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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | Correlation between tongue manifestations and glucose, total cholesterol, and high-density lipoprotein cholesterol in patients with acute cerebral infarction显示文摘OBJECTIVE: To analyze the association between tongue manifestations and the levels of glucose (GLU), total cholesterol(TCH), and high-density lipoprotein cholesterol(HDL-C) in subjects with acute cerebral infarction.METHODS: Hospitalized patients with first unilateral cerebral infarction in the Neurological Department of Xuanwu Hospital were included and the correlation between tongue fur color, fur nature,and the levels of GLU,TCH, HDL-C were analyzed.RESULTS: HDL level in the thin fur group was higher than that in the thick fur group(P=0.02). The difference in the levels of GLU,TCH, and HDL-C among the groups was significant(P<0.05), classified in terms of slippery, moist, and dry fur. Further comparison between the groups by Student-Newman-Keuls test showed that GLU level in the dry fur group was the highest. Moreover, the TCH level in the slippery fur group was higher than the other two groups.CONCLUSION: A correlation between tongue manifestations and GLU, TCH, HDL-C was identified in the patients with acute cerebral infarction. | Ping Liu Li Gao Juexian Song Haiping Zhao XiaoguangWu Liyuan Huang Pingping Wang Yumin Luo | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 14 |
| 3 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 4 | Quantitative trait loci for Fusarium head blight resistance in wheat cultivars Yangmai 158 and Zhengmai 9023显示文摘Fusarium head blight(FHB)is one of the prevalent fungal diseases of wheat worldwide.Exploring new FHB resistance quantitative trait loci(QTL)in adapted wheat cultivars is a critical step for breeding new FHB-resistant cultivars.In this study,we developed a population of 236 F5:7 recombinant inbred lines(RILs)using two popular Chinese wheat cultivars,Yangmai 158 and Zhengmai 9023,with moderate FHB resistance to identify the QTL for FHB type II resistance.This population was evaluated for percentage of symptomatic spikelets per spike(PSS)using single floret injection in repeated greenhouse experiments.Mean PSSs were 33.2%for Yangmai 158 and 30.3%for Zhengmai 9023.A genetic linkage map of 1002 single nucleotide polymorphisms(SNPs)generated by genotyping-by-sequencing(GBS)was constructed for the RIL population.Six QTL were identified for FHB resistance,and three of them were repeatable in the both experiments.Zhengmai 9023 contributed the resistance allele at one repeatable QTL,designated as Qfhb.7D,whereas Yangmai 158 contributed the resistance alleles at the other two repeatable QTL,Qfhb.3AL and Qfhb.2DS.The additional QTL,Qfhb.4AS was significant in the mean PSS,and Qfhb.2DL and Qfhb.7AS were significant in only one experiment.Replacement of each allele individually at the three repeatable QTL significantly changed PSSs.Qfhb.3AL,Qfhb.2DS,and Qfhb.7D explained 8.35%to 9.89%,5.13%to 7.43%,and 6.15%to 9.32%of the phenotypic variations,respectively.The three repeatable QTL contributed by the two parents were additive and stacking the resistance alleles from all the three repeatable QTL showed the highest level of resistance in the current RIL population.Ten SNPs in the QTL regions of Qfhb.3AL,Qfhb.2DS,and Qfhb.7D were converted into KBioscience competitive allele-specific PCR(KASP)assays.One KASP marker for Qfhb.3AL was validated in a panel of wheat cultivars from China.Some of these KASP markers could be useful for marker-assisted selection to stack these QTL. | Pingping Zhang Chenjin Guo Zhao Liu Amy Bernardo Hongxiang Maa Hongxiang Ma Peng Jiang Guicheng Song Guihua Bai | 2021 | The Crop Journal2021，9，1： | 8 |
| 5 | Application of ~1H NMR-based metabolomics for discrimination of different parts and development of a new processing workflow for Cistanche deserticola显示文摘Cistanche deserticola(CD) is one of the two authoritative source plants of Cistanches Herba, a well-known medicinal plant. Herein,~1H NMR spectroscopy was employed to characterize the chemical profile and to distinguish the different parts, as well as to propose a new processing workflow for CD.Signal assignment was achieved by multiple one and two dimensional NMR spectroscopic techniques in combination with available databases and authentic compounds. The upper parts of the plant were distinguished from the lower parts by combining ~1H NMR spectroscopic dataset with multivariate statistical analysis. A new processing method that hyphenated steaming with freeze-drying, was demonstrated to be superior to either steaming coupled with oven-drying or direct freeze-drying via holistic ~1H NMR-based metabolomic characterization. Phenylethanoid glycosides, mainly echinacoside and acteoside, were screened out and confirmed as the chemical markers responsible for exhibiting the superiority of the new processing workflow, whereas serial primary metabolites, especially carbohydrates and tricarboxylic acid cycle metabolites, were found as the primary molecules governing the discrimination between the upper and lower parts of the plant. Collectively,~1H NMR spectroscopy was demonstrated as a versatile analytical tool to characterize the chemical profile and to guide the indepth exploitation of CD by providing comprehensive qualitative and quantitative information. | Pingping Zou Yuelin Song Wei Lei Jun Li Pengfei Tu Yong Jiang | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 7 |
| 6 | Variations in silicate concentration affecting photosynthetic carbon fixation by spring phytoplankton assemblages in surface water of the Strait of Malacca显示文摘The Strait of Malacca (SoM), the world's busiest sea-route, is increasingly polluted as the rapid development of world trades, affecting phytoplankton primary productivity therein. The variations of surface phytoplankton biomass, size-structure and carbon fixation were investigated across the SoM during the spring period (May 4 to 9, 2011). Chlorophyll a concentration increased from 0.12 μg/L at the northwest entrance of the SoM to a maximal 0.63 μg/L at narrowest section, and decreased to 0.10 μg/L at the southeast entrance. Photosynthetic carbon fixation by phytoplankton coincided well with Chl a biomass, and increased from 10.8 to 22.3 μg C/(L d), then decreased to 9.21 μg C/(L d); while the carbon fixation rate showed an inverse pattern to the changes of Chl a, and decreased from 87.1 to 35.5 μg C/(μg Chl a d) and increased thereafter to 95.3 μg C/(μg Chla·d). Picophytoplankton cells (<3 μm) contributed to more than 60% and 50% of the total Chl a and carbon fixation at both the entry waters; while the contributions of pico-cells decreased sharply to the minimum of 18.3% and 27.5% at the narrowest part of the SoM. In particular, our results showed that the silicate concentration positively regulated Chl a biomass and carbon fixation, reflecting that the higher silicate favoured the growth of phytoplankton and thus led to higher primary production in this strait. | LI Gang LIN Qiang SHEN Pingping NI Guangyan SONG Xingyu WANG Shengfu FAN Yanzhi HUANG Liangmin TAN Yehui | 2013 | Acta Oceanologica Sinica2013，32，4： | 4 |
| 7 | The integrated characterization techniques on reservoir fractures 显示文摘 | Xinmin Song Pingping Shen Shiyi Yuan | 2000 | SPE 647662000，，： | 1 |
| 8 | Zinc glycerolate with lanthanum stearate to inhibit the thermal degradation of poly(vinyl chloride)显示文摘 | Jiang Pingping Song Yinyin Dong Yuming | 2013 | Appl Polym Sci2013，127，36： | 1 |
| 9 | Improved Oil Recovery Technology in China:Status & Outlook显示文摘 | Shen Pingping Song Jie Zhu Bin | 2005 | China Oil & Gas2005，12，4： | 1 |
| 10 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
| 11 | Using 18 F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus显示文摘 | Xiaojun Zhong Jinming Yu Baijiang Zhang Dianbin Mu Weidi Zhang Daotang Li Anqin Han Pingping Song Hui Li Guoren Yang Feng-Ming Kong Zheng Fu | 2009 | International Journal of Radiation Oncology Biology Physics2009，，1： | 1 |
| 12 | Zinc glycerolate with lanthanum stearate to inhibit the thermal degradation of poly (vinyl chlorlde) 显示文摘 | Jiang Pingping Song Yinyin Dong Yuming | 2013 | Journal of Applied Polymer Science2013，127，5： | 1 |
| 13 | Targeted disruption of RablO causes early embryonic lethality显示文摘 | Pingping Lv Yi Sheng Zhenao Zhao Wei Zhao Lusheng Gu Tao Xu Eli Song | 2015 | Protein & Cell2015，6，6： | 1 |
| 14 | Wideband diffusion metabsorber for perfect scattering field reduction显示文摘Both absorption and diffuse reflection can effectively suppress microwave backward reflection.However,the challenge of designing wideband absorptive elements with anti-phase reflection hinders the simultaneous working of the two principles.With aid of the wideband characteristic of bilateral complementary structure,we propose a strategy to design wideband absorptive elements with large reflection phase differences.For proof of concept,the proposed elements are arranged in a rectangular grid by optimizing scattering field distribution.The proposed diffusion metabsorber achieves over 20-dB scattering field reduction in the range of 8.5–20.3 GHz with good polarization stability and high angular insensitivity of up to±40°,which has been verified by real experiments.Furthermore,the proposed design strategy exhibits the potential to further reduce electromagnetic wave reflection,and the optical transparent characteristic is promising for window applications. | ZICHENG SONG PINGPING MIN JIAQI ZHU LEI YANG FENG HAN LIN | 2022 | Photonics Research2022，10，6： | 1 |
| 15 | A gauge-based analysis of daily precipitation over East Asia显示文摘 | XIE Pingping CHEN Mingyue YANG Song | 2007 | (7) : 607-6242007，，7： | 1 |
| 16 | Zinc glycerolate with lanthanum stearate to inhibit the thermal degradation of poly(vinyl chloride)显示文摘 | Jiang Pingping Song Yinyin Dong Yuming | 2013 | Journal of Applied Polymer Science2013，127，5： | 1 |
| 17 | Combination effects of graphene and layered double hydroxides on intumescent flame-retardant poly(methyl methacrylate) nanocomposites显示文摘 | Guobo Huang Suqing Chen Pingan Song Pingping Lu Chenglin Wu Huading Liang | 2013 | Applied Clay Science2013，，： | 1 |
| 18 | Using 18 F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus显示文摘 | Xiaojun Zhong Jinming Yu Baijiang Zhang Dianbin Mu Weidi Zhang Daotang Li Anqin Han Pingping Song Hui Li Guoren Yang Feng-Ming Kong Zheng Fu | 2009 | International Journal of Radiation Oncology Biology Physics2009，，1： | 1 |
| 19 | Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4显示文摘 | Jun Song Pingping Ren Lin Zhang Xing Li Wang Li Chen Ying H. Shen | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 20 | Zinc Glycerolate with Lanthanum Stearate to Inhibit the Ther- mal Degradation of Poly(vinyl chloride) 显示文摘 | Jiang Pingping Song Yinyin Dong Yuming | 2013 | Journal of Applied Polymer Science2013，127，5： | 1 |
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