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| 1 | 低脂肪饮食模式与浸润型乳腺癌风险的妇女健康初步随机对照饮食改良试验显示文摘Context: The hypothesis that a low- fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial. Objective: To assess the effects of undertaking a low- fat dietary pattern on breast cancer incidence. Design and Setting: A randomized, controlled, primary prevention trial conducted at 40 US clinical centers from 1993 to 2005. Participants: A total of 48 835 postmenopausal women, aged 50 to 79 years, without prior breast cancer, including 18.6% of minority race/ethnicity, were enrolled. Interventions: Women were randomly assigned to the dietary modification intervention group (40% [n = 19 541]) or the comparison group (60% [n = 29 294]). The intervention was designed to promote dietary change with the goals of reducing intake of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily. Comparison group participants were not asked to make dietary changes. Main Outcome Measure: Invasive breast cancer incidence. Results: Dietary fat intake was significantly lower in the dietary modification intervention group compared with the comparison group. The difference between groups in change from baseline for percentage of energy from fat varied from 10.7% at year 1 to 8.1% at year 6. Vegetable and fruit consumption was higher in the intervention group by at least 1 serving per day and a smaller, more transient difference was found for grain consumption. The number of women who developed invasive breast cancer (annualized incidence rate) over the 8.1- year average follow- up period was 655 (0.42% ) in the intervention group and 1072 (0.45% ) in the comparison group (hazard ratio, 0.91; 95% confidence interval, 0.83- 1.01 for the comparison between the 2 groups). Secondary analyses suggest a lower hazard ratio among adherent women, provide greater evidence of risk reduction among women having a high- fat diet at baseline, and suggest a dietary effect that varies by hormone receptor characteristics of the tumor. Conclusions: Among postmenopausal women, a low- fat dietary pattern did not result in a statistically significant reduction in invasive breast cancer risk over an 8.1- year average follow- up period. However, the nonsignificant trends observed suggesting reduced risk associated with a low- fat dietary pattern indicate that longer, planned, nonintervention follow- up may yield a more definitive comparison. | Prentice R.L. Caan B. Chlebowski R.T. 张旸 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，6： | 4 |
| 2 | Adipokines Linking Obesity with Colorectal Cancer Risk in Postmenopausal Women显示文摘 | Gloria Y.F. Ho Tao Wang Marc J. Gunter Howard D. Strickler Mary Cushman Robert C. Kaplan Sylvia Wassertheil-Smoller Xiaonan Xue Swapnil N. Rajpathak Rowan T. Chlebowski Mara Z. Vitolins Philipp E. Scherer Thomas E. Rohan | 2012 | Cancer Research2012，，12： | 2 |
| 3 | Estrogen plus progestin and colorectal cancer in postmenopausal women显示文摘 | Chlebowski RT Waaitawski-wende Ritenbaugh C | 2004 | N Engl J Med2004，350，： | 1 |
| 4 | Discordancer in estrogen(ER) and progestin receptor(PR) status between primary metastatic breast can- cer, a meta-analysis显示文摘 | Fraco A Col N Chlebowski N T | 2004 | J Clin Oneol2004，22，14： | 1 |
| 5 | Estrogen plus progestin and colorectal cancer in postmenopausal women显示文摘 | Chlebowski RT Wactawski-Wende J Ritenbaugh C | 2004 | N Engl J Med2004，350，： | 1 |
| 6 | A longitudinal study of the metabolic syndrome and risk of postmenopausal breast cancer 显示文摘 | Kabat GC Kim M Chlebowski RT | 2009 | Cancer Epidemiol Biomarkers Prev2009，18，： | 1 |
| 7 | Influence of estrogen plus progestin on breast cancer and mammog- raphy in healthy postmenopausal women :the women' s health initiative randomized trial 显示文摘 | Chlebowski RT Hendrix SL Langer RD | 2003 | J Am Med Assoc2003，289，24： | 1 |
| 8 | Estrogen plus progestin and risk of benign proliferative breast disease显示文摘 | Rohan T E Negassa A Chlebowski R T | | 0，，09： | 1 |
| 9 | Vitamin K in the treatment of cancer显示文摘 | Chlebowski RT Akman SA Block JB | 1985 | Cancer Treat Rev1985，12，： | 1 |
| 10 | Adherence to oral en- docrine therapy for breast cancer:a nursing perspective显示文摘 | Miaskowski C Shockney L Chlebowski RT | 2008 | Clini- cal Journal of Oncology Nursing2008，12，2： | 1 |
| 11 | Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women ;s Health Initiative Randomized Trial显示文摘 | Chlebowski RT Hendrix SL Langer RD | 2003 | JAMA2003，289，： | 1 |
| 12 | Estrogen plus progestin and risk of benign proliferative breast disease显示文摘 | Rohan TE Negassa A Chlebowski RT | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，9： | 1 |
| 13 | Estrogen plus progesdn and colorectal cancer in postmenopausal women显示文摘 | Chlebowski RT Wactawski-Wende J Ritenbaugh C | 2004 | N Engl J Med2004，350，10： | 1 |
| 14 | Conjugated equine estrogens and breast cancer risk in the Women's Health Initiative clinical trial and observational study 显示文摘 | Prentice RL Chlebowski RT Stefanick ML | 2008 | Am J Epidemiol2008，167，： | 1 |
| 15 | Management of bloody nipple discharge显示文摘 | Vargas HI Rornero L Chlebowski RT | 2002 | Curt Treat Options Oncol2002，3，2： | 1 |
| 16 | Randomized Trial of Denosunlab in Patients Receiving Adjuvant Aromatase lnhibitors for Nonmetastatic Breast Cancer显示文摘 | Ellis GK Bone HG Chlebowski R | 2008 | J Clin Oneol2008，26，30： | 1 |
| 17 | Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy:a randomized controlled trial显示文摘 | Lacroix AZ Chlebowski RT Manson JE | 2011 | JAMA2011，305，13： | 1 |
| 18 | Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial显示文摘 | LaCroix AZ Chlebowski RT Manson JE | 2011 | JAMA2011，305，： | 1 |
| 19 | Breast cancer and nonsteroidal anti-inflammatory drugs:prospective results from the women’s health initiative显示文摘 | Harris RE Chlebowski RT Jackson RD | 2003 | Cancer Res2003，63，18： | 1 |
| 20 | Body size,physical ac- tivity, and risk of triple-negative and estrogen receptor-positive breast cancer显示文摘 | Phipps AI Chlebowski RT Prentice R | 2011 | Cancer Epidemiol Biomarkers Prey2011，20，： | 1 |
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