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| 1 | Thermal-responsive genetic and epigenetic regulation of DAM cluster controlling dormancy and chilling requirement in peach floral buds显示文摘The Dormancy-associated MADS-box(DAM)gene cluster in peach serves as a key regulatory hub on which the seasonal temperatures act and orchestrate dormancy onset and exit,chilling response and floral bud developmental pace.Yet,how different temperature regimes interact with and regulate the six linked DAM genes remains unclear.Here,we demonstrate that chilling downregulates DAM1 and DAM3–6 in dormant floral buds with distinct patterns and identify DAM4 as the most abundantly expressed one.We reveal multiple epigenetic events,with tri-methyl histone H3 lysine 27(H3K27me3)induced by chilling specifically in DAM1 and DAM5,a 21-nt sRNA in DAM3 and a ncRNA induced in DAM4.Such induction is inversely correlated with downregulation of their cognate DAMs.We also show that the six DAMs were hypermethylated,associating with the production of 24-nt sRNAs.Hence,the chilling-responsive dynamic of the different epigenetic elements and their interactions likely define distinct expression abundance and downregulation pattern of each DAM.We further show that the expression of the five DAMs remains steadily unchanged or continuously downregulated at the ensuing warm temperature after chilling,and this state of regulation correlates with robust increase of sRNA expression,H3K27me3 and CHH methylation,which is particularly pronounced in DAM4.Such robust increase of repressive epigenetic marks may irreversibly reinforce the chillingimposed repression of DAMs to ensure flower-developmental programming free from any residual DAM inhibition.Taken together,we reveal novel information about genetic and epigenetic regulation of the DAM cluster in peach,which will be of fundamental significance in understanding of the regulatory mechanisms underlying chilling requirement and dormancy release,and of practical application for improvement of plasticity of flower time and bud break in fruit trees to adapt changing climates. | Hong Zhu Pao-Yang Chen Silin Zhong Chris Dardick Ann Callahan Yong-Qiang An Steve van Knocker Yingzhen Yang Gan-Yuan Zhong Albert Abbott Zongrang Liu | 2020 | Horticulture Research2020，7，1： | 9 |
| 2 | Genetic characterization of worldwide Prunus domestica(plum)germplasm using sequence-based genotyping显示文摘Prunus domestica commonly known as European plum is a hexaploid fruit tree species cultivated around the world.Locally it is used for fresh consumption,in jams or jellies,and the production of spirits while commercially the fruit is primarily sold dried(prunes).Despite its agricultural importance and long history of cultivation,many questions remain about the origin of this species,the relationships among its many pomological types,and its underlying genetics.Here,we used a sequence-based genotyping approach to characterize worldwide plum germplasm including the potential progenitor Eurasian plum species.Analysis of 405 DNA samples established a set of four clades consistent with the pomological groups Greengages,Mirabelles,European plums,and d’Agen(French)prune plums.A number of cultivars from each clade were identified as likely clonal selections,particularly among the“French”type prune germplasm that is widely cultivated today.Overall,there was relatively low genetic diversity across all cultivated plums suggesting they have been largely inbred and/or derived from a limited number of founders.The results agree with P.domestica having originated as an interspecific hybrid of a diploid P.cerasifera and a tetraploid P.spinosa that itself may have been an interspecific hybrid of P.cerasifera and an unknown Eurasian plum species.The low genetic diversity and lack of true wild-types coupled with the known cultivation history of Eurasian plums imply that P.domestica may have been a product of inter-specific cross breeding and artificial selection by early agrarian Eurasian societies. | Tetyana Zhebentyayeva Vijay Shankar Ralph Scorza Ann Callahan Michel Ravelonandro Sarah Castro Theodore DeJong Christopher A.Saski Chris Dardick | 2019 | Horticulture Research2019，6，1： | 4 |
| 3 | 初级医疗机构中协同护理对阿尔茨海默病老年患者的疗效观察:一项随机对照试验显示文摘Context: Most older adults with dementia will be cared for by primary care physicians, but the primary care practice environment presents important challenges to providing quality care. Objective: To test the effectiveness of a collaborative care model to improve the quality of care for patients with Alzheimer disease. Design, Setting, and Patients: Controlled clinical trial of 153 older adults with Alzheimer disease and their caregivers who were randomized by physician to receive collaborative care management (n=84) or augmented usual care (n=69)-at primary care practices within 2 US university-affiliated health care systems from January 2002 through August 2004. Eligible patients (identified via screening or medical record) met diagnostic criteria for Alzheimer disease and had a self-identified caregiver. Intervention: Intervention patients received 1 year of care management by an interdisciplinary team led by an advanced practice nurse working with the patient’s family caregiver and integrated within primary care. The team used standard protocols to initiate treatment and identify, monitor, and treat behavioral and psychological symptoms of dementia, stressing nonpharmacological management. Main Outcome Measures: Neuropsychiatric Inventory (NPI)-administered at baseline and at 6, 12, and 18 months. Secondary outcomes included the Cornell Scale for Depression in Dementia (CSDD), cognition, activities of daily living, resource use, and caregiver’s depression severity. Results: Initiated by caregivers’reports, 89%of intervention patients triggered at least 1 protocol for behavioral and psychological symptoms of dementia with a mean of 4 per patient from a total of 8 possible protocols. Intervention patients were more likely to receive cholinesterase inhibitors (79.8%vs 55.1%; P=.002) and antidepressants (45.2%vs 27.5%; P= .03). Intervention patients had significantly fewer behavioral and psychological symptoms of dementia as measured by the total NPI score at 12 months (mean difference, -5.6; P= .01) and at 18 months (mean difference, -5.4; P=.01). Intervention caregivers also reported significant improvements in distress as measured by the caregiver NPI at 12 months; at 18 months, caregivers showed improvement in depression as measured by the Patient Health Questionnaire-9. No group differences were found on the CSDD, cognition, activities of daily living, or on rates of hospitalization, nursing home placement, or death. Conclusions: Collaborative care for the treatment of Alzheimer disease resulted in significant improvement in the quality of care and in behavioral and psychological symptoms of dementia among primary care patients and their caregivers. These improvements were achieved without significantly increasing the use of antipsychotics or sedative-hypnotics. Trial Registration: clinicaltrials.gov Identifier: NCT00246896. | Callahan C. M. Boustani M. A. Unverzagt F. W. 周永(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 3 |
| 4 | Immune Modulation in Cancer with Antibodies显示文摘 | David B. Page Michael A. Postow Margaret K. Callahan James P. Allison Jedd D. Wolchok | 2014 | Annual Review of Medicine2014，，： | 2 |
| 5 | Effects of Intense Low-Density Lipoprotein Cholesterol Reduction in Patients With Stroke or Transient Ischemic Attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial显示文摘 | Pierre Amarenco Larry B. Goldstein Michael Szarek Henrik Sillesen Amy E. Rudolph Alfred Callahan Michael Hennerici Lisa Simunovic Justin A. Zivin K Michael A. Welch | 2007 | Stroke2007，，： | 2 |
| 6 | 儿科PET/CT的操作和剂量学显示文摘在儿科PET/CT诊疗领域,迄今还没有统一的CT扫描方法的指南。考虑到儿童更易受电离辐射的影响,在最短时间内和最小暴露剂量条件下提供具有诊断质量的图像十分必要。该文描述了CT辐射剂量测定以及儿童PET/CT采集的基本要点。根据对北美19所儿科PET/CT机构的调查,描述了儿科PET/CT技术的多样性。调查结果表明,尽管大多数机构采用自动管电流调制,但在实际应用中各机构间仍存在2~3倍的差异,这说明需要统一的指南。该文介绍了作者所在机构研发的多序列PET/CT采集技术,此技术可以兼顾在重要部位视野内获得有诊断质量的CT图像,以及在其余部位应用低辐射技术进行显像。这种方法使患者所受辐射剂量减少,同时将PET和具有诊断质量的CT集成在单次采集中。儿科PET/CT的标准化在保证适中水平的图像质量的同时,为患者提供了减少辐射剂量的机会。 | 王宽垠(译) 刘振(译) 兰晓莉(审校) Frederic H. Fahey Alison Goodkind Robert D. MacDougall Leah Oberg Sonja I.Ziniel Richard Cappock Michael J. Callahan Neha Kwatra S. Ted Treves Stephan D. Voss | 2019 | 中华核医学与分子影像杂志2019，39，5： | 2 |
| 7 | Perioperative Use of Dexmedetomidine Is Associated With Decreased Incidence of Ventricular and Supraventricular Tachyarrhythmias After Congenital Cardiac Operations显示文摘 | Constantinos Chrysostomou Joan Sanchez-de-Toledo Peter Wearden Edmund H. Jooste Steven E. Lichtenstein Patrick M. Callahan Tunga Suresh Elizabeth O’Malley Dana Shiderly Jamie Haney Masahiro Yoshida Richard Orr Ricardo Munoz Victor O. Morell | 2011 | The Annals of Thoracic Surgery2011，，3： | 2 |
| 8 | Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation显示文摘 | Ayman A. Hussein Walid I. Saliba David O. Martin Mazyar Shadman Mohamed Kanj Mandeep Bhargava Thomas Dresing Mina Chung Thomas Callahan Bryan Baranowski Patrick Tchou Bruce D. Lindsay Andrea Natale Oussama M. Wazni | 2011 | Circulation2011，，19： | 2 |
| 9 | Detection of U S, Lelystad, and European-Like porcine reproductive and respiratory syndrome viruses and relative quantitation in boar semen and serum samples by real-time PCR 显示文摘 | Wasilk A Callahan J D Christopher-Hennings J | 2004 | Journal of Clinical Microbiology2004，42，10： | 1 |
| 10 | Selective glucoeorticoid control of Rho kinase isoforms regulate cell-cell interactions 显示文摘 | Rubenstein N M Callahan J A Lo D H | 2007 | Biochem Biophys Res Commun2007，354，2： | 1 |
| 11 | Hemivertebral excision for congenital scoliosis显示文摘 | Georgopoulos G Eilert RE | 1997 | J Pediatr Orthop1997，17，1： | 1 |
| 12 | The Profession:Public Intrests andCommom Good显示文摘 | Bruce J Callahan D Wolf S M | 1987 | Hasting Center Report1987，，： | 1 |
| 13 | Bacterial roles in the forma- tion of high molecular weight dissolved organic matter in estuarine and coastal waters: Evidence from lipids and the compound-specificisotopic ratios 显示文摘 | Zou L Wang X C Callahan J | 2004 | Limnology and Oceanography2004，49，1： | 1 |
| 14 | Phenotypic and molecular evaluation of cotton hairy roots as a model system for studying nematode resistance 显示文摘 | MARTIN J WUBBEN F E CALLAHAN B A | 2009 | Plant Cell Reports2009，28，： | 1 |
| 15 | Severe functional de- clines, work disability, and increased mortality in seventy - fiverheumatoid arthritis patients studied over nine years 显示文摘 | Pincus T Callahan LF Sale WG | 1984 | Arthritis Rheum1984，27，8： | 1 |
| 16 | High-dose atorvastatin after stroke or transient ischemic attack显示文摘 | Amarenco P Bogousslavsky J Callahan A 3rd | | the New England Journal of Medicine0，，： | 1 |
| 17 | Serial morphology as a technique for deter- mination of reproductive patterns in the corn earworm, Heliothis zea显示文摘 | Callahan P S | 1958 | Annals of the Entomological Society of America1958，51，： | 1 |
| 18 | High-dose atorvastatin after stroke or transient isehemic attack显示文摘 | Amarenco P Bogousslavsky J Callahan AR | 2006 | N Engl J Med2006，355，6： | 1 |
| 19 | PEGylation of a vesicular stomatitis virus G pseudotyped lentivirus vector prevents inactivation in serum显示文摘 | Croyle MA Callahan SM Auricchio A | | 0，，： | 1 |
| 20 | Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells显示文摘 | Pei S Minhajuddin M Callahan KP | | 0，，47： | 1 |
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