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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice显示文摘Most of the important agronomic traits in crop plants,such as yield,quality and stress response,are quantitative and jointly controlled by many genomic loci or major genes.Improving these complex traits depends on the combination of beneficial alleles at the quantitative trait loci(QTLs).However,the conventional cross breeding method is extremely time-consuming and laborious for pyramiding multiple QTLs.In certain cases,this approach | Rongfang Xu Yachun Yang Ruiying Qin Hao Li Chunhong Qiu Li Li Pengcheng Wei Jianbo Yang | 2016 | Journal of Genetics and Genomics2016，43，8： | 47 |
| 3 | Features and Formation Mechanism of Faults and Potash-forming Effect in the Lop Nur Salt Lake,Xinjiang,China显示文摘The Lop Nur Salt Lake, located in the eastern part of the Tarim Basin, Xinjiang, China, has become a playa in the Quaternary. Rhombic in shape, the Lop Nur depression is mainly controlled by the NE-striking and nearly N-S-striking sets of faults. Since 1995, a superlarge brine potash deposit with potash resources of 2.50×108 t has been found in the Luobei subbasin in the northeastern part of the Lop Nur. We intensively studied the features and formation mechanism of faults inside the Lop Nur through satellite images, geomorphologic survey and continuous conductivity imaging and found seven subparallel graben faults formed under the action of nearly N 10o E principal compressional stress during deposition of the Lop Nur Salt Lake. These faults are up to >60 km long and 1–4 km wide and may extend downward for 1000 m or more. It is just under the action of these tensional faults that potash subbasins formed. The largest subbasin is the Luobei subbasin and the smaller ones are the Luoxi hollow, Erbei hollow and Tienan hollow. Investigation also indicates that the graben faults in the Lop Nur not only control the origin of the potash subbasins, but they themselves are also good brine reservoir structures, in which abundant potash-rich brines are stored. Therefore, The faults had played an important role in the potash formation of the Lop Nur. | LIU Chenglin WANG Mili JIAO Pengcheng LI Shude CHEN Yongzhi | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 33 |
| 4 | Overexpression of the tonoplast aquaporin AtTIP5;1 conferred tolerance to boron toxicity in Arabidopsis显示文摘Boron (B) toxicity to plants is responsible for low crop productivity in many regions of the world. Here we report a novel and effective means to alleviate the B toxicity to plants under high B circumstance. Functional characterization of AtTIP5;1, an aquaporin gene, re-vealed that overexpression of AtTIP5;1 (OxAtTIP5;1) in Arabidopsis significantly increased its tolerance to high B toxicity. Compared to wild-type plants, OxAtTIP5;1 plants exhibited longer hypocotyls, accelerated development, increased silique production under high B treatments. GUS staining and quantitative RT-PCR (qRT-PCR) results demonstrated that the expression of AtTIP5;1 was induced by high B concentration treatment. Subcellular localization analysis revealed that the AtTIP5;1-GFP fusion protein was localized on the tonoplast membrane, which was consistent with the prediction based on bioinformatics. Taken together, our results suggest that AtTIP5;1 is in-volved in B transport pathway possibly via vacuolar compartmentation for B, and that overexpression of AtTIP5;1 in plants may provide an effective way to overcome the problem resulting from high B concentration toxicity. | Yongqi Pang, Lijuan Li, Fei Ren, Pingli Lu, Pengcheng Wei, Jinghui Cai, Lingguo Xin, Juan Zhang, Jia Chen, Xuechen Wang State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China | 2010 | Journal of Genetics and Genomics2010，37，6： | 11 |
| 5 | Robust MVDR beamforming based on covariance matrix reconstruction显示文摘The minimum variance distortionless response(MVDR) beamformer has better resolution and much better interference rejection capability than the data-independent beamformers.However,the former is more sensitive to errors,such as the steering vector errors caused by direction of arrival mismatch,imprecise array calibration or any other possible factors,especially in the case of high signal-to-noise ratio(SNR).A new robust MVDR beamformer against the general steering vector errors is proposed in this paper.This method is based on the reconstruction of the covariance matrix which aims to reduce the power of the signal of interest(SOI) in the covariance matrix.The eigenanalysis is used in the process of removing the SOI component and modifying the residual covariance matrix.Simulation results show that the proposed method has excellent signal-to-interference-plus-noise ratio(SINR) performance under the mismatch condition. | MU PengCheng LI Dan YIN QinYe GUO Wei | 2013 | Science China(Information Sciences)2013，56，4： | 11 |
| 6 | Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals显示文摘尽管 myocyte 房间移植研究为心肌的梗塞建议了一个有希望的治疗学的潜力,到为心肌的修理的临床的治疗的发展的一个主要障碍是与为移植获得相对同类的室的 myocytes 联系的困难。人的胚胎的干细胞(hESCs ) 是 cardiomyocytes 的有希望的来源。这里,我们报导发信号的 retinoid 在 hESCs 的心脏的区别期间调整 atrial 对室的 myocytes 的命运说明。我们发现少量和 pan-retinoic 酸受体对手 BMS-189453 (RAi ) 显著地增加了 hESCs 的心脏的区别效率。为了调查 retinoid,工作,我们把对待 Noggin+RAi 的文化与对待 Noggin+RA 的文化作比较。我们的结果证明室特定的基因 IRX-4 的表示层次极端地在对待 Noggin+RAi 的文化被提高。MLC-2V,另一个室特定的标记,在对待 Noggin+RAi 的文化,然而并非在对待 Noggin+RA 的文化的 cardiomyocytes 在 cardiomyocytes 的多数被表示。流动 cytometry 分析和 electrophysiological 研究与 64.7 | Qiangzhe Zhang Junjie Jiang Pengcheng Han Qi Yuan Jing Zhang Xiaoqian Zhang Yanyan Xu Henghua Cao Qingzhang Meng Li Chen Tian Tian Xin Wang Pu Li Jurgen Hescheler Guangju Ji Yue Ma | 2011 | Cell Research2011，21，4： | 10 |
| 7 | Comparisons of microstructure homogeneity,texture and mechanical properties of AZ80 magnesium alloy fabricated by annular channel angular extrusion and backward extrusion显示文摘This paper provided an efficient single pass severe plastic deformation(SPD)method,annular channel angular extrusion(ACAE),for fabricating AZ80 magnesium alloy shell part.The effect of ACAE process on the microstructure homogeneity,texture,and mechanical properties of extruded part was experimentally investigated.For comparison,conventional backward extrusion(BE)was also conducted on processing AZ80 part with same specification.The results showed that ACAE process has a better capacity to refine the microstructure and dramatic improve the deformation homogeneity of the extruded part than BE process.Due to two strong shear deformations were implemented,ACAE process could also concurrently modify the basal texture more notably than BE process.In particular,a bimodal texture was found in ACAE extruded part,which was greatly related to the enhanced synergetic action of basal slip and secondaryslip caused by the effective shear stress.More uniform and superior hardness along the thickness and height of part were achieved via ACAE process.Further surveying of tensile tests also showed that the part fabricated by ACAE process exhibited significantly higher and far more homogeneous tensile properties with an excellent balance of strength and ductility.The remarkable enhanced tensile properties of ACAE extruded part could be primarily attributed to the significant grain refinement,which provided a powerful grain boundary strengthening effect and meaningfully suppressed the development of twin-sized cracks during tensile deformation.It was established that ACAE process seemed to be a very promising single pass SPD method for manufacturing Mg-based alloy shell parts with more homogeneous microstructure and superior performance. | Xi Zhao Shuchang Li Zhimin Zhang Pengcheng Gao Shuailing Kan Fafa Yan | 2020 | Journal of Magnesium and Alloys2020，8，3： | 10 |
| 8 | Development of Plant Prime-Editing Systems for Precise Genome Editing显示文摘Prime-editing systems have the capability to perform efficient and precise genome editing in human cells.In this study,we first developed a plant prime editor 2(pPE2)system and test its activity by generating a targeted mutation on an HPT^(-ATG) reporter in rice.Our results showed that the pPE2 system could induce programmable editing at different genome sites.In transgenic T0 plants,pPE2-generated mutants occurred with 0%–31.3%frequency,suggesting that the efficiency of pPE2 varied greatly at different genomic sites and with prime-editing guide RNAs of diverse structures.To optimize editing efficiency,guide RNAs were introduced into the pPE2 system following the PE3 and PE3b strategy in human cells.However,at the genomic sites tested in this study,pPE3 systems generated only comparable or even lower editing frequencies.Furthemore,we developed a surrogate pPE2 system by incorporating the HPT^(-ATG) reporter to enrich the prime-edited cells.The nucleotide editing was easily detected in the resistant calli transformed with the surrogate pPE2 system,presumably due to the enhanced screening efficiency of edited cells.Taken together,our results indicate that plant prime-editing systems we developed could provide versatile and flexible editing in rice genome. | Rongfang Xu Juan Li Xiaoshuang Liu Tiaofeng Shan Ruiying Qin Pengcheng Wei | 2020 | Plant Communications2020，1，3： | 10 |
| 9 | Determination of optimal samples for robot calibration based on error similarity显示文摘Industrial robots are used for automatic drilling and riveting.The absolute position accuracy of an industrial robot is one of the key performance indexes in aircraft assembly,and can be improved through error compensation to meet aircraft assembly requirements.The achievable accuracy and the difficulty of accuracy compensation implementation are closely related to the choice of sampling points.Therefore,based on the error similarity error compensation method,a method for choosing sampling points on a uniform grid is proposed.A simulation is conducted to analyze the influence of the sample point locations on error compensation.In addition,the grid steps of the sampling points are optimized using a statistical analysis method.The method is used to generate grids and optimize the grid steps of a Kuka KR-210 robot.The experimental results show that the method for planning sampling data can be used to effectively optimize the sampling grid.After error compensation,the position accuracy of the robot meets the position accuracy requirements. | Tian Wei Mei Dongqi Li Pengcheng Zeng Yuanfan Hong Peng Zhou Wei | 2015 | Chinese Journal of Aeronautics2015，28，3： | 10 |
| 10 | LMM5.1 and LMM5.4,two eukaryotic translation elongation factor 1Alike gene family members,negatively affect cell death and disease resistance in rice显示文摘Lesion mimic mutant(LMM) genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae(Xoo) by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A(e EF1A)-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice. | Jiying Zhao Pengcheng Liu Chunrong Li Yanyan Wang Lequn Guo Guanghuai Jiang Wenxue Zhai | 2017 | Journal of Genetics and Genomics2017，44，2： | 10 |
| 11 | Plate tectonic control on the formation and tectonic migration of Cenozoic basins in northern margin of the South China Sea显示文摘The tectonic evolution history of the South China Sea(SCS) is important for understanding the interaction between the Pacific Tectonic Domain and the Tethyan Tectonic Domain,as well as the regional tectonics and geodynamics during the multi-plate convergence in the Cenozoic.Several Cenozoic basins formed in the northern margin of the SCS,which preserve the sedimentary tectonic records of the opening of the SCS.Due to the spatial non-uniformity among different basins,a systematic study on the various basins in the northern margin of the SCS constituting the Northern Cenozoic Basin Group(NCBG) is essential.Here we present results from a detailed evaluation of the spatial-temporal migration of the boundary faults and primary unconformities to unravel the mechanism of formation of the NCBG.The NCBG is composed of the Beibu Gulf Basin(BBGB),Qiongdongnan Basin(QDNB),Pearl River Mouth Basin(PRMB) and Taixinan Basin(TXNB).Based on seismic profiles and gravity-magnetic anomalies,we confirm that the NE-striking onshore boundary faults propagated into the northern margin of the SCS.Combining the fault slip rate,fault combination and a comparison of the unconformities in different basins,we identify NE-striking rift composed of two-stage rifting events in the NCBG:an early-stage rifting(from the Paleocene to the Early Oligocene) and a late-stage rifting(from the Late Eocene to the beginning of the Miocene).Spatially only the late-stage faults occurs in the western part of the NCBG(the BBGB,the QDNB and the western PRMB),but the early-stage rifting is distributed in the whole NCBG.Temporally,the early-stage rifting can be subdivided into three phases which show an eastward migration,resulting in the same trend of the primary unconformities and peak faulting within the NCBG.The late-stage rifting is subdivided into two phases,which took place simultaneously in different basins.The first and second phase of the early-stage rifting is related to back-arc extension of the Pacific subduction retreat system.The third phase of the earlystage rifting resulted from the joint effect of slab-pull force due to southward subduction of the proto-SCS and the back-arc extension of the Pacific subduction retreat system.In addition,the first phase of the late-stage faulting corresponds with the combined effect of the post-collision extension along the Red River Fault and slab-pull force of the proto-SCS subduction.The second phase of the late-stage faulting fits well with the sinistral faulting of the Red River Fault in response to the Indochina Block escape tectonics and the slab-pull force of the proto-SCS. | Pengcheng Wang Sanzhong Li Yanhui Suo Lingli Guo Guangzeng Wang Gege Hui M.Santosh Ian D.Somerville Xianzhi Cao Yang Li | 2020 | Geoscience Frontiers2020，11，4： | 10 |
| 12 | The active principle region of Buyang Huanwu decoction induced differentiation of bone marrow-derived mesenchymal stem cells into neural-like cells Superior effects over original formula of Buyang Huanwu decoction显示文摘The present study induced in vitro-cultured passage 4 bone marrow-derived mesenchymal stem cells to differentiate into neural-like cells with a mixture of alkaloid, polysaccharide, aglycone, glycoside, essential oils, and effective components of Buyang Huanwu decoction (active principle region of decoction for invigorating yang for recuperation). After 28 days, nestin and neuron-specific enolase were expressed in the cytoplasm. Reverse transcription-PCR and western blot analyses showed that nestin and neuron-specific enolase mRNA and protein expression was greater in the active principle region group compared with the original formula group. Results demonstrated that the active principle region of Buyang Huanwu decoction induced greater differentiation of rat bone marrow-derived mesenchymal stem cells into neural-like cells in vitro than the original Buyang Huanwu decoction formula. | Jinghui Zheng Yi Wan Jianhuai Chi Dekai Shen Tingting Wu Weimin Li Pengcheng Du | 2012 | Neural Regeneration Research2012，7，4： | 9 |
| 13 | Use of genotype-environment interactions to elucidate the pattern of maize root plasticity to nitrogen deficiency显示文摘Maize(Zea mays L.) root morphology exhibits a high degree of phenotypic plasticity to nitrogen(N) de ficiency,but the underlying genetic architecture remains to be investigated Using an advanced BC_4F_3 population,we investigated the root growth plasticity under two contrasted N levels and identi fied the quantitative trait loci(QTLs) with QTL-environment(Q×E)interaction effects. Principal components analysis(PCA) on changes of root traits to N de ficiency(D LN-HN) showed that root length and biomass contributed for 45.8% in the same magnitude and direction on the first PC,while root traits scattered highly on PC_2 and PC_3. Hierarchical cluster analysis on traits for D LN-HN further assigned the BC_4F_3 lines into six groups,in which the special phenotypic responses to N de ficiency was presented These results revealed the complicated root plasticity of maize in response to N de ficiency that can be caused by genotype environment(G×E) interactions. Furthermore,QTL mapping using a multi-environment analysis identi fied 35 QTLs for root traits. Nine of these QTLs exhibited signi ficant Q×E interaction effects. Taken together,our findings contribute to understanding the phenotypic and genotypic pattern of root plasticity to N de ficiency,which will be useful for developing maize tolerance cultivars to N de ficiency. | Pengcheng Li Zhongjuan Zhuang Hongguang Cai Shuai Cheng Ayaz Ali Soomro Zhigang Liu Riliang Gu Guohua Mi Lixing Yuan Fanjun Chen | 2016 | Journal of Integrative Plant Biology2016，58，3： | 8 |
| 14 | Effects of Nitrogen Rate and Split Application Ratio on Nitrogen Use and Soil Nitrogen Balance in Cotton Fields显示文摘The Yellow River valley is one of the three largest cotton production areas in China.An experiment was performed in cotton fields of Anyang,China from 2013 to 2014 to investigate the effects of nitrogen(N) application rate and the ratio between basal and topdressing N fertilizer on N balance in a soil-plant system,N use efficiency,and cotton yield.Five N application rates as treatments were applied with the same split application ratio.Half of the N(50% basal fertilizer) was applied at pre-planting and the other half(50% topdressing fertilizer) at the initial flowering stage.These treatments were:zero N(N0,control),90 kg N ha^(-1)(N90(5/5)),180 kg N ha^(-1)(N180(5/5)),270 kg N ha^(-1)(N270(5/5),a reduced N rate),and 360 kg N ha^(-1)(N360(5/5),a conventional N rate).Additional 2 split application ratios as treatments were applied with the same N rate of 270 kg N ha^(-1).The split application ratios between basal N and topdressing N were 30%:70%(N270(3/7)) and 70%:30%(N270(7/3)).Results demonstrated that soil NH_4-N content in the 0–60 cm layer and NO3-N content in the 0–20 cm layer increased with increased N rate at the squaring and boll-opening stages and then decreased to lower levels at the initial flowering and harvest stages.Soil NO_3-N content in the 20–60 cm layer after the initial flowering stage increased with the increase of topdressing N rate.Soil apparent N surplus varied at different growth stages,while the soil apparent N surplus over the entire growth period exhibited a positive relationship at N rates over 180 kg ha^(-1).Seed cotton yield of N270(3/7) was the highest of all treatments.Plant N uptake,N agronomic efficiency,and apparent N recovery efficiency of N270(3/7) were significantly higher than those of N270(5/5) and N270(7/3) in both growing seasons.These suggest both economic and ecological benefits in cotton production in the Yellow River valley could be created,by appropriately reducing total N application rate and increasing the ratio of topdressing to basal N fertilizer at the initial flowering stage. | LI Pengcheng DONG Helin LIU Aizhong LIU Jingran SUN Miao LI Yabing LIU Shaodong ZHAO Xinhua MAO Shuchun | 2017 | Pedosphere2017，27，4： | 7 |
| 15 | Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma显示文摘Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma(HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C16-GNNQQNYKD-OH-based nanofibers as gelators and carriers for triptolide. Sustained triptolide release from the hydrogel was achieved over 14 days in vitro, with higher accumulation in and cytotoxicity against human HCC Bel-7402 in comparison with L-02 fetal hepatocytes. After intraperitoneal injection, the hydrogel showed prolonged retention over 13 days and preferential accumulation in the liver, realizing HCC growth inhibition by99.7 ± 0.1% and animal median survival extension from 19 to 43 days, without causing noticeable pathological changes in the major organs. These results demonstrate that injectable peptide hydrogel can be a potential carrier for localized chemotherapy of HCC. | Xiyue Zhao Xiaoyu Liu Pengcheng Zhang Yiran Liu Wei Ran Ying Cai Junyang Wang Yihui Zhai Guanru Wang Yaping Ding Yaping Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 7 |
| 16 | A Probabilistic View of Debris Flow显示文摘Most debris flows occur in valleys of area smaller than 50 km2. While associated with a valley, debris flow is by no means a full-valley event but originates from parts of the valley, i.e., the tributary sources. We propose that debris flow develops by extending from tributaries to the mainstream. The debris flow observed in the mainstream is the confluence of the tributary flows and the process of the confluence can be considered as a combination of the tributary elements. The frequency distribution of tributaries is found subject to the Weibull form (or its generalizations). And the same distribution form applies to the discharge of debris flow. Then the process of debris flow is related to the geometric structure of the valley. Moreover, viewed from a large scale of water system, all valleys are tributaries, which have been found to assume the same distribution. With each valley corresponding to a debris flow, the distribution can be taken as the frequency distribution of debris flow and therefore provides a quantitative description of the fact that debris flow is inclined to occur at valley of small size. Furthermore, different parameters appear in different regions, suggesting the regional differentials of debris flow potential. We can use the failure rate, instead of the size per se, to describe the risk of a valley of a given area. Finally we claim that the valleys of debris flow in different regions are in the similar episode of evolution. | LI Yong SU Pengcheng CUI Peng HU Kaiheng | 2008 | Journal of Mountain Science2008，5，2： | 7 |
| 17 | Oxymatrine reduces neuroinflammation in rat brain A signaling pathway显示文摘Cerebral neuroinflammation models were established by injecting 10 μg lipopolysaccharide into the hippocampus of male Sprague-Dawley rats. The rats were treated with an intraperitoneal injection of 120, 90, or 60 mg/kg oxymatrine daily for three days prior to the lipopolysaccharide injection. Twenty-four hours after model induction, the hippocampus was analyzed by real-time quantitative PCR, and the cerebral cortex was analyzed by enzyme-linked immunosorbent assay and western blot assay. The results of the enzyme-linked immunosorbent assay and the real-time quantitative PCR showed that the secretion and mRNA expression of the pro-inflammatory cytokines interleukin-1β and tumor necrosis factor-α were significantly decreased in the hippocampus and cerebral cortex of model rats treated with oxymatrine. Western blot assay and real-time quantitative PCR analysis indicated that toll-like receptor 4 mRNA and protein expression were significantly decreased in the groups receiving different doses of oxymatrine. Additionally, 120 and 90 mg/kg oxymatrine were shown to reduce protein levels of nuclear factor-κB p65 in the nucleus and of phosphorylated IκBα in the cytoplasm of brain cells, as detected by western blot assay. Experimental findings indicate that oxymatrine may inhibit neuroinflammation in rat brain via downregulating the expression of molecules in the toll-like receptor 4/nuclear factor-κB signaling pathway. | Jiahui Mao Yae Hu Ailing Zhou Bing Zheng Yi Liu Yueming Du Jia Li Jinyang Lu Pengcheng Zhou | 2012 | Neural Regeneration Research2012，7，30： | 7 |
| 18 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 19 | CRISPR/Cas9-Mediated Adenine Base Editing in Rice Genome显示文摘Precise base editing is highly desired in plant functional genomic research and crop molecular breeding. In this study, we constructed a rice-codon optimized adenine base editor(ABE)-nC as9 tool that induced targeted A·T to G·C point mutation of a key single nucleotide polymorphism site in an important agricultural gene. Combined with the modified single-guide RNA variant, our plant ABE tool can efficiently achieve adenine base editing in the rice genome. | LI Hao QIN Ruiying LIU Xiaoshuang LIAO Shengxiang XU Rongfang YANG Jianbo WEI Pengcheng | 2019 | Rice science2019，26，2： | 7 |
| 20 | Genetic mapping of quantitative trait loci in crops显示文摘Dissecting the genetic architecture of complex traits is an ongoing challenge for geneticists.Two complementary approaches for genetic mapping,linkage mapping and association mapping have led to successful dissection of complex traits in many crop species.Both of these methods detect quantitative trait loci(QTL) by identifying marker–trait associations,and the only fundamental difference between them is that between mapping populations,which directly determine mapping resolution and power.Based on this difference,we first summarize in this review the advances and limitations of family-based mapping and natural population-based mapping instead of linkage mapping and association mapping.We then describe statistical methods used for improving detection power and computational speed and outline emerging areas such as large-scale meta-analysis for genetic mapping in crops.In the era of next-generation sequencing,there has arisen an urgent need for proper population design,advanced statistical strategies,and precision phenotyping to fully exploit high-throughput genotyping. | Yang Xu Pengcheng Li Zefeng Yang Chenwu Xu | 2017 | The Crop Journal2017，5，2： | 7 |
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