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| 1 | 肾脏病学的新创意:“肾脏疾病:改善全球预后”(KDIGO)显示文摘慢性肾脏病(CKD)是世界范围的医疗和公共卫生问题,并开始呈现流行性的特点.美国肾脏数据系统(USRDS)的数据提示,终末期肾衰的发病率呈上升趋势,因此对于这一问题的重视日益增加.根据近期USRDS登记系统提供的资料,世界范围内需要肾脏替代治疗(RRT)的终末期肾病(ESRD)患者数目持续上升,其中我国台湾、美国和日本最多(254~365人/100万人)[1].卡塔尔和巴斯克地区的儿童患病率最高,分别为33.7人/100万人和22.7人/100万人;在大于等于20岁患者中患病率最高的是卡塔尔、美国和台湾.在欧洲,德国的患病率最高,2000年为175人/100万人.在RRT仍在发展中的东欧,报道的患病率低于西欧[2]. | Norbert Lameire Garabed Eknoyan Rashad Barsoum Kai-Uwe Eckardt Adeera Levin Nathan Levin Francesco Locatelli Alison Macleod Raymond Vanholder Rowan Walker Haiyan Wang 张路霞 王海燕 | 2005 | 中华肾脏病杂志2005，21，12： | 19 |
| 2 | Abrupt Summer Warming and Changes in Temperature Extremes over Northeast Asia Since the Mid-1990s: Drivers and Physical Processes显示文摘This study investigated the drivers and physical processes for the abrupt decadal summer surface warming and increases in hot temperature extremes that occurred over Northeast Asia in the mid-1990 s. Observations indicate an abrupt increase in summer mean surface air temperature(SAT) over Northeast Asia since the mid-1990 s. Accompanying this abrupt surface warming, significant changes in some temperature extremes, characterized by increases in summer mean daily maximum temperature(Tmax), daily minimum temperature(Tmin), annual hottest day temperature(TXx), and annual warmest night temperature(TNx) were observed. There were also increases in the frequency of summer days(SU) and tropical nights(TR).Atmospheric general circulation model experiments forced by changes in sea surface temperature(SST)/ sea ice extent(SIE),anthropogenic greenhouse gas(GHG) concentrations, and anthropogenic aerosol(AA) forcing, relative to the period 1964–93, reproduced the general patterns of observed summer mean SAT changes and associated changes in temperature extremes,although the abrupt decrease in precipitation since the mid-1990 s was not simulated. Additional model experiments with different forcings indicated that changes in SST/SIE explained 76% of the area-averaged summer mean surface warming signal over Northeast Asia, while the direct impact of changes in GHG and AA explained the remaining 24% of the surface warming signal. Analysis of physical processes indicated that the direct impact of the changes in AA(through aerosol–radiation and aerosol–cloud interactions), mainly related to the reduction of AA precursor emissions over Europe, played a dominant role in the increase in TXx and a similarly important role as SST/SIE changes in the increase in the frequency of SU over Northeast Asia via AA-induced coupled atmosphere–land surface and cloud feedbacks, rather than through a direct impact of AA changes on cloud condensation nuclei. The modelling results also imply that the abrupt summer surface warming and increases in hot temperature extremes over Northeast Asia since the mid-1990 s will probably sustain in the next few decades as GHG concentrations continue to increase and AA precursor emissions over both North America and Europe continue to decrease. | Buwen DONG Rowan T.SUTTON Wei CHEN Xiaodong LIU Riyu LU Ying SUN | 2016 | Advances in Atmospheric Sciences2016，33，9： | 17 |
| 3 | Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis显示文摘 | Delong Jiao Zhenyu Cai Swati Choksi Dan Ma Moran Choe Hyung-Joon Kwon Jin Young Balk Brian G. Rowan Chengyu Liu Zheng-gang Liu | 2018 | Cell Research2018，28，8： | 9 |
| 4 | Biofilm structure and its influence on clogging in drip irrigation emitters distributing reclaimed wastewater显示文摘Using reclaimed wastewater for crop irrigation is a practical alternative to discharge wastewater treatment plant effluents into surface waters.However,biofouling has been identified as a major contributor to emitter clogging in drip irrigation systems distributing reclaimed wastewater.Little is known about the biofilm structure and its influence on clogging in the drip emitter flow path.This study was first to investigate the microbial characteristics of mature biofilms present in the emitters and the effect of flow path structures on the biofilm microbial communities.The analysis of biofilm matrix structure using a scanning electron microscopy(SEM) revealed that particles in the matrix of the biofilm coupled extracellular polysaccharides(EPS) and formed sediment in the emitter flow path.Analysis of biofilm mass including protein,polysaccharide,and phospholipid fatty acids(PLFAs) showed that emitter flow path style influenced biofilm community structure and diversity.The correlations of biofilm biomass and discharge reduction after 360 h irrigation were computed and suggest that PFLAs provide the best correlation coeffcient.Comparatively,the emitter with the unsymmetrical dentate structure and shorter flow path(Emitter C) had the best anti-clogging capability.By optimizing the dentate structure,the internal flow pattern within the flow path could be enhanced as an important method to control the biofilm within emitter flow path.This study established electron microscope techniques and biochemical microbial analysis methods that may provide a framework for future emitter biofilm studies. | YAN Dazhuang BAI Zhihui Mike Rowan GU Likun Ren Shumei YANG Peiling | 2009 | Journal of Environmental Sciences2009，21，6： | 4 |
| 5 | Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds显示文摘Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been studied.Here, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization. | Zupeng Chen Evgeniya Vorobyeva Sharon Mitchell Edvin Fako Núria López Sean M.Collins Rowan K.Leary Paul A.Midgley Roland Hauert Javier Pérez-Ramírez | 2018 | National Science Review2018，5，5： | 4 |
| 6 | The synthetic form of a novel chicken β-defensin identified in silico is predominantly active against intestinal pathogens显示文摘 | Rowan Higgs David J. Lynn Susan Gaines Jessica McMahon Joanna Tierney Tharappel James Andrew T. Lloyd Grace Mulcahy Cliona O’Farrelly | 2005 | Immunogenetics (-)2005，，1： | 3 |
| 7 | 孕妇营养补充指南显示文摘常言道:孕妇一人吃两人补。但相对于纯粹地增加食物摄入量,孕妈妈们更应该注意摄入合适的膳食,以保证为自己和胎儿提供最佳的营养。事实上,胎儿的发育全赖于通过妈妈的脐带输送必需的营养。因此,孕妇缺乏任何一种营养都可能导致腹中胎儿营养不良。 | Angela Rowan | 2010 | 中国乳业2010，，4： | 3 |
| 8 | The utility of laparoscopic assessment in the preoperative staging of suspected hilar cholangiocarcinoma显示文摘 | Saxon Connor F.R.A.C.S. Emma Barron B.Sc. Stephen J. Wigmore M.D. F.R.C.S. Krishnakumar K. Madhavan M.S. F.R.C.S. Rowan W. Parks M.D. F.R.C.S. O. James Garden M.D. F.R.C.S | 2005 | Journal of Gastrointestinal Surgery2005，，4： | 3 |
| 9 | Exercise interventions for older adults: A systematic review of meta-analyses显示文摘Background:The evidence concerning which physical exercise characteristics are most effective for older adults is fragmented.We aimed to characterize the extent of this diversity and inconsistency and identify future directions for research by undertaking a systematic review of metaanalyses of exercise interventions in older adults.Methods:We searched the Cochrane Database of Systematic Reviews,PsycInfo,MEDLINE,Embase,CINAHL,AMED,SPORTDiscus,and Web of Science for articles that met the following criteria:(1)meta-analyses that synthesized measures of improvement(e.g.,effect sizes)on any outcome identified in studies of exercise interventions;(2)participants in the studies meta-analyzed were adults aged 65+or had a mean age of 70+;(3)meta-analyses that included studies of any type of exercise,including its duration,frequency,intensity,and mode of delivery;(4)interventions that included multiple components(e.g.,exercise and cognitive stimulation),with effect sizes that were computed separately for the exercise component;and(5)meta-analyses that were published in any year or language.The characteristics of the reviews,of the interventions,and of the parameters improved through exercise were reported through narrative synthesis.Identification of the interventions linked to the largest improvements was carried out by identifying the highest values for improvement recorded across the reviews.The study included 56 meta-analyses that were heterogeneous in relation to population,sample size,settings,outcomes,and intervention characteristics.Results:The largest effect sizes for improvement were found for resistance training,meditative movement interventions,and exercise-based active videogames.Conclusion:The review identified important gaps in research,including a lack of studies investigating the benefits of group interventions,the characteristics of professionals delivering the interventions associated with better outcomes,and the impact of motivational strategies and of significant others(e.g.,carers)on intervention delivery and outcomes. | Claudio Di Lorito Annabelle Long Adrian Byrne Rowan H.Harwood John R.F.Gladman Stefan Schneider Pip Logan Alessandro Bosco Veronika van der Wardt | 2021 | Journal of Sport and Health Science2021，10，1： | 3 |
| 10 | Lithologic mapping in the Mountain Pass, California area using Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data显示文摘 | Lawrence C Rowan John C Mars | 2002 | Remote Sensing of Environment2002，，3： | 2 |
| 11 | Adipokines Linking Obesity with Colorectal Cancer Risk in Postmenopausal Women显示文摘 | Gloria Y.F. Ho Tao Wang Marc J. Gunter Howard D. Strickler Mary Cushman Robert C. Kaplan Sylvia Wassertheil-Smoller Xiaonan Xue Swapnil N. Rajpathak Rowan T. Chlebowski Mara Z. Vitolins Philipp E. Scherer Thomas E. Rohan | 2012 | Cancer Research2012，，12： | 2 |
| 12 | Carbonaceous nanomaterials for the enhancement of TiO 2 photocatalysis显示文摘 | Rowan Leary Aidan Westwood | 2010 | Carbon2010，，3： | 2 |
| 13 | Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease显示文摘Background:Platelets and P-selectin(CD62P)play an unequivocal role in the pathology of hepatic ischemia/reperfusion(I/R)injury.Inhibition or knock-out of P-selectin or immunodepletion of platelets results in amelioration of post-ischemic inflammation,reduced hepatocellular damage,and improved survival.However,P-selectin expression on platelets and endothelial cells,which concurs with platelet activation,has never been clearly demonstrated in I/R-subjected livers.Aims:To determine whether platelets become activated and degranulate in the acute phase of liver I/R and whether the platelets interact with neutrophils.Methods:Hepatic I/R was induced in male C57BL/6J mice(N=12)using 37.5-min ischemia time.Platelets,endothelial cells,and neutrophils were fluorescently labeled by systemic administration of non-blocking antibodies.Cell kinetics were monitored by intravital spinning disk confocal microscopy during 90 min of reperfusion.Image analysis and quantification was performed with dedicated software.Results:Platelets adhered to sinusoids more extensively in post-ischemic livers compared to livers not subjected to I/R and formed aggregates,which occurred directly after ischemia.Platelets and endothelial cells did not express P-selectin in post-ischemic livers.There was no interaction between platelets and neutrophils.Conclusions:Platelets aggregate but do not become activated and do not degranulate in post-ischemic livers.There is no platelet-neutrophil interplay during the early reperfusion phase in a moderate model of hepatic I/R injury.The mechanisms underlying the biological effects of platelets and P-selectin in this setting warrant further investigation.Relevance for patients:I/R in surgical liver patients may compromise outcome due to post-ischemic oxidative stress and sterile inflammation.Both processes are mediated in part by platelets.Understanding platelet function during I/R is key to developing effective interventions for I/R injury and improving clinical outcomes. | Rowan F.van Golen Katarzyna M.Stevens Pina Colarusso Hartmut Jaeschke Michal Heger | 2015 | Journal of Clinical & Translational Research2015，1，2： | 2 |
| 14 | Quality of life issues in men undergoing androgen deprivation therapy: a review显示文摘雄激素剥夺治疗(ADT ) 是为治疗前列腺癌症(PCa ) 的一种必要治疗选择。为神经质的治疗的角色开始被限制为人与变形、不能实行,局部地先进的疾病。现在,它为外科和放射疗法被扩大了到 neoadjuvant 或辅助治疗,为在外科或放射以后的生物化学的恶化,并且为非变形的疾病弄平同样主要的治疗。对待的百分之五十个 PCa 病人将在某点收到 ADT。关于与更普遍的 ADT 使用联系的不利效果和费用正在种担心。生活(QoL ) 的质量上的不利效果,当人们是剥夺雄激素的时,包括物理、社会、心理的健康,可能可观。这评论在下列区域检验 QoL 问题:身体女性化,性变化,关系变化,认知、感情方面的症状,疲劳,睡觉骚乱,消沉和物理效果。推进建议因为减少这些改变的治疗学的途径被建议。 | Rowan G Casey Niall M Corcoran S Larry Goldenberg | 2012 | Asian Journal of Andrology2012，14，2： | 2 |
| 15 | Controlling the gelation temperature of biomimetic polyisocyanides显示文摘Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature(LCST) is often sharp, which allows for a wide range of smart material applications.At the LCST, oligo(ethylene glycol)-substituted polyisocyanides(PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol(EG) tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels. | Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers Chengfen Xing Jialiang xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 16 | Carbon and nitrogen stable isotope analyses of mammal bone fossils from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River,China显示文摘Based on AMS 14 C dating data,carbon and nitrogen isotope analyses were conducted on mammal bone collagen of deer,cattle and pigs from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River.These analyses were conducted to reconstruct palaeodiets of mammals,palaeoecology,palaeoenviroment and previous human activities in the study area.Results show that the collagen loss of bone did not change the in vivo isotopic composition of carbon and nitrogen stable isotopes,and most of the bone fossils were well preserved.The bone collagen of samples from deer had a mean δ 13 C of-23.1‰ and a mean δ 15 N of 4.7‰,suggesting that deer subsisted in a closed habitat and fed on branches and leaves.The bone collagen of cattle had a mean δ 13 C of-19.6‰ and a mean δ 15 N of 5.2‰,which indicates that cattle subsisted in an open habitat and fed on grasses and stems.The δ 13 C values show that both deer and cattle fed on C 3 plants and lived in the same ecosystem,but the t-test results show that deer δ 13 C and δ 15 N values were both more negative than those of cattle,indicating that they inhabited different niches.The δ 13 C and δ 15 N values of cattle partially overlapped those of deer,suggesting some competition in diets between them.The t-tests show that the δ 13 C and δ 15 N values of pigs were more positive than those of cattle and deer,which signifies that pigs occupied a higher trophic level compared to cattle and deer.The wide range of pig δ 13 C values demonstrates that pig trading had been taking place from early Neolithic Age to late Bronze Age.There were no significant differences in deer δ 13 C and δ 15 N values among different archaeological periods,making it clear that climatic,ecological and environmental conditions were kept relatively stable from 2200 to 4200 a BP.This stability may have been responsible for the extensive and complete cultural layers at the Zhongba site.The minimum number of samples required to estimate the mean δ 13 C values of deer,pigs and cattle are 8,73 and 16,respectively,and for mean δ 15 N values of deer,pigs and cattle,the minimum numbers are 4,5 and 6,respectively. | TIAN XiaoSi ZHU Cheng SUN ZhiBin SHUI Tao HUANG YunPing FLAD Rowan Kimon LI YuMei | 2011 | Chinese Science Bulletin2011，56，2： | 2 |
| 17 | Strong optical nonlinearities of self-assembled polymorphic microstructures of phenylethynyl functionalized fluorenones显示文摘Highly efficient nonlinear optical(NLO) materials with well-defined architectures in the wavelength and subwavelength length scales are of particular importance for next generation of integrated photonic circuits. Fluorenone analogues have been demonstrated to be promising candidates as building blocks for assembly of organic NLO materials thanks to their synergistic supramolecular interactions and brilliant optical properties. Here we have studied the polymorphs of a phenylethynyl functionalized fluorenone derivative, and their controlled self-assembly for microstructures with different morphologies. These polymorphic microcrystals exhibit very distinctive NLO properties, highly related to their supramolecular and electronic structures. | Xinyue Li Sergey Semin Leandro A. Estrada Chunqing Yuan Yulong Duan Jonathan Cremers Paul Tinnemans Paul Kouwer Alan E. Rowan Theo Rasing Jialiang Xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 18 | Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis显示文摘Background:Liver regeneration following partial hepatectomy(PHx)is a complicated process involving multiple organs and several types of signaling networks.The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story.PHx is characterized by rapid but transient bile acid overload in the liver,which constitutes the first wave of proliferative signaling in the remnant hepatocytes.Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors.Following biliary passage into the intestines,enterocytes reabsorb the bile acids,which results in the activation of farnesoid X receptor(FXR),the consequent excretion of fibroblast growth factor(FGF)19/FGF15,and its release into the enterohepatic circulation.FGF19/FGF15 subsequently binds to its cognate receptor,fibroblast growth factor receptor 4(FGFR4)complexed withβ-klotho,on the hepatocyte membrane,which initiates the second wave of proliferative signaling.Because some bile acids are toxic,the remnant hepatocytes must resolve the potentially detrimental state of bile acid excess.Therefore,the hepatocytes orchestrate a bile acid detoxification and elimination response as a protective mechanism in concurrence with the proliferative signaling.The response in part results in the excretion of(biotransformed)bile acids into the canalicular system,causing the bile acids to end up in the intestines.Relevance for patients:Recently,FXR agonists have been shown to promote regeneration via the gut-liver axis.This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx.In light of these developments,the review provides an in-depth account of the pathways that underlie post-PHx liver regeneration in the context of bile acid homeostasis in the liver and the gut-liver signaling axis. | Lianne de Haan Sarah Jvan der Lely Anne-Loes K.Warps Quincy Hofsink Pim B.Olthof Mark J.de Keijzer Daniel A.Lionarons Lionel Mendes-Dias Bote G.Bruinsma Korkut Uygun Hartmut Jaeschke Geoffrey C.Farrell Narci Teoh Rowan Fvan Golen Tiangang Li Michal Heger | 2018 | Journal of Clinical & Translational Research2018，4，1： | 2 |
| 19 | Pediatric asthma severity score is associated with critical care interventions显示文摘AIM To determine if a standardized asthma severity scoring system(PASS) was associated with the time spent on continuous albuterol and length of stay in the pediatric intensive care unit(PICU).METHODS This is a single center,retrospective chart review study at a major children's hospital in an urban location.To qualify for this study,participants must have been admitted to the PICU with a diagnosis of status asthmaticus.There were a total of 188 participants between the ages of two and nineteen,excluding patients receiving antibiotics for pneumonia.PASS was calculated upon PICU admission.Subjects were put into one of three categories based on PASS: ≤ 7(mild),8-11(moderate),and ≥ 12(severe).The groups were compared based on different variables,including length of continuous albuterol and PICU stay.RESULTS The age distribution across all groups was similar.The median length of continuous albuterol was longest in the severe group with a duration of 21.5 h(11.5-27.5),compared to 15(7.75-23.75) and 10(5-15) in the moderate and mild groups,respectively(P = 0.001).Thelength of stay was longest in the severe group,with a stay of 35.6 h(22-49) compared to 26.5(17-30) and 17.6(12-29) in the moderate and mild groups,respectively(P = 0.001).CONCLUSION A higher PASS is associated with a longer time on continuous albuterol,an increased likelihood to require noninvasive ventilation,and a longer stay in the ICU.This may help safely distribute asthmatics to lower and higher levels of care in the future. | Danielle K Maue Nadia Krupp Courtney M Rowan | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 20 | Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress显示文摘 | Xu L Holscher C Anwyl R Rowan M J | 1998 | Proc Natl Acad USA1998，95，： | 1 |
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