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| 1 | The influence of nanotopography on cell behaviour through interactions with the extracellular matrix-A review显示文摘Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions.The extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours,such as determination of integrin ligation and interaction with growth factors.These interactions with the extracellular matrix regulate downstream mechanotransductive pathways,such as rearrangements in the cytoskeleton and activation of signal cascades.Protein adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and,therefore,subsequent cell responses.In this review,we first discuss the interactive mechanisms of protein physical adsorption on nanotopography.Secondly,we summarise advances in creating nanotopographical features to instruct desired cell behaviours.Lastly,we focus on the cellular mechanotransductive pathways initiated by nanotopography.This review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future. | Jiajun Luo Matthew Walker Yinbo Xiao Hannah Donnelly Matthew J.Dalby Manuel Salmeron-Sanchez | 2022 | Bioactive Materials2022，7，9： | 3 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog显示文摘 | Michael Rera Sepehr Bahadorani Jaehyoung Cho Christopher L. Koehler Matthew Ulgherait Jae H. Hur William S. Ansari Thomas Lo D. Leanne Jones David W. Walker | 2011 | Cell Metabolism2011，，5： | 2 |
| 4 | 三维炭纤维预型体上烷烃气的催化炭沉积(英文)显示文摘研究了承载镍催化剂的三维(3D)炭纤维预型体,在含氢或无氢条件下,乙烷和合成天然气在其上面化学气相沉积形成的炭沉积率和碳纳米构结物。观察了炭沉积所获石墨纳米纤维、碳纳米管和石墨碳壳,得知沉积碳的纳米结构取决于沉积温度和碳源气组成。在650℃~800℃温间,总沉积时程直至12h,研究了烃类碳源气在氢气平衡下,从体积分数100%到20%变化情况。经Ni(NO3)2-6H2O甲醇溶液浸渍的3D炭纤维预型体在炭沉积前因溶液分解可还原出Ni。采用质量变化测定法、热谱-质谱分析仪、SEM、TEM和XRD对样品进行表征。结果表明:纤维状炭与囊包炭的比率随氢气含量的增加而增加,随反应温度的增高而减少。出乎意料的是,氢气的添加并不延长催化剂的寿命。该工艺过程对炭/炭复合材料的制备展示出良好的潜力。 | Matthew J Thornton Gavin S Walker | 2009 | 新型炭材料2009，24，3： | 2 |
| 5 | A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis显示文摘 | Matthew Walker Barry R. Campbell Karim Azer Christopher Tong Kaijie Fang Jacquelynn J. Cook Michael J. Forrest Kimberly Kempadoo Samuel D. Wright Jeffrey S. Saltzman Euan MacIntyre Richard Hargreaves | 2009 | Atherosclerosis2009，，1： | 1 |
| 6 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 7 | Measuring the Social ImpactsAssociated with Super Bowl XLIII : Preliminary Development of a PsychicIncome Scale显示文摘 | KIM Woosoon WALKER Matthew | 2012 | Sport Management Review2012，15，1： | 1 |
| 8 | Measuring the Social Impacts Associated with Super Bowl XLIII:Preliminary Development of a Psychic Income Scale显示文摘 | Woosoon Kima Matthew Walker | 2012 | Sport Management Review2012，15，： | 1 |
| 9 | Social Responsibility and the Olympic Games: The Mediating Role of Consumer Attributions显示文摘 | Matthew Walker Bob Heere Milena M. Parent Dan Drane | 2010 | Journal of Business Ethics2010，，： | 1 |
| 10 | Lactic acid bacteria as a potential source of enzymes for use in vinification显示文摘 | MATTHEWS A GRIMALDI A WALKER M | | 0，，10： | 1 |
| 11 | Lactic acid bacteria as a potential source of enzymes for use in vinification 显示文摘 | Matthews A Grimaldi A Walker M | 2004 | Applied and Environmental Microbiology2004，70，： | 1 |
| 12 | Sleep, Memory and Plasticity 显示文摘 | Matthew P Walker Robert Stickgold | 2006 | Annual Review of Psychology2006，57，9： | 1 |
| 13 | Elements affecting wound healing time: An evidence based analysis显示文摘 | Hanan Khalil Marianne Cullen Helen Chambers Matthew Carroll Judi Walker | 2015 | Wound Rep and Reg2015，，4： | 1 |
| 14 | Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humans显示文摘 | Serge Vulliemoz David W. Carmichael Karin Rosenkranz Beate Diehl Roman Rodionov Matthew C. Walker Andrew W. McEvoy Louis Lemieux | 2010 | Neuroimage2010，，1： | 1 |
| 15 | Case report: pulmonary blastoma : presentation of two atypical cases and review of the literature显示文摘 | Walker RI Suvarna K Matthews S | 2005 | Br J Radiol2005，78，929： | 1 |
| 16 | Overnight alchemy: sleep-dependent memory evolution 显示文摘 | Matthew P Walker Robert Stickgold | 2010 | Neuroscience2010，11，3： | 1 |
| 17 | Sleep-dependent memory triage:evolving generalization through selective processing 显示文摘 | Robert Stickgold Matthew P Walker | 2013 | Nature Neuroscience2013，016，2： | 1 |
| 18 | Cognitive consequences of sleep and sleep loss显示文摘 | Matthew P Walker | 2008 | Sleep Med2008，9，1： | 1 |
| 19 | Posterior Reversible Encephalopathy Syndrome and Venous Thrombosis显示文摘 | Bojan D. Petrovic Alexander J. Nemeth Erin N. McComb Matthew T. Walker | 2011 | Radiologic Clinics of North America2011，，1： | 1 |
| 20 | Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control显示文摘 | Thanh Nguyen Joyce Obeid Rachel G Walker Matthew P Krause Thomas J Hawke Karen McAssey John Vandermeulen Brian W Timmons | 2015 | Pediatr Diabetes2015，，1： | 1 |
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