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| 1 | Current approaches in treatment of triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is diagnosed more frequently in younger and premenopausal women and is highly prevalent in African American women. TNBC is a term derived from tumors that are characterized by the absence of ER, Pg R, and HER2. So patients with TNBC do not benefit from hormonal or trastuzumab-based therapies. TNBCs are biologically aggressive, although some reports suggest that they respond to chemotherapy better than other types of breast cancer, prognosis remains poor. This is due to: shortened disease-free interval in the adjuvant and neoadjuvant setting and a more aggressive course in the metastatic setting. | Hanan Ahmed Wahba Hend Ahmed El-Hadaad | 2015 | Cancer Biology & Medicine2015，12，2： | 20 |
| 2 | E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome显示文摘瞄准:调查在颜色在转移的进程期间发生在 E-cadherin 表示的变化表面的癌症。方法:E-cadherin 表示被免疫组织化学检测,表示的二个索引是计算的它反映了表示和地点(膜和细胞质) 的水平。Univariate 并且多,变量幸存分析被用来作为两个的预言者估计这二个 E-cadherin 索引的价值没有疾病(DFS ) 并且疾病特定(决策支持系统) 幸存。结果:E-cadherin 膜索引(MI ) ,然而并非细胞质的索引(CI ) ,比他们的转移在原发性瘤是显著地更高的(P = 0.0001 ) 。而且,原发性瘤 MI 和 CI 在开发了随后的转移的病人之中是更高的(P = 0.022 并且 P = 0.007,分别地) 。有趣地,两个索引在与另外的解剖地点相比的肝转移是更高的(MI, P = 0.034 并且 CI, P = 0.022 ) 。原发性瘤的 CI 是 DFS 的一个重要预言者(P = 0.042, univariate 分析) ,与在 CI 和 DFS 之间的强壮的反的关联(P = 0.006,多变量分析) 。最后,原发性瘤的 MI 证明了是决策支持系统的一个重要独立预言者,与与更有利的结果被联系的更高的索引(P = 0.016 ) 。结论:在颜色的 E-cadherin 表示和分发的检查表面的肿瘤能在预言是极其珍贵的疾病复发。E-cadherin 的异常细胞质的表示能预言疾病复发为病人和临床医生显然是很重要的,并且显著地有关病人的治疗和管理影响决定的观察。 | Adam Elzagheid Annika lgars Riyad Bendardaf Hanan Lamlum Raija Ristamaki Yrjo Collan Kari Syrjanen Seppo Pyrhonen | 2006 | World Journal of Gastroenterology2006，12，27： | 17 |
| 3 | Early diagnostic evaluation of miR-122 and miR-224 as biomarkers for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the common lethal types of tumor all over the world.The lethality of HCC accounts for many reasons.One of them,the lack of reliable diagnostic markers at the early stage,in this context,serum miRNAs became promising diagnostic biomarkers.Herein,we aimed to identify the predictive value of two miRNAs(miR-122 and miR-224)in plasma of patients with HCC preceded by chronic HCV infection.Taqman miRNA assays specific for hsa-miR-122 and hsa-miR-224 were used to assess the expression levels of the chosen miRNAs in plasma samples collected from three groups;40 patients with HCC related to HCV,40 with CHC patients and 20 healthy volunteers.This study revealed that the mean plasma values of miRNA-122 were significantly lower among HCC group when compared to CHC and control groups(P<0.001).Whereas,miR-224 mean plasma values were significantly higher among HCC group when compared to both CHC group and control group.Moreover,it was found that miR-122 can predict development of HCC at cut-off value<0.67(RQ)and(AUC Z 0.98,P<0.001).As regards miR-224,it can predict development of HCC at cut-off value>1.2(RQ)and(AUC Z 0.93,P<0.001),while the accuracy of AFP to diagnose HCC was(AUC:0.619;P Z 0.06).In conclusion,the expression plasma of miR-122 and miR-224 could be used as noninvasive biomarkers for the early prediction of developing HCC at the early stage. | Khalda S.Amr Hanan Abd Elmawgoud Atia Rehab Abd Elazeem Elbnhawy Wafaa M.Ezzat | 2017 | Genes & Diseases2017，4，4： | 17 |
| 4 | Autologous CD34^+ and CD133^+ stem cells transplantation in patients with end stage liver disease显示文摘AIM:To assess the utility of an autologous CD34 + and CD133 + stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases.METHODS:One hundred and forty patients with endstage liver diseases were randomized into two groups.Group 1,comprising 90 patients,received granulocyte colony stimulating factor for five days followed by autologous CD34 + and CD133 + stem cell infusion in the portal vein.Group 2,comprising 50 patients,received regular liver treatment only and served as a control group.RESULTS:Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients;13.6% of the patients showed stable states in the infused group.None of the patients in the control group showed improvement.No adverse effects were noted.CONCLUSION:Our data showed that a CD34 + and CD133 + stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability. | Hosny Salama Abdel-Rahman N Zekri Abeer A Bahnassy Eman Medhat Hanan A Halim Ola S Ahmed Ghada Mohamed Sheren A Al Alim Ghada M Sherif | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 5 | Biomass-Based Rice (Oryza sativa L.) Aboveground Architectural Parameter Models显示文摘To quantify the relationships between rice plant architecture parameters and the corresponding organ biomass, and to research on functional structural plant models of rice plant, this paper presented a biomass-based model of aboveground architectural parameters of rice (Oryza sativa L.) in the young seedling stage, designed to explain effects of cultivars and environmental conditions on rice aboveground morphogenesis at the individual leaf level. Various model variables, including biomass of blade and blade length, were parameterized for rice based on data derived from an outdoor experiment with rice cv. Liangyou 108, 86You 8, Nanjing 43, and Yangdao 6. The organ dimensions of rice aboveground were modelled taking corresponding organ biomass as an independent variable. Various variables in rice showed marked consistency in observation and simulation, suggesting possibilities for a general rice architectural model in the young seedling stage. Our descriptive model was suitable for our objective. However, they can set the stage for connection to physiological model via biomass and development of functional structural rice models (FSRM), and start with the localized production and partitioning of assimilates as affected by abiotic growth factors. The finding of biomass-based rice architectural parameter models also can be used in morphological models of blade, sheath, and tiller of the other stages in rice life. | CAO Hong-xin LIU Yan LIU Yong-xia Jim Scott Hanan YUE Yan-bin ZHU Da-wei LU Jian-fei SUN Jin-ying SHI Chun-lin GE Dao-kuo WEI Xiu-fang YAO An-qing TIAN Ping-ping BAO Tai-lin | 2012 | Journal of Integrative Agriculture2012，11，10： | 11 |
| 6 | 基于交叉耦合效应的车用内置式永磁电机转子位置估计显示文摘该文提出一种基于滑模观测器和基于凸极效应信号注入相结合的、考虑电机中电感交叉耦合效应的内置式永磁同步电机无速度传感器控制方法。系统在硬件在环平台中实验。直轴和交轴电感间的交叉耦合效应由有限元法算得。所提出的方法能使内置式永磁同步电机获得更好的运行性能。硬件在环平台验证了Matlab/Simulink的结果。样机实验得到的结果与Matlab仿真以及硬件在环实验的结果相吻合。实验结果表明,所提出的算法是有效的,硬件在环平台在一定程度上能模拟样机实验。 | Hanan M.Habbi 黄苏融 高瑾 朱培骏 | 2012 | 中国电机工程学报2012，32，15： | 10 |
| 7 | Phytotherapy in diabetes: Review on potential mechanistic perspectives显示文摘Diabetes mellitus(DM) is a widely spread epidemic dis ease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multi factorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Tradition ally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the differen literature resources and various database and in view o the above aspects, the present article provides a com prehensive review on the available antidiabetic plants that have been approved by pharmacological and clini cal evaluations, and which their mechanism(s) of ac tion is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from in testine, increasing insulin secretion from the pancreasinhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying. | Hanan S El-Abhar Mona F Schaalan | 2014 | World Journal of Diabetes2014，5，2： | 8 |
| 8 | 丙肝病毒相关的 hepatocellular 癌: 卓见进分子的机制和治疗学的策略显示文摘 Hepatitis C virus(HCV) infects more than 170 million people worldwide,and thereby becomes a series global health challenge.Chronic infection with HCV is considered one of the major causes of end-stage liver disease including cirrhosis and hepatocellular carcinoma.Although the multiple functions of the HCV proteins and their impacts on the modulation of the intracellular signaling transduction processes,the drive of carcinogenesis during the infection with HCV,is thought to result from the interactions of viral proteins with host cell proteins.Thus,the induction of mutator phenotype,in liver,by the expression of HCV proteins provides a key mechanism for the development of HCV-associated hepatocellular carcinoma(HCC).HCC is considered one of the most common malignancies worldwide with increasing incidence during the past decades.In many countries,the trend of HCC is attributed to several liver diseases including HCV infection.However,the development of HCC is very complicated and results mainly from the imbalance between tumor suppressor genes and oncogenes,as well as from the alteration of cellular factors leading to a genomic instability.Besides the poor prognosis of HCC patients,this type of tumor is quite resistance to the available therapies.Thus,understanding the molecular mechanisms,which are implicated in the development of HCC during the course of HCV infection,may help to design a general therapeutic protocol for the treatment and/or the prevention of this malignancy.This review summarizes the current knowledge of the molecular mechanisms,which are involved in the development of HCV-associated HCC and the possible therapeutic strategies. | Denis Selimovic Abdelouahid El-Khattouti Hanan Ghozlan Youssef Haikel Ola Abdelkader Mohamed Hassan | 2012 | World Journal of Hepatology2012，4，12： | 7 |
| 9 | Using passive cooling strategies to improve thermal performance and reduce energy consumption of residential buildings in U.A.E. buildings显示文摘 | Hanan M. Taleb | 2014 | Frontiers of Architectural Research2014，3，2： | 7 |
| 10 | Concomitant-chemoradiotherapy-associated oral lesions in patients with oral squamous-cell carcinoma显示文摘Objective:Oral squamous-cell carcinoma(OSCC)accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life.The most common OSCC treatment is concomitant chemoradiotherapy(CCRT)having both locoregional and distant control,but CCRT has acute and chronic toxic effects on adjacent normal tissue.This study aimed to determine the side effects of CCRT on the oral mucosa and to characterize the clinicopathology of oral lesions in patients with OSCC.Methods:This descriptive,cross-sectional study was certified by the Ethical Review Committee(UHS/Education/126-12/2728)of the University of Health Sciences,Lahore,Pakistan.OSSC patients(n=81)with various histological subtypes,grades,and stages were recruited,and findings on their oral examination were recorded.These patients received 70,90,and 119 Gy of radiotherapy dosages in combination with the chemotherapy drugs cisplatin and 5-fluorouracil.Data were analyzed using SPSS 20.0.Results:The most common presentation of OSCC was a nonhealing ulcer(63%) involving tongue(55.6%).Clinical findings included mucositis(92.6%)and xerostomia of mild,moderate,and severe degrees in 11.1%,46.9%,and 35.8% cases,respectively.Ulcers(87.7%),palpable lymph nodes(64.2%),limited mouth opening(64.2%)and fistula(40.7%) were also observed.In females,the association of radiotherapy dosage with limited mouth opening,xerostomia,and histological grading was statistically significant(P<0.05).The association of chemotherapy drugs with xerostomia(P=0.003)was also statistically significant.Conclusions:CCRT induced mucositis,xerostomia,and trismus in patients with OSCC. | Sadia Minhas Muhammad Kashif Wasif Altaf Nadeem Afzal Abdul Hanan Nagi | 2017 | Cancer Biology & Medicine2017，14，2： | 6 |
| 11 | Antioxidant Effect of Sepia Ink Extract on Extrahepatic Cholestasis Induced by Bile Duct Ligation in Rats显示文摘Objective The aim of our study was to assess the complications of hepatic fibrosis associated with bile duct ligation and the potential curative role of sepia ink extract in hepatic damage induced by bile duct ligation. Methods Rattus norvegicus rats were divided into 3 groups: Sham-operated group, model rats that underwent common bile duct ligation(BDL), and BDL rats treated orally with sepia ink extract(200 mg/kg body weight) for 7, 14, and 28 d after BDL. Results There was a significant reduction in hepatic enzymes, ALP, GGT, bilirubin levels, and oxidative stress in the BDL group after treatment with sepia ink extract. Collagen deposition reduced after sepia ink extract treatment as compared to BDL groups, suggesting that the liver was repaired. Histopathological examination of liver treated with sepia ink extract showed moderate degeneration in the hepatic architecture and mild degeneration in hepatocytes as compared to BDL groups. Conclusion Sepia ink extract provides a curative effect and an antioxidant capacity on BDL rats and could ameliorate the complications of liver cholestasis. | Hanan Saleh Amel M Soliman Ayman S Mohamed Mohamed-Assem S Marie | 2015 | Biomedical and Environmental Sciences2015，28，8： | 6 |
| 12 | Silicon-mediated highly efficient synthesis of 1,8-dioxo-octahydroxanthenes and their transformation to novel functionalized pyrano-tetrazolo[1,5-a]azepine derivatives显示文摘A facile and highly efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthene derivatives was achieved through cascade Knoevenagel-Michael condensations and cyclo-dehydration reaction utilizing tetrachlorosilane(TCS) as catalyst under mild conditions.Reaction of the titled compounds with TCSNaN_3 to give novel functionalized pyrano[3,2-c]tetrazolo[1,5-a]azepine derivatives is also described. | Hanan A.Soliman Tarek A.Salama | 2013 | Chinese Chemical Letters2013，24，5： | 5 |
| 13 | Layered double hydroxide(LDH)-based materials:A mini-review on strategies to improve the performance for photocatalytic water splitting显示文摘The high energy demand we currently face in society and the subsequent large consumption of fossil fuels cause its depletion and increase the pollution levels.The quest for the production of clean energy from renewable and sustainable sources remains open.The conversion of solar energy into hydrogen via the water-splitting process,assisted by pho tores pons ive semiconductor catalysts,is one of the most promising technologies.Significant progress has been made on water splitting in the past few years and a variety of photocatalysts active not only under ultra-violet(UV) light but especially with the visible part of the electromagnetic spectrum have been developed.Layered double hydroxides(LDH)-based materials have emerged as a promising class of nanomaterials for solar energy applications owing to their unique layered structure,compositional flexibility,tunable bandgaps,ease of synthesis and low manufacturing costs.This review covers the most recent research dedicated to LDH materials for photocatalytic water-splitting applications and encompasses a range of synthetic strategies and post-modifications used to enhance their performance.Moreover,we provide a thorough discussion of the experimental conditions crucial to obtaining improved photoactivity and highlight the impact of some specific parameters,namely,catalysts loading,cocatalysts,sacrificial agents,and irradiation sources.This review provides the necessary tools to select the election technique for adequately enhancing the photoactivity of LDH and modified LDH-based materials and concludes with a critical summary that outlines further research directions. | Hanane Boumeriame Eliana S.Da Silva Alexey S.Cherevan Tarik Chafik Joaquim L.Faria Dominik Eder | 2022 | Journal of Energy Chemistry2022，31，1： | 5 |
| 14 | 发生医疗差错后,医务人员也需要帮助第二受害者的需求常常被忽视显示文摘发生医疗差错或不良事件后,医务人员常因难以控制自己的情绪而陷入沉默。他们仍然需要照顾好下一个患者,却很少有机会讨论事件的细节,或表达事件对个人及工作的影响。如果患者和家属在此类事件中是第一受害者,那么牵扯人事件的医务人员则可以称为第二受害者。 | Hanan Edrees researcher Frank Fedefico executive director 黄鹂 吴东校 | 2015 | 英国医学杂志中文版2015，0，10： | 4 |
| 15 | L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction显示文摘Bone resorption requires the formation of complex, actin-rich cytoskeletal structures. During the early phase of sealing ring formation by osteoclasts, L-plastin regulates actin-bundling to form the nascent sealing zones(NSZ). Here, we show that L-plastin knockout mice produce osteoclasts that are deficient in the formation of NSZs, are hyporesorptive, and make superficial resorption pits in vitro. Transduction of TAT-fused full-length L-plastin peptide into osteoclasts from L-plastin knockout mice rescued the formation of nascent sealing zones and sealing rings in a time-dependent manner. This response was not observed with mutated full-length L-plastin(Ser-5 and-7 to Ala-5 and-7) peptide. In contrast to the observed defect in the NSZ, L-plastin deficiency did not affect podosome formation or adhesion of osteoclasts in vitro or in vivo. Histomorphometry analyses in 8-and 12-week-old female L-plastin knockout mice demonstrated a decrease in eroded perimeters and an increase in trabecular bone density, without a change in bone formation by osteoblasts. This decrease in eroded perimeters supports that osteoclast function is attenuated in L-plastin knockouts. Micro-CT analyses confirmed a marked increase in trabecular bone mass. In conclusion, female L-plastin knockout mice had increased trabecular bone density due to impaired bone resorption by osteoclasts. L-plastin could be a potential target for therapeutic interventions to treat trabecular bone loss. | Meenakshi AChellaiah Megan CMoorer Sunipa Majumdar Hanan Aljohani Sharon CMorley Vanessa Yingling Joseph PStains | 2020 | Bone Research2020，8，1： | 4 |
| 16 | Diabetic macular edema:New promising therapies显示文摘The treatment of diabetic macular edema is rapidly evolving.The era of laser therapy is being quickly replaced by an era of pharmacotherapy.Several pharmacotherapies have been recently developed for the treatment of retinal vascular diseases such as diabetic macular edema.Several intravitreal injections or sustained delivery devices have undergone phase 3 testing while others are currently being evaluated.The results of clinical trials have shown the superiority of some of these agents to laser therapy.However,with the availability of several of these newer agents,it may be difficult to individualize treatment options especially those patients respond differently to various therapies.As such,more effort is still needed in order to determine the best treatment regimen for a given patient.In this article,we briefly summarize the major new therapeutic additions for the treatment of diabetic macular edema and allude to some future promising therapies. | Hanan N Al Shamsi Jluwi S Masaud Nicola G Ghazi | 2013 | World Journal of Diabetes2013，4，6： | 4 |
| 17 | An efficient synthesis of bis(indolyl)methanes and N,N'-alkylidene bisamides by Silzic under solvent free conditions显示文摘An operationally simple and green method for the synthesis of a wide range of bis(indolyl)methanes,and N,N'-alkylidene bisamides under mild conditions,with excellent yields using Silzic,has been developed.This improved method furnishes in good yields bis(indolyl)methanes derivatives starting from indole and aldehydes,or ketones,and N,N'-alkylidene bisamides derivatives starting from acetamide and aldehydes.The catalytic system was reused up to three times with the same efficiency. | Hanan A.Soliman Ahmed Y.Mubarak Saad S.Elmorsy | 2016 | Chinese Chemical Letters2016，27，3： | 4 |
| 18 | Anti-inflammatory activity of the glandular extracts of Thunnus alalunga显示文摘Objective:To evaluate the anti-inflamattory activity of Thunnus alalunga by both in vitro and in vivo methods.Methods:Anti-inflammatory activity of the chloroform water extract of Thunnus alalunga was done by both in vitro and in vivo methods.In vitro method was done by human red blood cells membrane stabilization method(HRBC).In vivo evaluation was estimated on Wister albino rats.Acute toxicity studies were done on the extract and no toxicity was reported.Results: The percentage protection exhibited by 300 mg/mL concentration was more when compared to the other ones.The 400 mg/mL concentration showed potent activity on comparison with the standard during in vivo evaluation.Conclusions:In both means of estimation the extract of Thunnus alalunga was found to possess significant anti-inflammatory activity. | A.K.Azeem C Dilip S S Prasanth V Junise Hanan Shahima Kumsr Sajeev C.Naseera | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 3 |
| 19 | Adjuvant Pelvic Radiotherapy vs.Sequential Chemoradiotherapy for High-Risk StageⅠ-ⅡEndometrial Carcinoma显示文摘Objective To explore if the addition of adjuvant chemotherapy with paclitaxel and carboplatin to radiotherapy confers an advantage for overall survival(OAS),and progression free survival(PFS);to assess the incidence of relapses over standard pelvic radiotherapy; and to evaluate the related toxicity in high-risk stageⅠ-Ⅱendometrial carcinoma Methods Medical records were reviewed to identify high-risk stageⅠ-Ⅱendometrial carcinoma cases treated in the Clinical Oncology and Nuclear Medicine department between 2002 and 2008 with adjuvant radiotherapy alone(armⅠ)(57 patients) or with sequential carboplatin(AUC5-6) and paclitaxel(135-175 mg/m^2) with radiotherapy(armⅡ)(51 patients).Radiotherapy was performed through the four-field box technique at doses of 45-50 Gy(1.8 Gy/day×5 days/week). Results The toxicity was manageable and predominantly hematologic with a grade 3 neutropenia and thrombocytopenia in 9.8% and 6% of the patients in armⅠand armⅡ,respectively,without febrile neutropenia.All patients experienced hair loss. Chemoradiotherapy arm was associated with a lower incidence rate of relapse(9.8% vs.22.7% ).After a median follow-up period of 48 months,the 5-year OAS and PFS rates for chemoradiotherapy-treated patients were significantly more favorable than those who did not receive chemotherapy(P=0.02 and 0.03,respectively).In armⅠ,the OAS and PFS rates were 73.7% and 66.7% compared with those in armⅡ,whose rates were 90.2% and 84.3% . Conclusions Adjuvant chemoradiation with paclitaxel and carboplatin improved the survival rates and decreased the recurrence rates in patients with high-risk stageⅠ-Ⅱendometrial carcinoma.Chemotherapy was associated with an acceptable rate of toxicity. However,a prospective study with a larger number of patients is needed to define a standard adjuvant treatment for high-risk stageⅠ-Ⅱendometrial carcinoma. | Hend Ahmed El-Hadaad Hanan Ahmed Wahba Anas Mohamed Gamal Tamer Dawod | 2012 | Clinical oncology and cancer resexreh2012，9，3： | 3 |
| 20 | Lanthanide amino acid Schiff base complexes:synthesis,spectroscopic characterization,physical properties and in vitro antimicrobial studies显示文摘Complexes of La(Ⅲ),Nd(Ⅲ),Gd(Ⅲ),Sm(Ⅲ),and Ce(Ⅳ) were synthesized with Schiff base [(3,5-di-tert-butyl-2-hydroxybenzyl) amino] acetic acid(H 3 L).The ligand and its complexes were synthesized and characterized based on the following analysis:elemental analyses,FAB-mass,molar conductance measurements,magnetic measurement,UV-visible,IR,and NMR spectral studies.The spectral data revealed that the ligand acted as a neutral tridentate coordinating to metal ion through ONO donor sequence.Thermal degradation studies of the ligand and its complexes showed that the previous lanthanide complexes were more thermally stable than the ligand itself.The Schiff base and its complexes were screened for their antibacterial(Escherichia coli,Staphylococcus aureus) and antifungal(Aspergillus flavus and Candida Albicans). | Samir Alghool M.Sh.Zoromba Hanan F.Abd El-Halim | 2013 | Journal of Rare Earths2013，31，7： | 3 |
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