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| 1 | Cytoreductive surgery and hyperthermic intraperitonealchemotherapy in gastric cancer显示文摘Gastric cancer associated peritoneal carcinomatosis(GCPC) has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in GCPC. Since recurrent gastric cancer remains confined to the abdominal cavity in many patients, regional therapies like aggressive cytoreductive surgery( CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) have been investigated for GCPC. HIPEC has been used for three indications in GC- as an adjuvant therapy after a curative surgery, HIPEC has been shown to improve survival and reduce peritoneal recurrences in many randomised trials in Asian countries; as a definitive treatment in established PC, HIPEC along with CRS is the only therapeutic modality that has resulted in longterm survival in select groups of patients; as a palliative treatment in advanced PC with intractable ascites, HIPEC has been shown to control ascites and reduce the need for frequent paracentesis. While the results of randomised trials of adjuvant HIPEC from western centres are awaited, the role of HIPEC in the treatment of GCPC is still evolving and needs larger studies before it is accepted as a standard of care. | Ramakrishnan Ayloor Seshadri Olivier Glehen | 2016 | World Journal of Gastroenterology2016，22，3： | 34 |
| 2 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 3 | Robust stability criteria for uncertain linear systems with interval time-varying delay显示文摘This paper considers the robust delay-dependent stability problem of a class of linear uncertain system with interval time-varying delay and proposes less conservative stability criteria for computing the maximum allowable bound of the delay range. Less conservatism of the proposed stability criteria is attributed to the delay-central point method of stability analysis, wherein the delay interval is partitioned into two subintervals of equal length, and the time derivative of a candidate Lyapunov-Krasovskii functional based on delay decomposition technique is evaluated in each of these delay segments. In deriving the stability conditions in LMI framework, neither model transformations nor bounding techniques using free-weighting matrix variables are employed for dealing the cross-terms that emerge from the time derivative of the Lyapunov-Krasovskii functional; instead, they are dealt using tighter integral inequalities. The proposed analysis subsequently yields a stability condition in convex LMI framework that can be solved using standard numerical packages. For deriving robust stability conditions, two categories of system uncertainties, namely, time-varying structured and polytopic-type uncertainties, are considered. The effectiveness of the proposed stability criteria is validated through standard numerical examples. | Krishnan RAMAKRISHNAN Goshaidas RAY | 2011 | 控制理论与应用(英文版)2011，9，4： | 16 |
| 4 | Determination of 50% endpoint titer using a simple formula显示文摘Two commonly used methods for calculating 50% endpoint using serial dilutions are Spearman-Karber method and Reed and Muench method. To understand/apply the above formulas, moderate statistical/mathematical skills are necessary. In this paper, a simple formula/method for calculating 50% endpoints has been proposed. The formula yields essentially similar results as those of the SpearmanKarber method. The formula has been rigorously evaluated with several samples. | Muthannan Andavar Ramakrishnan | 2016 | World Journal of Virology2016，5，2： | 12 |
| 5 | 白喉-破伤风-无细胞百日咳-b型流行性感冒嗜血杆菌联合疫苗对中国婴儿安全性和免疫原性的研究显示文摘目的评价白喉-破伤风-无细胞百日咳-b型流行性感冒嗜血杆菌联合疫苗(Diphtheria,Tetanus,Acellular Pertussis and Haemophilus Influenzae Type b Combined Vaccine;DTaP-Hib),对中国婴儿的安全性和免疫原性。方法通过一项安全性研究(研究A)和一项安全性及免疫原性研究(研究B),评价DTaP-Hib联合疫苗接种于3、4、5月龄婴儿的安全性及免疫原性,并与DTaP联合疫苗及Hib疫苗(DTaP+Hib)同时分别接种进行比较。结果共690名健康婴儿接受了DTaP-Hib联合疫苗或DTaP联合疫苗与Hib疫苗分别同时接种的基础免疫。DTaP-Hib联合疫苗的耐受性与DTaP联合疫苗+Hib疫苗分别接种一致,两组局部及全身不良反应发生率差异无统计学意义。在接种DTaP-Hib联合疫苗的受试者中,至少有97.5%在基础免疫后一个月产生了针对白喉、破伤风、Hib的血清学保护性抗体,以及对无细胞百日咳抗原的免疫应答。按照预先制订的标准,DTaP-Hib联合疫苗的免疫应答与DTaP联合疫苗+Hib疫苗分别接种免疫应答应的差异无统计学意义。结论DTaP-Hib联合疫苗接种后可获得预期的安全性和免疫原性。临床试验注册国家食品药品监督管理局《药物临床批件》2003L03331。 | 李艳萍 张庶民 叶强 侯启明 李亚男 李红 徐颖华 马霄 刘幼平 陈晓玲 黄莉荣 Gunasekaran Ramakrishnan 李荣成 赵雷 唐海文 Olivier Van Der Meeren Hans L Bock | 2010 | 中国疫苗和免疫2010，16，2： | 7 |
| 6 | The AO/ASIF proximal femoral nail antirotation (PFNA): A new design for the treatment of unstable proximal femoral fractures显示文摘 | Praveen Mereddy Sri Kamath Muthukrishnan Ramakrishnan Hamad Malik Nigel Donnachie | 2008 | Injury2008，，4： | 6 |
| 7 | 时变滞后Lurie型系统的改进稳定性准则(英文)显示文摘In this technical note,we present a new stability analysis procedure for ascertaining the delay-dependent stability of a class of Lurie systems with time-varying delay and sector-bounded nonlinearity using Lyapunov-Krasovskii (LK) functional approach.The proposed analysis,owing to the candidate LK functional and tighter bounding of its time-derivative,yields less conservative absolute and robust stability criteria for nominal and uncertain systems respectively.The effectiveness of the proposed criteria over some of the recently reported results is demonstrated using a numerical example. | RAMAKRISHNAN Krishnan RAY Goshaidas | 2011 | 自动化学报2011，37，5： | 4 |
| 8 | Reference quality assembly of the 3.5-Gb genome of Capsicum annuum from a single linked-read library显示文摘Linked-Read sequencing technology has recently been employed successfully for de novo assembly of human genomes,however,the utility of this technology for complex plant genomes is unproven.We evaluated the technology for this purpose by sequencing the 3.5-gigabase(Gb)diploid pepper(Capsicum annuum)genome with a single Linked-Read library.Plant genomes,including pepper,are characterized by long,highly similar repetitive sequences.Accordingly,significant effort is used to ensure that the sequenced plant is highly homozygous and the resulting assembly is a haploid consensus.With a phased assembly approach,we targeted a heterozygous F1 derived from a wide cross to assess the ability to derive both haplotypes and characterize a pungency gene with a large insertion/deletion.The Supernova software generated a highly ordered,more contiguous sequence assembly than all currently available C.annuum reference genomes.Over 83%of the final assembly was anchored and oriented using four publicly available de novo linkage maps.A comparison of the annotation of conserved eukaryotic genes indicated the completeness of assembly.The validity of the phased assembly is further demonstrated with the complete recovery of both 2.5-Kb insertion/deletion haplotypes of the PUN1 locus in the F1 sample that represents pungent and nonpungent peppers,as well as nearly full recovery of the BUSCO2 gene set within each of the two haplotypes.The most contiguous pepper genome assembly to date has been generated which demonstrates that Linked-Read library technology provides a tool to de novo assemble complex highly repetitive heterozygous plant genomes.This technology can provide an opportunity to cost-effectively develop high-quality genome assemblies for other complex plants and compare structural and gene differences through accurate haplotype reconstruction. | Amanda M.Hulse-Kemp Shamoni Maheshwari Kevin Stoffel Theresa A.Hill David Jaffe Stephen R.Williams Neil Weisenfeld Srividya Ramakrishnan Vijay Kumar Preyas Shah Michael C.Schatz Deanna M.Church Allen Van Deynze | 2018 | Horticulture Research2018，5，1： | 4 |
| 9 | Emission and performance analysis of a diesel engine burning cashew nut shell oil bio diesel mixed with hexanol显示文摘In this study, the effect of doping hexanol into biodiesel which is from neat cashew nut shell biodiesel oil on the emissions and the performance characteristics was studied in a constant speed diesel engine. The main purpose of this work is to reduce various emissions and also to improve the performance of the diesel engine when fueled with blends of hexanol and neat cashew nut shell biodiesel. Cashew nut shell oil is not edible, and hence it can be used as a viable alternative to diesel.Cashew nut shell biodiesel is prepared by conventional transesterification. Hexanol with 99.2% purity was employed as an oxygenated additive. Experimental studies were conducted by fueling diesel as a baseline and by fueling hexanol and neat cashew nut shell biodiesel mixture. A fuel comprising 10%(by volume) of hexanol and 90%(by volume) neat cashew nut shell biodiesel was referred to as CNSBD900 H100 and fuel comprising 20%(by volume) of hexanol and 80%(by volume)of neat cashew nut shell biodiesel was referred to as CNSBD800 H200. This study also investigated the possibility of using pure biofuel in an unmodified naturally aspirated diesel engine. The outcome of this study showed that adding hexanol at10% and 20%(by volume) to cashew nut shell biodiesel results in a reduction in emissions. In addition, a significant improvement in brake thermal efficiency and reduction in brake-specific fuel consumptions were achieved. Hence, it could be concluded that hexanol could be a viable and promising additive for improving the drawbacks of biodiesel when it was used to fuel an unmodified diesel engine. | Amith Kishore Pandian Dinesh Babu Munuswamy Santhanakrishnan Radhakrishanan Yuvarajan Devarajan Ramesh Bapu Bathey Ramakrishnan Beemkumar Nagappan | 2018 | Petroleum Science2018，15，1： | 3 |
| 10 | Stability Criterion with Less LMI Variables for Linear Discrete-time Systems with Additive Time-delays显示文摘In this correspondence paper, an equivalent stability criterion with minimal number of linear matrix inequality (LMI) variables is presented for a delay-dependent stability criterion reported recently in the International Journal of Automation and Computing for a class of linear discrete-time systems with additive time delays. The reported stability criterion for the additive timedelay systems has more number of matrix variables in the LMI and, hence, demand additional computational burden. The proposed equivalent stability criterion, unlike the reported one, does not involve free-weighing matrices and encompass only the matrix variables that are associated in the Lyapunov-Krasovskii functional, making the criterion mathematically less complex and computationally more effective. | K. Ramakrishnan G. Ray | 2011 | International Journal of Automation and computing2011，8，4： | 3 |
| 11 | Sam68 is a regulator of Toll-like receptor signaling显示文摘由像使用费的受体(TLR ) 的病原体的识别激活定制装主要有免疫力的回答,发炎,房间幸存和 apoptosis 的基因的多重发信号的串联和表情。尽管小径的导致 TLR 的激活,例如原子因素 kappaB (NF-κ B ) 并且激活 mitogen 的蛋白质 kinases (MAPK ) ,在有免疫力的回答期间控制这些小径的量的规定的很好被学习的、分子的实体仍然保持糟糕定义。我们作为导致 TLR 的 NF-κ 的一个新奇管理者识别了 Sam68; B 和 MAPK 激活。我们发现 TLR2 和 TLR3 完全是依赖的,而 TLR4 部分仅仅依赖于导致 NF-κ 的激活的 Sam68; B c-Rel。Sam68 的缺席极大地减少了导致 TLR2 、导致 TLR3 的 NF-κ B p65 激活,而以一种 Sam68 独立的方式的导致 TLR4 的 p65 激活。相反,因为 Sam68 的缺席提高了细胞外的调整信号的 kinases (英皇家空军之阶级最低之兵) 和 c6 月 N 终端 kinases (JNK ) 的导致 TLR2 的激活, Sam68 看起来是 MAPK 小径的一个否定管理者。有趣地,导致 TLR2 、导致 TLR3 的基因表示显示出 Sam68 的一个微分要求。Sam68 的缺席损害了导致 TLR2 的基因表示,建议 Sam68 有在 myeloid 区别的一个关键角色主要反应基因 88 依赖者 TLR2 发信号。导致 TLR3 的基因表示利用 Toll/ Interleukin-1 receptor-domain-containing 导致改编者的贝它干扰素小径,仅仅部分取决于 Sam68。我们的调查结果建议 Sam68 可以作为平衡 NF-κ 的激活的一个有免疫力的变阻器工作; B p65 和 c-Rel,以及 MAPK,揭示一个潜在的新奇目标操作 TLR 发信号。 | Jeffrey A Tomalka Tristan J de Jesus Parameswaran Ramakrishnan | 2017 | Cellular & Molecular Immunology2017，14，1： | 3 |
| 12 | p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats显示文摘Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats.Methods: Ethanol(25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines(IL-6, IL1β, TNF-α), NF-κB activation and imbalance of proand anti-apoptotic proteins(Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and proapoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity. | Ramakrishnan Sabitha Kumari Nishi Vinoth Prasanna Gunasekaran Govindhan Annamalai Balupillai Agilan Mathan Ganeshan | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，5： | 2 |
| 13 | A signature of immune function genes associated with recurrence-free survival in breast cancer patients显示文摘 | Maria Libera Ascierto Maciej Kmieciak Michael O. Idowu Rose Manjili Yingdong Zhao Margaret Grimes Catherine Dumur Ena Wang Viswanathan Ramakrishnan Xiang-Yang Wang Harry D. Bear Francesco M. Marincola Masoud H. Manjili | 2012 | Breast Cancer Research and Treatment2012，，3： | 2 |
| 14 | Protective Effects of d ‐Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin‐Induced Diabetic Rats显示文摘 | Ramakrishnan Murali Arumugam Karthikeyan Ramalingam Saravanan | 2012 | Basic Clin Pharmacol Toxicol2012，，3： | 2 |
| 15 | 消化性溃疡病显示文摘消化性溃疡病是由胃蛋白酶和胃酸分泌过多引起的以黏膜损害为特征的疾病。大多数发生于胃和十二指肠的近端,少数发生于食管下段、十二指肠远端和空肠。在美国,每年大约有500000人患上溃疡病。其中70%的患者年龄介于25~64岁之间。每年直接或间接的治疗费用估计达百亿美元。尽管如此,可能是由于质子泵抑制剂应用的增加和幽门螺杆菌感染率的降低,溃疡病的发生率正在减少。 | Kalyankrishnan Ramakrishnan Robert C. Salinas 孙乃会 | 2008 | 中国实用乡村医生杂志2008，15，3： | 2 |
| 16 | Design and development of a high-performance Ni-based superalloy WSU 150 for additive manufacturing显示文摘This research proposes a design and development strategy of a new nickel-based superalloy for additive manufacturing.A new Ni-based superalloy has been developed by the application of the combinatorial alloy development technique coupled with CALPHAD based solidification modeling by effectively suppressing the precipitation kinetics.The suppression of precipitation during processing paved a way for prevention of cracks during deposition.The new alloy 'WSU 150' revealed excellent room temperature mechanical properties with a yield strength of 867 MPa,an ultimate tensile strength of 1188 MPa,and an elongation of 27.9% in the as-deposited condition.The mechanical properties of the heat-treated alloy were improved significantly to 1114 MPa yield strength,1396 MPa ultimate tensile strength,and an elongation of 16.1%.Improvement in the mechanical properties is attributed to the additional precipitation and coarsening of γ’ and carbides during heat-treatment.Microstructural investigation of the alloy revealed spherical γ’ with a rippled size distribution from the center to the interdendritic region.The average size of the γ’ particles in the as-deposited condition was found to be around 48 nm in the interdendritic region.Heat-treatment promoted the coarsening of γ’ which is explained in the paper. | Praveen Sreeramagiri Ajay Bhagavatam Abhishek Ramakrishnan Husam Alrehaili Guru Prasad Dinda | 2020 | Journal of Materials Science & Technology2020，47，12： | 2 |
| 17 | Robust object tracking with background-weighted local kernels显示文摘 | Jaideep Jeyakar R. Venkatesh Babu K.R. Ramakrishnan | 2008 | Computer Vision and Image Understanding2008，，3： | 2 |
| 18 | Utilization of plant-based natural coagulants as future alternatives towards sustainable water clarification显示文摘Rapid industrial developments coupled with surging population growth have complicated issues dealing with water scarcity as the quest for clean and sanitized water intensifies globally. Existing fresh water supplies could be contaminated with organic, inorganic and biological matters that have potential harm to the society. Turbidity in general is a measure of water cloudiness induced by such colloidal and suspended matters and is also one of the major criteria in raw water monitoring to meet the stipulated water quality guidelines.Turbidity reduction is often accomplished using chemical coagulants such as alum. The use of alum is widely associated with potential development of health issues and generation of voluminous sludge. Natural coagulants that are available in abundance can certainly be considered in addressing the drawbacks associated with the use of chemical coagulants.Twenty one types of plant-based natural coagulants categorized as fruit waste and others are identified and presented collectively with their research summary in this review. The barriers and prospects of commercialization of natural coagulants in near future are also discussed. | Sook Yan Choy Krishna Murthy Nagendra Prasad Ta Yeong Wu Mavinakere Eshwaraiah Raghunandan Ramakrishnan Nagasundara Ramanan | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 19 | A role for proteins S3 and S14 in the 30S ribosomal subunit 显示文摘 | RAMAKRISHNAN V GRAZIANO V CAPEL M S | 1986 | J Biol Chem1986，261，15： | 1 |
| 20 | A finite element solution for the 2D elastic contact problems with friction显示文摘 | Ramakrishnan C V | 1981 | International Journal for Numerical Methods in Engineering1981，17，： | 1 |
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