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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | Continuous Detonation Engine and Effects of Different Types of Nozzle on Its Propulsion Performance显示文摘The rotating propagation of a continuous detonation engine(CDE) with different types of nozzles is investigated in three-dimensional numerical simulation using a one-step chemical reaction model.Flux terms are solved by the so-called monotonicity-preserving weighted essentially non-oscillatory(MPWENO) scheme.The simulated flow field agrees well with the previous experimental results.Once the initial transient effects die down,the detonation wave maintains continuous oscillatory propagation in the annular chamber as long as fuel is continuously injected.Using a numerical flow field,the propulsion performance of a CDE is computed for four types of nozzles,namely the constant-area nozzle,Laval nozzle,diverging nozzle and converging nozzle.The gross specific impulse of the CDE ranges 1 540-1 750 s and the mass flux per square meter ranges 313-330 kg/(m2·s) for different nozzles.Among these four types of nozzles,Laval nozzle performs the best,and these parameters are 1 800 N,1 750 s and 313 kg/(m2·s).A nozzle can greatly improve the propulsion performance. | Shao Yetao Liu Meng Wang Jianping | 2010 | Chinese Journal of Aeronautics2010，23，6： | 26 |
| 3 | Controllable synthesis of nitrogen-doped porous carbon from metal-polluted miscanthus waste boosting for supercapacitors显示文摘High-value reclamation of metal-polluted plants involved in phytoremediation is a big challenge.In this study,nitrogen-doped nanoporous carbon with large specific area of 2359.1 m^(2)g^(-1) is facilely fabricated from metal-polluted miscanthus waste for efficient energy storage.The synergistic effect of KOH,urea and ammonia solution greatly improve the nitrogen quantity and surface area of the synthesized carbon.Electrodes fabricated with this carbon exhibit the excellent capacitance performance of 340.2 F g^(-1) at 0.5 A g^(-1) and a low combined resistance of 0.116Ω,which are competitive with most of previously reported carbon-based electrodes.In addition,the as-obtained carbon electrode shows a high specific capacitance retention of over 99.6%even after 5000 cycles.Furthermore,the symmetric supercapacitor fabricated using the synthesized carbon achieves a superior energy density of 25.3 Wh kg^(-1)(at 400 W kg^(-1))in 1 mol L^(-1) Na_(2)SO_(4)aqueous solution.This work provides an efficient route to upcycle metal-polluted plant waste for supercapacitor applications. | Zuo Chen Man Zhang Yuchen Wang Zhiyu Yang Di Hu Yetao Tang Kai Yan | 2021 | Green Energy & Environment2021，6，6： | 4 |
| 4 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 5 | Highly efficient production of 2,5-dihydroxymethylfuran from biomass-derived 5-hydroxymethylfurfural over an amorphous and mesoporous zirconium phosphonate catalyst显示文摘The development of high-efficiency and low-cost catalysts is very crucial for the MeerweinPonndorf-Verley (MPV) reduction of biomass-derived 5-hydroxymethylfurfural (HMF) into 2,5-dihydroxymethylfuran (DHMF). In this work, an amorphous and mesoporous zirconium phosphonate catalyst (Zr-DTMP), which is a zirconium-containing organic-inorganic nanohybrid, was successfully designed and synthesized by the simple assembly of zirconium tetrachloride (ZrCl4) and diethylene triaminepenta(methylene phosphonic acid)(DTMP). Satisfactorily, when Zr-DTMP was employed for the MPV reduction of HMF in the presence of 2-butanol (secBuOH), DHMF yield could be achieved as 96.5% in 3 h under a relatively mild reaction temperature of 140℃. Systematic investigations indicated that this high catalytic activity should be mainly due to the cooperative role of enhancive Lewis acid site (Zr4+) and Lewis base site (O2-) in activating the carbonyl group of HMF and dissociating the hydroxyl group of secBuOH, respectively. Additionally, Zr-DTMP showed excellent catalytic stability, when it was successively used 5 recycles, its surface characteristics and textural properties still remained almost unchanged, and so, the catalytic activity was not obviously affected. More interestingly, Zr-DTMP could also be applied for the selective reduction of other biomass-derived carbonyl compounds, such as 5-methylfurfural (MF), furfural (FF), levulinic acid (LA), ethyl levulinate (EL) and cyclohexanone (CHN), into the corresponding products with high yields, which is beneficial to the effective synthesis of various valuable bio-based chemicals. | Lei Hu Ning Li Xiaoli Dai Yuqi Guo Yetao Jiang Aiyong He Jiaxing Xu | 2019 | Journal of Energy Chemistry2019，28，10： | 1 |
| 6 | Five Zang-organs Harmonize Pitch: How the lost theory and technology of Huang Di Nei Jing can be applied to the modern clinical treatment显示文摘 | Gao Yetao | 2006 | APBN (Asia Pacific Biotech News)2006，10，14： | 1 |
| 7 | Root foraging for zinc and cadmium requirement in the Zn/Cd hyperaccumulator plant Sedum alfredii显示文摘 | LIU Fengjie TANG Yetao DU Ruijun | 2010 | Plant Soil2010，327，1： | 1 |
| 8 | Polyethylene glycol improves the purification of recombinant human tumor necrosis factor during ion exchange chromatography显示文摘 | Feng Xiaoli Gu Zhenyu Jin Yetao | 1998 | Biotechnology Techniques1998，12，4： | 1 |
| 9 | Olfactory route for cerebrospinal fluid drainage into the cervical lymphatic system in a rabbit experimental model显示文摘The present study analyzed the anatomical association between intracranial subarachnoid space and the cervical lymphatic system. X-ray contrast medium and Microfil (Microfil compounds fill and opacify microvascular and other spaces of non-surviving animals and post-mortem tissue under physiological injection pressure) were injected into the cisterna magna of the rabbit, and perineural routes of cerebrospinal fluid outflow into the lymphatic system were visualized. Under a surgical operating microscope, Microfil was found within the subarachnoid space and along the olfactory nerves. At the nasal mucosa, a lymphatic network was identified near the olfactory nerves, which crossed the nasopharyngeal region and finally emptied into the superficial and deep cervical lymph nodes. Under a light microscope, Microfil was visible around the olfactory nerves and within lymphatic vessels. These results suggested that cerebrospinal fluid drained from the subarachnoid space along the olfactory nerves to nasal lymphatic vessels, which in turn, emptied into the cervical lymph nodes. This anatomical route, therefore, allowed connection between the central nervous system and the lymphatic system. | Haisheng Liu Zhili Ni Yetao Chen Dong Wang Yan Qi Qiuhang Zhang Shijie Wang | 2012 | Neural Regeneration Research2012，7，10： | 1 |
| 10 | The Reliable and Intelligent Propulsion Pressurization System of the Long March 7 Launch Vehicle显示文摘The reliable and intelligent propulsion pressurization system is one of the key technologies of new Chinese generation launch vehicles; a high reliability design is an important guarantee for the success of launching. This paper analyzes the domestic and overseas liquid launch vehicles in the area of propulsion pressurization systems, based on comprehensive analysis, demonstrating the reliable and intelligent propulsion pressurization system of the Long March 7(Simplified as LM-7) has been raised. By applying a full chain redundancy design, setting proper pressure control bandwidth and control mode reconstruction under extreme fault conditions, the reliability and adaptability of the propulsion pressurization system has enhanced significantly. In addition, the complete system has been verified by the first two flights of LM-7. | FAN Ruixiang DENG Xinyu SHAO Yetao YANG Haoliang TIAN Yurong | 2017 | Aerospace China2017，18，4： | 1 |
| 11 | 显示文摘 | YETao(叶滔) MAZhi-Qiang(马志强) NIUFang-Sheng(牛芳胜) etal | | Nongyao0，，： | 1 |
| 12 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
| 13 | Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers显示文摘 | Jian Shu Chen Wu Yetao Wu Zhiyuan Li Sida Shao Wenhui Zhao Xing Tang Huan Yang Lijun Shen Xiaohan Zuo Weifeng Yang Yan Shi Xiaochun Chi Hongquan Zhang Ge Gao Youmin Shu Kehu Yuan Weiwu He Chao Tang Yang Zhao Hongkui Deng | 2013 | Cell2013，，5： | 1 |
| 14 | Perceptual matc- hing of shape design style between wheel hub and car type 显示文摘 | LUO Shijian FU Yetao ZHOU Yuxiao | 2012 | International Journal of Industrial Ergonomics2012，42，1： | 1 |
| 15 | Zinc hyperaccumulation and uptake by potentilla griffithii hook显示文摘 | QIU Rongliang FANG Xiaohang TANG Yetao | 2006 | International Journal of Phytoremediation2006，8，： | 1 |
| 16 | Lead, zinc and cadmium accumulation in herbaceous species and soils in Lanping Pb/Zn mining area,Yunnan Province, China显示文摘 | Yetao TANG Rongliang QIU Xiaowen ZENG Xiaohang FANG Xiaoyong ZHOU Fangming YU Yudu WU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
| 17 | Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway显示文摘Liver is an important organ for regulating glucose and lipid metabolism.Recent studies have shown that bone morphogenetic proteins(BMPs)may play important roles in regu-lating glucose and lipid metabolism.Inour previous studies,we demonstrated that BMP4 signif-icantly inhibits hepatic steatosis and lowers serum triglycerides,playing a protective role against the progression of non-alcoholic fatty liver disease(NAFLD).However,the direct impact of BMP4 on hepatic glucose metabolism is poorly understood.Here,we investigated the regulatory roles of BMP4 in hepatic glucose metabolism.Through a comprehensive analysis of the 14 types of BMPs,we found that BMP4 was one of the most potent BMPs in promoting hepatic glycogen accumulation,reducing the level of glucose in hepatocytes and effecting the expression of genes related to glucose metabolism.Mechanistically,we demonstrated that BMP4 reduced the hepatic glucose lewels through the activation of mTORC2 signaling pathway in vitro and in wivo.Collectively,our findings strongly suggest that BMP4 may play an essential role in regulating hepatic glucose metabolism.This knowledge should aid us to understand the molecular pathogenesis of NAFLD,and may lead to the development of novel therapeutics by exploiting the inhibitory effects of BMPs on hepatic glucose and lipid metabolism. | Liqin An Qiong Shi Ying Zhu Hao Wang Qi Peng Jinghong Wu Yu Cheng Wei Zhang Yanyu Yi Zihao Bao Hui Zhang Yetao Luo Jiaming Fan | 2021 | Genes & Diseases2021，8，4： | 1 |
| 18 | Research Progress of the Treatment of PD-1 Immune CheckpointInhibitors in Oral Squamous Cell Carcinoma显示文摘Targeted immune checkpoint-based immunotherapy has achieved remarkable success in the treatment of malignant tumors.Immune checkpoint inhibitor-programmed cell death protein 1(PD-1)antibody opens a new era of immunotherapy for platinum-refractory recurrent/metastatic oral squamous cell carcinoma(OSCC).The overall survival of patients treated with immunological checkpoint inhibitors was significantly prolonged,and the overall incidence of grade 3-4 drug-related adverse events(AEs)occurred was lower;however,there are still some challenges to the PD-1’s application in OSCC clinic treatment.This article is just to briefly highlight the development of such application to date. | Yetao Wang Suying Qian Kesang Li | 2020 | Journal of Oncology Research2020，2，2： | 0 |
| 19 | Node Search Contributions Based Long-Term Follow-Up Specific Individual Searching Model显示文摘In this paper,we introduce a long-term follow-up specific individual searching(SIS)model.This model introduces the concept of node search contributions by considering the characteristics of the network structure.A node search contribution indicates the ability of a certain node to correctly guide the search path and successfully complete an SIS.The influencing factors of node search contributions have three components:the individual influence index,attribute similarity,and node search willingness.On the basis of node search contributions and the PeopleRank idea,this paper proposes an SIS model based on node search contribution values and conducts comparison experiments with several mainstream SIS algorithms in three aspects:the search failure rate,the minimum number of search hops,and the search size.The experimental results verify the advanced nature and operability of the model proposed in this paper,which presents theoretical and practical significance to the quantitative study of the SIS process. | Yayong Shi Fei Chang Yetao Sun Guangcheng Yang Rui Wang Yuan Yao | 2023 | Tsinghua Science and Technology2023，28，4： | 0 |
| 20 | The acid dissolution characteristics of cadmium fixed by a novel Ca-Fe-Si composite material显示文摘Ca-Fe-Si material(CIS),a novel composite material rich in calcium,iron,manganese and silicon showed marvelous immobilization properties for heavy metal(loid)s in soils.To elucidate the acid stability of Cd fixed by CIS(CIS-Cd)and the underlying immobilizationmechanisms,the acid dissolution characteristics of CIS-Cdwere investigated by using acid titration method and X-ray diffraction(XRD)technique.The results showed that CIS-Cd had distinctive acid buffering capacity in different pH ranges.Based on the titration curve between dissolution rate of CIS-Cd and pH,CIS-Cd can be divided into non acid-stable Cd(9.4%),moderately acid-stable Cd(22.5%)and acid-stable Cd(68.1%).XRD analysis of CIS-Cd at different pH intervals and the correlation curves of dissolution rates of Cd and concomitant elements indicated that non acid-stable Cdwas mainly bound by carbonate,silicate and sulfate(CdCO_(3),Cd_(2)SiO_(4) and CdSO_(4))or co-precipitated with the corresponding calcium salts.Moderately acid-stable Cd was mainly bound by magnesium-aluminum-silicon containing minerals or electrically bound bymanganese iron minerals.Acid-stable Cd remaining undissolved at pH<2.42 included CdFe_(2)O_(4) and ferromanganese minerals strongly bound Cd.It was by multilateral fixation mechanisms that Ca-Fe-Si material possessed marvelous immobilization capability for Cd and strong resilience to environmental acidification as well.The findings implicated that proper combination of calcium-iron-silicon containing minerals could develop novel promising amendments with high efficiency in heavy metal(loid)s immobilization and strong resilience to environmental change. | Aijun Yao Xiang Guo Man Zhao Shizhong Wang Yetao Tang Rongliang Qiu | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
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