| 1 | Regulation of cholesterol homeostasis in health and diseases:from mechanisms to targeted therapeutics显示文摘Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases,such as cardiovascular diseases(CVD),neurodegenerative diseases and cancers,particularly the CVD in which the accumulation of lipids(mainly the cholesteryl esters)within macrophage/foam cells underneath the endothelial layer drives the formation of atherosclerotic lesions eventually.More and more studies have shown that lowering cholesterol level,especially low-density lipoprotein cholesterol level,protects cardiovascular system and prevents cardiovascular events effectively.Maintaining cholesterol homeostasis is determined by cholesterol biosynthesis,uptake,efflux,transport,storage,utilization,and/or excretion.All the processes should be precisely controlled by the multiple regulatory pathways.Based on the regulation of cholesterol homeostasis,many interventions have been developed to lower cholesterol by inhibiting cholesterol biosynthesis and uptake or enhancing cholesterol utilization and excretion.Herein,we summarize the historical review and research events,the current understandings of the molecular pathways playing key roles in regulating cholesterol homeostasis,and the cholesterol-lowering interventions in clinics or in preclinical studies as well as new cholesterol-lowering targets and their clinical advances.More importantly,we review and discuss the benefits of those interventions for the treatment of multiple diseases including atherosclerotic cardiovascular diseases,obesity,diabetes,nonalcoholic fatty liver disease,cancer,neurodegenerative diseases,osteoporosis and virus infection. | Yajun Duan Ke Gong Suowen Xu Feng Zhang Xianshe Meng Jihong Han | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 3 |
| 2 | 从代谢角度看冠状病毒与宿主的相互作用显示文摘严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)的出现引发了新型冠状病毒肺炎的全球大流行,也将“冠状病毒”拉进大众视野。目前已知,病毒快速复制的同时会引起宿主细胞代谢网络的剧烈变动,而近期的研究已经从这些关键变化中寻找到相应的抗病毒靶点。本综述,我们重点关注了冠状病毒对宿主代谢(包括脂类代谢、中心碳代谢、氨基酸代谢等)影响的相关研究。阐明病毒感染诱导的宿主细胞代谢重编程,不仅有助于更透彻地理解病毒与宿主的相互作用,更提供了通过靶向代谢的策略来开发抗病毒药物的新思路。 | 黄梓鑫 周书亭 王哲 | 2023 | 中国人兽共患病学报2023，39，11： | 0 |
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