pleural effusion of patients with lung cancer and patients with tuberculous pleurisy显示文摘 | Tada A Kawai H Matsumoto H | 2002 | Nihon Kokyuki Gakkai Zasshi2002，40，2： | 1 |
| 18 | Hyperhomocysteinemia is a risk factor for coronary arteriosclerosis in Japanese patientswith type 2 diabetes显示文摘 | Okada E Oida K Tada H | 1999 | Diabetes Care1999，22，3： | 1 |
| 19 | Reduction in non- fluorescence state of quantum dots on an immunofluorescence staining显示文摘 | Li-Shishido S Watanabe TM Tada H | 2006 | Biochem Biophys Res Commun2006，351，1： | 1 |
| 20 | Photoinduced Polymerization of 1,3,5,7 Tetramethylcyclotet raslloxane by TiOz Parti cles显示文摘 | Tada H Hyodo M Kawahara H | 1991 | J Phys chem1991，95，10： | 1 |
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