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| 1 | Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors显示文摘AIM:To investigate primarily the prognostic value of Ki-67,as well as other parameters,in gastrointestinal stromal tumors(GISTs).METHODS:Ki-67,c-KIT,platelet-derived growth factor receptor-alpha(PDGFRα),smooth muscle actin(SMA),CD34,S100 were stained for immunohistochemistry which was performed on formalin-fixed,paraffinembeded sections on representative block from each case.Proliferation index counted by Ki-67 antibody was calculated as a number of positive nuclear reaction over 100 cells.Immunoreactivity for c-KIT and PDGFRα was evaluated semiquantitatively(weak,intermediate,strong) and for c-KIT type of reactivity was analyzed(cytoplasmic,membrane and 'dot-like' staining).Immunoreactivity for SMA,CD34 and S100 were was evaluated as positive or negative antigen expression.Pathologic parameters investigated in this study included tumor size,cell type(pure spindle,pured epitheloid mixed spindle and epitheloid),mitotic count,hemorrhage,necrosis,mucosal ulceration.Clinical data included age,gender,primary tumor location and spread of disease.χ 2 test and Student's t-test were used for comparisons of baseline characteristics.The Cox's proportional hazard model was used for univariable and multivariable analyses.Survival rates were calculated by Kaplan-Meier method and statistical significance was determined by the log-rank test.RESULTS:According to the stage of disease,there were 36 patients with localized disease,29 patients with initially localized disease but with its recurrence in the period of follow up,and finally,35 patients had metastatic disease from the very beginning of disease.Tumor originated most commonly in the stomach(41%),small intestine was the second most common location(36%).The mean size of primary tumors was 6.5 cm.The mean duration of follow-up was 60 mo.Multiple parameters were analyzed for their effect on overall survival,but no one reached statistical significance(P = 0.06).Analysis of time to progression/relapse in initially localized disease(univariate analysis),tumor size,mitotic count,Ki-67 and type of d-KIT distribution(cytoplasmic vs membrane/'dot-like') showed statistically significant correlation.In multivariate analysis in the group of patients with localized disease,there were only 2 parameters that have impact on relapse,Ki-67 and SMA(P < 0.0001 and P < 0.034,respectively).Furthermore,Ki-67 was analyzed in localized diseasevs localized with recurrence and metastatic disease.It was shown that there is a strict difference between these 2 groups of patients(median value was 2.5 for localized disease vs 10.0 for recurrent/metastatic disease,P < 0.0001).It was also shown that the cut-off value which is still statistically significant in terms of relapse on the level of 6%.The curves for survival on that cut-off level are significantly different(P < 0.04,Cox F).CONCLUSION:Ki-67 presents a significant prognostic factor for GIST recurrence which could be of great importance in evaluating malignant potential of disease. | Borislav Belev Iva Bri Juraj Prejac Zrna Antunac Golubi Damir Vrbanec Jadranka Bozikov Ivan Aleri Marko Boban Jasminka Jaki Razumovi | 2013 | World Journal of Gastroenterology2013，19，4： | 14 |
| 2 | Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors显示文摘AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(Pan NET) in a caseload of a tertiary referral center.METHODS Patients submitted to surgery for Pan NET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. Passing-Bablok(PB) regression analysis was used to check the agreement between MR and CT.RESULTS Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning Pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-Pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-Pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and pathology.CONCLUSION MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of Pan NET. | Salvatore Paiella Harmony Impellizzeri Elisabetta Zanolin Giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev Paola Capelli Sara Cingarlini Giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto Salvia Luca Landoni | 2017 | World Journal of Gastroenterology2017，23，17： | 4 |
| 3 | Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair显示文摘Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor(BDNF) and its high-affinity tropomyosin-related kinase receptor(Trk B) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB(c AMP response element-binding protein) has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeutic outcomes may be expected for synergistic dual or multi-drug action aiming at(i) neurotrophic protein regulation in the central and peripheral nervous systems, and(ii) diminishment of the production of reactive oxygen species(ROS) and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines. | Angelina Angelova Borislav Angelov | 2017 | Neural Regeneration Research2017，12，6： | 3 |
| 4 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 5 | Time for the new approach in management of early phase of severe acute pancreatitis?显示文摘 | Darko Zdravkovic Dragoljub Bilanovic Tomislav Randjelovic Borislav Toskovic | 2010 | Chinese Medical Journal2010，，2： | 2 |
| 6 | KIM-a semantic platform for information extraction and retrieval显示文摘 | Borislav Popov Atanas Kiryakov Damyan Ognyanoff Dimitar Manov Angel Kirilov | 2004 | Natural Language Engineering2004，10，37： | 1 |
| 7 | Insulin Resistance and Proliferative Retinopathy: A Cross-Sectional, Case-Control Study in 115 Patients with Type 2 Diabetes显示文摘 | Aneliya Parvanova Ilian Iliev Marco Filipponi Borislav D. Dimitrov Monica Vedovato Antonio Tiengo Roberto Trevisan Giuseppe Remuzzi Piero Ruggenenti | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，： | 1 |
| 8 | Performance of steel frames with a new friction damper device under earthquake excitation显示文摘 | Imad H. Mualla Borislav Belev | 2002 | Engineering Structures2002，，3： | 1 |
| 9 | Pore classification in the characterization of porous materials: A perspective显示文摘 | Borislav D. Zdravkov Ji?í J. ?ermák Martin ?efara Josef Jank? | 2007 | Central European Journal of Chemistry2007，，4： | 1 |
| 10 | Ocular findings six years after in travitreal silicone injection 显示文摘 | Borislav D Okamura ID | 1993 | Doc Ophthalmol1993，83，： | 1 |
| 11 | Modeling of inherent SO2 capture in coal particles during combustion in fluidized bed显示文摘 | VASILIJE M BORISLAV G DAVOR L | 2006 | Chemical Engineering Science2006，61，： | 1 |
| 12 | Rate of formation and characterization of magnesium anthracene显示文摘 | Borislav Bogdanovic Shih-tsien Liao Richard Mynott | 1984 | Chem Ber1984，117，： | 1 |
| 13 | Cultural cross-border co-operation among Balkan's countries with the case of Serbia and Bulgaria显示文摘 | Stojkov Borislav Nikolov Ana | 2008 | Glasnik Srpskog Geografskog Dra(s)tva2008，，： | 1 |
| 14 | Mechanical response of friction stir welded AA2024:experiment and modeling显示文摘 | Lockwood W D Borislav Tomaz Reynolds A P | 2002 | Materials Science and Engineering:A2002，232，2： | 1 |
| 15 | Semantic annotation, indexing, and retrieval显示文摘 | Atanas Kiryakov Borislav Popov Ivan Terziev Dimitar Manov Damyan Ognyanoff | 2004 | Web Semantics: Science, Services and Agents on the World Wide Web2004，，1： | 1 |
| 16 | Tumors in Kidney Fusion Anomalies Report of Five Cases and Review of the Literature显示文摘 | Goran Stimac Jordan Dimanovski Boris Ruzic Borislav Spajic Ognjen Kraus | 2004 | Scandinavian Journal of Urology and Nephrology2004，，6： | 1 |
| 17 | Mechanical response of friction stir welded AA2024:experiment and modeling显示文摘 | Lock W D Borislav Tomaz Reynolds A P | 2002 | Mater Sci Eng A2002，232，2： | 1 |
| 18 | Mechanical response of friction stir welded AA2024: experimentand medeling显示文摘 | William D Lockwoed Borislav Tomaz | 2002 | Materials Science and Engineering2002，，323： | 1 |
| 19 | Cycling properties of Sc- and Ce-doped NaA1H4 hydrogen storage materials prepared by the one-step direct synthesis method 显示文摘 | Bogdanovic Borislav Felderhoff Michael Pommerin Andr6 Schtlth Ferdi Spielkamp Nick Stark Arne | 2009 | Journal of Alloys and Compounds2009，471，12： | 1 |
| 20 | Finite-time blow-up for wave equations with a potential 显示文摘 | YORDANOV BORISLAV ZHANG Qi S | 2005 | SIAM J Math Anal2005，36，5： | 1 |
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