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| 1 | From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. | Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis | 2017 | World Journal of Gastroenterology2017，23，29： | 44 |
| 2 | Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway显示文摘动脉粥样硬化当前被认为煽动性的疾病。许多注意作为预示 / 诊断的标记或动脉粥样硬化患者的治疗学的目标集中于煽动性的调停人的潜在的角色心血管的疾病。CX3CL1 (或 fractalkine ) 有一口井的在结构上和机能上地独特的 chemokine 被记录在动脉粥样硬化的角色。在它的膜界限形式,它支持卷白细胞到容器墙上的坚挺的粘附,当在它的可溶的形式它为表示 CX3CR1 房间用作有势力 chemoattractant 时。另外, CX3CL1 在脉管的房间上在内皮细胞层以及 anti-apoptotic 和 proliferative 效果上施加细胞毒素的效果,影响动脉粥样硬化患者匾的上下文和稳定性。动物模型上的研究证明了 CX3CL1/CX3CR1 小径的封锁改善动脉粥样硬化的严厉,当基因传染病学证实了那时,一条遗传上定义的不太活跃的 CX3CL1/CX3CR1 小径在人与动脉粥样硬化患者疾病的减少的风险被联系。尽管几研究在 atherogenesis 和匾 destabilization 支持 CX3CL1/CX3CR1 的一个重要病原的角色,这未必确实建议这条小径是一个合适的治疗学的目标或 CX3CL1 能用作预示 / 诊断的 biomarker。CX3CL1/CX3CR1 chemokine 小径上的进一步的研究清楚地被保证在动脉粥样硬化认为它的角色的临床的关联正当。 | Stavros APOSTOLAKIS Demetrios SPANDIDOS | 2013 | Acta Pharmacologica Sinica2013，34，10： | 17 |
| 3 | 多艾里光束合成自聚焦光束的实验实现显示文摘多光束合成和单光束聚焦一直是提高激光束功率和功率密度的两个重要方法.结合艾里光束在自由空间中沿弯曲路径传播的特性,从数值模拟和实验两个方面,研究了利用多个一维艾里光束合成自由空间自聚焦光束的方法,并对所得到的模拟和实验结果进行了对比.采用分步束传播法,分别模拟了由四个和八个一维艾里光束合成的自聚焦光束在自由空间中的传播过程,给出了自聚焦光束在传播过程中横向和纵向的光强分布和变化趋势.采用计算全息和空间光调制器技术实验,实现了多个一维艾里光束合成的自聚焦光束.实验中分别测量了四个和八个一维艾里光束合成的自聚焦光束的横向光强分布.实验结果和理论结果符合得较好.另外,为了进一步增大自聚焦光束的功率,可以增加参与合成的一维艾里光束的数量.同时,自聚焦光束的焦距可以通过调整各个一维艾里光束的相对位置进行调节. | 张泽 刘京郊 张鹏 倪培根 Prakash Jai 胡洋 姜东升 Christodoulides Demetrios N 陈志刚 | 2013 | 物理学报2013，62，3： | 16 |
| 4 | Effects of length and application rate of rice straw mulch on surface runoff and soil loss under laboratory simulated rainfall显示文摘Forest land affected by deforestation yields high soil and water losses.Suitable management practices need to be found that can reduce these losses and achieve ecological and hydrological sustainability of the deforested areas.Mulch has been found to be effective in reducing soil losses;straw mulch is easy to apply,contributes soil organic matter,and is efficient since the day of application.However,the complex effects of rice straw mulch with different application rates and lengths on surface runoff and soil loss have not been clarified in depth.The current paper evaluates the efficiency of rice straw mulch in reducing the hydrological response of a silty clay loam soil under high intensity and low frequency rainfall events(tap water with total depth of 49 mm and intensity of 98 mm/h)simulated in the laboratory.Surface runoff and soil loss at three lengths of the straw(10,30,and 200 mm)and three application rates(1,2,and 3 Mg/ha)were measured in 50 cm(width)×100 cm(length)×10 cm(depth)plots with disturbed soil samples(aggregate soil size<4 mm)collected in a deforested area.Bare soil was used as control experiment.Runoff volume and erosion were significantly(at p<0.05)lower in mulched soils compared to control plots.These reductions were ascribed to the water absorption capacity of the rice straw and the protection cover of the mulch layer.The minimum runoff was observed for a mulch layer of3 Mg/ha of straw with a length of 200 mm.The lowest soil losses were found with straw length of10 mm.The models developed predict runoff and erosion based on simple linear functions of mulch application rate and length,and can be used for a suitable hydrological management of soil.It is concluded that,thanks to rice straw mulch used as an organic soil conditioner,soil erosion and surface runoff are significantly(at p<0.05)reduced,and the mulch protection contributes to reduce the risk of soil degradation.Further research is,however,needed to analyze the upscaling of the hydrological effects of mulching from the plot to the hillslope scale. | Misagh Parhizkar Mahmood Shabanpour Manuel Esteban Lucas-Borja Demetrio Antonio Zema Siyue Li Nobuaki Tanaka Artemio Cerdà | 2021 | International Journal of Sediment Research2021，36，4： | 8 |
| 5 | 室内空气品质研究的趋势和面对的挑战显示文摘人类90%的时间在非工业建筑环境中度过,而室内空气品质(IAQ)学就是研究在非工业建筑环境下,空气中影响人体健康的污染物来源、污染程度大小、产生的后果及其控制和管理方法等。本文主要讨论目前的研究发展趋势,介绍最新的研究成果。首先,提出并分析了本领域研究的七大发展趋势,取得的成就及存在的问题;然后,指出了五个研究发展中应注意的问题,藉此对未来短期内的发展方向提出建议;最后,讨论了三个长期发展的目标。提出IAQ领域的战略性发展方向。 | Demetrios J.Moschandreas 周军莉 王瑱 张国强 | 2002 | 洁净与空调技术2002，，3： | 7 |
| 6 | Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats: What we know so far?显示文摘We read with great interest the article entitled ‘‘Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats’’ by Ulmer et al. [1]. The aim of this study was to analyse the impact of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70% partial hepatectomy. Ulmer and his colleagues concluded that neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. This is a very interesting research in our understanding regarding the study of postoperative liver failure and liver regeneration after modulation of portal vein pressure. However, there are some questions which demand further consideration. | antonios athanasiou eleftherios spartalis mairead hennessy michael spartalis demetrios moris christos damaskos emmanouil pikoulis | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 5 |
| 7 | Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review显示文摘一个腹的大动脉的动脉瘤(AAA ) 的修理是与有煽动性的串联的随后的激活的神经质、新陈代谢的压力相关的反应有关的一个高风险的外科的过程。与开的修理相对照(或) , endovascular 大动脉的动脉瘤修理(EVAR ) 由为更少提供广泛的切口,解剖,和织物操作似乎是手术后的压力到减少。然而,这些有益的效果可以是由代谢物在用在 endovascular 的导管的血栓的 intra 钠操作期间修理的 cytokines 和 arachidonic 酸的版本的偏移量,导致全身的煽动性的反应(先生) ,它是临床上叫的培植以后的症候群。在我们比较了的这系统的评论或与 EVAR,以 post-interventional,从改变导致传播 cytokine 的煽动性的反应铺平。我们寻求了在 EVAR 以后关于培植以后的症候群总结所有最近的证据。我们寻找了为临床的研究作为煽动性的反应的部分在 cytokines 的版本上报导在以后的 Medline (PubMed ) , ClinicalTrials.gov 和 Cochrane 图书馆开 / 常规并且 AAA 的 endovascular 修理。我们鉴别 17 学习检验 cytokine 层次在以后或对 EVAR。或似乎特别地比 EVAR 与一位更大的先生被联系,由增加的 cytokine 层次证实了 IL-6 和 IL-8 而 IL-1, IL-10 和 TNF- 出现了,冲突在二之间的结果或没有差别组织。聚酯 endografts 看起来断然在 EVAR 以后与培植以后的症候群的发生被相关。未来大未来的研究被保证位于在 surgical 以后的 cytokine 相互作用下面描出的机制煽动性的反应背景。 | Diamantis I TSILIMIGRAS Fragiska SIGALA Georgios KARAOLANIS Ioannis NTANASIS-STATHOPOULOS Eleftherios SPARTALIS Michael SPARTALIS Nikolaos PATELIS Alexandros PAPALAMPROS Chandler LONG Demetrios MORIS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 8 | Steatosis and steatohepatitis in postmortem material from Northwestern Greece显示文摘AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to def ine the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece. | Christos D Zois Gerasimos H Baltayiannis Anna Bekiari Anna Goussia Peter Karayiannis Michalis Doukas Demetrios Demopoulos Antigoni Mitsellou Theodoros Vougiouklakis Vasiliki Mitsi Epameinondas V Tsianos | 2010 | World Journal of Gastroenterology2010，16，31： | 4 |
| 9 | HIV entry inhibitors: a new generation of antiretroviral drugs显示文摘爱滋病是目前对待能,并且病人们能由于高度活跃的 antiretroviral 治疗(HAART ) 的成功有好预后,但是它仍然不可医好或可防止。HAART 的高毒性,和药抵抗的出现增加命令继续研究进新策略和干预。在进主机房间的 HIV 附件和入口的理解的可观的进步为讲道理地设计防碍这进程的代理人建议了新可能性。为临床的使用的熔化禁止者 enfuvirtide (Fuzeon ) 的赞同和介绍在爱滋病治疗学表明一个新时代。这里,我们考察病毒使用完成房间入口的关键步,它在现出症状之前的潜、临床的发展阶段作为潜在的目标,和混合物应得注意,报导了有效地禁止房间入口。 | Elias KRAMBOVITIS Filippos PORICHIS Demetrios A SPANDIDOS | 2005 | Acta Pharmacologica Sinica2005，26，10： | 4 |
| 10 | Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance(Review)显示文摘 | Sameh Hafsi Franca Pezzino Saverio Candido Giovanni Ligresti Demetrios Spandidos Zohra Soua James McCubrey Salvatore Travali Massimo Libra | 2012 | International Journal of Oncology2012，，3： | 4 |
| 11 | Cemented Müller straight stem total hip replacement:18 year survival,clinical and radiological outcomes显示文摘AIM: To present the 18 year survival and the clinical and radiological outcomes of the Müller straight stem, cemented, total hip arthroplasty(THA).METHODS: Between 1989 and 2007, 176 primary total hip arthroplasties in 164 consecutive patients were performed in our institution by the senior author. All patients received a Müller cemented straight stem and a cemented polyethylene liner. The mean age of the patients was 62 years(45-78). The diagnosis was primary osteoarthritis in 151 hips, dysplasia of the hip in 12 and subcapital fracture of the femur in 13. Following discharge, serial follow-up consisted of clinical evaluation based on the Harris Hip Score and radiological assessment. The survival of the prosthesis using revision for any reason as an end-point was calculated by KaplanMeier analysis.RESULTS: Twenty-four(15%) patients died during the follow-up study, 6(4%) patients were lost, while the remaining 134 patients(141 hips) were followedup for a mean of 10 years(3-18 years). HSS score at the latest follow-up revealed that 84 hips(59.5%) had excellent results, 30(22.2%) good, 11(7.8%) fair and 9(6.3%) poor. There were 3 acetabular revisions due to aseptic loosening. Six(4.2%) stems were diagnosed as having radiographic definitive loosening; however, only 1 was revised. 30% of the surviving stems showed no radiological changes of radiolucency, while 70% showed some changes. Survival of the prosthesis for any reason was 96% at 10 years and 81% at 18 years. CONCLUSION: The 18 year survival of the Müller straight stem, cemented THA is comparable to those of other successful cemented systems. | Vasileios S Nikolaou Demetrios Korres Stergios Lallos Andreas Mavrogenis Ioannis Lazarettos Ioannis Sourlas Nicolas Efstathopoulos | 2013 | World Journal of Orthopedics2013，4，4： | 4 |
| 12 | Not only ACE2-the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19显示文摘Two recently published studies published in Science by Daly et al.1 and Cantuti-Castelvetri et al.2 identified neuropilin-1(NRP1)as an additional cellular mediator which may facilitate the entry of the new severe acute respiratory syndrome(SARS)-coronavirus(CoV)-2(SARS-CoV-2)into host cells.The findings of these elegant studies collectively indicate that,in addition to the role of angiotensin-converting enzyme 2(ACE2)in mediating the cellular entry of SARS-CoV-2;NRP1 may act as a host cell mediator that can increase the infectivity and may thus contribute to the tissue/organ tropism of this coronavirus. | loannis Kyrou Harpal S.Randeva Demetrios A.Spandidos Emmanouil Karteris | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 13 | Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice显示文摘 | Konstantinos Triantafyllou Nikos Viazis Panagiotis Tsibouris Georgios Zacharakis Chryssostomos Kalantzis Demetrios G. Karamanolis Spiros D. Ladas | 2014 | Gastrointestinal Endoscopy2014，，2： | 3 |
| 14 | The tumor microenvironment in hepatocellular carcinoma (Review)显示文摘 | Giulia Leonardi Saverio Candido Melchiorre Cervello Daria Nicolosi Fabio Raiti Salvatore Travali Demetrios Spandidos Massimo Libra | 2012 | International Journal of Oncology2012，，6： | 3 |
| 15 | 巨大的精索 leiomyosarcoma 的成像特征: 文学的评论显示文摘 Spermatic cord leiomyosarcomas (LMSs) are rare tumors which may cause significant morbidity and mortality if inadequately diagnosed or treated. We report a case of a paratesticular LMS in a 60-year-old man who presented with a right scrotal mass. The patient was evaluated by scrotal ultrasound and computed tomography of the abdomen and pelvis (including scans of the scrotum), which revealed a large extratesticular mass. The lesion proved to be malignant and the patient underwent radical orchiectomy with high cord ligation. To improve the assignment of this lesion, we further analyze the imaging features of LMS and corre-late them with pathologic findings. | Irene Kyratzi Evangelos Lolis Eleni Antypa Maria Alexandra Lianou Demetrios Exarhos | 2011 | World Journal of Radiology2011，3，4： | 3 |
| 16 | Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation显示文摘Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation. | Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas Ricardo D Garcia-Monaco Pablo R Ros | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 3 |
| 17 | Advances in quantitative analysis of astrocytes using machine learning显示文摘Astrocytes,a subtype of glial cells,are star-shaped cells that are involved in the homeostasis and blood flow control of the central nervous system(CNS).They are known to provide structural and functional support to neurons,including the regulation of neuronal activation through extracellular ion concentrations,the regulation of energy dynamics in the brain through the transfer of lactate to neurons,and the modulation of synaptic transmission via the release of neurotransmitters such as glutamate and adenosine triphosphate.In addition,astrocytes play a critical role in neuronal reconstruction after brain injury,including neurogenesis,synaptogenesis,angiogenesis,repair of the blood-brain barrier,and glial scar formation after traumatic brain injury(Zhou et al.,2020). | Demetrio Labate Cihan Kayasandik | 2023 | Neural Regeneration Research2023，18，2： | 2 |
| 18 | Erythropoiesis Stimulating Agent Administration Improves Survival After Severe Traumatic Brain Injury: A Matched Case Control Study显示文摘 | Peep Talving Thomas Lustenberger Leslie Kobayashi Kenji Inaba Galinos Barmparas Beat Schnüriger Lydia Lam Linda S. Chan Demetrios Demetriades | 2010 | Annals of Surgery2010，，1： | 2 |
| 19 | Sparse directional image representations using the discrete shearlet transform显示文摘 | Glenn Easley Demetrio Labate Wang-Q Lim | 2007 | Applied and Computational Harmonic Analysis2007，，1： | 2 |
| 20 | Complications after tibia plateau fracture surgery显示文摘 | Panayiotis J. Papagelopoulos Antonios A. Partsinevelos George S. Themistocleous Andreas F. Mavrogenis Demetrios S. Korres Panayotis N. Soucacos | 2005 | Injury2005，，6： | 2 |
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