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| 1 | Honey:its medicinal property and antibacterial activity显示文摘Indeed,medicinal importance of honey has been documented in the world's oldest medical literatures,and since the ancient times,it has been known to possess antimicrobial property as well as wound-healing activity.The healing property of honey is due to the fact that it offers antibacterial activity,maintains a moist wound condition,and its high viscosity helps to provide a protective barrier to prevent infection.Its immunomodulatory property is relevant to wound repair too.The antimicrobial activity in most honeys is due to the enzymatic production of hydrogen peroxide.However,another kind of honey,called non-peroxide honey(viz.,manuka honey),displays significant antibacterial effects even when the hydrogen peroxide activity is blocked.Its mechanism may be related to the low pH level of honey and its high sugar content(high osmolality) that is enough to hinder the growth of microbes.The medical grade honeys have potent in vitro bactericidal activity against antibiotic-resistant bacteria causing several life-threatening infections to humans. But,there is a large variation in the antimicrobial activity of some natural honeys,which is due to spatial and temporal variation in sources of nectar.Thus,identification and characterization of the active principle(s) may provide valuable information on the quality and possible therapeutic potential of honeys(against several health disorders of humans),and hence we discussed the medicinal property of honeys with emphasis on their antibacterial activities. | Manisha Deb Mandal Shyamapada Mandal | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 26 |
| 2 | Human cystic echinococcosis:epidemiologic,zoonotic,clinical,diagnostic and therapeutic aspects显示文摘This review represents an updated scenario on the transmission cycle,epidemiology,clinical features and pathogenicity,diagnosis and treatment,and prevention and control measures of a cestode parasite Echincoccus granulosus(E.granulosus) infection causing cystic echinococcosis (CE) in humans.Human CE is a serious life-threatening neglected zoonotic disease that occurs in both developing and developed countries,and is recognized as a major public health problem. The life cycle of E.granulosus involves a definitive host(dogs and other canids) for the adult E.granulosus that resides in the intestine,and an intermediate host(sheep and other herbivores) for the tissue-invading metacestode(larval) stage.Humans are only incidentally infected;since the completion of the life cycle of E.granulosus depends on carnivores feeding on herbivores bearing hydatid cysts with viable protoscoleces,humans represent usually the dead end for the parasite.On ingestion of E.granulosus eggs,hydatid cysts are formed mostly in liver and lungs, and occasionally in other organs of human body,which are considered as uncommon sites of localization of hydatid cysts.The diagnosis of extrahepatic echinococcal disease is more accurate today because of the availability of new imaging techniques,and the current treatments include surgery and percutaneous drainage,and chemotherapy(albendazole and mebendazole).But.the wild animals that involve in sylvatic cycle may overlap and interact with the domestic sheepdog cycle,and thus complicating the control efforts.The updated facts and phenomena regarding human and animal CE presented herein are due to the web search of SCI and non-SCI journals. | Shyamapada Mandal Manisha Deb Mandal | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 21 |
| 3 | Potential fly-ash utilization in agriculture:A global review显示文摘Though in last four decades various alternate energy sources have come into the limelight, the hyperbolic use of coal as a prime energy source cannot be counterbalanced. Disposal of high amount of fly-ash from thermal power plants absorbs huge amount of water, energy and land area by ash ponds. In order to meet the growing energy demand, various environmental, economic and social problems associated with the disposal of fly-ash would continue to increase. Therefore, fly-ash management would remain a great concern of the century. Fly-ash has great potentiality in agriculture due to its efficacy in modification of soil health and crop performance. The high concentration of elements (K, Na, Zn, Ca, Mg and Fe) in fly-ash increases the yield of many agricultural crops. But compared to other sectors, the use of fly-ash in agriculture is limited. An exhaustive review of numerous studies of last four decades took place in this paper, which systematically covers the importance, scope and apprehension regarding utilization of fly-ash in agriculture. The authors concluded that though studies have established some solutions to handle the problems of radioactivity and heavy metal content in fly-ash, long-term confirmatory research and demonstration are necessary. This paper also identified some areas, like proper handling of dry ash in plants as well as in fields, ash pond management (i.e., faster decantation, recycling of water, vertical expansion rather than horizontal), monitoring of soil health, crop quality, and fate of fly-ash in time domain, where research thrust is required. Agricultural lime application contributes to global warming as Intergovernmental Panel on Climate Change (IPCC) assumes that all the carbon in agricultural lime is finally released as CO2 to the atmosphere. It is expected that use of fly-ash instead of lime in agriculture can reduce net CO2 emission, thus reduce global warming also. | Manisha Basu Manish Pande P.B.S.Bhadoria S.C.Mahapatra | 2009 | Progress in Natural Science:Materials International2009，19，10： | 18 |
| 4 | Coconut(Cocos nucifera L.:Arecaceae):In health promotion and disease prevention显示文摘Coconut,Cocos nucifera L.,is a tree that is cultivated for its multiple utilities,mainly for its nutritional and medicinal values.The various products of coconut include tender coconut water,copra,coconut oil,raw kernel,coconut cake,coconut toddy,coconut shell and wood based products,coconut leaves,coir pith etc.Its all parts are used in someway or another in the daily life of the people in the traditional coconut growing areas.It is the unique source of various natural products for the development of medicines against various diseases and also for the development of industrial products.The parts of its fruit like coconut kernel and tender coconut water have numerous medicinal properties such as antibacterial,antifungal,antiviral, antiparasitic,antidermatophytic,antioxidant,hypoglycemic,hepatoprotective,immunostimulant. Coconut water and coconut kernel contain microminerals and nutrients,which are essential to human health,and hence coconut is used as food by the peoples in the globe,mainly in the tropical countries.The coconut palm is,therefore,eulogised as ’Kalpavriksha’(the all giving tree) in Indian classics,and thus the current review describes the facts and phenomena related to its use in health and disease prevention. | Manisha DebMandal Shyamapada Mandal | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 18 |
| 5 | Ileoscopy in patients with ileocolonic tuberculosis显示文摘AIM: To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis. METHODS: A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocolonic tuberculosis between January 2000 and June 2004, in whom retrograde ileoscopy had been performed. Only patients diagnosed with tuberculosis on the basis of histological findings of either a caseating granuloma or those having non-caseating granuloma or a collection of epithelioid cells at a minimum of one endoscopic lesion (either in the colon or the terminal ileum) on histology with good responses to conventional anti-tuberculous drugs were enrolled for the study. RESULTS: Fifty-three patients were included. The terminal ileum was involved in only 11 patients. Eight of these patients had involvement of the cecum too. Two patients had ileal lesions without cecal involvement; however, lesions were noted in the ascending colon. In one patient the whole colon was normal and only the terminal ileum showed nodularity and ulceration. Histological examination of the ileal biopsies obtained from the ileal lesions showed noncaseating granulomas in five, collection of epithelioid cells in four and nonspecific histology in two patients. Mucosal biopsies obtained from the lesion in the terminal ileum, in the patient in whom mucosal abnormality was observed to be confined to the ileum, showed noncaseating granulomas. In two other patients the ileal biopsies alone showed histological evidence of tuberculosis with biopsies from the colonic lesions showing non-specific inflammatory changes only. CONCLUSION: Retrograde ileoscopy should be performed in all patients undergoing colonoscopy for suspected ileocolonic tuberculosis. In some patients only the terminal ileum may be involved and histological examination may reveal evidence of tuberculosis only from the lesions in the terminal ileum. This approach would lead to additional lesions being picked up andincreasing the chances of well-timed diagnosis of tuberculosis. | SP Misra Vatsala Misra Manisha Dwivedi | 2007 | World Journal of Gastroenterology2007，13，11： | 16 |
| 6 | Adoption of precision agriculture technologies in India and in some developing countries:Scope,present status and strategies显示文摘Rapid socio-economic changes in some developing countries, including India, are creating new scopes for application of precision agriculture (PA). The implications of dramatic shifts for economic development, urbanization and energy consumption in some developing countries are immense. High-tech nature of traditional PA technologies developed in advanced countries created a real challenge for engineers to search suitable PA technologies for developing countries. It is expected that application of balanced soft and hard PA technologies based on the need of specific socio-economic condition of a country will make PA suitable for developing countries also. ‘Soft' PA depends mainly on visual observation of crop and soil and management decision based on experience and intuition, rather than on statistical and scientific analysis. ‘Hard' PA utilizes all modern technologies such as GPS, RS, and VRT. Three components, namely, ‘single PA technology', ‘PA technology package' (for the user to select one or combination) and ‘integrated PA technology', have been identified as a part of adoption strategies of PA in the developing countries. Therefore, the objective of this paper is to find out the scope, the present status and the strategies for adoption of PA in India and in some developing countries. Application of PA in cash crop, plantation crop, etc. has been discussed. Application of some medium and low-tech PA tools such as chlorophyll meter and leaf colour chart. in small farms has been included. This exhaustive review of the present status of PA in India and in some developing countries is expected to help to find out the adoption trend and direction of future research. Detailed strategy for the adoption of PA in India has also been proposed. | Pinaki Mondal Manisha Basu | 2009 | Progress in Natural Science:Materials International2009，19，6： | 14 |
| 7 | 广西南宁市5岁儿童乳牙龋患病率及其影响因素分析显示文摘目的:调查广西南宁市5岁儿童乳牙龋的患病率,并分析其影响因素。方法:于2016年10月至2017年10月整群随机抽取广西南宁市5岁的儿童进行调查。收集调查对象的社会人口学、口腔健康行为等资料,并调查乳牙患龋情况。患龋状况通过患龋率及龋、失、补牙面(dmfs)指数来评估。根据乳牙患龋的等级强度将调查样本分为无龋组(dmfs=0)、早期低龄儿童龋(ECC)组(0 | 姚君钰 莫丹 Malla Manisha Dhakal Neha 黄华 林焕彩 邱荣敏 | 2018 | 广西医科大学学报2018，35，12： | 10 |
| 8 | Antibacterial activity of honey against clinical isolates of Escherichia coli,Pseudomonas aeruginosa and Salmonella enterica serovar Typhi显示文摘Objective:To ascertain the potential antibacterial activity of honey against clinical isolates of Escherichia coli(E.coli),Pseudomonas aeruginosa(P.aeruginosa) and Salmonella enterica serovar Typhi(S.enterica serovar Typhi) by in vitro methods.Methods:The partial inhibitory concentration(PIC),minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC) values of the autoclaved honey(extracted from Apis indica hive by indigenous method) were determined for S.enterica serovar Typhi(n=8:from blood cultute), E.coli(n=5:from urine culture) and P.aeruginosa(n=5:from pus culture) isolates by in vitro methods.Results:The PICs of the honey tested for the isolates ranged 0.50%-1.25%(v/v) for S. enterica serovar Typhi,0.75%-1.50%(v/v) for E.coli and 1.00%-1.25%(v/v) for P.aeruginosa, while the MICs ranged 1.75%-3.00%(v/v),3.00%-3.50%(v/v) and 3.50%(v/v),respectively.The P.aeruginosa and E.coli isolates had MBC value of 4.00%(v/v):the S.enterica serovar Typhi showed MBCs in between 3.00%and 3.50%(v/v).The bactericidal activity of honey was achieved at concentration 3.00%(v/v) for S.enterica serovar Typhi and E.coli,and at 3.50%(v/v) for P. aeruginosa.Conclusions:The excellent antibacterial activity of honey against clinical bacterial isolates indicates the usefulness of honey in clinical practice against bacterial infection. | Shyamapada Mandal Manisha DebMandal Nishith Kumar Pal Krishnendu Saha | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 8 |
| 9 | Magnetic resonance imaging in glenohumeral instability显示文摘The glenohumeral joint is the most commonly dislocated joint of the body and anterior instability is the most common type of shoulder instability.Magnetic resonance (MR) imaging,and more recently,MR arthrography,have become the essential investigation modalities of glenohumeral instability,especially for pre-procedure evaluation before arthroscopic surgery.Injuries associated with glenohumeral instability are variable,and can involve the bones,the labor-ligamentous components,or the rotator cuff.Anterior instability is associated with injuries of the anterior labrum and the anterior band of the inferior glenohumeral ligament,in the form of Bankart lesion and its variants;whereas posterior instability is associated with reverse Bankart and reverse Hill-Sachs lesion.Multidirectional instability often has no labral pathology on imaging but shows specific osseous changes such as increased chondrolabral retroversion.This article reviews the relevant anatomy in brief,the MR imaging technique and the arthrographic technique,and describes the MR findings in each type of instability as well as common imaging pitfalls. | Manisha Jana Shivanand Gamanagatti | 2011 | World Journal of Radiology2011，3，9： | 7 |
| 10 | Variation in cone and seed characters in blue pine (Pinus wallichiana) across natural distribution in western Himalayas显示文摘We analyzed 17 seed sources (seed stands) of Pinus wallichiana for variations present in cone and seed characters, scattered over natural distribution in north-west Himalayan states (Uttarakhand and Himachal Pradesh) of India. The significant variations were observed in cone weight, cone length, cone width, seed length, seed width, seed weight, seed germination, radicle length, and plumule length among different seed sources of the species. Significant positive correlation between seed weight, cone weight and cone width showed that seed weight in the species depend more on the cone size. Seed germination was also positively correlated with seed weight, cone weight and radicle length in the study. The estimates of variability with regard to genetic parameters for seed weight, seed germination, cone length, cone width, cone weight showed wide range of variation in the study. Seed weight showed high heritability values coupled with maximum genetic gain. Traits with such values indicate presence of good amount of heritable additive components and are under strong genetic control. The findings of the study revealed that seed sources expressed both phenotypic and genotypic differences in the seed and cone traits which might be due to the differences in genetic make up of various seed sources and environmental factors i.e. genotypic and environmental interaction. The study suggests that the seed weight should be given the top priority for the further improvement of this species. | Ombir Singh Manisha Thapliyal | 2012 | Journal of Forestry Research2012，23，2： | 7 |
| 11 | Synergistic anti - Staphylococcus aureus activity of amoxicillin in combination with Emblica officinalis and Nymphae odorata extracts显示文摘Objective:To evaluate the antibacterial activity of Emblica officinalis Gaertn(E.officinalis: Family:Euphorbiaceae) seed and Nymphae odorala Aiton(N.odorala:Family:Nymphaeaceae) stamen extracts,alone and in combination,and in combination with amoxicillin(Ax) against Staphylococcus aureus(S.aureus).Methods:Antibacterial activity of ethanolic extracts of amla,E.officinalis,seed(AMS:500μg) and sapla,N.odorala,stamen(SAP:500 p g) for 12 methicillin-resistant S.aureus(MRSA) isolates was determined following agar diffusion:in order to assess the combined antibacterial activity,AMS(250μg) plus SAP(250μg) were considered.The Ax(10μg) activity alone and in combination with AMS(250μg),and SAP(250μg) was determined by disk diffusion.The zone diameters of inhibition(ZDIs) for the agents were recorded,and growth inhibitory indices(GIIs) were calculated.Results:The MRSA isolates (n=12) had AMS(500μg) and SAP(500μg) ZDIs of 12-19 mm and 21-24 mm,respectively.The ZDIs(range 24-27 mm) increased by 3-4 mm due to combined action of AMS(250μg) and SAP(250μg) indicating synergy between extracts for MRSA(GII 0.634-0.742).The MRSA isolates were resistant to Ax(ZDI:8-11 mm),which in combination with AMS and SAP had synergistic effect,both due to increased ZDI[mean±SD=(3.5±0.577) mm]and GII(0.631-0.894).Conclusions:The data suggest that the plants,E.officinalis and N.odorala alone or in combination,are promising in the development of phytomedicines,which may be used,alone or in combination with the antibiotic. Ax,against MRSA infection. | Shyamapada Mandal Manisha DebMandal Nishith Kumar Pal Krishnendu Saha | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 6 |
| 12 | Helicobacter pylori and gastric cancer: Indian enigma显示文摘Helicobacter pylori(H. pylori) is a gram negative microaerophilic bacterium which resides in the mucous linings of the stomach. It has been implicated in the causation of various gastric disorders including gastric cancer. The geographical distribution and etiology of gastric cancer differ widely in different geographical regions and H. pylori, despite being labeled as a grade Ⅰ carcinogen, has not been found to be associated with gastric cancer in many areas. Studies in Asian countries such as Thailand, India, Bangladesh, Pakistan, Iran, Saudi Arabian countries, Israel and Malaysia, have reported a high frequency of H. pylori infection co-existing with a low incidence of gastric cancer. In India, a difference in the prevalence of H. pylori infection and gastric cancer has been noted even in different regions of the country leading to a puzzle when attempting to find the causes of these variations. This puzzle of H. pylori distribution and gastric cancer epidemiology is known as the Indian enigma. In this review we have attempted to explain the Indian enigma using evidence from various Indian studies and from around the globe. This review covers aspects of epidemiology, the various biological strains present in different parts of the country and within individuals, the status of different H. pylori-related diseases and the molecular pathogenesis of the bacterium. | Vatsala Misra Renu Pandey Sri Prakash Misra Manisha Dwivedi | 2014 | World Journal of Gastroenterology2014，20，6： | 6 |
| 13 | Endovascular management in abdominal visceral arterial aneurysms:A pictorial essay显示文摘Visceral artery aneurysms(VAAs) include aneurysms of the splanchnic circulation and those of the renal artery.Their diagnosis is clinically important because of the associated high mortality and potential complications.Splenic,superior mesenteric,gastroduodenal,hepatic and renal arteries are some of the common arteries affected by VAAs.Though surgical resection and anastomosis still remains the treatment of choice in some of the cases,especially cases involving the proximal arteries,increasingly endovascular treatment is being used for more distal vessels.We present a pictorial review of various intra-abdominal VAAs and their endovascular management. | Manisha Jana Shivanand Gamanagatti Amar Mukund Sujoy Paul Pankaj Gupta Pramod Garg Tushar K Chattopadhyay Peush Sahni | 2011 | World Journal of Radiology2011，3，7： | 5 |
| 14 | Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux显示文摘AIM: To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and af- ter 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symp- tom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbroncho- dilator forced expiratory volume in 1 second (FEV1) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS: Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9%), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antire- flux therapy compared to mean change in placebo group (P < 0.001). There was significant improvement in morn- ing PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEV1 (11.1% vs 3.78%) and FVC (9.3% vs 1.52%) in the antireflux therapy group compared to placebo on compar-ing the mean change from baseline after 16 wk (P < 0.01). | Bhavneesh Sharma Manisha Sharma Mradul Kumar Daga Gopal Krishan Sachdev Elliott Bondi | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 15 | Carcinogenic Helicobacter pylori in gastric pre-cancer and cancer lesions: Association with tobacco-chewing显示文摘AIM:To investigate the low gastric cancer incidence rate relative to the highly prevalent Helicobacter pylori(H.pylori)infection;data relevant to H.pylori infection during gastric carcinogenesis in Indian patients is currently lacking.METHODS:The present study examines the prevalence of H.pylori infection in DNA derived from 156endoscopic gastric biopsies of different disease groups that represent gastric pre-cancer[intestinal metaplasia(n=15),dysplasia(n=15)],cancer[diffuse adenocarcinoma(n=44),intestinal adenocarcinoma(n=21)],and symptomatic but histopathologically-normal controls(n=61).This was done by generic ureC polymerase chain reaction(PCR)and cagA-specific PCR that could specifically identify the carcinogenic H.pylori strain.RESULTS:Our analysis showed the presence of H.pylori infection in 61%of symptomatic histopathologically-normal individuals,however only 34%of control tissues were harboring the cagA+H.pylori strain.A similar proportion of H.pylori infection(52%)and cagA(26%)positivity was observed in the tumor tissue of the gastric cancer group.In comparison,H.pylori infection(90%)and cagA positivity(73%)were the highest in gastric pre-cancer lesions.In relation to tobacco and alcohol abuse,H.pylori infection showed an association with tobacco chewing,whereas we did not observe any association between tobacco smoking or alcohol abuse with prevalence of H.pylori infection in the tissue of any of the patient groups studied.CONCLUSION:High incidence of H.pylori infection and carcinogenic cagA positive strain in pre-cancer lesions during gastric carcinogenesis may be | Arvind Pandey Satyendra Chandra Tripathi Sutapa Mahata Kanchan Vishnoi Shirish Shukla Sri Prakash Misra Vatsala Misra Suresh Hedau Ravi Mehrotra Manisha DwivediZ Alok C Bharti | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 16 | E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer显示文摘 | Fabio Petrocca Rosa Visone Mariadele Rapazzotti Onelli Manisha H. Shah Milena S. Nicoloso Ivana de Martino Dimitrios Iliopoulos Emanuela Pilozzi Chang-Gong Liu Massimo Negrini Luigi Cavazzini Stefano Volinia Hansjuerg Alder Luigi P. Ruco Gustavo Baldassar | 2008 | Cancer Cell2008，，3： | 4 |
| 17 | Effect of doping of different rare earth(europium,gadolinium,dysprosium and neodymium) metal ions on structural,optical and photocatalytic properties of LaFeO3 perovskites显示文摘Different rare earth substituted perovskites LaRExFe1-xO3(where RE=Eu3+,Gd3+,Dy3+,Nd3+and x=0.02,0.04,0.06,0.08,0.1)with orthorhombic structure and narrow band gaps were successfully fabricated via sol-gel autocombustion method.All the substituted perovskites are found to exhibit excellent photocatalytic activity towards the oxidative degradation of dye molecules.An excellent increase in the rate constant values of pure perovskite(LaFeO3)photocatalytic reactions is observed with the substitution of rare earth metal ions.Best results are obtained for LaNd0.1Fe0.9O3 which exhibits around 7 times increase in the rate constant values for degradation reaction of SO(1.76×10-1 min-1)and RBY(1.69×10-1 min-1)dyes. | Manisha Dhiman Sonal Singhal | 2019 | Journal of Rare Earths2019，37，12： | 4 |
| 18 | Coriander(Coriandrum sativum L.) essential oil: chemistry and biological activity显示文摘Coriandrum sativum L.(C. sativum) is one of the most useful essential oil bearing spices as well as medicinal plants, belonging to the family Umbelliferae/Apiaceae. The leaves and seeds of the plant are widely used in folk medicine in addition to its use as a seasoning in food preparation. The C. sativum essential oil and extracts possess promising antibacterial, antifungal and anti-oxidative activities as various chemical components in dif erent parts of the plant, which thus play a great role in maintaining the shelf-life of foods by preventing their spoilage. This edible plant is non-toxic to humans, and the C. sativum essential oil is thus used in dif erent ways, viz., in foods(like l avoring and preservatives) and in pharmaceutical products(therapeutic action) as well as in perfumes(fragancias and lotions). The current updates on the usefulness of the plant C. sativum are due to scientii c research published in dif erent web-based journals. | Shyamapada Mandal Manisha Mandal | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 4 |
| 19 | Skin-gut axis:The relationship between intestinal bacteria and skin health显示文摘The gut microbiome is an emerging area of interest in medicine. Imbalances in the gut microbiome have been linked to a number of disease states such as obesity and type 2 diabetes. The relationship between normally residing intestinal bacteria(the gut microbiota) and their potential role in the pathogenesis of skin diseases is an area of research for which we are only beginning to understand. Small studies have demonstrated underlying changes in the gut microbiome of patients with certain dermatological diseases. Interestingly, studies suggest that probiotics may have a role in the treatment of atopic dermatitis. However, the concept of the 'skin-gut axis' is a newly emerging and important avenue of investigation, still lacking in pathobiological explanations. This review will introduce and describe the intestinal microbiome as it relates to skin health in a complex communication network between the immune system, endocrine system, metabolic system, and nervous system. | Alexandra R Vaughn Manisha Notay Ashley K Clark Raja K Sivamani | 2017 | World Journal of Dermatology2017，6，4： | 4 |
| 20 | Cabozantinib in Progressive Medullary Thyroid Cancer显示文摘 | Rossella Elisei Martin J. Schlumberger Stefan P. Müller Patrick Sch?ffski Marcia S. Brose Manisha H. Shah Lisa Licitra Barbara Jarzab Viktor Medvedev Michael C. Kreissl Bruno Niederle Ezra E.W. Cohen Lori J. Wirth Haythem Ali Colin Hessel Yifah Yaron Doug | 2013 | Journal of Clinical Oncology2013，，29： | 3 |
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