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| 1 | Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease显示文摘All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways in the cells. Retinoic acid signaling is extremely important in the central nervous system. Impairment of retinoic acid signaling pathways causes severe pathological processes in the central nervous system, especially in the adult brain. Retinoids have major roles in neural patterning, differentiation, axon outgrowth in normal development, and function of the brain. Impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive Alzheimer’s disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques(aggregated amyloid-beta) and intra-neurofibrillary tangles(hyperphosphorylated tau protein) in the temporal lobe of the brain. Alzheimer’s disease is the most common cause of dementia and loss of memory in old adults. Inactive cholinergic neurotransmission is responsible for cognitive deficits in Alzheimer’s disease patients. Deficiency or deprivation of retinoic acid in mice is associated with loss of spatial learning and memory. Retinoids inhibit expression of chemokines and neuroinflammatory cytokines in microglia and astrocytes, which are activated in Alzheimer’s disease. Stimulation of retinoic acid receptors and retinoid X receptors slows down accumulation of amyloids, reduces neurodegeneration, and thereby prevents pathogenesis of Alzheimer’s disease in mice. In this review, we described chemistry and biochemistry of some natural and synthetic retinoids and potentials of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease. | Bhaskar C. Das Somsankar Dasgupta Swapan K. Ray | 2019 | Neural Regeneration Research2019，14，11： | 12 |
| 2 | 日灼对酿酒葡萄‘霞多丽’果实品质与解剖结构的影响显示文摘以酿酒葡萄品种‘霞多丽’为试验材料,采用石蜡切片与CFDA荧光染色观察日灼果皮细胞结构与细胞活性变化,同时测定日灼发生后葡萄果实品质及相关生理指标变化,以揭示日灼对果实品质与细胞结构的影响。结果表明:(1)随着葡萄日灼病加重,果实表皮颜色由浅黄色逐渐加深,后期甚至出现细胞坏死。(2)果实发生日灼后,果实硬度与含水量下降,细胞壁含量增加,果皮从外向内第1~3层细胞明显变小,细胞壁增厚。(3)随着日灼病加重,果皮细胞破裂,且破裂数量增加,细胞活性也随之下降,果皮保护功能逐渐丧失,果肉细胞逐渐失水导致了果实皱缩;重度日灼果实周缘维管束木质部导管受到果皮细胞失水断裂的影响,出现断裂变形。(4)在葡萄果实日灼发生过程中,受到高温与强光照胁迫影响,同时伴随着水分散失增加,果实可溶性固形物含量和总糖含量增加,但有机酸含量降低,糖酸比随之增加;以上各品质指标值的大小与果实水分含量密切相关。研究发现,日灼引起了葡萄果实结构变化与生理代谢的紊乱,随着日灼程度加重,果皮细胞逐渐死亡,果实内水分大量散失,果实糖含量增加,严重影响了葡萄果实的外观和内在品质。 | 谢兆森 Bhaskar | 2018 | 西北植物学报2018，38，1： | 8 |
| 3 | 组织透明法观察葡萄叶片生长过程中气孔与叶脉形态结构特征变化显示文摘本文以‘摩尔多瓦’葡萄叶片为试验材料,采用组织透明法观察了葡萄叶片生长过程中叶片表皮细胞、气孔和叶脉形态结构的变化,测定与气孔和叶脉功能相关的生理指标变化,比较了组织透明法、指甲油法和撕取法在观察葡萄叶片气孔上的实验效果。结果表明:组织透明法能够清晰观察到葡萄叶片生长过程中叶片表皮细胞、气孔和叶脉形态结构的变化。相对于指甲油法、撕取法,组织透明法操作简单,且能保持组织完整性,提升观察叶片细胞结构的实验效果。从叶片生长过程中气孔形态结构变化规律来看,葡萄嫩叶齿尖存在大量的大气孔,而叶片中部只观察到中央大气孔和正在发育的气孔保卫细胞母细胞。随着叶片生长,叶片气孔保卫细胞母细胞逐渐发育形成成熟气孔,叶片末端叶脉也是随叶片生长而生长,叶脉密度逐渐增加,提高了树体往叶片供水的效率。从与气孔和叶脉功能相关的各项生理指标变化来看,气孔导度随着气孔逐渐形成和成熟而逐渐升高,但叶片含水量和水势下降,有利于拉升水分和养分从根系往地上树体各器官运输,满足整个植株生长发育的需要。 | 谢兆森 杜鸿儒 李建宝 Bhaskar Bondada | 2018 | 植物生理学报2018，54，2： | 8 |
| 4 | 由膨胀土内比表面及孔径分布来评价其膨胀行为显示文摘要更完全和精确地预测膨胀土隆胀变形,需先确认其微观结构性质与胀缩性能间的相关性。按最新研究,膨胀土的孔径分布和表面积两微观性质相关参数被试着用于鉴定、检验对膨胀行为的协同影响。为深入该项研究,从膨胀土地区取8种土样,对压实样开展常规一维膨胀试验及新型三维体积膨胀变形试验;用压汞仪法(MIP)测微结构孔隙分布;用化学乙二醇乙醚法(EGME)测内比表面积,分析孔径分布和比表面积两参数预测其宏观膨胀性能。模型分析结果表明:所选土样膨胀行为取决于粘土矿物成分及内部孔隙分布的新引入参数,新建膨胀模型在描述选定土样重要矿物成分和孔隙结构细节的同时能准确预测土的膨胀变形。 | 童超(编译) 杨和平(编译) pedarlaa aravind puppala anand j. hoyos laureano r. chittoori bhaskar | 2017 | 中外公路2017，37，1： | 7 |
| 5 | Triboelectric nanogenerators with gold-thin-film-coated conductive textile as floating electrode for scavenging wind energy显示文摘我们报导由一件灵活、划算的黄金涂的传导性的纺织品(CT ) 组成把风精力变换成电的摩擦电 nanogenerators (TENG ) 。因为它源于在 microsized 纤维上散布的 Au nanodots 的高表面粗糙, Au 涂的 CT 被采用。因此,有 nano/microarchitecture 的 Au 涂的 CT 在提高有效接触区域以及 TENG 的产量表演起一个重要作用。而且, Au 涂的 CT 的表面粗糙被调整 Au 控制热免职时间或定制 Au nanodots 的直径。以 10 mtion 房间的应用的风速度搏动产生局部性的成穴源于反映的压缩,它被一个球形的钢罢工者和 Polymethyl methacrylate (PMMA ) 事件酒吧产生。事件酒吧的一个数字模型与 24 独立测试被开发并且验证(跨关联:0.970-0.997 ) ,并且这包括房间被递仪器的一个数字模型,与 27 独立测试验证了(跨关联:0.921 ) 在房间预言张力的液体压力。提取的水上的测试与房间紧张的可比较的数字结果被执行(R 2 :0.875 ) 并且房间结束墙速度(R 2 :0.992 ) 。在房间的压力从模型被决定避免经由一个压力计量器介绍一个成核地点,并且与显示出好同意的一阶的近似被验证(R 2 :0.892 ) 。为提取的水的成穴的 50% 概率是 3.32 ? 有拉曼紧张的 MPa ip (72 吗?? | Bhaskar Dudem Dong Hyun Kim Jae Su Yu | 2018 | Nano Research2018，11，1： | 6 |
| 6 | Flotation studies on low grade graphite ore from eastern India显示文摘A low grade graphite ore from eastern India was beneficiated by flotation to improve its quality. The ore was composed of 87.80% ash and 8.59% fixed carbon. Primary coarse wet grinding(d80: 186 lm) followed by rougher flotation in Denver flotation cell using diesel as collector and pine oil as frother yielded a rougher concentrate. Regrinding(d80: 144 lm) of this rougher concentrate was opted for further liberation of graphite. It was followed by cleaning in laboratory flotation column. This combined process of relatively coarse primary grinding followed by regrinding and cleaning in flotation column resulted in final concentrate of 7.44% yield with 89.65% fixed carbon and 6.00% ash. This approach of two-stage grinding to recover the flake graphite at the coarsest possible grind can help to minimize grinding energy costs. A conceptual flow sheet which is cost effective was developed based on this methodology. | Vasumathi N. Vijaya Kumar T.V. Ratchambigai S. Subba Rao S. Bhaskar Raju G. | 2015 | International Journal of Mining Science and Technology2015，25，3： | 6 |
| 7 | Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ显示文摘AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon cancer.METHODS: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was assessed using standard immunohis-tochemical methods.Biopsies were obtained from individuals undergoing colonoscopies for screening purposes or for a medically indicated reason.Tissue samples were also obtained from surgical colonic resections.Samples from resections were taken from colonic mucosa 1 and 10 cm from tumors and from the tumors themselves.Samples were evaluated for frequency of crypts with reduced or absent expression of CcOI.In most crypts the loss was apparent throughout the entire crypt,while in a small minority the loss was segmental.The strong immunoreactivity using this monoclonal antibody makes the scoring unambiguous.The percent of crypts with reduced or absent expression of CcOI or (infrequent) segmented loss of expression was then calculated.Data analyses were performed using SPSS statistical package 17.0.RESULTS: The average frequency of CcOI deficient crypts (CcOI-DC) is low in individuals between 20 and 39 years of age,with 0.48% ± 0.40% CcOI-DC for women and 1.80% ± 0.35% for men.CcOI-DC increases after age 40 years,so that between the ages of 40 and 44 years the average frequency of CcOI- DC goes up to 5.89% ± 0.84% in women and 2.15% ± 1.27% in men.By 80-84 years of age,the average frequency of CcOI-DC goes up in women to 15.77% ± 0.97% and in men to 22.6% ± 0.65%.The increases in CcOI-DC from ages 40-44 years compared to 80-84 years in women and men are significantly different with P < 0.01.For women over age 60 years,deficiency of CcOI expression is greater in those women who have had a cancer in their colon.The frequency of CcOI-DC,measured in men,increased in tissues adjacent to colon cancer,being 4.03% ± 0.27% in individuals free of neoplasia in the age range 55-64 yearsand 14.13% ± 0.35% in resected histologically normal tissue of men with cancer in the same age range,P < 0.001.Similar signifi cant differences were noted in older age ranges.The frequency of CcOI-DC crypts in the cecum and sigmoid colon of an individual are signifi cantly correlated,with an R2 = 0.414 for women and R2 = 0.528 for men,P < 0.001.This suggests that the factors determining the level of CcOI deficiency act throughout the colon.Most defective crypts are in clusters of two or more,a likely consequence of crypt fission.In the non-neoplastic margins of cancers,crypts are frequently defi cient for CcOI,and such crypts may appear in large clusters,some containing more than 100 defi cient crypts.CcOI defi ciency is also apparent in colon cancers and sometimes involves a large section of the tumor.Overall,CcOI deficient cells can be visualized in segments of crypts,in whole crypts that increase in frequency with age,in crypts undergoing f ission,in clusters of crypts where the clusters increase in size with age,in increased frequency near tumors,in large clusters in the intimate margins of tumors,and in the tumors themselves.There is no clear dividing line between early stages that can be considered aspects of aging and later stages that can be considered aspects of the progression to cancer.This ambiguity may re ect a rather general situation leading to adult cancer where the early stages of cellular change appear to be relatively innocuous features of the aging process but over decades may evolve into malignancy.CONCLUSION: CcOI defi cient crypts increase in frequency with age,and clusters of defi cient crypts are associated with,and may give rise to,colon cancer. | Carol Bernstein Alexander Facista Huy Nguyen Beryl Zaitlin Nadia Hassounah Cristy Loustaunau Claire Margaret Payne Bhaskar Banerjee Steve Goldschmid V Liana Tsikitis Robert Krouse Harris Bernstein | 2010 | World Journal of Gastrointestinal Oncology2010，2，12： | 5 |
| 8 | Comparison of a plant based natural surfactant with SDS for washing of As(V) from Fe rich soil显示文摘This study explores the possible application of a biodegradable plant based surfactant,obtained from Sapindus mukorossi,for washing low levels of arsenic(As)from an iron(Fe)rich soil.Natural association of As(V)with Fe(III)makes the process difcult.Soapnut solution was compared to anionic surfactant sodium dodecyl sulfate(SDS)in down-flow and a newly introduced suction mode for soil column washing.It was observed that soapnut attained up to 86%efciency with respect to SDS in removing As.Full factorial design of experiment revealed a very good fit of data.The suction mode generated up to 83 kPa pressure inside column whilst down-flow mode generated a much higher pressure of 214 kPa,thus making the suction mode more efcient.Micellar solubilisation was found to be responsible for As desorption from the soil and it followed 1st order kinetics.Desorption rate coefcient of suction mode was found to be in the range of 0.005 to 0.01,much higher than down-flow mode values.Analysis of the FT-IR data suggested that the soapnut solution did not interact chemically with As,ofering an option for reusing the surfactant.Soapnut can be considered as a soil washing agent for removing As even from soil with high Fe content. | Soumyadeep Mukhopadhyay Mohd. Ali Hashim Jaya Narayan Sahu Ismail Yusoff Bhaskar Sen Gupta | 2013 | Journal of Environmental Sciences2013，25，11： | 5 |
| 9 | Beneficiation of an Indian non-coking coal by column flotation显示文摘 | N. Vasumathi T. V. Vijaya Kumar S. Ratchambigai S. Subba Rao S. Prabhakar G. Bhaskar Raju | 2016 | International Journal of Coal Science & Technology2016，3，2： | 5 |
| 10 | Donors for Resistance to Brown Planthopper Nilaparvata lugens(St?l) from Wild Rice Species显示文摘Out of 1 989 wild accessions sown in seed boxes for screening, only 1 003 wild accessions with good germination were screened against brown planthopper(BPH), Nilaparvata lugens(St?l) under greenhouse conditions. The collection comprised of accessions from 11 wild species and African cultivated rice. The germplasm was screened for BPH following standard seed box screening technique in the greenhouse. As many as 159 accessions were identified as resistant during the year 2012 based on one year screening. A selected set of BPH resistant accessions were screened again during 2013. Based on the two years screening, seven accessions of O. nivara(AA), one accession of O. officinalis(CC), seven accessions of O. australiensis(EE), five accessions of O. punctata(BB and BBCC) and nine accessions of O. latifolia(CCDD) were confirmed to be resistant to BPH. So far no BPH resistance genes have been identified and designated from O. nivara and O. punctata, hence these may act as new sources of resistance. | Preetinder S. SARAO Gurpreet K. SAHI Kumari NEELAM Gurjit S. MANGAT Bhaskar C. PATRA Kuldeep SINGH | 2016 | Rice science2016，23，4： | 5 |
| 11 | Invited Paper: The Audacity of Fiber-Wireless(FiWi) Networks: Revisited for Clouds and Cloudlets显示文摘There is a growing awareness among industry players of reaping the benefits of mobile-cloud convergence by extending today's unmodified cloud to a decentralized two-level cloud-cloudlet architecture based on emerging mobile-edge computing(MEC) capabilities. In light of future 5G mobile networks moving toward decentralization based on cloudlets, intelligent base stations, and MEC, the inherent distributed processing and storage capabilities of radio-and-fiber(R&F) networks may be exploited for new applications, e.g., cognitive assistance, augmented reality, or cloud robotics. In this paper, we first revisit fiber-wireless(Fi Wi) networks in the context of conventional clouds and emerging cloudlets, thereby highlighting the limitations of conventional radio-overfiber(Ro F) networks such as China Mobile's centralized cloud radio access network(C-RAN) to meet the aforementioned trends. Furthermore, we pay close attention to the specific design challenges of data center networks and revisit our switchless arrayedwaveguide grating(AWG) based network with efficient support of east-west flows and enhanced scalability. | Martin Maier Bhaskar Prasad Rimal | 2015 | China Communications2015，12，8： | 5 |
| 12 | Polyethylene glycol(PEG-400):An efficient and recyclable reaction medium for the synthesis of novel 1,5-benzodiazepines and their antimicrobial activity显示文摘一个新系列包含咪唑 1, 5-benzodiazepines 被 chalcones 的冷凝作用与在聚乙烯乙二醇(PEG-400 ) 把哌啶用作有效、绿的反应溶剂的 o-phenylenediamine 综合了。这个协议的优点是环境友好,容易的病情的检查,高收益,温和反应条件和昂贵的催化剂的回避。而且,最新综合了混合物为他们的抗菌剂活动被评估。 | Shankaraiah G.Konda Baseer M.Shaikh Sanjay A.Chavan Bhaskar S.Dawane | 2011 | Chinese Chemical Letters2011，22，1： | 4 |
| 13 | Biomechanics of knee joint-- A review显示文摘现在的纸是知道工作怎么在膝的 biomechanics 的领域里被执行。各种各样的模型明确的表达被讨论并且进一步分类进数学模型,二维的模型和三维的模型。膝几何学是人的身体运动,膝看怎么各种各样,在不同飞机在并且怎么被看的关键部分胫骨和腿节上的力量行为被学习。它导致知道对膝关节起作用的力量。对各种各样的研究人员显示出的膝起作用的膝几何学和力量的试验性的研究被讨论了,并且结果的比较被做。另外,膝的静态、动态的分析也分别地被讨论了到某程度。 | Bhaskar Kumar MADETI Srinivasa Rao CHALAMALASETTI S. K. Sundara siva rao BOLLA PRAGADA | 2015 | Frontiers of Mechanical Engineering2015，10，2： | 4 |
| 14 | 利用杆状病毒Bac-to-Bac系统在家蚕表达猪繁殖与呼吸综合征病毒的E蛋白和M蛋白显示文摘猪繁殖与呼吸综合征病毒(PRRSV)是一种严重危害养猪业的传染性病原。PRRSV病毒的E蛋白和M蛋白基因是开发PRRSV病毒新型疫苗的目标基因。利用杆状病毒Bac-to-Bac表达系统,将PRRSV病毒的E蛋白和M蛋白的基因亚克隆到杆状病毒转移载体pFastBacHTb中,获得重组转移质粒pFastBacHTb-E和pFastBacHTb-M,转化大肠杆菌Bm DH10 Bac感受态细胞,获得重组杆粒BmNPV Bacmid-E、BmNPV Bacmid-M,将这些重组杆粒转染家蚕培养细胞Bm5,获得重组病毒BmNPV-E和BmNPV-M。将2种重组病毒分别接种5龄起蚕,用SDS-PAGE和Western blotting方法在重组Bacmid DNA转染的Bm5细胞和感染重组病毒的家蚕幼虫血细胞中分别检测到分子质量约20 kD和18 kD的E蛋白和M蛋白,表明PRRSV病毒的E蛋白和M蛋白在家蚕培养细胞及幼虫体内获得了表达,为利用家蚕-杆状病毒表达系统研制PRRSV的新型疫苗与诊断试剂奠定了基础。 | 王丹 BHASKAR Roy 李兴华 杨华军 周芳 缪云根 云涛 刘光清 | 2010 | 蚕业科学2010，36，5： | 4 |
| 15 | 采用染料示踪法可视化研究葡萄新梢水分运输途径显示文摘当前,对于葡萄(Vitis vinifera)新梢中水分在不同器官与组织间运输途径的研究鲜有报道,本文以八年生‘霞多丽’(‘Chardonnay’)葡萄为实验材料,采用染料示踪法观察葡萄新梢中水分运输途径及关联组织结构。结果表明,在水分沿新梢纵向运输过程中,各器官的水势大小影响着水分在各器官中的运输与分配,同一节位上葡萄果穗水势最高,其次为叶片,副梢水势最低;新梢不同节位叶片水势和气孔导度都存在差异,从新梢基部到顶端所保留的11片叶中,从基部第1叶到第6叶水势逐渐减小,第6叶水势值最低,但从第6叶到顶端第11叶水势有小幅增加,而叶片气孔导度从基部到顶端则呈先增加后下降趋势;从不同节位叶柄的染色率来看,随着水分沿新梢纵向往上运输,从基部到顶端叶片,叶柄染色率下降;从各器官与新梢的水分联系途径来看,叶柄与新梢间通过4-9条从新梢木质部分离出来的维管束(叶迹)相联系,而卷须、果柄和副梢等器官与新梢间维管束连成一体,在节处出现分支通向以上器官,尽管果实与果柄存在木质部运输通道,但在果实发育的第二次快速生长期,只在果刷与果肉细胞相连的维管束中观察到染料分布,与此同时,冬芽处于独立状态,与新梢无木质部相连。因此,新梢着生的各器官与新梢间的水分运输途径存在差异,水分在各器官的运转与分配规律受到运转途径解剖结构的制约,同时,维持各器官水分平衡关系和生理活动需水也调控着新梢水分在各器官的运输与分配。 | 谢兆森 Bhaskar Bondada 李勃 丁杰 | 2016 | 植物生理学报2016，52，8： | 4 |
| 16 | Long term outcomes for patients treated with half-fluence photodynamic therapy for chronic central serous chorioretinopathy: a case series显示文摘A case series was used to evaluate the efficacy of halffluence photodynamic therapy(PDT) for chronic central serous chorioretinopathy(CSCR). Patients were treated with standard-dose verteporfin and half-fluence PDT. Totally 13 eyes from 11 patients were included. The mean patient age was 52.0 y. There was a mean reduction in central retinal thickness of 107.0 microns. Totally 7/13 eyes(53.8%) achieved resolution of subretinal fluid(SRF) on optical coherence tomography(OCT) scan after 1 treatment with PDT. Four eyes had further treatment with PDT; of these 1 eye achieved resolution of SRF. Seven of the 13 eyes(53.8%) achieved an improvement of more than 5 ETDRS letters. One patient experienced acute macula oedema 1 d post PDT treatment. These results support the hypothesis that half-fluence PDT can have a positive effect in chronic CSCR for a gain in visual acuity and reduction in sub-retinal fluid. Acute macula oedema is a rare but potential adverse effect of half-fluence PDT. | Jennifer Doyle Bhaskar Gupta Irfan Tahir | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 3 |
| 17 | Identification of parameter to assess cracking resistance of asphalt mixtures subjected to aging and moisture conditioning显示文摘This study comprehensively evaluated different parameters based on tensile strength testing to assess the cracking resistance of asphalt mixtures subjected to aging and moisture conditioning.For this purpose,two sources of aggregates were selected to produce hot and warm mix asphalt mixtures.Asphalt mixtures were subjected to short term and long term aging,three levels of moisture conditioning(freeze thaw cycles),and tested at two temperatures(15℃and 25℃).The load-displacement data was used to determine the fracture work density,fracture energy,toughness index,cracking resistance index,cracking tolerance index,and rate dependent cracking index.It was noticed that moisture conditioning increased the variability of the different parameters.The cracking tolerance index and rate dependent cracking index parameter had a much higher coefficient of variation(Co V)with a maximum value close to 50%.Indirect tensile strength,fracture energy,and fracture work density appropriately captured the effect of moisture on cracking resistance of mixtures.The cracking resistance index,cracking tolerance index,and rate dependent cracking index increased with an increase in the moisture conditioning level.The Statistical analysis showed that tensile strength,fracture work density,and fracture energy were significantly influenced by different aging and moisture conditions evaluated.Fracture energy showed better association with fatigue life of asphalt mixtures subjected to three freeze-thaw cycles compared to tensile strength.Further,the fatigue life prediction models showed that both indirect tensile strength and fracture energy significantly influence the fatigue life of asphalt mixtures subjected to aging and moisture conditioning. | Bhaskar Pratim Das Anjan Kumar Siddagangaiah | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，2： | 3 |
| 18 | Self-assembled vertically aligned gold nanorod super-lattices for ultra-high sensitive detection of molecules显示文摘我们显示出超点阵能作为探针或底层服务为的那自我装配的垂直地排列的金 nanorod (VA-GNRs ) 超离频各种各样的分子的敏感察觉。d葡萄糖和2,4,6强烈炸药( TNT )由于他们的很低的拉曼剖面图被选择了为模型系统( 5.6 佩?????汣獡????汰獵瀭畬???㈠?猯'T￣慮潮畴敢??????????????????????吗???????????????????￡???霔?? | Amey Apte Prashant Bhaskar Raja Das Smita Chaturvedi PankajPoddar Sulabha Kulkarni | 2015 | Nano Research2015，8，3： | 3 |
| 19 | 二进制代码块:面向二进制程序的细粒度控制流完整性校验方法显示文摘控制流完整性(CFI)是一种在程序中通过保护间接转移有效减少代码注入和代码重用攻击等威胁的技术。由于二进制程序缺少源代码级别的语义,CFI策略的设定需要很谨慎。现有的面向二进制的CFI解决方案,如Bin CFI和CCFIR,虽然能够提供对二进制程序的防护能力,但它们应用的策略过于宽松,依然会受到复杂的代码重用攻击。本文提出一种新的面向二进制的CFI保护方案,称为Bin CC。它可以通过静态二进制重写为x86下的二进制程序提供细粒度保护。通过代码复制和静态分析,我们把二进制代码分成几个互斥代码块。再进一步将代码中的每个间接转移块归类为块间转移或块内转移,并分别应用严格CFI策略来限制这些转移。为了评估Bin CC,我们引入新的指标来评估每种间接转移中合法目标的平均数量,以及利用call-preceded gadgets产生ROP漏洞利用的难度。实验结果表明与Bin CFI比较,Bin CC显著地将合法转移目标降低了81.34%,并显著增加了攻击者绕过CFI限制实施复杂的ROP攻击的难度。另外,与Bin CC可以降低大约14%的空间开销,而只提升了4%的运行开销。 | 王明华 尹恒 Abhishek Vasisht Bhaskar 苏璞睿 冯登国 | 2016 | 信息安全学报2016，1，2： | 3 |
| 20 | Comprehensive screening for reg1α gene rules out association with tropical calcific pancreatitis显示文摘AIM: To investigate the allelic and haplotypic association of reg1α gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1α polymorphisms. METHODS: We analyzed the polymorphisms in the reg1α gene by sequencing the gene including its promoter region in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathogenesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes. RESULTS: We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1α. None of the 5' UTR variants altered any known transcription factor binding sites, neither did any show a statistically significant association with TCP. No association with any reg1α variants was observed on dichotomization of patients based on their N34S SPINK1 or L26V CTSB status. CONCLUSION: Polymorphisms in reg1α gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis. | Swapna Mahurkar Seema Bhaskar D Nageshwar Reddy G Venkat Rao Giriraj Ratan Chandak | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
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