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| 1 | 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation显示文摘Vitamin D_3 has been found to produce therapeutic effects on obesity-associated insulin resistance and dyslipidemia through its potent anti-inflammatory activity, but the precise immunomodulatory mechanism remains poorly understood. In the present study we found that 1,25-dihydroxyvitamin D_3[1,25(OH)_2D_3], the biologically active form of vitamin D_3, significantly attenuated monosodium glutamate(MSG)-induced obesity and insulin resistance as indicated by body weight reduction, oral glucose tolerance improvement, and a glucose infusion rate increase as detected with hyperinsulinemiceuglycemic clamp. Moreover, 1,25(OH)_2D_3 not only restored pancreatic islet functions but also improved lipid metabolism in insulin-targeted tissues. The protective effects of 1,25(OH)_2D_3 on glycolipid metabolism were attributed to its ability to inhibit an obesity-activated inflammatory response in insulin secretory and targeted tissues, as indicated by reduced infiltration of macrophages in pancreas islets and adipose tissue while enhancing the expression of Tgf-β1 in liver tissue, which was accompanied byincreased infiltration of Treg cells in immune organs such as spleen and lymph node as well as in insulintargeted tissues such as liver, adipose, and muscle. Together, our findings suggest that 1,25(OH)_2D_3 serves as a beneficial immunomodulator for the prevention and treatment of obesity or metabolic syndrome through its anti-inflammatory effects. | Wen Jin Bing Cui Pingping Li Fang Hua Xiaoxi Lv Jichao Zhou Zhuowei Hu Xiaowei Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 9 |
| 2 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 3 | TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target显示文摘Pulmonary fibrosis(PF)is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic strategies.We recently reported that the protein kinase glycogen synthase kinase-3β(GSK-3β)interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta(C/EBPβ)in alveolar macrophages(AMs),resulting in a profibrotic phenotype of AMs and promoting the development of PF.Here,we showed that chronic lung injury upregulated the stress response protein tribbles homolog 3(TRIB3),which interacted with GSK-3βand stabilized GSK-3βfrom ubiquitination and degradation.Elevated GSK-3βexpression phosphorylated A20 to inhibit its ubiquitin-editing activity,causing the accumulation of C/EBPβand the production of several profibrotic factors in AMs and promoting PF development.Activated C/EBPβ,in turn,increased the transcription of TRIB3 and GSK-3β,thereby establishing a positive feedback loop in AMs.The knockdown of TRIB3 expression or the pharmacologic disruption of the TRIB3-GSK-3βinteraction was an effective PF treatment.Our study reveals an intact profibrotic axis of TRIB3-GSK-3β-A20-C/EBPβin AMs,which represents a target that may provide a promising treatment strategy for PF. | Shanshan Liu Xiaoxi Lv Xupeng Wei Chang Liu Qiao Li Jiali Min Fang Hua Xiaowei Zhang Ke Li Pingping Li Yang Xiao Zhuowei Hu Bing Cui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 2 |
| 4 | A new model for embryoimplantation:coculture of blastocysts and Ishikawa cells显示文摘 | Dan Zhang Pingping Lv Hefeng Huang | 2011 | Gyneco- logical Endocrinology2011，28，4： | 1 |
| 5 | Direct Synthesis of Co-doped Graphene on Dielectric Substrates Using Solid Carbon Sources显示文摘Direct synthesis of high-quality doped graphene on dielectric substrates without transfer is highly desired for simplified device processing in electronic applications.However,graphene synthesis directly on substrates suitable for device applications,though highly demanded,remains unattainable and challenging.Here,a simple and transfer-free synthesis of high-quality doped graphene on the dielectric substrate has been developed using a thin Cu layer as the top catalyst and polycyclic aromatic hydrocarbons as both carbon precursors and doping sources.N-doped and N,F-co-doped graphene have been achieved using TPB and F16Cu Pc as solid carbon sources,respectively.The growth conditions were systematically optimized and the as-grown doped graphene were well characterized.The growth strategy provides a controllable transfer-free route for high-quality doped graphene synthesis,which will facilitate the practical applications of graphene. | Qi Wang Pingping Zhang Qiqi Zhuo Xiaoxin Lv Jiwei Wang Xuhui Sun | 2015 | Nano-Micro Letters2015，7，4： | 1 |
| 6 | Targeted disruption of RablO causes early embryonic lethality显示文摘 | Pingping Lv Yi Sheng Zhenao Zhao Wei Zhao Lusheng Gu Tao Xu Eli Song | 2015 | Protein & Cell2015，6，6： | 1 |
| 7 | Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology显示文摘Immune cells play key roles in cancer and chronic inflammatory disease. A better understanding of the mechanisms and risks will help develop novel target therapies. At the 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology held in Beijing, China, on May 12, 2017, a number of speakers reported new findings and ongoing studies on immune-related diseases such as cancer, fibrotic disease, diabetes, and others. A considerably insightful overview was provided on cancer immunity, tumor microenvironments,and new immunotherapy for cancer. In addition, chronic inflammatory diseases were discussed. These findings may offer new insights into targeted immunotherapy. | Bing Cui Xuetao Cao Weiping Zou Yonghong Wan Ning Wang Yaohe Wang Pingping Li Fang Hua Yuying Liu Xiaowei Zhang Ke Li Xiaoxi Lv Bo Huang Zhuowei Hu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 1 |
| 8 | Erratum to“Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Approach”[Engineering 13(2022)186–196]显示文摘There was a mistake in affiliation a,the correct one should be“MOE Key Laboratory of Marine Genetics and Breeding and Sars-Fang Center,Ocean University of China,Qingdao 266003,China”as updated above;Affiliations c and d should be reversed:Affiliation c should be“Laboratory for Marine Fisheries Science and Food Production Processes,Pilot Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China,”and the affiliation d should be“Laboratory of Tropical Marine Germplasm Resources and Breeding Engineering,Sanya Oceanographic Institution,Ocean University of China,Sanya 572000,China.” | Pingping Liu Jia Lv Cen Ma Tianqi Zhang Xiaowen Huang Zhihui Yang Lingling Zhang Jingjie Hu Shi Wang Zhenmin Bao | 2022 | Engineering2022，，11： | 1 |
| 9 | Decreased decidual epithelial sodium channel(ENaC) alpha and gamma subunits in recurrent pregnancy loss(RPL)显示文摘Dear Editor,Recurrent pregnancy loss (RPL) in early pregnancy is a devastating problem for couples who want to become parents and a difficult challenge for their physician.RPL is also referred to as recurrent miscarriage or habitual abortion.It is defined as two or more consecutive clinical miscarriages (CMs) before 20 weeks of gestation (Practice Committee of the American Society for Reproductive Medicine,2012). | Tiantian Yu Chun Feng Pingping Lv Gufeng Xu Lihua Hong Yimeng Xiong Xiaoyan Guo Tong Li Jianzhong Sheng Hefeng Huang Xinmei Liu | 2019 | Science China(Life Sciences)2019，62，7： | 1 |
| 10 | Hydrocarbon Generation Potential Evaluation of Coal Shale Gas of Permo-Carboniferous in Jiyang Depression显示文摘In order to study the hydrocarbon-generating potential of Carboniferous-Permian coal shale in Jiyang Depression,geochemistry,petroleum geology and coal geology were applied to study the residual strata distribution of Carboniferous-Permian in Jiyang Depression,organic matter abundance,organic matter types and organic matter maturity of mudstone.The results show that the thickness of the Carboniferous-Permian residual strata in Jiyang Depression is generally 200-800 m,with a maximum thickness of 900 m;the organic matter abundance of coal-bearing shale is good,and it is type III kerogen,which is conducive to gas generation,and the maturity of organic matter reaches a mature-higher maturity stage;the hydrocarbon generation potential of Benxi Formation and Taiyuan Formation is better;Medium to good hydrocarbon source rocks is able to be found in every sag of Shanxi Formation hydrocarbon source rocks,but the scope is limited,and the overall evaluation is still medium.Generally speaking,the Permo-Carboniferous coal-bearing shale in Jiyang Depression has certain shale gas exploration potential. | Pingping Li Dawei Lv Huiyong Wang Wengui Fan Changyong Lu | 2019 | Journal of Geological Research2019，1，2： | 0 |
| 11 | 中国北京地区部分医院患者疼痛现状调查(英文)显示文摘Objective:This study aimed to survey the characteristics and treatments of cancer pain in Beijing hospitals,China.Methods:At 20:00 on December 22,2009,there conducted a questionnaire survey in 2238 patients with malignant tumors of 26 hospitals in Beijing,and the survey results were statistically analyzed.Results:The 531 cases in 2238 patients had pained and 121 cases (22.79%) had outbreak pain with one week.At 20:00 on December 22,2009,199 cases (38%) in the above-mentioned 531 pain patients suffered the moderate to severe pain (pain scores ≥ 4).The number of pain (pain scores ≥ 4) patients in the consecutive three days from December 20 to December 22 were 150.Conclusion:In the 531 cancer pain patients of the surveyed hospitals,38% of the patients were not satisfied with the pain control.Doctors believed that the main reason for pain not controlled was the non-standard treatment,but patients considered to be afraid of addiction. | Shikai Wu Fang Li Pingping Li Jian Luo Xiaoming Wu Heling Shi Xiaohong Ning Yufei Yang Huangying Tan Ping Yang Guangqing Zhu Jianhua Zhu Guoqing Liao Huoming Chen Dapeng Lv Ye Fang Hong Dai Xiaoming Xi Xiuhua Li Yuan Qin Li Feng Su Wang Xiaoyan Chen Hongyong Wang Hongyan Li Duanqi Liu | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
| 12 | Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Approach显示文摘Targeted genotyping is an extremely powerful approach for the detection of known genetic variations that are biologically or clinically important.However,for non-model organisms,large-scale target geno-typing in a cost-effective manner remains a major challenge.To address this issue,we present an ultrahigh-multiplex,in-solution probe array-based high-throughput diverse marker genotyping(HD-Marker)approach that is capable of targeted genotyping of up to 86000 loci,with coverage of the whole gene repertoire,in what is a 27-fold and six-fold multiplex increase in comparison with the conventional Illumina GoldenGate and original HD-Marker assays,respectively.We perform extensive analyses of var-ious ultrahigh-multiplex levels of HD-Marker(30 k-plex,56 k-plex,and 86 k-plex)and show the power and excellent performance of the proposed method with an extremely high capture rate(about 96%)and genotyping accuracy(about 96%).With great advantages in terms of cost(as low as 0.0006 USD per geno-type)and high technical flexibility,HD-Marker is a highly efficient and powerful tool with broad appli-cation potential for genetic,ecological,and evolutionary studies of non-model organisms. | Pingping Liu Jia Lv Cen Ma Tianqi Zhang Xiaowen Huang Zhihui Yang Lingling Zhang Jingjie Hu Shi Wang Zhenmin Bao | 2022 | Engineering2022，8，6： | 0 |
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