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| 1 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 2 | Contrast-enhanced ultrasound in diagnosis and characterization of focal hepatic lesions显示文摘The extensive use of imaging techniques in differential diagnosis of abdominal conditions and screening of hepatocellular carcinoma in patients with chronic hepatic diseases,has led to an important increase in identification of focal liver lesions.The development of contrastenhanced ultrasound(CEUS) opens a new window in the diagnosis and follow-up of these lesions.This technique offers obvious advantages over the computed tomography and magnetic resonance,without a decrease in its sensitivity and specificity.The new second generation contrast agents,due to their intravascular distribution,allow a continuous evaluation of the enhancement pattern,which is crucial in characterization of liver lesions.The dual blood supply in the liver shows three different phases,namely arterial,portal and late phases.The enhancement during portal and late phases can give important information about the lesion's behavior.Each liver lesion has a different enhancement pattern that makes possible an accurate approach to their diagnosis.The role of emerging techniques as a contrastenhanced three-dimensional US is also discussed.In this article,the advantages,indications and technique employed during CEUS and the different enhancement patterns of most benign and malignant focal liver lesions are discussed. | Inés Gómez Molins Juan Manuel Fernández Font Juan Carrero álvaro Jose Luís Lledó Navarro Marta Fernández Gil Conrado M Fernández Rodríguez | 2010 | World Journal of Radiology2010，2，12： | 14 |
| 3 | Current understanding of multi-species biofilms显示文摘Direct observation of a wide range of natural microorganisms has revealed the fact that the majority of microbes persist as surface-attached communities surrounded by matrix materials, called biofilms. Biofilms can be formed by a single bacterial strain. However, most natural biofilms are actually formed by multiple bacterial species. Conventional methods for bacterial cleaning, such as applications of antibiotics and/or disinfectants are often ineffective for biofilm populations due to their special physiology and physical matrix barrier. It has been estimated that billions of dollars are spent every year worldwide to deal with damage to equipment, contaminations of products, energy losses, and infections in human beings resulted from microbial biofilms. Microorganisms compete, cooperate, and communicate with each other in multi-species biofilms. Understanding the mechanisms of multi-species biofilm formation will facilitate the development of methods for combating bacterial biofilms in clinical, environmental, industrial, and agricultural areas. The most recent advances in the understanding of multi-species biofilms are summarized and discussed in the review. | Liang Yang Yang Liu Hong Wu Niels Hoiby Soren Molin Zhi-jun Song | 2011 | International Journal of Oral Science2011，3，2： | 6 |
| 4 | Landing gear noise control using perforated fairings显示文摘商业飞机的登陆齿轮做重要贡献在途径配置总计飞机噪音。用到从高速度冲击的盾部件的 fairings 减少噪音。而且,穿孔这些 fairings 被飞行测试证实了进一步启用噪音减小。跟随穿孔 fairings 的申请的更早基本的研究,研究被执行了调查并且优化通过打齿轮 fairings 为空气放血的好处。借助于风隧道测试,空气动力学、声学的调查被执行了在上一简化了通用主要登陆齿轮探索影响(穿孔) 齿轮的更低的部分上的 fairings。结果证明为这个特定的案例,透不过的 fairings 的申请减少噪音在中间 -- 并且由从高速度冲击防护锋利的 edged 部件的高频率范围。然而,在 1 kHz 下面,噪音被显示显著地增加。穿孔的申请被显示减少这低频率增加虽然维持减小在中间 -- 并且高频率范围。空气动力学、声学的大小指在与为低频率噪音增加负责的下游的齿轮部件交往的 fairings 的分开的流动的方向。通过 fairings 空气流血在这些部件的最近减少大规模骚乱并且因此减少低频率噪音增加。关键词登陆齿轮 - 气体动力学 - | K. Boorsma X. Zhang N. Molin | 2010 | Acta Mechanica Sinica2010，26，2： | 4 |
| 5 | Spouting behaviour of binary mixtures in square-based spouted beds显示文摘From experime nts, the influe nee of the physical characteristics of different bin ary mixtures of solids on the spouting regime of a pyramidal square-based spouted bed reactor is assessed. The applied methodology permits a more precise evaluation of the effects of the tested variables (diameter, density, sphericity) on the response variables (minimum air flows at which spouting begins and at which to maintain spouting con ditions). The associated pressure drops along the bed of particles a nd the height of the formed fountai n are analysed in each case. During the initial stages of fluidisation, binary mixtures containing different density ratios show dead zones. Segregation becomes more evident at large-size and high-density ratios. The lack of sphericity was found to be the main reason leading to blocking, channelling, and start-up problems when system failures occur. Nevertheless, the extent of segregation in all cases decreases with increasing the spouting velocity. In addition, a computational fluid dynamic model based on the discrete element method, previously validated for a single solid bed, is proposed as a tool to predict and evaluate potential segregation phenomena in binary mixtures. This model reproduced with high accuracy the encountered segregation phenomena. Its use may help define the technical limts inherent in the pyramidal spouted bed reactor. | Cristina Moliner Filippo Marchelli Massimo Curti Barbara Bosio Giorgio Rovero Elisabetta Arato | 2019 | Particuology2019，17，2： | 4 |
| 6 | 运动与重症肌无力显示文摘重症肌无力(MG)是一种以肌无力为主要症状的神经肌肉疾病。目前很少有针对MG患者进行有氧运动或肌耐力训练的研究。本研究目的是研究运动对MG患者的影响。这一前瞻性研究纳入由瑞典三个神经专科门诊确诊为慢性MG的患者。被试者于12周内在监护下进行每周2次、每次75分钟的运动,运动内容包括有氧运动、肌耐力训练以及平衡训练。受试者在训练前后接受神经传导检测、肌力与功能评定、血液检测(包括特异microRNA、白介素-6、肌酶、CRP以及肌酸)、 | 吴毅 Westerberg E Molin CJ Lindblad I | 2017 | 中国康复2017，32，2： | 4 |
| 7 | A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival显示文摘 | Amelie Kinch Eva Baecklund Carin Backlin Tor Ekman Daniel Molin Gunnar Tufveson Pia Fernberg Christer Sundstr? m Karlis Pauksens Gunilla Enblad | 2014 | Acta Oncologica2014，，5： | 2 |
| 8 | Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores显示文摘The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging.In this work,we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors.C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most nearinfrared dyes.We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+and Fe^(3+)ions in aqueous media. | Fabio de Moliner Ina Biazruchka Karolina Konsewicz Sam Benson Suraj Singh Jun-Seok Lee Marc Vendrell | 2022 | Frontiers of Chemical Science and Engineering2022，16，1： | 2 |
| 9 | Innovations on components and testing for precast panels to be used in reinforced earth retaining walls显示文摘 | Albert de la Fuente Antonio Aguado Climent Molins Jaume Armengou | 2010 | Construction and Building Materials2010，，： | 2 |
| 10 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 11 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 12 | From demand response to integrated demand response: review and prospect of research and application显示文摘In the traditional power system demand response, customers respond to electricity price or incentive and change their original power consumption pattern accordingly to gain additional benefits. With the development of multi-energy systems (MES) in which electricity, heat, natural gas and other forms of energy are coupled with each other, all types of energy customers are able to participate in demand response, leading to the concept of integrated demand response (IDR). In IDR, energy consumers can response not only by reducing energy consumption or opting for off-peak energy consumption but also by changing the type of the consumed energy. Taking the traditional demand response in power system as a starting point, the studies of the fundamental theory, framework design and potential estimation of demand response in power system are reviewed, and the practical cases and software development of demand response are introduced. Finally, the current theoretical research and application of IDR are assessed. | Wujing Huang Ning Zhang Chongqing Kang Mingxuan Li Molin Huo | 2019 | Protection and Control of Modern Power Systems2019，4，1： | 2 |
| 13 | Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas显示文摘 | Marco Dal Molin Hanno Matthaei Jian Wu Amanda Blackford Marija Debeljak Neda Rezaee Christopher L. Wolfgang Giovanni Butturini Roberto Salvia Claudio Bassi Michael G. Goggins Kenneth W. Kinzler Bert Vogelstein James R. Eshleman Ralph H. Hruban Anirban Mai | 2013 | Annals of Surgical Oncology2013，，12： | 2 |
| 14 | miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts显示文摘 | Hanno Matthaei Dennis Wylie Maura B. Lloyd Marco Dal Molin Jon Kemppainen Skye C. Mayo Christopher L. Wolfgang Richard D. Schulick Laura Langfield Bernard F. Andruss Alex T. Adai Ralph H. Hruban Anna E. Szafranska-Schwarzbach Anirban Maitra | 2012 | Clinical Cancer Research2012，，17： | 2 |
| 15 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 16 | FTIR study of the evolution of coal structure during the coalification process 显示文摘 | Ibarra J V Munoz E Moliner R | 1996 | Organic Geochemistry1996，24，67： | 1 |
| 17 | Clonidine induces rat aorta relaxation by nitric oxide-dependent and independent mechanisms 显示文摘 | MOLIN J C BENDHACK L M | 2004 | Vascul Pharmacol2004，42，1： | 1 |
| 18 | The choice of park and ride facilities: an analysis using a context-dependent hierarchical choice experiment 显示文摘 | Bos I D M Heijden R V D Molin E J E | 2004 | Environment and Planning A2004，36，9： | 1 |
| 19 | Tin - con- taining zeolites are highly active catalysts for the isomeri- zation of glucose in water 显示文摘 | Moliner M Rom(m - Leshkov Y Davis M E | 2010 | Proc Natl Acad Sci USA2010，107，： | 1 |
| 20 | Unrave- ling the Chronic Toxicity of Lead:an Essential Pri- ority for Environmental Health 显示文摘 | Todd A C Wetmur J G Moline J M | 1996 | Environ Health Perspect1996，104，4： | 1 |
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