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| 1 | Vascular complications following liver transplantation:Aliterature review of advances in 2015显示文摘Although vascular complications(VCs) following orthotopic liver transplantation(OLT) seldom occur, they are the most feared complications with a high incidence of both graft loss and mortality, as they compromise the blood flow of the transplant(either inflow or outflow). Diagnosis and therapeutic management of VCs constitute a major challenge in terms of increasing the success rate of liver transplantation. While surgical treatment used to be considered the first choice for management, advances in endovascular intervention have increased to make this a viable therapeutic option. Considering VC as a rare but a major and dreadful issue in OLT history, and in view of the continuing and rapid progress in recent years, an update on these uncommon conditions seemed necessary. In this sense, this review comprehensively discusses the important features(epidemiological, clinical, paraclinical, prognostic and therapeutic) of VCs following OLT. | Tullio Piardi Martin Lhuaire Onorina Bruno Riccardo Memeo Patrick Pessaux Reza Kianmanesh DanieleSommacale | 2016 | World Journal of Hepatology2016，8，1： | 20 |
| 2 | Functional Characterization and RNAi-Mediated Suppression Reveals Roles for Hexose Transporters in Sugar Accumulation by Tomato Fruit显示文摘Hexoses 积累到高集中(200 ? 公里) 在西红柿的存储实质房间水果。Hexoses 作为进口韧皮部的蔗糖的水解作用产品从水果 apoplasm 被采购。三 hexose transporters (LeHT1, LeHT2, LeHT3 ) ,在水果存储实质房间表示了,可以由这些房间贡献 hexose 举起。他们的全身的序列的分析证明所有三 transporters 属于 monosaccharide transporters 的 STP 亚科本地化到血浆膜。LeHT1 的 Heterologous 表示(并且以前 LeHT2,齿轮等, 2000 ) ,然而并非 LeHT3,救了 hexose 损害运输的酵母异种当在葡萄糖上涨了时或象唯一的碳来源果糖。生物化学地, LeHT1,同样到 LeHT2,与高亲密关系的 glucose/H+ symporter 一致的展出运输性质。显著地, LeHT1 和 LeHT2 也与水果纸巾的与那些同量的明显的 Km 价值作为低亲密关系的 fructose/H+ symporters 工作了。在所有 LeHT 基因由的水果表示层次的实质的减小(8090%)调停 RNAi 击倒在水果 hexose 累积引起了 55% 减少。相反,由来源叶子的 photoassimilate 生产和到水果的韧皮部运输能力由 transporter 是未受影响的击倒。一起,这些调查结果证明 LeHTs 玩在在西红柿水果开发期间驾驶 hexoses 的累积进存储实质房间给角色调音。 | David W. McCurdy Stephen Dibley Ricky Cahyanegara Antony Martin John W. Patrick | 2010 | Molecular Plant2010，3，6： | 7 |
| 3 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 4 | 全科医学科研的范畴、研究需求和适用方法——《欧洲全科医学/家庭医学和基本医疗保健科研纲要》中文摘译显示文摘本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对欧洲的全科医学学科和科研发展产生了深远的影响。欧洲的全科医学体系和以此为基础而构建的学科理论共识与我国全科医学当前的实际情况可能更为接近。因篇幅所限,本文刊登了其中最重要,对中国研究者也最实用的5部分内容,包括:(1)导言——全科医学的核心能力/特征以及全科医学科研的意义;(2)结果——全科医学的6个核心领域(基本保健管理、'以人为本'的照护、解决具体问题的技能、综合的方法、以社区为导向、整体的方法)的科研范畴,研究需求和适用方法;(3)独立章节——如何发展基本的科研能力和避免常见的科研失误;(4)讨论——未来的全科医学科研重点;(5)启示——科学协会、研究机构、患者参与、科研工作、期刊、科研政策在发展学科方面应注重的问题。因欧洲的全科医学体制和我国较为相似,且存在一定的科研发展代差,该文件在当前阶段也可为我国全科医学研究者所用,基于全科医学学科的视角,从概念、分类学、范围和科研方法等方面,为我国全科医学科研的发展提供参照。 | Eva Hummers-Pradier Martin Beyer Patrick Chevallier Sophia Eilat-Tsanani Christos Lionis Lieve Peremans Davorina Petek Imre Rurik Jean Karl Soler Henri E.J.H.Stoffers Pinar Topsever Mehmet Ungan Paul van Royen Hanny Prick 无 | 2022 | 中国全科医学2022，25，9： | 4 |
| 5 | GOBO projection for 3D measurements at highest frame rates: a performance analysis显示文摘Aperiodic sinusoidal patterns that are cast by a GOBO(GOes Before Optics)projector are a powerful tool for optically measuring the surface topography of moving or deforming objects with very high speed and accuracy.We optimised the first experimental setup that we were able to measure inflating car airbags at frame rates of more than 50 kHz while achieving a 3D point standard deviation of~500μm.Here,we theoretically investigate the method of GOBO projection of aperiodic sinusoidal fringes.In a simulation-based performance analysis,we examine the parameters that influence the accuracy of the measurement result and identify an optimal pattern design that yields the highest measurement accuracy.We compare the results with those that were obtained via GOBO projection of phase-shifted sinusoidal fringes.Finally,we experimentally verify the theoretical findings.We show that the proposed technique has several advantages over conventional fringe projection techniques,as the easy-to-build and cost-effective GOBO projector can provide a high radiant flux,allows high frame rates,and can be used over a wide spectral range. | Stefan Heist Patrick Dietrich Martin Landmann Peter Kühmstedt Gunther Notni Andreas Tünnermann | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 6 | Cabozantinib in Progressive Medullary Thyroid Cancer显示文摘 | Rossella Elisei Martin J. Schlumberger Stefan P. Müller Patrick Sch?ffski Marcia S. Brose Manisha H. Shah Lisa Licitra Barbara Jarzab Viktor Medvedev Michael C. Kreissl Bruno Niederle Ezra E.W. Cohen Lori J. Wirth Haythem Ali Colin Hessel Yifah Yaron Doug | 2013 | Journal of Clinical Oncology2013，，29： | 3 |
| 7 | HB sAg quantification: useful for monitoring natural history and treatment outcome显示文摘 | Michelle Martinot‐Peignoux Martine Lapalus Tarik Asselah Patrick Marcellin | 2014 | Liver Int2014，，： | 3 |
| 8 | The diagnostic odds ratio: a single indicator of test performance显示文摘 | Afina S. Glas Jeroen G. Lijmer Martin H. Prins Gouke J. Bonsel Patrick M.M. Bossuyt | 2003 | Journal of Clinical Epidemiology2003，，11： | 3 |
| 9 | Evaluation of Weather Research and Forecasting Model Parameterizations under Sea-Breeze Conditions in a North Sea Coastal Environment显示文摘Three atmospheric boundary layer(ABL) schemes and two land surface models that are used in the Weather Research and Forecasting(WRF) model, version 3.4.1, were evaluated with numerical simulations by using data from the north coast of France(Dunkerque). The ABL schemes YSU(Yonsei University),ACM2(Asymmetric Convective Model version 2), and MYJ(Mellor–Yamada–Janjic) were combined with two land surface models, Noah and RUC(Rapid Update Cycle), in order to determine the performances under sea-breeze conditions. Particular attention is given in the determination of the thermal internal boundary layer(TIBL), which is very important in air pollution scenarios. The other physics parameterizations used in the model were consistent for all simulations. The predictions of the sea-breeze dynamics output from the WRF model were compared with observations taken from sonic detection and ranging, light detection and ranging systems and a meteorological surface station to verify that the model had reasonable accuracy in predicting the behavior of local circulations. The temporal comparisons of the vertical and horizontal wind speeds and wind directions predicted by the WRF model showed that all runs detected the passage of the sea-breeze front. However, except for the combination of MYJ and Noah, all runs had a time delay compared with the frontal passage measured by the instruments. The proposed study shows that the synoptic wind attenuated the intensity and penetration of the sea breeze. This provided changes in the vertical mixing in a short period of time and on soil temperature that could not be detected by the WRF model simulations with the computational grid used. Additionally, among the tested schemes, the combination of the localclosure MYJ scheme with the land surface Noah scheme was able to produce the most accurate ABL height compared with observations, and it was also able to capture the TIBL. | SALVADOR Nadir REIS Jr. Neyval Costa SANTOS Jane Meri ALBUQUERQUE Taciana Toledo de Almeida LORIATO Ayres Geraldo DELBARRE Herve AUGUSTIN Patrick SOKOLOV Anton MOREIRA Davidson Martins | 2016 | Journal of Meteorological Research2016，30，6： | 3 |
| 10 | Immune profiling and cancer post transplantation显示文摘Half of all long-term(> 10 year) australian kidney transplant recipients(KTR) will develop squamous cell carcinoma(SCC) or solid organ cancer(SOC), making cancer the leading cause of death with a functioning graft. At least 30% of KTR with a history of SCC or SOC will develop a subsequent SCC orSOC lesion. Pharmacological immunosuppression is a major contributor of the increased risk of cancer for KTR, with the cancer lesions themselves further adding to systemic immunosuppression and could explain, in part, these phenomena. Immune profiling includes; measuring immunosuppressive drug levels and pharmacokinetics, enumerating leucocytes and leucocyte subsets as well as testing leucocyte function in either an antigen specific or non-specific manner. Outputs can vary from assay to assay according to methods used. In this review we define the rationale behind post-transplant immune monitoring assays and focus on assays that associate and/or have the ability to predict cancer and rejection in the KTR. We find that immune monitoring can identify those KTR of developing multiple SCC lesions and provide evidence they may benefit from pharmacological immunosuppressive drug dose reductions. In these KTR risk of rejection needs to be assessed to determine if reduction of immunosuppression will not harm the graft. | Christopher Martin Hope Patrick Toby H Coates Robert Peter Carroll | 2015 | World Journal of Nephrology2015，4，1： | 3 |
| 11 | C-Reactive Protein Elevation in Patients With Atrial Arrhythmias: Inflammatory Mechanisms and Persistence of Atrial Fibrillation显示文摘 | Mina K. Chung David O. Martin Dennis Sprecher Oussama Wazni Anne Kanderian Cynthia A. Carnes John A. Bauer Patrick J. Tchou Mark J. Niebauer Andrea Natale David R. Van Wagoner | 2001 | Circulation: Journal of the American Heart Association2001，，24： | 3 |
| 12 | Development of new electromagnetic suspension-based high-speed Maglev vehicles in China:Historical and recent progress in the field of dynamical simulation显示文摘High-speed Maglev is a cutting-edge technology brought back into the focus of research by plans of the Chinese government for the development of a new 600 km/h Maglev train.A Chinese‐German cooperation with industrial and academic partners has been established to pursue this ambitious goal and bring together experts from multiple disciplines.This contribution presents the joint work and achievements of CRRC Qingdao Sifang,thyssenkrupp Transrapid,CDFEB,and the ITM of the University of Stuttgart,regarding research and development in the field of high‐speed Maglev systems.Furthermore,an overview is given of the historical development of the Transrapid in Germany,the associated development of dynamical simulation models,and recent developments regarding high-speed Maglev trains in China. | Sansan Ding Peter Eberhard Georg Schneider Patrick Schmid Arnim Kargl Yong Cui Ullrich Martin Xin Liang Chao Huang Markus Bauer Florian Dignath Qinghua Zheng | 2023 | International Journal of Mechanical System Dynamics2023，3，2： | 3 |
| 13 | Long-term maintenance effect of radiofrequency energy delivery for refractory GERD: a decade later显示文摘 | Mark Noar Patrick Squires Emmanuelle Noar Martin Lee | 2014 | Surgical Endoscopy2014，，8： | 2 |
| 14 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 15 | Adaptive optics in laser processing显示文摘Adaptive optics are becoming a valuable tool for laser processing,providing enhanced functionality and flexibility for a range of systems.Using a single adaptive element,it is possible to correct for aberrations introduced when focusing inside the workpiece,tailor the focal intensity distribution for the particular fabrication task and/or provide parallelisation to reduce processing times.This is particularly promising for applications using ultrafast lasers for threedimensional fabrication.We review recent developments in adaptive laser processing,including methods and applications,before discussing prospects for the future. | Patrick S.Salter Martin J.Booth | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 16 | Architecting Fault Tolerance with Exception Handling: Verification and Validation显示文摘When building dependable systems by integrating untrusted software components that were not originally designed to interact with each other, it is likely the occurrence of architectural mismatches related to assumptions in their failure behaviour. These mismatches, if not prevented during system design, have to be tolerated during runtime. This paper presents an architectural abstraction based on exception handling for structuring fault-tolerant software systems. This abstraction comprises several components and connectors that promote an existing untrusted software element into an idealised fault-tolerant architectural element. Moreover, it is considered in the context of a rigorous software development approach based on formal methods for representing the structure and behaviour of the software architecture. The proposed approach relies on a formal specification and verification for analysing exception propagation, and verifying important dependability properties, such as deadlock freedom, and scenarios of architectural reconfiguration. The formal models are automatically generated using model transformation from UML diagrams: component diagram representing the system structure, and sequence diagrams representing the system behaviour. Finally, the formal models are also used for generating unit and integration test cases that are used for assessing the correctness of the source code. The feasibility of the proposed architectural approach was evaluated on an embedded critical case study. | Patrick H. S. Brito Rogério de Lemos Cecília M. F. Rubira Eliane Martins | 2009 | Journal of Computer Science & Technology2009，24，2： | 2 |
| 17 | The role of HBsAg quantification for monitoring natural history and treatment outcome显示文摘 | Michelle Martinot‐Peignoux Martine Lapalus Tarik Asselah Patrick Marcellin | 2013 | Liver Int2013，，： | 2 |
| 18 | Two-Year Outcomes After Sirolimus-Eluting Stent Implantation显示文摘 | Giora Weisz Martin B. Leon David R. Holmes Dean J. Kereiakes Mel R. Clark Barry M. Cohen Stephen G. Ellis Patrick Coleman Carolyn Hill Chunxue Shi Donald E. Cutlip Richard E. Kuntz Jeffrey W. Moses | 2006 | Journal of the American College of Cardiology2006，，7： | 2 |
| 19 | Revealing complex optical phenomena through vectorial metrics显示文摘Advances in vectorial polarization-resolved imaging are bringing new capabilities to applications ranging from fundamental physics through to clinical diagnosis.Imaging polarimetry requires determination of the Mueller matrix(MM)at every point,providing a complete description of an object’s vectorial properties.Despite forming a comprehensive representation,the MM does not usually provide easily interpretable information about the object’s internal structure.Certain simpler vectorial metrics are derived from subsets of the MM elements.These metrics permit extraction of signatures that provide direct indicators of hidden optical properties of complex systems,while featuring an intriguing asymmetry about what information can or cannot be inferred via these metrics.We harness such characteristics to reveal the spin Hall effect of light,infer microscopic structure within laser-written photonic waveguides,and conduct rapid pathological diagnosis through analysis of healthy and cancerous tissue.This provides new insight for the broader usage of such asymmetric inferred vectorial information. | Chao He Jintao Chang Patrick S.Salter Yuanxing Shen Ben Dai Pengcheng Li Yihan Jin Samlan Chandran Thodik Mengmeng Li Aziz Tariq Jingyu Wang Jacopo Antonello Yang Dong Ji Qi Jianyu Lin Daniel S.Elson Min Zhang Honghui He Hui Ma Martin J.Booth | 2022 | Advanced Photonics2022，4，2： | 2 |
| 20 | Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation显示文摘 | Ayman A. Hussein Walid I. Saliba David O. Martin Mazyar Shadman Mohamed Kanj Mandeep Bhargava Thomas Dresing Mina Chung Thomas Callahan Bryan Baranowski Patrick Tchou Bruce D. Lindsay Andrea Natale Oussama M. Wazni | 2011 | Circulation2011，，19： | 2 |
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