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| 1 | 北京市怀柔区儿童维生素D营养状况及其与体成分的关系显示文摘目的分析儿童维生素D的营养状况及其与体成分的关系。方法选取北京市怀柔区(北纬40.3°)7~11岁学龄儿童381名,于2008年3月采集静脉血并采用酶联免疫吸附试验(ELISA,英国IDS公司)测定血清中25-羟维生素D[25(0H)D]的浓度,双能X线吸收仪(DExA,美国Norland公司)测定前臂及全身的体成分,分析维生素D与体成分的相关性。结果研究对象血清25(OH)D的平均浓度为(44.4±12.5)nmol/L,维生素D缺乏和不足率[血清25(OH)D≤50nmol/L]达68.5%。男生血清25(OH)D浓度(46.3±13.3)nmol/L高于女生(42.0±11.1)nmol/L,差异有统计学意义(t=3.38,P〈0.01)。血清25(OH)D浓度与前臂近端、远端、全身及分部位中四肢的瘦体重呈正相关(r=0.13~0.19,P〈0.05),与前臂近端、远端的体脂百分比呈负相关(r=-0.14,P〈0.05;r=-0.1],P〈0.05),均有统计学意义。调整年龄、性别、身高、体重等混杂因素后,与前臂近端、全身分部位中双下肢的瘦体重相关性仍有统计学意义(r=0.12~0.14,P〈0.05)。血清25(OH)D浓度与各部位体脂的相关性均无统计学意义。结论维生素D缺乏在北京市郊区儿童中较为普遍,而维生素D营养状况对体成分,尤其对瘦体重有促进作用。 | 赵静 张倩 张环美 郭宏霞 Rickard Oste 郝利楠 Gunilla Onning Lella Hulthen 胡小琪 | 2010 | 中华流行病学杂志2010，31，1： | 41 |
| 2 | Tissue factor in predicted severe acute pancreatitis显示文摘AIM: To study tissue factor (TF) in acute pancreatitis and evaluate the role of TF as a predictive marker of severity. METHODS: Forty-nine consecutive patients admitted to Lund University Hospital, fulfilling the criteria of predicted severe acute pancreatitis (AP), were recruited prospectively between 2002 and 2004. Blood samples for TF analyses were drawn at inclusion in the study and 12 h, 1 d and 3 d later. RESULTS: Twenty-seven patients developed mild AP, and 22 patients severe AP. At inclusion in the study, the groups were comparable with respect to gender, aetiology, Acute Physiology and Chronic Health Evaluation Ⅱ score, and duration of pain. At inclusion in the study and at 12 h, TF was higher in the severe AP group (P = 0.035 and P = 0.049, respectively). After 1 and 3 d, no differences in TF levels were noted. Interleukin (IL)-6 was significantly higher in the severe AP group at all of the studied time points. C-reactive protein (CRP) was significantly higher in the AP group at 1 and 3 d. In receiver operating characteristic-curves, the area under the curve (AUC) for TF was 0.679 (P = 0.035) at inclusion in the study, and a cut off level for TF of 40 pg/mL showed a sensitivity of 71% and a specificity of 67%, whereas corresponding AUC for IL-6 was 0.775, P = 0.001, and for CRP was 0.653. IL-6 showed better AUC-values than TF at all time points studied. CONCLUSION: TF-levels are raised early in severe AP. TF as an early predictive marker of severe AP is superior to CRP, but inferior to IL-6. | Ellen Andersson Jakob Axelsson Gunilla Eckerwall Daniel Ansari Roland Andersson | 2010 | World Journal of Gastroenterology2010，16，48： | 26 |
| 3 | 北京市郊区儿童维生素D营养状况与骨量的关系显示文摘目的了解北京市怀柔区儿童维生素D营养状况与骨量的关系,为改善我国儿童骨骼健康提供基础资料。方法采用横断面研究的方法 ,随机选取北京市怀柔区(北纬40.3°)381名7-11岁儿童,采集静脉血,用酶联免疫吸附法测定血清25-羟维生素D[25(OH)D]浓度,双能X线吸收仪测定前臂及全身骨矿物含量(BMC)、骨矿物密度(BMD)和骨面积(BA)。结果研究对象血清25(OH)D浓度平均为(44.4±12.5)nmol/L。血清25(OH)D浓度与身高、体重及全身和前臂的BMC、BMD和BA呈显著正相关(r=0.10~0.17;P〈0.05);调整年龄、性别、身高和体重后,仅全身分部位中的左上肢BMC和左上肢及右上肢BA与血清25(OH)D浓度呈正相关(r=0.11-0.14;P〈0.05),其余部位显著性消失。维生素D营养状况适宜儿童[25(OH)D〉50 nmol/L]的全身BMC比维生素D不足儿童[25(OH)D≤50 nmol/L]平均高4.2%(P〈0.05),但调整混杂因素后差异消失。结论维生素D营养状况与北京郊区儿童体格发育正相关,从而对儿童骨量增加起到间接促进作用。 | 张倩 赵静 张环美 郭宏霞 Rickard Oste 郝利楠 Gunilla Onning Lena Hulthén 胡小琪 | 2010 | 中国预防医学杂志2010，11，8： | 25 |
| 4 | 太原市学龄前儿童哮喘、过敏性鼻炎及湿疹与出生前及早期家居环境的相关性显示文摘为了探讨出生前及早期家居生活环境与儿童的哮喘及过敏性疾病的相关性, 在山西省太原市区学龄前儿童(3700名)中开展了一项横断面流行病学研究. 研究采用问卷调查的方式, 问卷内容包括儿童的哮喘和相关过敏性疾病的患病情况, 采用了International Study on Asthma and Allergies in Childhood(ISAAC)的核心问卷; 儿童的家居生活环境采用了瑞典的Dampness in Buildings and Health(DBH)的问卷内容, 并根据中国的生活习惯进行了部分调整. 通过多因素Logistic回归分析并调整了儿童年龄、性别、家族遗传, 市区或郊区/农村, 被动吸烟和母乳喂养, 结果显示, 出生前(指母亲怀孕前一年或/和怀孕期间)居住地添置新家居(HNF)与儿童报告的既往哮鸣音[比对比(OR) 1.23, 95%置信区间CI(1.03~1.48)], 及过去12个月内的哮鸣音(1.24, 1.00~1.54)、鼻炎症状(1.26, 1.06~1.51)以及湿疹(1.42, 1.01~1.99)呈正相关. 在0~1岁间的HNF与过去12个月的哮鸣音症状, 及0~1岁间家里新装修(HND)与儿童的既往鼻炎及过去12个月鼻炎和湿疹的症状均呈现正相关. 室内发霉的迹象或室内潮湿几乎与所有儿童的哮喘和过敏性疾病的症状呈现更强的正相关(OR范围在1.23~1.85, P〈0.05). 进一步相互调整了出生前HNF和室内发霉或潮湿的因素, 所有的显著性结果均没有明显变化. 本次研究表明, 出生前居住地添置新家具和室内发霉或潮湿是太原市学龄前儿童哮喘和相关过敏性疾病及症状的独立危险因素. | 赵卓慧 张昕 刘冉冉 NORBACK Dan WIESLANDER Gunilla 陈杰 SUNDELL Jan | 2013 | 科学通报2013，58，25： | 13 |
| 5 | Prenatal and early life home environment exposure in relation to preschool children's asthma, allergic rhinitis and eczema in Taiyuan, China显示文摘Prenatal and early life home environment might be related to children’s asthma or allergic diseases later in life.A cross-sectional epidemiological study was designed and a questionnaire survey was performed in 3700 preschool children in urban areas in Taiyuan,Shanxi Province,China.Questions on children’s asthma and allergic diseases from the International Study on Asthma and Allergies in Childhood(ISAAC)were integrated with questions on home environment from the Swedish Dampness in Buildings and Health(DBH)study,appropriately modified for Chinese life habits.By multivariate regression analyses controlling for age,gender,heredity,location in urban/suburban or rural areas,environmental tobacco smoke(ETS)and breastfeeding,we found that home new furniture(HNF)before birth(referring to 1 year before pregnancy and during pregnancy)was positively associated with wheezing ever(odds ratio(OR)1.23 with 95%CI of 1.03–1.48)and wheezing last 12 months(1.24,1.00–1.54),allergic rhinitis(AR)(1.26,1.06–1.51),and eczema(1.42,1.01–1.99).HNF between 0–1 years old was also positively associated with wheezing last 12 months.Home new decoration(HND)during 0–1 years old was positively associated with AR symptoms and eczema symptoms,more in the last 12 months.Stronger positive associations were found for signs of home mold and dampness with almost all children’s asthmatic and allergic symptoms(OR ranging from 1.23–1.85,P<0.05).By mutual adjustment between HNF before children’s birth and home mold or dampness,all the significance remained unchanged.Prenatal HNF and home mold or dampness was independently associated with children’s asthmatic and allergic diseases later in life. | ZHAO ZhuoHui ZHANG Xin LIU RanRan NORBACK Dan WIESLANDER Gunilla CHEN Jie SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 13 |
| 6 | 一种苦荞麦种子蛋白酶抑制剂的纯化、特性及其抗虫活性(英文)显示文摘蛋白酶抑制剂广泛存在于生物体内,是自然界含量最为丰富且具有一定防御作用的蛋白种类之一.本文采用离子交换层析和凝胶层析等方法,从苦荞麦种子中分离出一种胰蛋白酶抑制剂(TBTI-Ⅱ) .SDS-PAGE分析表明,TBTI-Ⅱ的分子量约9·0 kD,由80个氨基酸残基组成,分子中含有较多的Glu, Asp和Arg. TBTI-Ⅱ具有较高热稳定性.当在100℃加热处理10 min后,仍保留有67·6 %的抑制剂活性.动力学测定显示,来自苦荞麦中的TBTI-Ⅱ对胰蛋白酶的抑制作用常数(Ki)为1·01×10-4mol/L.另外,将含有不同活力单位的苦荞麦蛋白酶抑制剂掺入到棉铃虫的饲料中进行饲养试验显示,TBTI-Ⅱ具有明显的抑制棉铃虫生长的作用.这些结果表明,来自苦荞麦种子中的小分子蛋白酶抑制剂可能是一种潜在的抗虫因子. | 王转花 赵卓慧 张政 袁静明 NOBACK Dan WIESLANDER Gunilla | 2006 | 中国生物化学与分子生物学报2006，22，12： | 7 |
| 7 | 超高效液相色谱/电喷雾串联质谱(UPLC/MS/MS)分析全氟代化合物(PFCs)显示文摘 | Antonietta Gledhill Anna Karman Ingrid Ericson Bert van Bavel Gunilla Linstrom Gordon Kearney | 2007 | 环境化学2007，26，5： | 6 |
| 8 | A Research-Based Teacher Education in Finland --A Dilemma for the Students显示文摘 | Gunilla Eklund | 2014 | Psychology Research2014，4，7： | 3 |
| 9 | A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival显示文摘 | Amelie Kinch Eva Baecklund Carin Backlin Tor Ekman Daniel Molin Gunnar Tufveson Pia Fernberg Christer Sundstr? m Karlis Pauksens Gunilla Enblad | 2014 | Acta Oncologica2014，，5： | 2 |
| 10 | Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock显示文摘 | Jonas Sundén-Cullberg Anna Norrby-Teglund Ari Rouhiainen Heikki Rauvala Gunilla Herman Kevin J. Tracey Martin L. Lee Jan Andersson Leif Tokics Carl Johan Treutiger | 2005 | Critical Care Medicine2005，，3： | 2 |
| 11 | Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage显示文摘一个高精子 DNA 破碎索引(DFI ) 与减少的富饶被联系。DFI 被在反应的氧种类和抗氧化剂之间的平衡影响。在 melatonin,一种抗氧化剂和免费激进的 scavenger 的一个 circannual 变化,能因此影响精液质量和富饶。在主要 melatonin 代谢物,尿 6-sulfatoxymelatonin (aMT6s ) ,和 DFI 之间的协会在 110 个奥斯陆人(北极圈的南方) 和 86 个 Tromsoe 人(北极圈的北方) 被分析。二精液分析,夏天和冬季,和四件尿样品(早 / 晚的夏天;早 / 晚的冬季) ,被分析。在在尿和 DFI 的 aMT6s 之间的协会用关联分析和线性回归以一种代表性、纵的方式被描绘。不管季节和地点,在 aMT6s 和 DFI 之间的重要关联都没被观察。(早冬季早的夏天) 为在变化之间的协会的关联系数随着时间的过去在 aMT6s 和 DFI 为全部的队:rho =− 0.08 (P = 0.322 ) ,为奥斯陆队:rho =− 0.07 (P = 0.485 ) ,并且为 Tromsoe 队:rho =− 0.14 (P = 0.273 ) 分别地。类似的结果被看是否比较迟了的冬季和迟了的夏天。为有 DFI 在下面并且在中部的价值(10%) 上面的人在 aMT6s 和 DFI 随着时间的过去在变化之间没有任何统计上重要的关联分别地。在 melatonin 排泄的季节的变化似乎不在 DFI 上有任何影响。 | Gunilla Maim Trine B Haugen Lars Rylander Aleksander Giwercman | 2017 | Asian Journal of Andrology2017，19，1： | 2 |
| 12 | Hierarchical Chamfer Match- ing:A Parameter Edge Matching Algorithm显示文摘 | | 1988 | IEEE Trans Pattern Anal Machine Intell1988，10，6： | 1 |
| 13 | Increased P53 mutation frequency during tumor progression-results from a breast cancer cohort显示文摘 | Torbjorn N Sigrid K Gunilla K | 2001 | Cancer Res2001，5，61： | 1 |
| 14 | Photolytic debromination of decabromodiphenyl ether(BDE209)显示文摘 | Gunilla Sö derströ m Ulla Sellströ m Cynthiaa Dewit | 2004 | Environ Sci Technol2004，38，1： | 1 |
| 15 | Vegetation changes in semi-natural meadows with unchanged management in southern Sweden, 1965-1990显示文摘 | GUDRUN A L B ANNA-CARIN L E GUNILLA A O | 2000 | Acta Oecologica2000，21，2： | 1 |
| 16 | Photolytic debromination of decabromodiphenyl ether(BDE 209)显示文摘 | Gunilla S Ulla S Wit C A D | 2004 | Environmental Science & Technology2004，38，1： | 1 |
| 17 | Cyclosporin A prevents calpain aetivation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome e and caspase-3 activation in neurons exposed to transient hypoglycemia显示文摘 | MICHEL FERRAND-DRAKE CHANGLIAN ZHU GUNILLA GIDO | 2003 | J Neurochem2003，85，： | 1 |
| 18 | Changing the Amylopectin - Sodium Dodecyl Sulphate Interaction by Modifying the Exterior Chain Length 显示文摘 | Henrik L Gunilla S | 2002 | Starch2002，54，： | 1 |
| 19 | Landscape patterns in mountains,land use and environmental diversity,Mid-Norway 1960-1993显示文摘 | GUNILLA GUNNAR A SYNNOVE N | 2000 | Landscape Ecology2000，15，： | 1 |
| 20 | Application of a perfectly matched layer to the nonlinear wave equation显示文摘 | Daniel Appel? Gunilla Kreiss | 2007 | Wave Motion2007，，7： | 1 |
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