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| 1 | Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis显示文摘AIM: To evaluate whether Helicobacter pylori(H. pylori) eradication therapy benefits patients with functional dyspepsia(FD).METHODS: Randomized controlled trials(RCTs) investigating the efficacy and safety of H. pylori eradication therapy for patients with functional dyspepsia published in English(up to May 2015) were identified by searching Pub Med, EMBASE, and The Cochrane Library. Pooled estimates were measured using the fixed or random effect model. Overall effect was expressed as a pooled risk ratio(RR) or a standard mean difference(SMD). All data were analyzed with Review Manager 5.3 and Stata 12.0.RESULTS: This systematic review included 25 RCTs with a total of 5555 patients with FD. Twenty-three of these studies were used to evaluate the benefits of H. pylori eradication therapy for symptom improvement; the pooled RR was 1.23(95%CI: 1.12-1.36, P < 0.0001). H. pylori eradication therapy demonstrated symptom improvement during long-term follow-up at ≥ 1 year(RR = 1.24; 95%CI: 1.12-1.37, P < 0.0001) but not during short-term follow-up at < 1 year(RR = 1.26; 95%CI: 0.83-1.92, P = 0.27). Seven studies showed no benefit of H. pylori eradication therapy on quality of life with an SMD of-0.01(95%CI:-0.11 to 0.08, P = 0.80). Six studies demonstrated that H. pylori eradication therapy reduced the development of peptic ulcer disease compared to no eradication therapy(RR = 0.35; 95%CI: 0.18-0.68, P = 0.002). Eight studies showed that H. pylori eradication therapy increased the likelihood of treatment-related side effects compared to no eradication therapy(RR = 2.02; 95%CI: 1.12-3.65, P = 0.02). Ten studies demonstrated that patients who received H. pylori eradication therapy were more likely to obtain histologic resolution of chronic gastritis compared to those who did not receive eradication therapy(RR = 7.13; 95%CI: 3.68-13.81, P < 0.00001).CONCLUSION: The decision to eradicate H. pylori in patients with functional dyspepsia requires individual assessment. | Li-Jun Du Bin-Rui Chen John J Kim Sarah Kim Jin-Hua Shen Ning Dai | 2016 | World Journal of Gastroenterology2016，22，12： | 30 |
| 2 | Currently Clinical Views on Genetics of Wilson's Disease显示文摘 | Chen Chen Bo Shen Jia-Jia Xiao Rong Wu Sarah Jane Duff Canning Xiao-Ping Wang | 2015 | Chinese Medical Journal2015，，13： | 13 |
| 3 | Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared显示文摘Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity.Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs.Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor growth.This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser excitation.Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species. | Zhuang Liu Scott Tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai | 2010 | Nano Research2010，3，3： | 11 |
| 4 | The electrolyte comprising more robust water and superhalides transforms Zn-metal anode reversibly and dendrite-free显示文摘A great challenge for all aqueous batteries,including Zn-metal batteries,is the parasitic hydrogen evolution reaction on the low-potential anode.Herein,we report the formula of a highly concentrated aqueous electrolyte that mitigates hydrogen evolution by transforming water molecules more inert.The electrolyte comprises primarily ZnCl_(2) and LiCl as an additive,both of which are inexpensive salts.The O-H covalent bonds in water get strengthened in a chemical environment that has fewer hydrogen bonding interactions and a greater number of Zn-Cl superhalides,as suggested by integrated characterization and simulation.As a result,the average Coulombic efficiency of zincmetal anode is raised to an unprecedented>99.7%at 1mA cm^(−2).In the new electrolyte,the plating/stripping processes leave the zinc-metal anode dendrite-free,and the zinc-metal anode delivers stable plating/stripping cycles for 4000 hours with an areal capacity of 4 mAh cm^(−2) at 2mA cm^(−2).Furthermore,the high Coulombic efficiency of zinc-metal anode in the ZnCl_(2)-LiCl mixture electrolyte is demonstrated in full cells with a limited anode.The V_(2)O_(5)·H_(2)O||Zn full cell with an N/P mass ratio of 1.2 delivers a stable life of more than 2500 cycles,and the LiMn_(2)O_(4)||Zn hybrid cell with an N/P mass ratio of 0.6 exhibits 1500 cycles in its stable life. | Chong Zhang Woochul Shin Liangdong Zhu Cheng Chen Joerg C.Neuefeind Yunkai Xu Sarah I.Allec Cong Liu Zhixuan Wei Aigerim Daniyar Jia‐Xing Jiang Chong Fang P.Alex Greaney Xiulei Ji | 2021 | Carbon Energy2021，3，2： | 3 |
| 5 | Cross-regulation of the Nanog and Cdx2 promoters显示文摘在哺乳动物的胚胎,内部房间团(ICM ) 的分离和 trophectoderm (TE ) 的第一种房间命运选择,,被抄写因素, Oct4 和 Cdx2 的互相对抗的效果调整 pluripotency 因素, Nanog,是必要的指定 epiblast。我们分析了 Nanog 和 Cdx2 的倡导者,并且发现了这二个抄写因素同样相互地被调整。用有有条件的 TE 区别的一根胚胎的干细胞线,我们证明 Nanog overexpression 压制 TE 标记的 upregulation,当时 Nanog 击倒的 upregulates TE 标记的表示。我们推进 Nanog 和 Cdx2 绑在并且镇压的表演对方的倡导者。而 Nanog 大美人在 ICM 导致可检测的 Cdx2 表示,我们不管多么不观察胚囊开发的公开混乱,显示 Nanog 起到在 ICM 和 TE 的分离的 Oct4 的一个谄媚的作用。 | Lingyi Chen Akiko Yabuuchi Sarah Eminli Ayumu Takeuchi Chi-Wei Lu Konrad Hochedlinger George Q Daley | 2009 | Cell Research2009，19，9： | 3 |
| 6 | 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor显示文摘Dear Editor,As of July,2020,the ongoing pandemic of coronavirus diseases 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2,previously 2019-nCoV)has caused more than 10.3 million human infections,with more than 506,000 deaths worldwide according to the World Health Organization.The clinical manifestations of COVID-19 vary from no asymptomatic infection,mild“flu-like”symptoms,to lethal acute respiratory distress syndrome.The case mortality and fatality rates in people infected with SARS-CoV-2 increase steeply with age,and fatal outcomes are almost exclusively seen in people older than 50 years.1 Although the Food and Drug Administration has authorized emergency use of remdesivir for COVID-19 treatment in the US,the need for safe and effective antiviral drugs against SARS-CoV-2 remains urgent and unmet. | Shulong Zu Yong-Qiang Deng Chao Zhou Jie Li Lili Li Qi Chen Xiao-Feng Li Hui Zhao Sarah Gold Jun He Xiang Li Changqing Zhang Heng Yang Genhong Cheng Cheng-Feng Qin | 2020 | Cell Research2020，30，11： | 3 |
| 7 | HIV care continuum among newly diagnosed student and non-student youths between 2012 and 2016 in Hangzhou, China显示文摘Background: Youths are disproportionally affected by the human immunodeficiency virus (HIV) infection. We aimed to assess antiretroviral therapy (ART) initiation and viral suppression rates among student and non-student youths in Hangzhou, China. Methods: Data were taken from the Chinese HIV/acquired immune deficiency syndrome Comprehensive Response Information Management System. Youths aged 15 to 24 years who were newly diagnosed with HIV between 2012 and 2016 and were living in Hangzhou were included in the study. Comparisons between student and non-student youths were made for ART initiation within 30 days, 90 days, and 12 months of HIV diagnosis, and the viral suppression rate at 12 months of HIV diagnosis and at 12 months of ART initiation. Results: A total of 707 cases met inclusion criteria, 29.6% of which were students and 70.4% were non-student youths. The student group had a higher proportion of ART initiation compared with the non-student group within 30 days of diagnosis (45.5% vs. 37.0%, P = 0.044), and a slightly higher but not statistically significant proportion at 90 days (67.0% vs. 62.7%), and 12 months (83.7% vs. 78.5%) of HIV diagnosis. ART initiation within 30 days improved from <15% in 2012 to over 65% in 2016 in both groups, and ART initiation within 90 days improved from <30% in 2012 to >90% in 2016. A smaller proportion of students experienced viral suppression compared with the non-student group (9.6% vs. 17.1%, P = 0.011) at 12 months after HIV diagnosis, but the suppression rate was similar at 12 months of ART initiation (69.9% vs. 71.1%, P = 0.743). Conclusions: ART initiation in both student and non-student youths has significantly improved between 2012 and 2016. However, the viral suppression rate remained unacceptably low at 12 months of HIV diagnosis in both student and non-student groups. Specific intervention strategies must be taken to address this challenge. | Yan Luo Hong Wu Xing-Liang Zhang Xi-Ting Li Sarah Robbins Scott Jun-Fang Chen Zun-You Wu | 2019 | Chinese Medical Journal2019，，12： | 2 |
| 8 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 9 | A community-based comprehensive intervention to reduce syphilis infection—among low-fee female sex workers in China:a matched-pair,community-based randomized study显示文摘Background:Low-fee female sex workers(FSWs)are at high risk of acquiring and spreading human immunodeficiency virus(HIV)/sexually transmitted diseases(STDs)in China.There is an urgent need to develop comprehensive intervention measures targeted towards low-fee FSWs to reduce HIV/STD infections.Thus,this study aimed to reduce HIV/STD infections among low-fee FSW through a matched-pair,comiDunity-based randomized intervention trial carried out in 12 cities in three provinces in China.Methods:Four cities from Guangxi Zhuang Autonomous Region,four from Yunnan Province,and four from Hunan Province were paired and participants received either the intervention package(including condom promotion,HIV and syphilis testing,reimbursement for syphilis treatment costs,and free anti-retroviral therapy or the current standard of care.Venue-based,convenience sampling was used to recruit FSWs.A face-to-face interview and HIV and syphilis blood testing was conducted at baseline and follow-up intervals of 24 months.Generalized linear mixed models(GLMM)were used to evaluate the effect of the intervention package on reducing HIV/STD infection in the FSWs.Results:A total of 1024 eligible FSWs were enrolled in the baseline survey and 843 in the follow-up.GLMM results showed that syphilis infeaion was reduced by 49%in the intervention group compared to the current standard of care group(P=0.0378,OR=0.51;95%CI:0.27-0.96).FSWs aged 35 years or older were 2.38 times more likely to get syphilis infection compared to those younger than 35 years old(P<0.0001,OR=2.38,95%CI:1.55-3.65).The risk of syphilis infection among more educated FSWs was 0.43 times less than those with lower levels of education(P<0.05,OR=0.43,95%CI:0.63-0.93).Conclusions:This study demonstrates that comprehensive interventions can lead to significant declines in syphilis infection amongst low-tier FSWs.Integrating both behavioral and biomedical intervention measures should be considered when developing programs for low-fee FSWs.Trial registration:CHiCTR-TRC-12002655. | Wei Dong Chu Zhou Ke-Ming Rou Zun-You Wu Jun Chen Sarah Robbins Scott Man-Hong Jia Yue-Jiao Zhou Xi Chen | 2019 | Infectious Diseases of Poverty2019，8，6： | 2 |
| 10 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 11 | Doped graphene/carbon black hybrid catalyst giving enhanced oxygen reduction reaction activity with high resistance to corrosion in proton exchange membrane fuel cells显示文摘Nitrogen doping of the carbon is an important method to improve the performance and durability of catalysts for proton exchange membrane fuel cells by platinum–nitrogen and carbon–nitrogen bonds. This study shows that p-phenyl groups and graphitic N acting bridges linking platinum and the graphene/carbon black(the ratio graphene/carbon black = 2/3) hybrid support materials achieved the average size of platinum nanoparticles with(4.88 ± 1.79) nm. It improved the performance of the lower-temperature hydrogen fuel cell up to 0.934 W cm^(-2) at 0.60 V, which is 1.55 times greater than that of commercial Pt/C. Doping also enhanced the interaction between Pt and the support materials, and the resistance to corrosion, thus improving the durability of the low-temperature hydrogen fuel cell with a much lower decay of 10 mV at 0.80 A cm^(-2) after 30 k cycles of an in-situ accelerated stress test of catalyst degradation than that of 92 mV in Pt/C, which achieves the target of Department of Energy(<30 mV). Meanwhile,Pt/Nr EGO_(2)-CB_(3) remains 78% of initial power density at 1.5 A cm^(-2) after 5 k cycles of in-situ accelerated stress test of carbon corrosion, which is more stable than the power density of commercial Pt/C, keeping only 54% after accelerated stress test. | Zhaoqi Ji Jianuo Chen María Pérez-Page Zunmin Guo Ziyu Zhao Rongsheng Cai Maxwell T.P.Rigby Sarah J.Haigh Stuart M.Holmes | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 12 | Ranibizumab for Macular Edema following Central Retinal Vein Occlusion显示文摘 | David M. Brown Peter A. Campochiaro Rishi P. Singh Zhengrong Li Sarah Gray Namrata Saroj Amy Chen Rundle Roman G. Rubio Wendy Yee Murahashi | 2010 | Ophthalmology2010，，6： | 2 |
| 13 | Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction显示文摘 | Cheuk-Kwan Sun Yen-Yi Zhen Steve Leu Tzu-Hsien Tsai Li-Teh Chang Jiunn-Jye Sheu Yung-Lung Chen Sarah Chua Han-Tan Chai Hung-I Lu Hsueh-Wen Chang Fan-Yen Lee Hon-Kan Yip | 2014 | International Journal of Cardiology2014，，： | 1 |
| 14 | Serum Brain–Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Levels Are Associated With Risk of Stroke and Vascular Brain Injury显示文摘 | Aleksandra Pikula Alexa S. Beiser Tai C. Chen Sarah R. Preis Demetrios Vorgias Charles DeCarli Rhoda Au Margaret Kelly-Hayes Carlos S. Kase Philip A. Wolf Ramachandran S. Vasan Sudha Seshadri | 2013 | Stroke2013，，： | 1 |
| 15 | Roles of safety climate and shift work on perceived injury risk: a multi-level analysis显示文摘 | HUANG Yueng-Hsiang CHEN Jiu-Chiuan Sarah DEARMOND | 2007 | Accident Analysis & Prevention2007，39，6： | 1 |
| 16 | Compressed sensing for resolution enhancement of hyperpolarized 13 C flyback 3D-MRSI显示文摘 | Simon Hu Michael Lustig Albert P. Chen Jason Crane Adam Kerr Douglas A.C. Kelley Ralph Hurd John Kurhanewicz Sarah J. Nelson John M. Pauly Daniel B. Vigneron | 2008 | Journal of Magnetic Resonance2008，，2： | 1 |
| 17 | Human resources for health: overcoming the crisis显示文摘 | Lincoln Chen Timothy Evans Sudhir Anand Jo Ivey Boufford Hilary Brown Mushtaque Chowdhury Marcos Cueto Lola Dare Gilles Dussault Gijs Elzinga Elizabeth Fee Demissie Habte Piya Hanvoravongchai Marian Jacobs Christoph Kurowski Sarah Michael Ariel Pablos-Men | 2004 | The Lancet . 2004 (9449)2004，，： | 1 |
| 18 | Isolation and characterization of two knotted-like homeobox genes from tomato显示文摘 | Bart-Jan Janssen Andrina Williams Ju-Jiun Chen Julie Mathern Sarah Hake Neelima Sinha | 1998 | Plant Molecular Biology1998，，3： | 1 |
| 19 | Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-κB-mediated IL-8 gene expression显示文摘 | Stavros Sougioultzis Simos Simeonidis K. Ramakrishnan Bhaskar Xinhua Chen Pauline M. Anton Sarah Keates Charalabos Pothoulakis Ciarán P. Kelly | 2006 | Biochemical and Biophysical Research Communications2006，，1： | 1 |
| 20 | Local perceptions of the conversion of cropland to forestland program in Jiangxi, Shaanxi, and Sichuan, China显示文摘Numerous land-use policies have been implemented in China in recent decades for ecological restoration and conservation to reduce environmental disasters and promote environmental sustainability.Many of these policies follow a top-down approach to implementation and as such,emphasize the hierarchical control within government structures.An understanding of local perceptions of land-use policies is important if the disconnect between policy makers and the target population is to be reduced and if program support is to improve.This study aimed to help improve local implementation,attitude toward,and engagement by examining the influence of socio-economic characteristics on the target population’s(local farmers)perception of the conversion of cropland to forestland program(CFPP)land use policy in Jiangxi,Sichuan,and Shaanxi provinces.It uses logistical regression models,with robust aspects of perception including confidence,support,transparency,prospects,fairness,and willingness to participate.Results indicate that social aspects as well as economic aspects are most important in influencing farmers’perceptions towards the CFPP.The farmers who have received technical support,rural male habitants,educated,and non-middle-aged farmers exhibit more positive perceptions of the program and are much more likely to support it,whereas farmers without any technical support or formal education,and female and middle-aged farmers are less likely to support the program.Importantly,this study also reveals the differences in responses,experiences and perceptions of the farmers living across different provinces.These empirical results provide insight into the influence of socio-economic characteristics on the perception of farmers towards land-use policies,which has important implications for designing targeted policy instruments and increasing farmer support for these policies.This knowledge can be harnessed and further evaluated in future research to improve citizen engagement,support,and understanding in order to help ecological restoration and conservation objectives be more effectively achieved. | Guangyu Wang Oliver Z.Ma Liguo Wang Anil Shrestha Baozhang Chen Feng Mi Shirong Liu Xiaomin Guo Sarah Eshpeter John L.Innes | 2019 | Journal of Forestry Research2019，30，5： | 1 |
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