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| 1 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 2 | Role of PERK/eIF2α/CHOP Endoplasmic Reticulum Stress Pathway in Oxidized Low-density Lipoprotein Mediated Induction of Endothelial Apoptosis显示文摘Objective PERK/eI F2α/CHOP is a major signaling pathway mediating endoplasmic reticulum(ER) stress related with atherosclerosis.Oxidized LDL(ox-LDL) also induces endothelial apoptosis and plays a vital role in the initiation and progression of atherosclerosis.The present study was conducted to explore the regulatory effect of ox-LDL on PERK/e IF2α/CHOP signaling pathway in vascular endothelial cells.Methods The effects of ox-LDL on PERK and p-e IF2α protein expression of primary human umbilical vein endothelial cells(HUVECs) were investigated by Western blot analysis.PERK gene silencing and selective eI F2α phosphatase inhibitor,salubrinal were used to inhibit the process of ox-LDL induced endothelial cell apoptosis,caspase-3 activity,and CHOP mR NA level.Results Ox-LDL treatment significantly increased the expression of PERK,PERK-mediated inactivation of e IF2α phosphorylation,and the expression of CHOP,as well as the caspase-3 activity and apoptosis.The effects of ox-LDL were markedly decreased by knocking down PERK with stable transduction of lentiviral sh RNA or by selective eI F2α phosphatase inhibitor,salubrinal.Conclusion This study provides the first evidence that ox-LDL induces apoptosis in vascular endothelial cells mediated largely via the PERK/eI F2α/CHOP ER-stress pathway.It adds new insights into the molecular mechanisms underlying the pathogenesis and progression of atherosclerosis. | TAO Yong Kang YU Pu Lin BAI Yong Ping YAN Sheng Tao ZHAO Shui Ping ZHANG Guo Qiang | 2016 | Biomedical and Environmental Sciences2016，29，12： | 21 |
| 3 | Elevated Platelet Activating Factor Level in Ischemia-Related Arrhythmia and Its Electrophysiological Effect on Myocardium显示文摘Objective The mechanism through which platelet activating factor (PAF) induces cardiac electrical activity and arrhythmia is not well understood and previous studies have suggested a potential involvement of ion channels in its action. The present study was aimed to clarify the role of PAF in fatal arrhythmias following acute myocardia infarction (AMI) and the underlying mechanism. Methods (1) Blood PAF levels were measured among 72 AMI patients at the time of diagnosis with AMI and 48 h later, and their electrocardiogram (ECG) was recorded continuously. (2) Ischemia simulation and surface electrocardiogram were conducted in 20 pigs and their PAF levels were measured. (3) PAF perfusion and standard microelectrode recording were performed on guinea pig papillarymuscles. Results In both humans and pigs, elevated PAF levels were detected in AMI and simulated ischemia, respectively, and even higher PAF levels were found when fatal arrhythmias occurred. In guinea pig myocardium, PAF induced a shortening of action potential duration at 90% level of repolarization (APD 90 )under non-ischemic conditions and a more pronounced shortening under early simulated ischemic conditions. Conclusion AMI and ischemia are associated with increased PAF levels in humans and pigs, which are further raised when fatal arrhythmia follows. The effects of PAF on the myocardium may be mediated by multiple ion channels. | TAO Yong Kang ZHAO Shui Ping YU Pu Lin SHI Jing GU Cheng Dong SUN Hong Tao ZHANG Guo Qiang | 2013 | Biomedical and Environmental Sciences2013，26，5： | 5 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 6 | Effect of PCEs with Different Functional Groups on the Performance of Cement Paste显示文摘The adsorption behaviors and dispersing properties of polycarboxylate superplasticizer(PCE) with different functional groups were systematically analyzed to reveal the theory and methods of modifying PCE molecular structures and regulating PCE performances. By substituting carboxylic groups with sulfonic groups, ester groups or acylamino groups, respectively, modified PCEs with different functional groups were synthesized. Results show that introducing low amount of ester groups or sulfonic groups into the PCE molecules has no negative effects on the fluidity of cement paste, while introducing acylamino groups into PCE molecules significantly weakens the fluidity of cement paste. At low amount(when the molar ratio of sodium methallyl sulfonate to TPEG is lower than 0.4), the rapid adsorption of sulfonic groups onto the cement particles contributes to the high dispersing performance of the sulfonic group modified PCEs. When the substitution ratio of acrylic acid by sulfonic acid is higher than 0.4, the viscosity and the yield stress of cement paste increases sharply. Redundant sulfonic groups lead to the excessive charge density of the PCE, which contributes to the inhomogeneous adsorption on the cement grains and hence results in the decline of the dispersing performance. Substitution of carboxylic group by acylamino group or ester group slightly changes the viscosity as well as the yield stress of cement paste. Introducing sulfonic group into PCE molecule improves the adsorption behavior of PCEs, while introducing ester group or acylamino group into PCE depresses the adsorption properties. | 何燕 ZHANG Xiong WANG Yiting KONG Yaning JI Tao SHUI Liangliang WANG Xiaofu WANG Haoren | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，5： | 3 |
| 7 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 8 | G protein-coupled receptors: structure- and function-based drug discovery显示文摘As one of the most successful therapeutic target families,G protein-coupled receptors(GPCRs)have experienced a transformation from random ligand screening to knowledge-driven drug design.We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace.This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery. | Dehua Yang Qingtong Zhou Viktorija Labroska Shanshan Qin Sanaz Darbalaei Yiran Wu Elita Yuliantie Linshan Xie Houchao Tao Jianjun Cheng Qing Liu Suwen Zhao Wenqing Shui Yi Jjiang Ming-Wei Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 9 | Influence of precipitate morphology on tensile creep of a single crystal nickel-base superalloy显示文摘 | Li Shui Tao Jin Sugui Tian Zhuangqi Hu | 2006 | Materials Science & Engineering A2006，，： | 2 |
| 10 | CD8 + T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer显示文摘 | Yuan Zhuang Liu–Sheng Peng Yong–Liang Zhao Yun Shi Xu–Hu Mao Weisan Chen Ken C. Pang Xiao–Fei Liu Tao Liu Jin–Yu Zhang Hao Zeng Kai–Yun Liu Gang Guo Wen–De Tong Yan Shi Bin Tang Na Li Shu Yu Ping Luo Wei–Jun Zhang Dong–Shui Lu Pei–Wu Yu Quan–Ming Zou | 2012 | Gastroenterology2012，，4： | 2 |
| 11 | Relation between human existence and environment viewing from the distribution of prehistoric archaeological sites in the Three Gorges reservoir region of the Yangtze River,China显示文摘Based on archaeological research findings in the Three Gorges region as well as the distribution of prehistoric sites in this area,the following conclusion can be derived:the unique physical and geographical conditions and variations in the Three Gorges region make local people of different ages seek their survival and development in the favorable environment along the riverbanks.Environment evolution has direct impact on the selection of location for survival.The increase of sites quantity reflects the favorable natural environment,but the decrease just reflects the consequence of such natural disasters as flood. | ZHAO DongSheng SHUI Tao | 2008 | Chinese Science Bulletin2008，53，S1： | 2 |
| 12 | Carbon and nitrogen stable isotope analyses of mammal bone fossils from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River,China显示文摘Based on AMS 14 C dating data,carbon and nitrogen isotope analyses were conducted on mammal bone collagen of deer,cattle and pigs from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River.These analyses were conducted to reconstruct palaeodiets of mammals,palaeoecology,palaeoenviroment and previous human activities in the study area.Results show that the collagen loss of bone did not change the in vivo isotopic composition of carbon and nitrogen stable isotopes,and most of the bone fossils were well preserved.The bone collagen of samples from deer had a mean δ 13 C of-23.1‰ and a mean δ 15 N of 4.7‰,suggesting that deer subsisted in a closed habitat and fed on branches and leaves.The bone collagen of cattle had a mean δ 13 C of-19.6‰ and a mean δ 15 N of 5.2‰,which indicates that cattle subsisted in an open habitat and fed on grasses and stems.The δ 13 C values show that both deer and cattle fed on C 3 plants and lived in the same ecosystem,but the t-test results show that deer δ 13 C and δ 15 N values were both more negative than those of cattle,indicating that they inhabited different niches.The δ 13 C and δ 15 N values of cattle partially overlapped those of deer,suggesting some competition in diets between them.The t-tests show that the δ 13 C and δ 15 N values of pigs were more positive than those of cattle and deer,which signifies that pigs occupied a higher trophic level compared to cattle and deer.The wide range of pig δ 13 C values demonstrates that pig trading had been taking place from early Neolithic Age to late Bronze Age.There were no significant differences in deer δ 13 C and δ 15 N values among different archaeological periods,making it clear that climatic,ecological and environmental conditions were kept relatively stable from 2200 to 4200 a BP.This stability may have been responsible for the extensive and complete cultural layers at the Zhongba site.The minimum number of samples required to estimate the mean δ 13 C values of deer,pigs and cattle are 8,73 and 16,respectively,and for mean δ 15 N values of deer,pigs and cattle,the minimum numbers are 4,5 and 6,respectively. | TIAN XiaoSi ZHU Cheng SUN ZhiBin SHUI Tao HUANG YunPing FLAD Rowan Kimon LI YuMei | 2011 | Chinese Science Bulletin2011，56，2： | 2 |
| 13 | Security and privacy in 6G networks:New areas and new challenges显示文摘With the deployment of more and more 5g networks,the limitations of 5g networks have been found,which undoubtedly promotes the exploratory research of 6G networks as the next generation solutions.These investigations include the fundamental security and privacy problems associated with 6G technologies.Therefore,in order to consolidate and solidify this foundational research as a basis for future investigations,we have prepared a survey on the status quo of 6G security and privacy.The survey begins with a historical review of previous networking technologies and how they have informed the current trends in 6G networking.We then discuss four key aspects of 6G networks–real-time intelligent edge computing,distributed artificial intelligence,intelligent radio,and 3D intercoms–and some promising emerging technologies in each area,along with the relevant security and privacy issues.The survey concludes with a report on the potential use of 6G.Some of the references used in this paper along and further details of several points raised can be found at:security-privacyin5g-6g.github.io. | Minghao Wang Tianqing Zhu Tao Zhang Jun Zhang Shui Yu Wanlei Zhou | 2020 | Digital Communications and Networks2020，6，3： | 2 |
| 14 | Effects of Organosilane-modified PCE on the Fluidity and Hydration Properties of Cement-Fly Ash Composite Binder显示文摘Effects of organosilane-modified PCE (OS-PCE) on the fluidity and the hydration properties of cement-fly ash (FA) composite binder were systematically analyzed.The experimental results show that OS-PCE possesses respectively 36.98% and 36.67% higher saturated adsorption amount on cement and FA,in comparison with ordinary PCE,and can contribute to higher fluidity of cement-FA composite binder.The addition of OS-PCE retards hydration process of cement-FA composite binder proportionally with the dosage of OS-PCE,but promotes the hydration kinetics of the composite binder.The reactivity enhancement is attributed to the well-dispersed FA by OS-PCE,which provides more nucleation sites for the reaction of heterogeneous C-S-H and enhances the contact with water to react with CH forming pozzolanic C-S-H.Well-distributed hydration products are exhibited in the hardened binder added with OS-PCE,with a large number of hydrated gels uniformly fill in the pores and gaps,which improves the compaction of the hardened structure. | 何燕 LIU Shuhua JI Tao KONG Yaning SHUI Liangliang | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，6： | 2 |
| 15 | Development of a novel energy-absorbing bolt with extraordinarily large elongation and constant resistance显示文摘 | Manchao He Weili Gong Jiong Wang Peng Qi Zhigang Tao Shui Du Yanyan Peng | 2014 | International Journal of Rock Mechanics and Mining Sciences2014，，： | 2 |
| 16 | Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis显示文摘RNF20,an E3 ligase critical for monoubiquitination of histone H2B at lysine 120(H2Bub),has been implicated in the regulation of various cellar processes;however,its physiological roles in adipocytes remain poorly characterized.Here,we report that the adipocyte-specific knockout of Rnf20(ASKO)in mice led to progressive fat toss,organomegaly and hyperinsulinemia.Despite signs of hyperinsulinemia,normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice.In addition,high-fat diet-fed ASKO mice developed severe liver steatosis.Moreover,we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue(BAT)selective genes,including uncoupling protein 1(l/cpf),and impaired mitochondrial functions.Significantly decreased levels of peroxisome proliterator-activated receptor gamma(Ppary)were observed in the gonadal white adipose tissues(gWAT)from the ASKO mice,suggesting that Rnf20 regulates adipogenesis,at least in part,through Ppary.Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice.Collectively,our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function. | Xiaojuan Liang Cong Tao Jianfei Pan Lilan Zhang Lulu Liu Ying Zhao Yiping Fan Chunwei Cao Jiali Liu Jin Zhang Sin Man Lam Guanghou Shui Wanzhu Jin Wei Li Jianguo Zhao Kui Li Yanfang Wang | 2021 | Protein & Cell2021，12，6： | 1 |
| 17 | Configuration of nucleolar DNA in situ in nucleolus of Allium cepa cells显示文摘The location and configuration of nucleolar DNA have not been determined for a long time. In this paper, we have observed the nucleolar infrastructure and the character of nucleolar DNA in Allium cepa cells by conventional electron microscopy and the cytochemical NAMA-Ur DNA specific staining method. Furthermore, we have properly improved the NAMA-Ur method so as to analyze the location and configuration of nucleolar DNA in situ. Our results indicated that the nucleolar DNA in Allium cepa cells is mainly located at the border between fibrillar centers and dense fibribllar component, especially distributed in the configuration of encircling the fibrillar centers. | TAO Wei HE Jie JIAO Mingda HE Mengyuan HAO Shui | 2001 | Chinese Science Bulletin2001，46，1： | 1 |
| 18 | Synthesis and characterization of poly(lactic-acid) and aliphatic polycarbonate copolymers显示文摘 | Yu Tao Ren Jie Gu Shuying | 2009 | Polymer International2009，58，9： | 1 |
| 19 | Switchable dual- wavelength erbi u m-doped fiber ring laser with tunable wavelength spacing based on a compact fiber filter显示文摘 | Cao Zhigang Zhang Zhao Shui Tao | 2014 | Optics and Laser Technology2014，56，： | 1 |
| 20 | Micropropa- gation and pharmacological analysis of a medicinal herb Sarcandra glabra 显示文摘 | Shuying Zhu Tao Liu Zhongming Fang | 2011 | Medicinal and Aromatic Plant Science and Biotechnology2011，5，1： | 1 |
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