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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 3 | Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL显示文摘 | Dichgans M Markus HS Salloway S | 2008 | Lancet Neurol2008，7，4： | 1 |
| 4 | Donepezil in patients with subcortical vascular cognitive impairment:a randomised double-blind trial in CADASIL 显示文摘 | Dichgans M Markus HS Salloway S | 2008 | Lancet Neurol2008，7，4： | 1 |
| 5 | Twophase3trialsofbap-ineuzumabinmild-to-moderateAlzheimer′sdisease显示文摘 | SallowayS SperlingR FoxNC etal | 2014 | NEnglJMed2014，370，4： | 1 |
| 6 | A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer dis~se显示文摘 | Salloway S Sperling R Gilman S | 2009 | Neurology2009，73，24： | 1 |
| 7 | Glial vascular degeneration in CADASIL 显示文摘 | Brerman-Krohn T Salloway S Correia S | 2010 | J Alzheimers Dis2010，21，4： | 1 |
| 8 | Efficacy of donepezil in mild cognitive impairment:a randomized placebo-controlled trial显示文摘 | Salloway S Ferris S Kluger A Goldman R Griesing T Kumar D Richardson S Donepezil 401 Study Group | | 0，，04： | 1 |
| 9 | Air pollution and the demand for hospital services: a review显示文摘 | WILSON A M SALLOWAY J C WAKE C P | 2004 | Environment International2004，30，8： | 1 |
| 10 | Glial vascular degeneration in CADASIL 显示文摘 | Brennan-Krohn T Salloway S Correia S | 2010 | J Alzheimers Dis2010，21，4： | 1 |
| 11 | Efficacy of donepe-zil in mild cognitive impairment:a randomized placebo-controlled trial显示文摘 | Salloway S Ferris S Kiuger A | 2004 | Neurology2004，63，4： | 1 |
| 12 | Efficacy of donepezil in mild cognitive impairment:a randomized placebo-controlled trial显示文摘 | Ferris S Kluger A | 2004 | Neurology2004，63，： | 1 |
| 13 | (31ial vascular degeneration in CADASIL显示文摘 | Brennan-Krohn T Salloway S+ Correia S | 2010 | J Alzheimers Dis2010，21，： | 1 |
| 14 | Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial显示文摘 | Doody RS Ferris SH Salloway S | 2009 | Neurology2009，72，18： | 1 |
| 15 | Glial vascular degenera- tion in CADASIL显示文摘 | Brennan-Krohn T Salloway S Correia S | 2010 | J Alzheimers Dis2010，21，4： | 1 |
| 16 | Two phase 3 trials of bapi- neuzumab in mild-to-moderate Alzheimer's disease显示文摘 | Salloway S Sperling R Fox N C | 2014 | N Engl J Med2014，370，4： | 1 |
| 17 | Galantamine treatment of vascular dementia:a rando-mized trial显示文摘 | BRASHEAR H R SALLOWAY S KORCZYN A D | 2007 | Neurology2007，69，5： | 1 |
| 18 | Current and future treatments for Alzheimer's disease 显示文摘 | Salloway S | 2009 | CNS Spectr2009，14，87： | 1 |
| 19 | Donepezil in patients with subcortical vascular cognitive impairment:a randomised double-blind trial in CADASIL显示文摘 | Dichgans M Markus HS Salloway S | | 0，，04： | 1 |
| 20 | Donepezil treatment of patients with MCI: A 48-week randomized, placebo-controlled trial显示文摘 | R S. Doody S H. Ferris S Salloway Y Sun R Goldman W E. Watkins Y Xu A K. Murthy | 2009 | Neurology2009，，18： | 1 |
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